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The map label for this gene is betA [H]

Identifier: 238024008

GI number: 238024008

Start: 674429

End: 676126

Strand: Reverse

Name: betA [H]

Synonym: bglu_2g05620

Alternate gene names: 238024008

Gene position: 676126-674429 (Counterclockwise)

Preceding gene: 238024009

Following gene: 238024007

Centisome position: 23.91

GC content: 69.61

Gene sequence:

>1698_bases
ATGACGACCACGCTCGAATACGACTACATCATCTGCGGCGCCGGCTCGGCCGGCAACGTGCTCGCCGCGCGGCTGACCGA
GGACCCCGGCGTGACCGTGCTGCTGCTCGAGGCGGGCGGCCCCGACTACCGTTTCGACTTCCGCACCCAGATGCCGGCCG
CGCTCGCCTATCCGCTGCAGGGCCGCCGCTACAATTGGGCCTACGAGACCGATCCCGAGCCGCACATGGACAACCGCCGC
ATGGAATGCGGACGCGGCAAGGGGCTCGGCGGCTCGTCGCTGATCAACGGCATGTGCTACATCCGCGGCAACGCGCTCGA
CTACGACAACTGGGCGACGCACGCGGGACTCGAGGACTGGACCTATCTCGACTGCCTGCCCTACTTCCGCCGCGCCGAGA
CGCGCGACGCGGGCCCCAACGACTACCACGGCGGCGACGGGCCGGTGTCGGTCACCACCAGCAAGCCCGGCGTGAATCCG
CTGTTCGAGGCGATGGTGGAGGCCGGCGTGCAGGCCGGCTACCCGCGCACCGACGACCTGAACGGCTATCGGCAGGAAGG
CTTCGGGCCGATGGACCGCACCGTCACGCCGCGCGGGCGCCGCGCCTCCACCGCGCGCGGCTACCTGGACCAGGCACGCG
CGCGGCCGAACCTGGAGATCGTCACGCACGCGGTGGCCGACCGCGTGCTGTTCTCGGGCAAGCGCGCCTACGGCGTGGCC
TACCTGCGCCGCGGCCAGCCCGTGACGGCGCACGCGCGCCGCGAGGTGCTGGTATGCAGCGGCGCGATCGCCTCGCCGCA
GCTGCTGCAGCGCTCGGGCGTGGGTCCCGGCCAGTGGCTGCGCGAGCTCGACATTCCGGTGGTGCACGAGCTGCCCGGCG
TGGGCCAGAACCTGCAGGACCATCTGGAGATGTACATTCAATACGCCTGCAAGGAGCCCGTGTCGCTGTACCCGGCGCTG
AAGTGGTGGAACCAGCCGAAGATCGGCCTCGAATGGATGCTCAACGGCACCGGCCTCGGCGCGAGCAACCATTTCGAGGC
GGGCGGCTTCATCCGCACCCGCGACGAAGACCTCTGGCCGAACATCCAGTACCACTTCCTGCCGGTGGCGATCAACTACA
ACGGCTCGAACGCGATCGAGATGCACGGCTTCCAGGCCCACGTCGGCTCGATGCGCTCGCCGAGCCGCGGCCGCGTGAAG
CTGACCTCGCGCGATCCGAACGCGCATCCGAGCATCCTGTTCAATTACATGTCCGAGCCGCTCGACTGGCGCGAGTTCCG
CGACGCAATCCGCGTCACGCGCGAGATCATGCGCCAGCCCGCGCTCGACCGCTTCCGCGGCCAGGAGCTGAATCCCGGTG
CCGAGCTGAAATCGGACGCACAGCTCGACGCGTTCGTGCGCCAGCGCGCCGAGACGGCCTTCCATCCGTCGTGCTCGAAC
AAGATGGGCTACGACGCGATGGCGGTGGTCGACAACGAGGGGCGCGTCCACGGCCTGGACGGGCTGCGCGTGGTGGACGC
GTCGATCATGCCGATCATCACGACCGGCAACCTCAACGCGCCCACCATCATGATCGCCGAGAAGATCGCCGACCGGATTC
GCGGGCGCGTCCCGCTGGCGCGCGCGACGGCGAAATACTTCGTCGCGAACGGCGCGCCGGCGCGCGGCAAGCCGCTGCGG
GAAGCGCAAGCCGCCTGA

Upstream 100 bases:

>100_bases
ATCACCACGCTCGAGCACTACACGCGCATCAAGTCGGTGCAGGTCGAGCTCGGCCGCTACCACCCGGTGTTCTGATGTTC
CGACGACAGGAGGCAAGGCG

Downstream 100 bases:

>100_bases
CGCGCGCGGCGGCGCGGCAGCCGGGCGCCCCAGCGCGCGGCATTGCCGGACGCCGCGCCGTCGTCACACTCCAGCCCCCC
CCTCGCGGGGCGGGACGCGC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MTTTLEYDYIICGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRFDFRTQMPAALAYPLQGRRYNWAYETDPEPHMDNRR
MECGRGKGLGGSSLINGMCYIRGNALDYDNWATHAGLEDWTYLDCLPYFRRAETRDAGPNDYHGGDGPVSVTTSKPGVNP
LFEAMVEAGVQAGYPRTDDLNGYRQEGFGPMDRTVTPRGRRASTARGYLDQARARPNLEIVTHAVADRVLFSGKRAYGVA
YLRRGQPVTAHARREVLVCSGAIASPQLLQRSGVGPGQWLRELDIPVVHELPGVGQNLQDHLEMYIQYACKEPVSLYPAL
KWWNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDEDLWPNIQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVK
LTSRDPNAHPSILFNYMSEPLDWREFRDAIRVTREIMRQPALDRFRGQELNPGAELKSDAQLDAFVRQRAETAFHPSCSN
KMGYDAMAVVDNEGRVHGLDGLRVVDASIMPIITTGNLNAPTIMIAEKIADRIRGRVPLARATAKYFVANGAPARGKPLR
EAQAA

Sequences:

>Translated_565_residues
MTTTLEYDYIICGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRFDFRTQMPAALAYPLQGRRYNWAYETDPEPHMDNRR
MECGRGKGLGGSSLINGMCYIRGNALDYDNWATHAGLEDWTYLDCLPYFRRAETRDAGPNDYHGGDGPVSVTTSKPGVNP
LFEAMVEAGVQAGYPRTDDLNGYRQEGFGPMDRTVTPRGRRASTARGYLDQARARPNLEIVTHAVADRVLFSGKRAYGVA
YLRRGQPVTAHARREVLVCSGAIASPQLLQRSGVGPGQWLRELDIPVVHELPGVGQNLQDHLEMYIQYACKEPVSLYPAL
KWWNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDEDLWPNIQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVK
LTSRDPNAHPSILFNYMSEPLDWREFRDAIRVTREIMRQPALDRFRGQELNPGAELKSDAQLDAFVRQRAETAFHPSCSN
KMGYDAMAVVDNEGRVHGLDGLRVVDASIMPIITTGNLNAPTIMIAEKIADRIRGRVPLARATAKYFVANGAPARGKPLR
EAQAA
>Mature_564_residues
TTTLEYDYIICGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRFDFRTQMPAALAYPLQGRRYNWAYETDPEPHMDNRRM
ECGRGKGLGGSSLINGMCYIRGNALDYDNWATHAGLEDWTYLDCLPYFRRAETRDAGPNDYHGGDGPVSVTTSKPGVNPL
FEAMVEAGVQAGYPRTDDLNGYRQEGFGPMDRTVTPRGRRASTARGYLDQARARPNLEIVTHAVADRVLFSGKRAYGVAY
LRRGQPVTAHARREVLVCSGAIASPQLLQRSGVGPGQWLRELDIPVVHELPGVGQNLQDHLEMYIQYACKEPVSLYPALK
WWNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDEDLWPNIQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVKL
TSRDPNAHPSILFNYMSEPLDWREFRDAIRVTREIMRQPALDRFRGQELNPGAELKSDAQLDAFVRQRAETAFHPSCSNK
MGYDAMAVVDNEGRVHGLDGLRVVDASIMPIITTGNLNAPTIMIAEKIADRIRGRVPLARATAKYFVANGAPARGKPLRE
AQAA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=541, Percent_Identity=50.2772643253235, Blast_Score=508, Evalue=1e-144,
Organism=Escherichia coli, GI1786503, Length=555, Percent_Identity=77.4774774774775, Blast_Score=916, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=551, Percent_Identity=47.3684210526316, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24642048, Length=572, Percent_Identity=37.7622377622378, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24642042, Length=572, Percent_Identity=37.4125874125874, Blast_Score=302, Evalue=4e-82,
Organism=Drosophila melanogaster, GI45551458, Length=570, Percent_Identity=35.4385964912281, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI45549471, Length=570, Percent_Identity=35.4385964912281, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24642059, Length=571, Percent_Identity=35.9019264448336, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24642055, Length=582, Percent_Identity=36.426116838488, Blast_Score=272, Evalue=6e-73,
Organism=Drosophila melanogaster, GI18859995, Length=574, Percent_Identity=35.3658536585366, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24642039, Length=571, Percent_Identity=36.077057793345, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI17137792, Length=555, Percent_Identity=35.1351351351351, Blast_Score=256, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24650267, Length=578, Percent_Identity=33.5640138408304, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24642035, Length=573, Percent_Identity=32.8097731239092, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI24642051, Length=572, Percent_Identity=31.4685314685315, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24642037, Length=572, Percent_Identity=33.5664335664336, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI18859993, Length=575, Percent_Identity=32.5217391304348, Blast_Score=215, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24645930, Length=583, Percent_Identity=26.9296740994854, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24642057, Length=581, Percent_Identity=28.0550774526678, Blast_Score=125, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 62606; Mature: 62474

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTLEYDYIICGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRFDFRTQMPAALAYPLQ
CCCEEEECEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCCCEEEECCCCCHHEECCCC
GRRYNWAYETDPEPHMDNRRMECGRGKGLGGSSLINGMCYIRGNALDYDNWATHAGLEDW
CCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCCCCHHCCCCCCC
TYLDCLPYFRRAETRDAGPNDYHGGDGPVSVTTSKPGVNPLFEAMVEAGVQAGYPRTDDL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
NGYRQEGFGPMDRTVTPRGRRASTARGYLDQARARPNLEIVTHAVADRVLFSGKRAYGVA
CCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHEEE
YLRRGQPVTAHARREVLVCSGAIASPQLLQRSGVGPGQWLRELDIPVVHELPGVGQNLQD
EEECCCCEEHHCCCEEEEECCCCCCHHHHHHCCCCHHHHHHHCCCCHHHHCCCCCCCHHH
HLEMYIQYACKEPVSLYPALKWWNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDEDLWP
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCC
NIQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVKLTSRDPNAHPSILFNYMSEP
CCEEEEEEEEEEECCCCEEEECCHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCC
LDWREFRDAIRVTREIMRQPALDRFRGQELNPGAELKSDAQLDAFVRQRAETAFHPSCSN
CCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
KMGYDAMAVVDNEGRVHGLDGLRVVDASIMPIITTGNLNAPTIMIAEKIADRIRGRVPLA
CCCCCEEEEEECCCCEECCCCEEEECCCEEEEEEECCCCCCEEHHHHHHHHHHHCCCCHH
RATAKYFVANGAPARGKPLREAQAA
HHHHEEEEECCCCCCCCCCHHHCCC
>Mature Secondary Structure 
TTTLEYDYIICGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRFDFRTQMPAALAYPLQ
CCEEEECEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCCCEEEECCCCCHHEECCCC
GRRYNWAYETDPEPHMDNRRMECGRGKGLGGSSLINGMCYIRGNALDYDNWATHAGLEDW
CCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCCCCHHCCCCCCC
TYLDCLPYFRRAETRDAGPNDYHGGDGPVSVTTSKPGVNPLFEAMVEAGVQAGYPRTDDL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
NGYRQEGFGPMDRTVTPRGRRASTARGYLDQARARPNLEIVTHAVADRVLFSGKRAYGVA
CCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHEEE
YLRRGQPVTAHARREVLVCSGAIASPQLLQRSGVGPGQWLRELDIPVVHELPGVGQNLQD
EEECCCCEEHHCCCEEEEECCCCCCHHHHHHCCCCHHHHHHHCCCCHHHHCCCCCCCHHH
HLEMYIQYACKEPVSLYPALKWWNQPKIGLEWMLNGTGLGASNHFEAGGFIRTRDEDLWP
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCC
NIQYHFLPVAINYNGSNAIEMHGFQAHVGSMRSPSRGRVKLTSRDPNAHPSILFNYMSEP
CCEEEEEEEEEEECCCCEEEECCHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCC
LDWREFRDAIRVTREIMRQPALDRFRGQELNPGAELKSDAQLDAFVRQRAETAFHPSCSN
CCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
KMGYDAMAVVDNEGRVHGLDGLRVVDASIMPIITTGNLNAPTIMIAEKIADRIRGRVPLA
CCCCCEEEEEECCCCEECCCCEEEECCCEEEEEEECCCCCCEEHHHHHHHHHHHCCCCHH
RATAKYFVANGAPARGKPLREAQAA
HHHHEEEEECCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA