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The map label for this gene is ghrA [H]

Identifier: 238024435

GI number: 238024435

Start: 1319854

End: 1320780

Strand: Reverse

Name: ghrA [H]

Synonym: bglu_2g10310

Alternate gene names: 238024435

Gene position: 1320780-1319854 (Counterclockwise)

Preceding gene: 238024436

Following gene: 339717972

Centisome position: 46.71

GC content: 74.33

Gene sequence:

>927_bases
ATGAGCTTCCTTTACAAGGCGGACCCGGTCCGCGGCGCGCAATGGGCACAGCGCTTCGCGCAGCGAGCGCCCGACCTCGC
GTTCCGGATCTGGCCCGACATCGGCGACCCCGAGGCGGTCCGCTATCTCGCGGCCTGGCAGCCGCCGGACGATCCGGTCG
CGCTGCTGCCGAACCTCGAGGTGGTGTTCTCGGTGGGCGCCGGCATCGACCAGTTCGACCTGTCGCGCGTGCCGGCGCAT
CTGCCCGTGGTGCGGATGATCGAGCCCGGCATCGTCGAGGGCATGGTCGAGTACGTGACGCAGGCGGTGCTGACCGTGCA
CCGCGACCTGTTCGACTACGCGGCGCAGCAGCGCGCGCAGGCCTGGCAGCCCAAGGCCGTGCGCGCGGCCGCGTCGCGCC
GGGTCGGCGTGCTCGGGCTCGGCACGCTCGGGCAGGCCGTGCTCGACATGCTGCGCCGCTTCGGCTTCCCCTGCGCCGGC
TGGAGCCGCACGCCGCGCACGCTCGACGGCGTCGCTTGCCATGCGGGCGAGGCGGCACTCGACGCGTTCCTCGCCCGCAC
CGACATCCTGGTCTGCCTGCTGCCGCTCACCGACAGCACGCGCGGGCTGCTCGGCGCGCGCGTGTTCGACGCGCTGCCGG
CGGGCGCCTCGCTCGTGCAGGTCGGCCGCGGCCCGCAGCTCGACGCGGCAGCGCTGCTCGCGGCACTCGACAGCGGCCGG
CTCGACAGTGCCATCCTGGATGTGACCGATCCGGAGCCGCTGCCGGCGGGCCATCCGTTCTGGCACCATCCGCGCATCCG
GATCACGCCGCACATCGCCAGCGCGACGCGGCCCGACACGGCGGTGGACGCCGTGCTCGCGAACCTGGCGCGCCACCGCG
CGGGACAGCCGATGCTCGGCGTGGTCGACCGCGCGCGCGGCTACTGA

Upstream 100 bases:

>100_bases
ATACGGTGGTGGCGATGGCGCGCGGCGAGGTGCCCGCGCGCGACGCGCGGATGCGCGTGTTCGGCGTCGTCAACCAGGCA
CTCGGCTGAAGCCGCGCGCG

Downstream 100 bases:

>100_bases
CGCCGGCGCCCGGCCGGGCGGCGCGCGCAGCAGAAAATGCCGCGCCGCGCCGTGCAAACGCCGCGTCCATACGTTCCGCA
CGGCAAATTGAAGACGCAGG

Product: d-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSFLYKADPVRGAQWAQRFAQRAPDLAFRIWPDIGDPEAVRYLAAWQPPDDPVALLPNLEVVFSVGAGIDQFDLSRVPAH
LPVVRMIEPGIVEGMVEYVTQAVLTVHRDLFDYAAQQRAQAWQPKAVRAAASRRVGVLGLGTLGQAVLDMLRRFGFPCAG
WSRTPRTLDGVACHAGEAALDAFLARTDILVCLLPLTDSTRGLLGARVFDALPAGASLVQVGRGPQLDAAALLAALDSGR
LDSAILDVTDPEPLPAGHPFWHHPRIRITPHIASATRPDTAVDAVLANLARHRAGQPMLGVVDRARGY

Sequences:

