Click here to switch to the map view.

The map label for this gene is sdhB [H]

Identifier: 238024135

GI number: 238024135

Start: 839789

End: 840496

Strand: Direct

Name: sdhB [H]

Synonym: bglu_2g07110

Alternate gene names: 238024135

Gene position: 839789-840496 (Clockwise)

Preceding gene: 238024134

Following gene: 238024136

Centisome position: 29.7

GC content: 67.09

Gene sequence:

>708_bases
ATGAGCGACCACCGCGTGCTGCATGTGTACCGCTATGATCCCGACCGCGACGCGCGGCCGAGGCTGCAGACCTACGAGAT
CGAACTGGCCGCGGGCGAGCGCATGCTGCTCGACGTGCTCGGCAGGCTGAAGGCGCTCGACGAGACGCTGGCGTATCGGC
GTTCGTGCCGCGAGGGCATCTGCGGGTCCGATGCGATGAACATCAACGGCCGCAACGGCCTCGCGTGCCTGACCAACCTG
CGCGAGTTGCCGGCCGAGATCACGCTGCGGCCGCTGCCGGGGCTGCCGGTGGTGCGTGACCTGATCGTCGACATGACCGA
TTTTTTCAACCAGTACCACTCGATCCGCCCGTACCTCATCAACGACACGCCGCCGCCCGAGCGGGAGCGGCCGCAGTCGC
CCGAGGAGCGCGAGCAGCTCGACGGGCTCTACGAATGCATTCTCTGCGCCTGCTGCTCGACGCAATGCCCATCGTACTGG
TGGAATCCCGACAAGTTCGTCGGGCCGGCCGGGTTGCTGCAGGCCTACCGCTTCATCGCCGACTCGCGCGACCAGGCCAC
CGCCTCGCGGCTCGACGATCTCGAGGACCCCTACCGGCTGTTTCGCTGCCGCACCATCATGAACTGCGCGAGCGTGTGCC
CGAAGGGCCTGAACCCGGCGCAGGCGATCGGAAACATTCGTTCCATGCTGACGCGCCGCACGGTCTGA

Upstream 100 bases:

>100_bases
GGCCTCGAGCGCGGGCGCTATGTCATCGACCACGGCGAGGCCTTCGAATGAGCCGGTCATGCCCGAGCCCGCACGGGCGC
CGCGAACCGGAGACACGACT

Downstream 100 bases:

>100_bases
GGCGCGAGCGATGCATCCGTTGTGGCGATGCCGCGCCGCCTCGCGCGCGACCTCGCAGCCCCGGTGGCGTCCGCGCCGCA
GCCGGCCCACCCCATCTACG

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MSDHRVLHVYRYDPDRDARPRLQTYEIELAAGERMLLDVLGRLKALDETLAYRRSCREGICGSDAMNINGRNGLACLTNL
RELPAEITLRPLPGLPVVRDLIVDMTDFFNQYHSIRPYLINDTPPPERERPQSPEEREQLDGLYECILCACCSTQCPSYW
WNPDKFVGPAGLLQAYRFIADSRDQATASRLDDLEDPYRLFRCRTIMNCASVCPKGLNPAQAIGNIRSMLTRRTV

Sequences:

>Translated_235_residues
MSDHRVLHVYRYDPDRDARPRLQTYEIELAAGERMLLDVLGRLKALDETLAYRRSCREGICGSDAMNINGRNGLACLTNL
RELPAEITLRPLPGLPVVRDLIVDMTDFFNQYHSIRPYLINDTPPPERERPQSPEEREQLDGLYECILCACCSTQCPSYW
WNPDKFVGPAGLLQAYRFIADSRDQATASRLDDLEDPYRLFRCRTIMNCASVCPKGLNPAQAIGNIRSMLTRRTV
>Mature_234_residues
SDHRVLHVYRYDPDRDARPRLQTYEIELAAGERMLLDVLGRLKALDETLAYRRSCREGICGSDAMNINGRNGLACLTNLR
ELPAEITLRPLPGLPVVRDLIVDMTDFFNQYHSIRPYLINDTPPPERERPQSPEEREQLDGLYECILCACCSTQCPSYWW
NPDKFVGPAGLLQAYRFIADSRDQATASRLDDLEDPYRLFRCRTIMNCASVCPKGLNPAQAIGNIRSMLTRRTV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=234, Percent_Identity=53.4188034188034, Blast_Score=257, Evalue=7e-69,
Organism=Escherichia coli, GI1786943, Length=234, Percent_Identity=61.5384615384615, Blast_Score=307, Evalue=5e-85,
Organism=Escherichia coli, GI1790596, Length=226, Percent_Identity=36.283185840708, Blast_Score=144, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17533915, Length=235, Percent_Identity=50.6382978723404, Blast_Score=247, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6322987, Length=230, Percent_Identity=52.1739130434783, Blast_Score=246, Evalue=3e-66,
Organism=Drosophila melanogaster, GI17137106, Length=234, Percent_Identity=50.8547008547009, Blast_Score=251, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24643156, Length=232, Percent_Identity=51.2931034482759, Blast_Score=241, Evalue=3e-64,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26868; Mature: 26737

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHRVLHVYRYDPDRDARPRLQTYEIELAAGERMLLDVLGRLKALDETLAYRRSCREGI
CCCCEEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
CGSDAMNINGRNGLACLTNLRELPAEITLRPLPGLPVVRDLIVDMTDFFNQYHSIRPYLI
CCCCCCCCCCCCCHHHHHHHHHCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
NDTPPPERERPQSPEEREQLDGLYECILCACCSTQCPSYWWNPDKFVGPAGLLQAYRFIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
DSRDQATASRLDDLEDPYRLFRCRTIMNCASVCPKGLNPAQAIGNIRSMLTRRTV
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDHRVLHVYRYDPDRDARPRLQTYEIELAAGERMLLDVLGRLKALDETLAYRRSCREGI
CCCEEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
CGSDAMNINGRNGLACLTNLRELPAEITLRPLPGLPVVRDLIVDMTDFFNQYHSIRPYLI
CCCCCCCCCCCCCHHHHHHHHHCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEE
NDTPPPERERPQSPEEREQLDGLYECILCACCSTQCPSYWWNPDKFVGPAGLLQAYRFIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
DSRDQATASRLDDLEDPYRLFRCRTIMNCASVCPKGLNPAQAIGNIRSMLTRRTV
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]