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The map label for this gene is mhpE [C]

Identifier: 238023745

GI number: 238023745

Start: 324165

End: 325211

Strand: Direct

Name: mhpE [C]

Synonym: bglu_2g02770

Alternate gene names: 238023745

Gene position: 324165-325211 (Clockwise)

Preceding gene: 238023744

Following gene: 238023746

Centisome position: 11.47

GC content: 70.58

Gene sequence:

>1047_bases
ATGAACCTCATCAGTGATGCGACGCTGCGGGACGGCAATCATGCGATCCGCCACCAGCTGACGAGCGCGCAGATCGCCGA
CTATGCGCGCGCGGCCAACGCGGCCGGCATCGACATCGTGGAAGTGGGCCACGGCAATGGCCTGGGGGGCTCGTCGTGCC
TGCTCGGCCAGACCCCGATCGACGACCGCGCCATGCTCGACACCGCGCGCGCGGCGCTCACCACCAGCCGGCTCGGCGTG
CATTTCATCCCGGGCCTCGGCAAGTCGGCCGACATCGAGCTGGCGATCGAGACGGGCGTGGACGTGGTGCGCGTGGCCAC
CCACTGCACCGAGGCCAACGTCGCGCGGCGCTTTATCGACCAGACGCGCCAGGCCGGCCGCACCGCGTTCGGCGTCCTGA
TGATGTCGCACATGGCGCCGGCCGAGGTGCTGCTCGCCCAGGCGCGGCTGATGCAGGGCTACGGCGCGCAGGCGGTGATC
CTGATGGACAGCGCCGGCTATTCCACGCCGTCGCTGGTGCGCGAGAAGGTGCGGCGCCTGGTGGGCGAGCTGGAGGTGGC
GGTGGGCTTCCATGCGCACAACAACCTCGGCCTCGCCGTGGCCAACAGCCTGGTCGCGCTGGAGGAGGGCGCCACCGTCG
TCGACGCCTGCGTGAAGGGCTTCGGCGCCGGCGCCGGCAATACGCAGCTGGAAACCCTGGTGGCCGCGATGGAGCGCGAG
GGGCACGCGACCAACACCAGCTTCGAGCGCGTGACGCTGCTGGCGCGCGAGTCCGAAGCGTTTCTGAGTCCGAAGACGCC
GCACATTCCGGCCGCGAACATCGCCAGTGGCCTGTACGGGCTCTTTTCCGGCTACGTGCCGCACATCCAGAAGGCCGCGC
TCGAGTTCGGCGTCAACGAGTTCGAGCTGTACCGGCGGCTCGCGGAGCGCAAGCTGGTGGCCGGCCAGGAAGACATCATC
ACCGAGGAAGCGAGCCGGCTCGCGCGCGCGCGCGACGCGCAGCAGGCCGGGCGGCGCCAGGAAACCGCGCGCGAGCTGTC
CGCCTGA

Upstream 100 bases:

>100_bases
ACTACCTGCCCGAGTACGCGGGCAACCTCGACATCATCAACTGCGCGGCGCTCGCGGTGGCCACGCACCGGCATGCAACC
CTTCGCTCAGGAGTGACGCA

Downstream 100 bases:

>100_bases
GCGGCGCGGCGCCGGCATTGGGCAATCGATCGATCCGAACCAGGAGGCAGACGAGATGGCAGGGCTCAACGAACACGGCC
ACGGCACGTGGGACGCTATC

Product: 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase

Products: NA

Alternate protein names: HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MNLISDATLRDGNHAIRHQLTSAQIADYARAANAAGIDIVEVGHGNGLGGSSCLLGQTPIDDRAMLDTARAALTTSRLGV
HFIPGLGKSADIELAIETGVDVVRVATHCTEANVARRFIDQTRQAGRTAFGVLMMSHMAPAEVLLAQARLMQGYGAQAVI
LMDSAGYSTPSLVREKVRRLVGELEVAVGFHAHNNLGLAVANSLVALEEGATVVDACVKGFGAGAGNTQLETLVAAMERE
GHATNTSFERVTLLARESEAFLSPKTPHIPAANIASGLYGLFSGYVPHIQKAALEFGVNEFELYRRLAERKLVAGQEDII
TEEASRLARARDAQQAGRRQETARELSA

Sequences:

>Translated_348_residues
MNLISDATLRDGNHAIRHQLTSAQIADYARAANAAGIDIVEVGHGNGLGGSSCLLGQTPIDDRAMLDTARAALTTSRLGV
HFIPGLGKSADIELAIETGVDVVRVATHCTEANVARRFIDQTRQAGRTAFGVLMMSHMAPAEVLLAQARLMQGYGAQAVI
LMDSAGYSTPSLVREKVRRLVGELEVAVGFHAHNNLGLAVANSLVALEEGATVVDACVKGFGAGAGNTQLETLVAAMERE
GHATNTSFERVTLLARESEAFLSPKTPHIPAANIASGLYGLFSGYVPHIQKAALEFGVNEFELYRRLAERKLVAGQEDII
TEEASRLARARDAQQAGRRQETARELSA
>Mature_348_residues
MNLISDATLRDGNHAIRHQLTSAQIADYARAANAAGIDIVEVGHGNGLGGSSCLLGQTPIDDRAMLDTARAALTTSRLGV
HFIPGLGKSADIELAIETGVDVVRVATHCTEANVARRFIDQTRQAGRTAFGVLMMSHMAPAEVLLAQARLMQGYGAQAVI
LMDSAGYSTPSLVREKVRRLVGELEVAVGFHAHNNLGLAVANSLVALEEGATVVDACVKGFGAGAGNTQLETLVAAMERE
GHATNTSFERVTLLARESEAFLSPKTPHIPAANIASGLYGLFSGYVPHIQKAALEFGVNEFELYRRLAERKLVAGQEDII
TEEASRLARARDAQQAGRRQETARELSA

Specific function: Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4-hydroxy-2-oxovalerate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1786548, Length=326, Percent_Identity=39.2638036809816, Blast_Score=209, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017629
- InterPro:   IPR013785
- InterPro:   IPR012425
- InterPro:   IPR000891
- ProDom:   PD005364 [H]

Pfam domain/function: PF07836 DmpG_comm; PF00682 HMGL-like [H]

EC number: =4.1.3.39 [H]

Molecular weight: Translated: 36989; Mature: 36989

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLISDATLRDGNHAIRHQLTSAQIADYARAANAAGIDIVEVGHGNGLGGSSCLLGQTPI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEECCCCCC
DDRAMLDTARAALTTSRLGVHFIPGLGKSADIELAIETGVDVVRVATHCTEANVARRFID
CCHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
QTRQAGRTAFGVLMMSHMAPAEVLLAQARLMQGYGAQAVILMDSAGYSTPSLVREKVRRL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHH
VGELEVAVGFHAHNNLGLAVANSLVALEEGATVVDACVKGFGAGAGNTQLETLVAAMERE
HHHHHHHEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GHATNTSFERVTLLARESEAFLSPKTPHIPAANIASGLYGLFSGYVPHIQKAALEFGVNE
CCCCCCCHHHHEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FELYRRLAERKLVAGQEDIITEEASRLARARDAQQAGRRQETARELSA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLISDATLRDGNHAIRHQLTSAQIADYARAANAAGIDIVEVGHGNGLGGSSCLLGQTPI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEECCCCCC
DDRAMLDTARAALTTSRLGVHFIPGLGKSADIELAIETGVDVVRVATHCTEANVARRFID
CCHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
QTRQAGRTAFGVLMMSHMAPAEVLLAQARLMQGYGAQAVILMDSAGYSTPSLVREKVRRL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHH
VGELEVAVGFHAHNNLGLAVANSLVALEEGATVVDACVKGFGAGAGNTQLETLVAAMERE
HHHHHHHEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GHATNTSFERVTLLARESEAFLSPKTPHIPAANIASGLYGLFSGYVPHIQKAALEFGVNE
CCCCCCCHHHHEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FELYRRLAERKLVAGQEDIITEEASRLARARDAQQAGRRQETARELSA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA