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The map label for this gene is shc [H]

Identifier: 238023755

GI number: 238023755

Start: 333326

End: 335356

Strand: Direct

Name: shc [H]

Synonym: bglu_2g02870

Alternate gene names: 238023755

Gene position: 333326-335356 (Clockwise)

Preceding gene: 238023752

Following gene: 238023756

Centisome position: 11.79

GC content: 70.01

Gene sequence:

>2031_bases
ATGATCCGGCCGATGAAAAATTCCGATCTTCCGCTTCCATCCCTGCTGGACGCCGCGATCCTGCGCGGCCGCGATGCGCT
CGCGCAGCGCCAGAGCGCCGACGGCAGCTGGTGCTTCGAACTCGAATCCGACGCCACGATCACCGCCGAATACATCCTGA
TGATGCATTTCATGGGGAAGATCGACGAAGCGCGGCAGGCGCGCATGGCGCGCTACCTGCGTGGCATTCAGCGGCTCGCC
ACGCACGGCGCGTGGGACCTCTACGTGGACGGCGCGCCCGACGTGTCGTGCAGCGTGAAGGCCTATTTCGCGCTGAAGGC
GGCCGGCGACAGCGAGGACGCGCCGCACATGGCGCGCGCGCGCGAAACCATCCTCAAGCTCGGCGGCGCGGCGAAATCGA
ACGTGTTCACGCGCATCCTGCTTGCCACGTTCGGGCAGGTGCCGTGGCGCGCCACGCCGTTCATGCCGGTCGAGTTCGTG
CTGTTCCCGAAGTGGGTGCCGATCTCGATGTACAAGGTCGCGTACTGGGCGCGCACCACCATGGTGCCGCTGCTGGTGCT
CTGTTCGCTGAAGGCGCGCGCGAAGAACCCGCGCAACGTGTCGATTCGCGAGCTGTTCGTGACCGCGCCCGAAGCGGAGC
GCCACTACTTCGCGCGCGGCGGCTTCGTGCGCAACCTGTTCCTGGGAATCGACCGCGCGCTGCGGCCCCTCGATGCGCTG
ATCCCGAAGGCGCTGCGCCGCCGCGCGATCCGCCATGCCGAGGCGTGGTGCGCCGAGCGCATGAACGGCGAGGACGGCAT
GGGCGGGATCTTCCCGCCGATCGTCTACAGCTACCAGATGATGGACGTGCTCGGCTATCCCGAGGATCACCCGCTGCGGC
GCGATTGCGAGAACGCGCTCGACAAGCTGCTGGTCGAGCGGCCGGACGGCAGCGTCTATTGCCAGCCGTGCCTGTCGCCG
GTGTGGGATACCGCATGGAGCACGATGGCGCTCGAGCAGGCGCGCGCGGTGCCCGACCCGCGCGACGCTCCCCCGGTGTC
CGACGCGCAGTTGCAGCGGTGCATCGCGGCGTCCTACGAATGGCTCGCCGGCAAGCAGGTCACGCAGGTGCGCGGCGACT
GGGTCGAGAACGCGCCGGCCGCGACGCCGGCGGGCGGCTGGGCGTTCCAGTACGAGAACCCGTACTACCCCGACATCGAC
GACAGCGCCGTGGTGGCCGCGATGCTGCACCGGCGCGGCCGCCTGCTCGCGCGCAGCACCGGCACCGATCCGTATGCGCA
GGTGGTCGCGCGCGGGCTCGACTGGATGCGCGGGCTGCAATCGCGCAACGGCGGCTTCGGCGCGTTCGACGCCGATTGCG
ACCGGCTCTACCTGAACCTGATCCCGTTCGCCGATCACGGCGCGCTGCTCGACCCGCCCACCGAGGACGTGTCGGGGCGC
GTGCTGCTCTGCTTGGGCGTGACCGGCCGCGACGAGGACAAGCCCGCGCTGGCGCGCGCGATCGAGTACGTGAAGCGCAT
GCAGCGCGCCGACGGCTGCTGGTGGGGCCGCTGGGGCACCAACTACATCTACGGGACCTGGAGCGTGCTGGCCGGCCTTG
CGCTGGCCGGCGAGAACCCCTCGCAGCCCTACATCGCGCGCGCGATCGCCTGGCTGCGCGCCTGCCAGAACGCCGACGGC
GGCTGGGGCGAAACCAACGACAGCTATCTCGATCCGGCGCTGGCCGGGACCAACGGCGGCGAGAGCGCATCGAACGTCAC
GGCCTGGGCGCTGCTCGCGCAGATGGCGTTCGGCGACTGGCAGTCGGAGTCGGTGCAGCGCGGCATCCGCTATCTGCTGT
CGGTGCAGCAGGCCGACGGCTTCTGGTGGCATCGCTCGCACAATGCGCCGGGCTTCCCGCGCATCTACTACCTGAAATAT
CACGGCTACACGGCGTACTTCCCGCTGTGGGCGCTGGCGCGCTACCGGCGGCTCTCGCAGGCGGGCGCAGCGCGCGACGT
CACCGACGGGGCGGCGCTGGCCGCGAGCTGA

Upstream 100 bases:

>100_bases
GCCTGGTCGGGCAGCGTGCCGGGCGCGGGAGGCCGGGTGTCGTTCATGCGCGCATCTTACCATCGCGGTTTCGGCACGCC
CAACAATCCGGCCGGATGGT

Downstream 100 bases:

>100_bases
GGCGGCGCGGCCGCCGCGCTGGCGCATCCGGCGCATCCGGTGCCACGGCGCCACGGCGCGCGCTGCGCCGCGCCCGGGCC
GCCGATCCGGCCGGCAACCG

Product: Squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 676

Protein sequence:

>676_residues
MIRPMKNSDLPLPSLLDAAILRGRDALAQRQSADGSWCFELESDATITAEYILMMHFMGKIDEARQARMARYLRGIQRLA
THGAWDLYVDGAPDVSCSVKAYFALKAAGDSEDAPHMARARETILKLGGAAKSNVFTRILLATFGQVPWRATPFMPVEFV
LFPKWVPISMYKVAYWARTTMVPLLVLCSLKARAKNPRNVSIRELFVTAPEAERHYFARGGFVRNLFLGIDRALRPLDAL
IPKALRRRAIRHAEAWCAERMNGEDGMGGIFPPIVYSYQMMDVLGYPEDHPLRRDCENALDKLLVERPDGSVYCQPCLSP
VWDTAWSTMALEQARAVPDPRDAPPVSDAQLQRCIAASYEWLAGKQVTQVRGDWVENAPAATPAGGWAFQYENPYYPDID
DSAVVAAMLHRRGRLLARSTGTDPYAQVVARGLDWMRGLQSRNGGFGAFDADCDRLYLNLIPFADHGALLDPPTEDVSGR
VLLCLGVTGRDEDKPALARAIEYVKRMQRADGCWWGRWGTNYIYGTWSVLAGLALAGENPSQPYIARAIAWLRACQNADG
GWGETNDSYLDPALAGTNGGESASNVTAWALLAQMAFGDWQSESVQRGIRYLLSVQQADGFWWHRSHNAPGFPRIYYLKY
HGYTAYFPLWALARYRRLSQAGAARDVTDGAALAAS

Sequences:

>Translated_676_residues
MIRPMKNSDLPLPSLLDAAILRGRDALAQRQSADGSWCFELESDATITAEYILMMHFMGKIDEARQARMARYLRGIQRLA
THGAWDLYVDGAPDVSCSVKAYFALKAAGDSEDAPHMARARETILKLGGAAKSNVFTRILLATFGQVPWRATPFMPVEFV
LFPKWVPISMYKVAYWARTTMVPLLVLCSLKARAKNPRNVSIRELFVTAPEAERHYFARGGFVRNLFLGIDRALRPLDAL
IPKALRRRAIRHAEAWCAERMNGEDGMGGIFPPIVYSYQMMDVLGYPEDHPLRRDCENALDKLLVERPDGSVYCQPCLSP
VWDTAWSTMALEQARAVPDPRDAPPVSDAQLQRCIAASYEWLAGKQVTQVRGDWVENAPAATPAGGWAFQYENPYYPDID
DSAVVAAMLHRRGRLLARSTGTDPYAQVVARGLDWMRGLQSRNGGFGAFDADCDRLYLNLIPFADHGALLDPPTEDVSGR
VLLCLGVTGRDEDKPALARAIEYVKRMQRADGCWWGRWGTNYIYGTWSVLAGLALAGENPSQPYIARAIAWLRACQNADG
GWGETNDSYLDPALAGTNGGESASNVTAWALLAQMAFGDWQSESVQRGIRYLLSVQQADGFWWHRSHNAPGFPRIYYLKY
HGYTAYFPLWALARYRRLSQAGAARDVTDGAALAAS
>Mature_676_residues
MIRPMKNSDLPLPSLLDAAILRGRDALAQRQSADGSWCFELESDATITAEYILMMHFMGKIDEARQARMARYLRGIQRLA
THGAWDLYVDGAPDVSCSVKAYFALKAAGDSEDAPHMARARETILKLGGAAKSNVFTRILLATFGQVPWRATPFMPVEFV
LFPKWVPISMYKVAYWARTTMVPLLVLCSLKARAKNPRNVSIRELFVTAPEAERHYFARGGFVRNLFLGIDRALRPLDAL
IPKALRRRAIRHAEAWCAERMNGEDGMGGIFPPIVYSYQMMDVLGYPEDHPLRRDCENALDKLLVERPDGSVYCQPCLSP
VWDTAWSTMALEQARAVPDPRDAPPVSDAQLQRCIAASYEWLAGKQVTQVRGDWVENAPAATPAGGWAFQYENPYYPDID
DSAVVAAMLHRRGRLLARSTGTDPYAQVVARGLDWMRGLQSRNGGFGAFDADCDRLYLNLIPFADHGALLDPPTEDVSGR
VLLCLGVTGRDEDKPALARAIEYVKRMQRADGCWWGRWGTNYIYGTWSVLAGLALAGENPSQPYIARAIAWLRACQNADG
GWGETNDSYLDPALAGTNGGESASNVTAWALLAQMAFGDWQSESVQRGIRYLLSVQQADGFWWHRSHNAPGFPRIYYLKY
HGYTAYFPLWALARYRRLSQAGAARDVTDGAALAAS

