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The map label for this gene is glxR [H]

Identifier: 238023750

GI number: 238023750

Start: 328745

End: 329626

Strand: Direct

Name: glxR [H]

Synonym: bglu_2g02820

Alternate gene names: 238023750

Gene position: 328745-329626 (Clockwise)

Preceding gene: 238023749

Following gene: 238023752

Centisome position: 11.63

GC content: 70.29

Gene sequence:

>882_bases
ATGAAAGTCGGATTCATCGGCATCGGCGTGATGGGGCAGCCCATGGCGCTCAATCTCGCGCGCGCGGGCACCGCGCTGAT
CGTCTGGAATCGCTCCCCGGAACGCTGCGCGCCGCTCGCCGAGGCGGGCGCGCAAGTCGCCGGATCGGTCGACGAGGTCT
ATCGCGAGGCGCGCACCGTGATCCTGATGATGGCGACCGACGAGGCGCTCGATACCGTGCTCGGCCGCGGCACGCCCGAT
TTCGCACGGCGCGTGGCCGGCCACCTGATCGTGCACATGGGCACCGTGTCGGCCGACTATTCGCGCCGGCTCGACGCCGA
CATCCGCGCGGCCGGCGGCCGTTACGTGGAGGCGCCCGTGTCGGGCTCCCGCAAGCCGGCCGAGGCCGGGCAGCTGGTGG
CGATGCTGGCCGGCGAGCCGGCCGACATCGAGGCAGTGCGCCCGCTGCTCAAGCCGATGTGTCATGAATCCGTGGTTTGC
GGGCCGGTGCCCACCGGGCTGCTGATGAAGCTGTCGGTCAATACCTTCCTGATCCCGATGGTGACCGCGGTGGCCGAGGC
CTCGCACCTCGCGCGCTGCTACGGGCTCGACATGAAGCAGTTCCAGACCGTGCTCGACGCCGGGCCGATGGCGAGCGCCG
TCTCGCGCGTGAAGATCGACAAGCTGGTGCGCGAGGATTTCGAGGTGCAGGCATCGATTGCCGACGTGCTGAAGAACAAC
CGGCTCGCCGCCGAGGCCGCGCGCAACGCCAACCTCGCCTCGCCGCTGCTCGACACCTGCTTCGAGCTTTACACCGAGAC
GCTGAAGCTCGGCCACGGCGGCGAGGACATGGCCGCCGTGGTGCGCGCGATCGAGGCGCGCACGGCGGCCCGGCGCGCCT
GA

Upstream 100 bases:

>100_bases
CGCCCGCCGTTTGCCGTGGGCCGTCGTCCCGTGAGCGGAACCCGCAGCCATCCCCACCTGGCCATCGCCACGAGCGATGG
TGAAGATACGGAGACACTCA

Downstream 100 bases:

>100_bases
GGCCGGGAGCGGCGCGCATCGCGCCGGCTCTTCAGCGGGCCGCGGTGCCGCGCCGGCACGGCCCTGTCGGCGTAGCCGGT
GCGGCCGGCCGGCCGCCCTC

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKVGFIGIGVMGQPMALNLARAGTALIVWNRSPERCAPLAEAGAQVAGSVDEVYREARTVILMMATDEALDTVLGRGTPD
FARRVAGHLIVHMGTVSADYSRRLDADIRAAGGRYVEAPVSGSRKPAEAGQLVAMLAGEPADIEAVRPLLKPMCHESVVC
GPVPTGLLMKLSVNTFLIPMVTAVAEASHLARCYGLDMKQFQTVLDAGPMASAVSRVKIDKLVREDFEVQASIADVLKNN
RLAAEAARNANLASPLLDTCFELYTETLKLGHGGEDMAAVVRAIEARTAARRA

Sequences:

>Translated_293_residues
MKVGFIGIGVMGQPMALNLARAGTALIVWNRSPERCAPLAEAGAQVAGSVDEVYREARTVILMMATDEALDTVLGRGTPD
FARRVAGHLIVHMGTVSADYSRRLDADIRAAGGRYVEAPVSGSRKPAEAGQLVAMLAGEPADIEAVRPLLKPMCHESVVC
GPVPTGLLMKLSVNTFLIPMVTAVAEASHLARCYGLDMKQFQTVLDAGPMASAVSRVKIDKLVREDFEVQASIADVLKNN
RLAAEAARNANLASPLLDTCFELYTETLKLGHGGEDMAAVVRAIEARTAARRA
>Mature_293_residues
MKVGFIGIGVMGQPMALNLARAGTALIVWNRSPERCAPLAEAGAQVAGSVDEVYREARTVILMMATDEALDTVLGRGTPD
FARRVAGHLIVHMGTVSADYSRRLDADIRAAGGRYVEAPVSGSRKPAEAGQLVAMLAGEPADIEAVRPLLKPMCHESVVC
GPVPTGLLMKLSVNTFLIPMVTAVAEASHLARCYGLDMKQFQTVLDAGPMASAVSRVKIDKLVREDFEVQASIADVLKNN
RLAAEAARNANLASPLLDTCFELYTETLKLGHGGEDMAAVVRAIEARTAARRA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=284, Percent_Identity=29.9295774647887, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI23308751, Length=206, Percent_Identity=33.495145631068, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1786719, Length=285, Percent_Identity=29.8245614035088, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI145693186, Length=242, Percent_Identity=29.7520661157025, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1790315, Length=283, Percent_Identity=24.3816254416961, Blast_Score=73, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574115, Length=279, Percent_Identity=27.9569892473118, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24655230, Length=286, Percent_Identity=29.7202797202797, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI19922568, Length=286, Percent_Identity=29.7202797202797, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31136; Mature: 31136

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGFIGIGVMGQPMALNLARAGTALIVWNRSPERCAPLAEAGAQVAGSVDEVYREARTV
CEEEEEEECCCCCCCEEEHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHEE
ILMMATDEALDTVLGRGTPDFARRVAGHLIVHMGTVSADYSRRLDADIRAAGGRYVEAPV
EEEEECHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCHHHHHCCCHHHHCCCEEEECCC
SGSRKPAEAGQLVAMLAGEPADIEAVRPLLKPMCHESVVCGPVPTGLLMKLSVNTFLIPM
CCCCCCHHHHHEEHHHCCCCCCHHHHHHHHHHHHHCCEECCCCCCCCEEEHHHHHHHHHH
VTAVAEASHLARCYGLDMKQFQTVLDAGPMASAVSRVKIDKLVREDFEVQASIADVLKNN
HHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RLAAEAARNANLASPLLDTCFELYTETLKLGHGGEDMAAVVRAIEARTAARRA
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVGFIGIGVMGQPMALNLARAGTALIVWNRSPERCAPLAEAGAQVAGSVDEVYREARTV
CEEEEEEECCCCCCCEEEHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHEE
ILMMATDEALDTVLGRGTPDFARRVAGHLIVHMGTVSADYSRRLDADIRAAGGRYVEAPV
EEEEECHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCHHHHHCCCHHHHCCCEEEECCC
SGSRKPAEAGQLVAMLAGEPADIEAVRPLLKPMCHESVVCGPVPTGLLMKLSVNTFLIPM
CCCCCCHHHHHEEHHHCCCCCCHHHHHHHHHHHHHCCEECCCCCCCCEEEHHHHHHHHHH
VTAVAEASHLARCYGLDMKQFQTVLDAGPMASAVSRVKIDKLVREDFEVQASIADVLKNN
HHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RLAAEAARNANLASPLLDTCFELYTETLKLGHGGEDMAAVVRAIEARTAARRA
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]