>Translated_308_residues
MSFLYKADPVRGAQWAQRFAQRAPDLAFRIWPDIGDPEAVRYLAAWQPPDDPVALLPNLEVVFSVGAGIDQFDLSRVPAH
LPVVRMIEPGIVEGMVEYVTQAVLTVHRDLFDYAAQQRAQAWQPKAVRAAASRRVGVLGLGTLGQAVLDMLRRFGFPCAG
WSRTPRTLDGVACHAGEAALDAFLARTDILVCLLPLTDSTRGLLGARVFDALPAGASLVQVGRGPQLDAAALLAALDSGR
LDSAILDVTDPEPLPAGHPFWHHPRIRITPHIASATRPDTAVDAVLANLARHRAGQPMLGVVDRARGY
>Mature_307_residues
SFLYKADPVRGAQWAQRFAQRAPDLAFRIWPDIGDPEAVRYLAAWQPPDDPVALLPNLEVVFSVGAGIDQFDLSRVPAHL
PVVRMIEPGIVEGMVEYVTQAVLTVHRDLFDYAAQQRAQAWQPKAVRAAASRRVGVLGLGTLGQAVLDMLRRFGFPCAGW
SRTPRTLDGVACHAGEAALDAFLARTDILVCLLPLTDSTRGLLGARVFDALPAGASLVQVGRGPQLDAAALLAALDSGRL
DSAILDVTDPEPLPAGHPFWHHPRIRITPHIASATRPDTAVDAVLANLARHRAGQPMLGVVDRARGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=249, Percent_Identity=29.3172690763052, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI23308577, Length=275, Percent_Identity=24, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI87081824, Length=301, Percent_Identity=38.5382059800665, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI87082289, Length=229, Percent_Identity=28.82096069869, Blast_Score=94, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17532191, Length=254, Percent_Identity=24.8031496062992, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324055, Length=122, Percent_Identity=34.4262295081967, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28574286, Length=172, Percent_Identity=38.3720930232558, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45552429, Length=170, Percent_Identity=34.1176470588235, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585514, Length=169, Percent_Identity=34.3195266272189, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574282, Length=169, Percent_Identity=34.3195266272189, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574284, Length=169, Percent_Identity=34.3195266272189, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551003, Length=169, Percent_Identity=34.3195266272189, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585516, Length=270, Percent_Identity=26.2962962962963, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571528, Length=225, Percent_Identity=28, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921140, Length=225, Percent_Identity=27.1111111111111, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33225; Mature: 33093

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLYKADPVRGAQWAQRFAQRAPDLAFRIWPDIGDPEAVRYLAAWQPPDDPVALLPNLE
CCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCCCEEECCCCE
VVFSVGAGIDQFDLSRVPAHLPVVRMIEPGIVEGMVEYVTQAVLTVHRDLFDYAAQQRAQ
EEEECCCCCCHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWQPKAVRAAASRRVGVLGLGTLGQAVLDMLRRFGFPCAGWSRTPRTLDGVACHAGEAAL
HCCCHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHH
DAFLARTDILVCLLPLTDSTRGLLGARVFDALPAGASLVQVGRGPQLDAAALLAALDSGR
HHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHCCCC
LDSAILDVTDPEPLPAGHPFWHHPRIRITPHIASATRPDTAVDAVLANLARHRAGQPMLG
CCCEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
VVDRARGY
HHHHHCCC
>Mature Secondary Structure 
SFLYKADPVRGAQWAQRFAQRAPDLAFRIWPDIGDPEAVRYLAAWQPPDDPVALLPNLE
CCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCCCEEECCCCE
VVFSVGAGIDQFDLSRVPAHLPVVRMIEPGIVEGMVEYVTQAVLTVHRDLFDYAAQQRAQ
EEEECCCCCCHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWQPKAVRAAASRRVGVLGLGTLGQAVLDMLRRFGFPCAGWSRTPRTLDGVACHAGEAAL
HCCCHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHH
DAFLARTDILVCLLPLTDSTRGLLGARVFDALPAGASLVQVGRGPQLDAAALLAALDSGR
HHHHHHHCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHCCCC
LDSAILDVTDPEPLPAGHPFWHHPRIRITPHIASATRPDTAVDAVLANLARHRAGQPMLG
CCCEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
VVDRARGY
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA