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The map label for this gene is trxA [H]

Identifier: 238024468

GI number: 238024468

Start: 1358988

End: 1360211

Strand: Direct

Name: trxA [H]

Synonym: bglu_2g10640

Alternate gene names: 238024468

Gene position: 1358988-1360211 (Clockwise)

Preceding gene: 238024467

Following gene: 238024469

Centisome position: 48.07

GC content: 67.57

Gene sequence:

>1224_bases
ATGAGCAGCTTGAAAAGTGTGACCGAAGCGAGCTTCGAGGCCGATGTGACGCTGAACAGCCGTCCGGTGCTGATCGACTT
CTGGGCGGAATGGTGCGGGCCGTGCAAGGCGCTGGCGCCGACGCTCGAGAAAGTGGCGCGGAACTTCGAAGGCAAGGTCG
ACATCGTCAAGGTCAACGTCGATGAGCATCCTGGCCTGCGCGAGCGCTTTGGCGTGCGCGGCATTCCCGCGCTGGTGCTG
ATGAACGGCGCCGACGAGGCGGGCCGCATCGTGGGCAACCGCACCGCCACGCAGCTCGCGAGCTACCTGGATGCGCACCT
GGGAACCGCCACGCAACTGGCCAAGCCCGCCGTCACGCTGTCCGCGTTCGGCGGCGATGCGCAGCTGAAAGCCGAGCGGA
TCGCTCGATTGCGCGACTATCTCGAACTCAAGCAGGCCGATCCGAATACGCCCATGTGGCCGGAAAAGGTCACCGGCGCG
CTCGCCTACGTGGCCGGCACCTCCGATCCGGACGAGTGCGCGGTCGCGCTGGGCATGCCGACCGACGTGCTCGATACCGT
GGCGTCGCTCTCGACCTACCGGAGCACGCATTTGAACGGCGCGCGGTTCGTCGCCGACTGGCTGGAGAGCGTCCCGGTGG
GCGCCGACCTCTCGGCGTTGCCGGGCCGGCTGCTCAACGAGATTCTGGCGAGTCCGCTCGTCTCGGACACCTTGGACGGC
GACGCGGCGTTGCTCGCGATTCGCGACGAACTTGCCGCGCTGCATGCCGCGGAGGCGGGCGGTGCCCAGCTGCCGGAGGA
GAAGTGGGCGGCCGTCGCGCAAGCGGCCCGCGAGGTGGTCGCCGCGCCCGCCGAAGGAAACCGGACGAGGGCCGCCGCGG
TGCTGGTCGCCGCGTCGTCGTCGCTGGCCCGCAACCCGGACATGCTGAAGGACTTCGTCAGCGTGCTTTGCCGATTCGTC
CAGGAATGCCTGAAGGCCAAGTGCCACTGGGGCGCCGAGGATGAATCGCGTCTGTTCAAATTGATGGACGGCATCTTCAA
GCATGCGCTCGACACCGGCGCCGAGCCGCCGAGAGGCCCCGCAATGATGAAACATGTCGCGGAGATCGATCCCCGGCTGG
CCGAGCGATTCCTGTTCCAGTACGAAGAAGGCGACCGTGCCTCGCGCGAACGGGGCGGCGCGATCGGCGACATGCTGATT
TCGCTGACCCGCCGGTGTGCCTGA

Upstream 100 bases:

>100_bases
GTCCGCGTATCCGGCATGACCCCGCGATGGCGTCGCGACGATGCCGGTGGGTCGGTCGGGCAAGGCCCGACGAGATAGAA
CTTGTAAACAGGAATCTGAA

Downstream 100 bases:

>100_bases
GACATGCGATGCACGATGCCGGATGGCGAAGGAGGAGCAGGCTGATGCAATCGAGCCGTATGCAGTGGCAGGAGCTTGCC
GCGGAGCTGGAGACTTCGGC

Product: Thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSSLKSVTEASFEADVTLNSRPVLIDFWAEWCGPCKALAPTLEKVARNFEGKVDIVKVNVDEHPGLRERFGVRGIPALVL
MNGADEAGRIVGNRTATQLASYLDAHLGTATQLAKPAVTLSAFGGDAQLKAERIARLRDYLELKQADPNTPMWPEKVTGA
LAYVAGTSDPDECAVALGMPTDVLDTVASLSTYRSTHLNGARFVADWLESVPVGADLSALPGRLLNEILASPLVSDTLDG
DAALLAIRDELAALHAAEAGGAQLPEEKWAAVAQAAREVVAAPAEGNRTRAAAVLVAASSSLARNPDMLKDFVSVLCRFV
QECLKAKCHWGAEDESRLFKLMDGIFKHALDTGAEPPRGPAMMKHVAEIDPRLAERFLFQYEEGDRASRERGGAIGDMLI
SLTRRCA

Sequences:

>Translated_407_residues
MSSLKSVTEASFEADVTLNSRPVLIDFWAEWCGPCKALAPTLEKVARNFEGKVDIVKVNVDEHPGLRERFGVRGIPALVL
MNGADEAGRIVGNRTATQLASYLDAHLGTATQLAKPAVTLSAFGGDAQLKAERIARLRDYLELKQADPNTPMWPEKVTGA
LAYVAGTSDPDECAVALGMPTDVLDTVASLSTYRSTHLNGARFVADWLESVPVGADLSALPGRLLNEILASPLVSDTLDG
DAALLAIRDELAALHAAEAGGAQLPEEKWAAVAQAAREVVAAPAEGNRTRAAAVLVAASSSLARNPDMLKDFVSVLCRFV
QECLKAKCHWGAEDESRLFKLMDGIFKHALDTGAEPPRGPAMMKHVAEIDPRLAERFLFQYEEGDRASRERGGAIGDMLI
SLTRRCA
>Mature_406_residues
SSLKSVTEASFEADVTLNSRPVLIDFWAEWCGPCKALAPTLEKVARNFEGKVDIVKVNVDEHPGLRERFGVRGIPALVLM
NGADEAGRIVGNRTATQLASYLDAHLGTATQLAKPAVTLSAFGGDAQLKAERIARLRDYLELKQADPNTPMWPEKVTGAL
AYVAGTSDPDECAVALGMPTDVLDTVASLSTYRSTHLNGARFVADWLESVPVGADLSALPGRLLNEILASPLVSDTLDGD
AALLAIRDELAALHAAEAGGAQLPEEKWAAVAQAAREVVAAPAEGNRTRAAAVLVAASSSLARNPDMLKDFVSVLCRFVQ
ECLKAKCHWGAEDESRLFKLMDGIFKHALDTGAEPPRGPAMMKHVAEIDPRLAERFLFQYEEGDRASRERGGAIGDMLIS
LTRRCA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=37.1134020618557, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI21361657, Length=112, Percent_Identity=33.9285714285714, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=43.1372549019608, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788936, Length=86, Percent_Identity=40.6976744186046, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=103, Percent_Identity=30.0970873786408, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=96, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=41.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639826, Length=95, Percent_Identity=35.7894736842105, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 43639; Mature: 43508

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLKSVTEASFEADVTLNSRPVLIDFWAEWCGPCKALAPTLEKVARNFEGKVDIVKVNV
CCCHHHHHHHCCCEEEEECCCCEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEC
DEHPGLRERFGVRGIPALVLMNGADEAGRIVGNRTATQLASYLDAHLGTATQLAKPAVTL
CCCCCHHHHCCCCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHCCCEEE
SAFGGDAQLKAERIARLRDYLELKQADPNTPMWPEKVTGALAYVAGTSDPDECAVALGMP
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEECCCCHHHHEEEECCC
TDVLDTVASLSTYRSTHLNGARFVADWLESVPVGADLSALPGRLLNEILASPLVSDTLDG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCHHHHHCCCC
DAALLAIRDELAALHAAEAGGAQLPEEKWAAVAQAAREVVAAPAEGNRTRAAAVLVAASS
CCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEEECCH
SLARNPDMLKDFVSVLCRFVQECLKAKCHWGAEDESRLFKLMDGIFKHALDTGAEPPRGP
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
AMMKHVAEIDPRLAERFLFQYEEGDRASRERGGAIGDMLISLTRRCA
HHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSLKSVTEASFEADVTLNSRPVLIDFWAEWCGPCKALAPTLEKVARNFEGKVDIVKVNV
CCHHHHHHHCCCEEEEECCCCEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEEC
DEHPGLRERFGVRGIPALVLMNGADEAGRIVGNRTATQLASYLDAHLGTATQLAKPAVTL
CCCCCHHHHCCCCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHCCCEEE
SAFGGDAQLKAERIARLRDYLELKQADPNTPMWPEKVTGALAYVAGTSDPDECAVALGMP
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEECCCCHHHHEEEECCC
TDVLDTVASLSTYRSTHLNGARFVADWLESVPVGADLSALPGRLLNEILASPLVSDTLDG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHCHHHHHCCCC
DAALLAIRDELAALHAAEAGGAQLPEEKWAAVAQAAREVVAAPAEGNRTRAAAVLVAASS
CCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEEECCH
SLARNPDMLKDFVSVLCRFVQECLKAKCHWGAEDESRLFKLMDGIFKHALDTGAEPPRGP
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
AMMKHVAEIDPRLAERFLFQYEEGDRASRERGGAIGDMLISLTRRCA
HHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]