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=690, Percent_Identity=23.6231884057971, Blast_Score=133, Evalue=7e-31,
Organism=Homo sapiens, GI47933397, Length=690, Percent_Identity=23.6231884057971, Blast_Score=133, Evalue=7e-31,
Organism=Homo sapiens, GI224177558, Length=667, Percent_Identity=23.688155922039, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI224177556, Length=690, Percent_Identity=23.3333333333333, Blast_Score=121, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321863, Length=692, Percent_Identity=22.2543352601156, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 75207; Mature: 75207

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRPMKNSDLPLPSLLDAAILRGRDALAQRQSADGSWCFELESDATITAEYILMMHFMGK
CCCCCCCCCCCCHHHHHHHHHHCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
IDEARQARMARYLRGIQRLATHGAWDLYVDGAPDVSCSVKAYFALKAAGDSEDAPHMARA
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEEEECCCCCCCCHHHHH
RETILKLGGAAKSNVFTRILLATFGQVPWRATPFMPVEFVLFPKWVPISMYKVAYWARTT
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
MVPLLVLCSLKARAKNPRNVSIRELFVTAPEAERHYFARGGFVRNLFLGIDRALRPLDAL
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IPKALRRRAIRHAEAWCAERMNGEDGMGGIFPPIVYSYQMMDVLGYPEDHPLRRDCENAL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DKLLVERPDGSVYCQPCLSPVWDTAWSTMALEQARAVPDPRDAPPVSDAQLQRCIAASYE
HHHHEECCCCCEEEHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
WLAGKQVTQVRGDWVENAPAATPAGGWAFQYENPYYPDIDDSAVVAAMLHRRGRLLARST
HHCCCHHHHHHCCHHCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEECC
GTDPYAQVVARGLDWMRGLQSRNGGFGAFDADCDRLYLNLIPFADHGALLDPPTEDVSGR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCCCCC
VLLCLGVTGRDEDKPALARAIEYVKRMQRADGCWWGRWGTNYIYGTWSVLAGLALAGENP
EEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCEEEECHHHHHHHHHCCCCC
SQPYIARAIAWLRACQNADGGWGETNDSYLDPALAGTNGGESASNVTAWALLAQMAFGDW
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCC
QSESVQRGIRYLLSVQQADGFWWHRSHNAPGFPRIYYLKYHGYTAYFPLWALARYRRLSQ
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCEEHHHHHHHHHHHHHHHH
AGAARDVTDGAALAAS
CCCCCCCCCCCHHCCC
>Mature Secondary Structure
MIRPMKNSDLPLPSLLDAAILRGRDALAQRQSADGSWCFELESDATITAEYILMMHFMGK
CCCCCCCCCCCCHHHHHHHHHHCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
IDEARQARMARYLRGIQRLATHGAWDLYVDGAPDVSCSVKAYFALKAAGDSEDAPHMARA
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEEEECCCCCCCCHHHHH
RETILKLGGAAKSNVFTRILLATFGQVPWRATPFMPVEFVLFPKWVPISMYKVAYWARTT
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
MVPLLVLCSLKARAKNPRNVSIRELFVTAPEAERHYFARGGFVRNLFLGIDRALRPLDAL
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IPKALRRRAIRHAEAWCAERMNGEDGMGGIFPPIVYSYQMMDVLGYPEDHPLRRDCENAL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
DKLLVERPDGSVYCQPCLSPVWDTAWSTMALEQARAVPDPRDAPPVSDAQLQRCIAASYE
HHHHEECCCCCEEEHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
WLAGKQVTQVRGDWVENAPAATPAGGWAFQYENPYYPDIDDSAVVAAMLHRRGRLLARST
HHCCCHHHHHHCCHHCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEECC
GTDPYAQVVARGLDWMRGLQSRNGGFGAFDADCDRLYLNLIPFADHGALLDPPTEDVSGR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCCCCC
VLLCLGVTGRDEDKPALARAIEYVKRMQRADGCWWGRWGTNYIYGTWSVLAGLALAGENP
EEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCEEEECHHHHHHHHHCCCCC
SQPYIARAIAWLRACQNADGGWGETNDSYLDPALAGTNGGESASNVTAWALLAQMAFGDW
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCC
QSESVQRGIRYLLSVQQADGFWWHRSHNAPGFPRIYYLKYHGYTAYFPLWALARYRRLSQ
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCEEHHHHHHHHHHHHHHHH
AGAARDVTDGAALAAS
CCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7894707 [H]