Click here to switch to the map view.

The map label for this gene is mmsB [H]

Identifier: 238024068

GI number: 238024068

Start: 755462

End: 756364

Strand: Direct

Name: mmsB [H]

Synonym: bglu_2g06290

Alternate gene names: 238024068

Gene position: 755462-756364 (Clockwise)

Preceding gene: 238024067

Following gene: 238024069

Centisome position: 26.72

GC content: 72.76

Gene sequence:

>903_bases
ATGAAGATCGGATTCATCGGCCTCGGCCACATGGGTGCGCCGATGGCGCTCAACCTGGTGAAGGCGGGCCACGACGTGCA
GGCGTTCGATATGAACGGCGACGCGCTGCGGCGGGTGGCCGACGGCGGCGCCATGCCGGCGCGCACGGCGCGCGAGGCCA
GCGCCGATGCCGCGTTCGTGATCACCATGCTGCCGGCCGCGGCCCACGTGCGCGCCGCGCTGACGGCCGCCGACGGCGTG
CTGGCGGGCCTCGCGGCCGGCGCGACGGTGATCGATTCGAGCACCATCGATCCGGCCAGCGCGCAGGCGTTCGGCGAGCT
GGTGCGCGCCCGCGGCGGCGCGTTCGTGGATGCGCCGGTGTCGGGCGGCACGGGCGGCGCGGCGGCCGGCACGCTGACCT
TCATGGTGGGCGGCGCGGCGGCCGATTTCGCGCGGGTCGGCCCGGTGCTGGGCGCGATGGGCAAGAACCTCGTGCATTGC
GGCGCGGTGGGGATGGGGCAGGTGGCGAAGATCTGCAACAACCTGGTGCTCGGCATCTCGATGGCGGGCGTGGCCGAATC
GATGGCGCTGGGCGCCGCGCTCGGCATCGATCCGAAAGTGCTGGGCGGCATCCTCAGCACCTCCACCGGGCGCTGCTGGA
GCGCGGACACCTACAACCCCTACCCGGGCGTGATCGAGACCGCGCCGGCCTCGCGCGGCTACACCGGCGGCTTCGGCACC
GACCTGATGCTGAAGGACCTGGGCCTTGCCGGCGACGCCGCGAAGCAGGCGCGCCAGCCGGTCTATCTCGGCGCGCTCGC
GCAGCAGCTCTACCAGGCGCTCAGCAGCCGCGGCGACGGCAAGCTCGATTTCTCGGCGGTGATCCGCCTTTATCAGCAAC
CCGCGAACGAGGAGCCGCGATGA

Upstream 100 bases:

>100_bases
ACCAAGACCGTGACGGCGCGCTGGTTCGACGACGCGACCGTCAACGACGGCGTGAACACCACCATCAGCCTGCGCTGAGC
CGCGACGAGGACAGGACATC

Downstream 100 bases:

>100_bases
TCGAACTGAGCGAACACGACGACGGCGCGATCGCGCTCGTCACCCTGTCCCGGCCGCCCGCCAACGCGTTCCATGCCGAC
GGCCTCGCCGCGCTCGAACG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKIGFIGLGHMGAPMALNLVKAGHDVQAFDMNGDALRRVADGGAMPARTAREASADAAFVITMLPAAAHVRAALTAADGV
LAGLAAGATVIDSSTIDPASAQAFGELVRARGGAFVDAPVSGGTGGAAAGTLTFMVGGAAADFARVGPVLGAMGKNLVHC
GAVGMGQVAKICNNLVLGISMAGVAESMALGAALGIDPKVLGGILSTSTGRCWSADTYNPYPGVIETAPASRGYTGGFGT
DLMLKDLGLAGDAAKQARQPVYLGALAQQLYQALSSRGDGKLDFSAVIRLYQQPANEEPR

Sequences:

>Translated_300_residues
MKIGFIGLGHMGAPMALNLVKAGHDVQAFDMNGDALRRVADGGAMPARTAREASADAAFVITMLPAAAHVRAALTAADGV
LAGLAAGATVIDSSTIDPASAQAFGELVRARGGAFVDAPVSGGTGGAAAGTLTFMVGGAAADFARVGPVLGAMGKNLVHC
GAVGMGQVAKICNNLVLGISMAGVAESMALGAALGIDPKVLGGILSTSTGRCWSADTYNPYPGVIETAPASRGYTGGFGT
DLMLKDLGLAGDAAKQARQPVYLGALAQQLYQALSSRGDGKLDFSAVIRLYQQPANEEPR
>Mature_300_residues
MKIGFIGLGHMGAPMALNLVKAGHDVQAFDMNGDALRRVADGGAMPARTAREASADAAFVITMLPAAAHVRAALTAADGV
LAGLAAGATVIDSSTIDPASAQAFGELVRARGGAFVDAPVSGGTGGAAAGTLTFMVGGAAADFARVGPVLGAMGKNLVHC
GAVGMGQVAKICNNLVLGISMAGVAESMALGAALGIDPKVLGGILSTSTGRCWSADTYNPYPGVIETAPASRGYTGGFGT
DLMLKDLGLAGDAAKQARQPVYLGALAQQLYQALSSRGDGKLDFSAVIRLYQQPANEEPR

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=49.1408934707904, Blast_Score=297, Evalue=6e-81,
Organism=Homo sapiens, GI40556376, Length=299, Percent_Identity=29.7658862876254, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=37.5, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI145693186, Length=298, Percent_Identity=33.8926174496644, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1786719, Length=307, Percent_Identity=32.8990228013029, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1789092, Length=297, Percent_Identity=34.3434343434343, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=273, Percent_Identity=46.8864468864469, Blast_Score=247, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=47.6190476190476, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=47.6190476190476, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI28574115, Length=297, Percent_Identity=24.2424242424242, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30017; Mature: 30017

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGLGHMGAPMALNLVKAGHDVQAFDMNGDALRRVADGGAMPARTAREASADAAFV
CEEEEEECCCCCCCHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCHHHHHHCCCCEEE
ITMLPAAAHVRAALTAADGVLAGLAAGATVIDSSTIDPASAQAFGELVRARGGAFVDAPV
EHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCEEEECCC
SGGTGGAAAGTLTFMVGGAAADFARVGPVLGAMGKNLVHCGAVGMGQVAKICNNLVLGIS
CCCCCCHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHH
MAGVAESMALGAALGIDPKVLGGILSTSTGRCWSADTYNPYPGVIETAPASRGYTGGFGT
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCEECCCCCCCCCCCCCC
DLMLKDLGLAGDAAKQARQPVYLGALAQQLYQALSSRGDGKLDFSAVIRLYQQPANEEPR
HHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKIGFIGLGHMGAPMALNLVKAGHDVQAFDMNGDALRRVADGGAMPARTAREASADAAFV
CEEEEEECCCCCCCHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCHHHHHHCCCCEEE
ITMLPAAAHVRAALTAADGVLAGLAAGATVIDSSTIDPASAQAFGELVRARGGAFVDAPV
EHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCEEEECCC
SGGTGGAAAGTLTFMVGGAAADFARVGPVLGAMGKNLVHCGAVGMGQVAKICNNLVLGIS
CCCCCCHHHHEEEEEECCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHH
MAGVAESMALGAALGIDPKVLGGILSTSTGRCWSADTYNPYPGVIETAPASRGYTGGFGT
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCEECCCCCCCCCCCCCC
DLMLKDLGLAGDAAKQARQPVYLGALAQQLYQALSSRGDGKLDFSAVIRLYQQPANEEPR
HHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]