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The map label for this gene is cynR [H]

Identifier: 238024375

GI number: 238024375

Start: 1189714

End: 1190613

Strand: Direct

Name: cynR [H]

Synonym: bglu_2g09680

Alternate gene names: 238024375

Gene position: 1189714-1190613 (Clockwise)

Preceding gene: 238024370

Following gene: 238024379

Centisome position: 42.08

GC content: 72.78

Gene sequence:

>900_bases
GTGCTGCTCCGGCACATTCGTTATTTCCTGGCGGTCGCCGACCACGGCAACTTCACGCGCGCGGCCGAGGCGCTGCACGT
CTCGCAGCCGACGCTGTCGCAGCAGGTCCGGCAGCTGGAGGGCACGCTCGGCGTGCCGCTCTTCGACCGCTCGGGCCGCT
CGATCCGGCTGACCGACGCCGGCGCGGCGTATGCCTGCTACGCGCGGCGCGCGCTGCAGGATCTGGAGGCGGGCCGGCGC
GCGATCCACGACGTCGGCGAACTGAGCCGCGGCTCGCTGCGGATCGGCATCACGCCGACCTTCGCCCCCTACCTGATCGG
ACCGCTGCTGGACCGCTATCACCGCCGCTATCCGAGCATCGCGCTGAGCGTGCTGGAGATGCCGCAGGAGCGCATGGAGC
CGTTGCTGGCCCAGGATGCGCTCGACGTCGGGATCGCCTTCAGCGAGACCGGTTCGCCCGATCTCGAGGTGCAGGCGCTG
TTCGTCGAGGCGCTGGCGGTGGTGGTGGGCAAGTCGCATCCGTATGCGGGCAGGCGCACGGCGCTGACGCTGCGCGAGTT
CGCCGGCGCGGCGCTGGTGCTGCTGAACGGCGAGTTCGCCACGCGTCATCACCTGGACCGCTATTGCCGGCGGCACGGCG
TGGCGCCGCGCATCGCGATGGAGGTCAATTCGATCAGCGCGGCCGTCGAGGTGGTGCGGCGCGGGGCGCTGGCCACGCTG
CTGCCGGCCGCGATCGCGCGCGAGCAGGCCGGGCTGCGCCTGGTGGGCCTGAAGCCCGCGCTGCCGCGCCGCACCGTGGC
GCTGCTGATGCGCCGCGATGCGTATCGCAGCGCGGCGTTGGCGGCATTCGTGACGATGGCGCAGGAGCAAGGCGCGCGGT
GCGCGCAGGCGCCGGCCTGA

Upstream 100 bases:

>100_bases
CGAGCCGCGCTGGACAGAGAATGCGCCGGCATGCCGATAGCGTCAAAGACCGGTTTATTATCGCGGCCATAGGCATGGCC
AATAGTATTCGGGAGGCGCG

Downstream 100 bases:

>100_bases
GCGCCGTGCGGCCGCGCCCGCGGGGCGTTTGCGCGGCGCCTCGGGGGGCCTCAGAGTGCCATCTGCATCTCGTGCCACGC
CATGCCGCCATGCGCGGAAC

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLLRHIRYFLAVADHGNFTRAAEALHVSQPTLSQQVRQLEGTLGVPLFDRSGRSIRLTDAGAAYACYARRALQDLEAGRR
AIHDVGELSRGSLRIGITPTFAPYLIGPLLDRYHRRYPSIALSVLEMPQERMEPLLAQDALDVGIAFSETGSPDLEVQAL
FVEALAVVVGKSHPYAGRRTALTLREFAGAALVLLNGEFATRHHLDRYCRRHGVAPRIAMEVNSISAAVEVVRRGALATL
LPAAIAREQAGLRLVGLKPALPRRTVALLMRRDAYRSAALAAFVTMAQEQGARCAQAPA

Sequences:

>Translated_299_residues
MLLRHIRYFLAVADHGNFTRAAEALHVSQPTLSQQVRQLEGTLGVPLFDRSGRSIRLTDAGAAYACYARRALQDLEAGRR
AIHDVGELSRGSLRIGITPTFAPYLIGPLLDRYHRRYPSIALSVLEMPQERMEPLLAQDALDVGIAFSETGSPDLEVQAL
FVEALAVVVGKSHPYAGRRTALTLREFAGAALVLLNGEFATRHHLDRYCRRHGVAPRIAMEVNSISAAVEVVRRGALATL
LPAAIAREQAGLRLVGLKPALPRRTVALLMRRDAYRSAALAAFVTMAQEQGARCAQAPA
>Mature_299_residues
MLLRHIRYFLAVADHGNFTRAAEALHVSQPTLSQQVRQLEGTLGVPLFDRSGRSIRLTDAGAAYACYARRALQDLEAGRR
AIHDVGELSRGSLRIGITPTFAPYLIGPLLDRYHRRYPSIALSVLEMPQERMEPLLAQDALDVGIAFSETGSPDLEVQAL
FVEALAVVVGKSHPYAGRRTALTLREFAGAALVLLNGEFATRHHLDRYCRRHGVAPRIAMEVNSISAAVEVVRRGALATL
LPAAIAREQAGLRLVGLKPALPRRTVALLMRRDAYRSAALAAFVTMAQEQGARCAQAPA

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=292, Percent_Identity=56.5068493150685, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI1790399, Length=276, Percent_Identity=31.8840579710145, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788887, Length=299, Percent_Identity=31.438127090301, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787879, Length=252, Percent_Identity=32.5396825396825, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788297, Length=252, Percent_Identity=30.1587301587302, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788748, Length=297, Percent_Identity=28.2828282828283, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1787530, Length=238, Percent_Identity=31.0924369747899, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787601, Length=289, Percent_Identity=25.2595155709343, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI145693105, Length=287, Percent_Identity=23.3449477351916, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87081904, Length=251, Percent_Identity=27.8884462151394, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789173, Length=163, Percent_Identity=34.3558282208589, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789204, Length=233, Percent_Identity=28.3261802575107, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI2367136, Length=262, Percent_Identity=29.0076335877863, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790208, Length=251, Percent_Identity=29.8804780876494, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787806, Length=289, Percent_Identity=24.9134948096886, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789639, Length=144, Percent_Identity=34.0277777777778, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786401, Length=117, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788481, Length=287, Percent_Identity=27.8745644599303, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788706, Length=183, Percent_Identity=32.7868852459016, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790262, Length=243, Percent_Identity=25.1028806584362, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788296, Length=207, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787949, Length=116, Percent_Identity=31.8965517241379, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32601; Mature: 32601

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRHIRYFLAVADHGNFTRAAEALHVSQPTLSQQVRQLEGTLGVPLFDRSGRSIRLTDA
CHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEECCCCCEEEEECC
GAAYACYARRALQDLEAGRRAIHDVGELSRGSLRIGITPTFAPYLIGPLLDRYHRRYPSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCHHH
ALSVLEMPQERMEPLLAQDALDVGIAFSETGSPDLEVQALFVEALAVVVGKSHPYAGRRT
HHHHHHCCHHHHHHHHHHHHHHHCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
ALTLREFAGAALVLLNGEFATRHHLDRYCRRHGVAPRIAMEVNSISAAVEVVRRGALATL
HHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCHHHHH
LPAAIAREQAGLRLVGLKPALPRRTVALLMRRDAYRSAALAAFVTMAQEQGARCAQAPA
HHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLLRHIRYFLAVADHGNFTRAAEALHVSQPTLSQQVRQLEGTLGVPLFDRSGRSIRLTDA
CHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEECCCCCEEEEECC
GAAYACYARRALQDLEAGRRAIHDVGELSRGSLRIGITPTFAPYLIGPLLDRYHRRYPSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCHHH
ALSVLEMPQERMEPLLAQDALDVGIAFSETGSPDLEVQALFVEALAVVVGKSHPYAGRRT
HHHHHHCCHHHHHHHHHHHHHHHCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHH
ALTLREFAGAALVLLNGEFATRHHLDRYCRRHGVAPRIAMEVNSISAAVEVVRRGALATL
HHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCHHHHH
LPAAIAREQAGLRLVGLKPALPRRTVALLMRRDAYRSAALAAFVTMAQEQGARCAQAPA
HHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]