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The map label for this gene is folE [H]

Identifier: 238024327

GI number: 238024327

Start: 1133832

End: 1134566

Strand: Direct

Name: folE [H]

Synonym: bglu_2g09150

Alternate gene names: 238024327

Gene position: 1133832-1134566 (Clockwise)

Preceding gene: 238024326

Following gene: 238024329

Centisome position: 40.1

GC content: 67.21

Gene sequence:

>735_bases
ATGGGTAATCTGATCGACGCTCCCGAGCTCACGCGGACCGCCGTGGACGAGGGCGTGCCGCTGTCGCGAATCATTCGTGG
CCGCATCGAGCGCGCCGGCGCGCGCTTTCACGCGAACGACAATATCGCGGCCTACCTGCGCGACGGCGAGCTGGAGGCCT
TGCAGAGCGAGGTCGCGCAAGGCCTGGAAGGCGTGCTGCGCTCGCTCGTGATCGACGTCGACCACGACCACAACACGCGC
GAAACCGCCGCGCGCGTGGCCAAGATGTTCGTGCGCGAGGTGTTCGCCGGCCGTTACGAGGCGGCGCCCGCCGTCACCGA
GTTTCCGAACGTCGAGCGCCTCGACGAGCTGCTGATCGTCGGCCCGCTGCGCGTGCGCAGCGCATGCTCGCATCACTTGT
GTCCGATCATGGGCCGGATCTGGATCGGCGTGCTGCCCAGCGCCACCTCGAACCTGATCGGCCTGTCCAAGTACGGGCGC
CTGGTGAACTGGGTCATGACGCGCCCGCAGATCCAGGAGGAAGCGATCAAGCAGATCGCCGACCTCCTGGAGTCGCGCAT
CGCGCCCGACGGGCTTGCGGTGGTGCTCGAGGCCGAGCATTTCTGCATGCACTGGCGCGGCACCAAGGACGATCAGGCGA
AGATGACCAATAGCGTCATGCGCGGGAAATTCCTGGCCGATCCCGCGCTGCGCCGCGAGTTTCTCTCGCTGCTGCCGGAA
AAGGGCGGGGCGTGA

Upstream 100 bases:

>100_bases
CGGGCCGTGCGGCGTCTCACGCCGCGCCGGCGGGCCGCGCCTGGAAAGGCGGATGCCCGGCGTCGCGCGCCACGCCATCT
AACCGGGGAAACGAACCGAA

Downstream 100 bases:

>100_bases
GTCGGGCGCGGCCGGCCGCGCGTTGAACGAGCCGGCGAGCGCGCCGGCGGCGCGCTACAGCGACGCCAGCCCGTCGCGCA
GCCGGGCCGCCTGCGCGCGC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MGNLIDAPELTRTAVDEGVPLSRIIRGRIERAGARFHANDNIAAYLRDGELEALQSEVAQGLEGVLRSLVIDVDHDHNTR
ETAARVAKMFVREVFAGRYEAAPAVTEFPNVERLDELLIVGPLRVRSACSHHLCPIMGRIWIGVLPSATSNLIGLSKYGR
LVNWVMTRPQIQEEAIKQIADLLESRIAPDGLAVVLEAEHFCMHWRGTKDDQAKMTNSVMRGKFLADPALRREFLSLLPE
KGGA

Sequences:

>Translated_244_residues
MGNLIDAPELTRTAVDEGVPLSRIIRGRIERAGARFHANDNIAAYLRDGELEALQSEVAQGLEGVLRSLVIDVDHDHNTR
ETAARVAKMFVREVFAGRYEAAPAVTEFPNVERLDELLIVGPLRVRSACSHHLCPIMGRIWIGVLPSATSNLIGLSKYGR
LVNWVMTRPQIQEEAIKQIADLLESRIAPDGLAVVLEAEHFCMHWRGTKDDQAKMTNSVMRGKFLADPALRREFLSLLPE
KGGA
>Mature_243_residues
GNLIDAPELTRTAVDEGVPLSRIIRGRIERAGARFHANDNIAAYLRDGELEALQSEVAQGLEGVLRSLVIDVDHDHNTRE
TAARVAKMFVREVFAGRYEAAPAVTEFPNVERLDELLIVGPLRVRSACSHHLCPIMGRIWIGVLPSATSNLIGLSKYGRL
VNWVMTRPQIQEEAIKQIADLLESRIAPDGLAVVLEAEHFCMHWRGTKDDQAKMTNSVMRGKFLADPALRREFLSLLPEK
GGA

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=124, Percent_Identity=41.9354838709677, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4503949, Length=124, Percent_Identity=41.9354838709677, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI66932970, Length=96, Percent_Identity=38.5416666666667, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI66932972, Length=87, Percent_Identity=41.3793103448276, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788476, Length=185, Percent_Identity=32.4324324324324, Blast_Score=107, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17560486, Length=130, Percent_Identity=42.3076923076923, Blast_Score=110, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6321706, Length=185, Percent_Identity=35.1351351351351, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24656782, Length=130, Percent_Identity=40.7692307692308, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24656796, Length=130, Percent_Identity=40.7692307692308, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656791, Length=130, Percent_Identity=40.7692307692308, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 27053; Mature: 26921

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNLIDAPELTRTAVDEGVPLSRIIRGRIERAGARFHANDNIAAYLRDGELEALQSEVAQ
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCCEEEEEECCHHHHHHHHHHH
GLEGVLRSLVIDVDHDHNTRETAARVAKMFVREVFAGRYEAAPAVTEFPNVERLDELLIV
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHC
GPLRVRSACSHHLCPIMGRIWIGVLPSATSNLIGLSKYGRLVNWVMTRPQIQEEAIKQIA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DLLESRIAPDGLAVVLEAEHFCMHWRGTKDDQAKMTNSVMRGKFLADPALRREFLSLLPE
HHHHHHCCCCCEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHCHHHCCHHHHHHHHHHCCC
KGGA
CCCC
>Mature Secondary Structure 
GNLIDAPELTRTAVDEGVPLSRIIRGRIERAGARFHANDNIAAYLRDGELEALQSEVAQ
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCCEEEEEECCHHHHHHHHHHH
GLEGVLRSLVIDVDHDHNTRETAARVAKMFVREVFAGRYEAAPAVTEFPNVERLDELLIV
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHC
GPLRVRSACSHHLCPIMGRIWIGVLPSATSNLIGLSKYGRLVNWVMTRPQIQEEAIKQIA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DLLESRIAPDGLAVVLEAEHFCMHWRGTKDDQAKMTNSVMRGKFLADPALRREFLSLLPE
HHHHHHCCCCCEEEEEEHHHHHHHCCCCCHHHHHHHHHHHHCHHHCCHHHHHHHHHHCCC
KGGA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA