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The map label for this gene is hssR [H]

Identifier: 238023722

GI number: 238023722

Start: 292136

End: 293173

Strand: Reverse

Name: hssR [H]

Synonym: bglu_2g02500

Alternate gene names: 238023722

Gene position: 293173-292136 (Counterclockwise)

Preceding gene: 238023723

Following gene: 238023710

Centisome position: 10.37

GC content: 70.52

Gene sequence:

>1038_bases
TTGAAGTTTGCCGTATTAACGCCCAACGTCAGCATGTTTGAACGACTGCGCCAGCATTTTCTCGATGCCTCCGTCGAATG
CATCCAATTCGAGGACGACGTCGCATTGGCGCGCGGCCTTTACCGCGACGATTACCGGGTGATCCTGGTCGACGCTGCCA
CCGGCATTGACGGCACGCGCACCGTGTTCGCACGCCGCGCGTTCTATGGCGGCCGGCGGGCGCCGCTGCTGGTGGTCGGC
ACGTTCACCGATCGCGACAGCCTCGAGCGCGCCTTCGACACCGGCGCCGACGACGTGGTGCTGGCGCCCTTCGACCGCAA
CGAGCTGGCGGCCCGCGCCTTTCGCGCGATGCGCCGCGTGGAGGCGGAGCCCGCTCCGCGCGACGAGCAGCGCGTCACGC
TCGGCGCCTATACGCTCGACCAGCAGGCCAGCACCGTGCAGATCGCGGGCCGCAACGTGCGCGTGACCACGCGCGAGTTC
GCGATCGCCTGGCTGCTGTTCTCGCGCGCCGGCGAATACGTCACGCGCCGCCAGCTGGCGGGCGCGATCTGGGGCAGCAC
GGAGGATATCGTCGGCCGGCGGCTGGAACAGCACATCTACAAGCTGCGCCGCAAACTGGAACTGACGGGAGAATCGGGCG
TCGCGCTGCGCACCATGTATGCGCACGGCTACCGGATCGAGCAGACCGACGGCGTGGCGATCGACGCCGACGCGGAGGCG
GCCCGGCACGCGCTGGCCGAGGCCCAGCTCGACAGCCTGGGGGTGCGCACGCCCGCGGCGGGGGCCGCCTGCGCACCGCA
GCCCTGCGGTGGGCTGCCGTTGCCAGCCGATCGCGCAAACGTTGTCACGCCAGGCGCGGTGGCCACGGTGCATGCGCGCC
ACAGCCTCACGGCCTCGCTCGCGCAGCCCTGGGCCTCGTATGCGAACCCGTGGCACATCGGCGCCACCATGATCGCGAAG
GCCGTACACGACGACGGCGCCGCAGCCGGCCAGCCGCTGCGCGTGCCGACGCTGTCGGGCTCGTGCAGCGAAGGTTGA

Upstream 100 bases:

>100_bases
ACAATAAGTTACACCCCTGGGTTTTCGATGCCTGTACTTTCGCTCCGTGCCAGTAGCCTGCCGATTCATTTCATGTCGGG
ACAAGTAGAGGAGGTTCAGG

Downstream 100 bases:

>100_bases
GCCTGCAACCACCGGGGCCGCCGGCCCCGCCGTCCCGCCATCCGCAACATCCCGCCGCCGGCGGGATGTTGTCGTTTACG
CGGGCGCCGGCGGTGATGCC

Product: putative response regulator transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKFAVLTPNVSMFERLRQHFLDASVECIQFEDDVALARGLYRDDYRVILVDAATGIDGTRTVFARRAFYGGRRAPLLVVG
TFTDRDSLERAFDTGADDVVLAPFDRNELAARAFRAMRRVEAEPAPRDEQRVTLGAYTLDQQASTVQIAGRNVRVTTREF
AIAWLLFSRAGEYVTRRQLAGAIWGSTEDIVGRRLEQHIYKLRRKLELTGESGVALRTMYAHGYRIEQTDGVAIDADAEA
ARHALAEAQLDSLGVRTPAAGAACAPQPCGGLPLPADRANVVTPGAVATVHARHSLTASLAQPWASYANPWHIGATMIAK
AVHDDGAAAGQPLRVPTLSGSCSEG

Sequences:

>Translated_345_residues
MKFAVLTPNVSMFERLRQHFLDASVECIQFEDDVALARGLYRDDYRVILVDAATGIDGTRTVFARRAFYGGRRAPLLVVG
TFTDRDSLERAFDTGADDVVLAPFDRNELAARAFRAMRRVEAEPAPRDEQRVTLGAYTLDQQASTVQIAGRNVRVTTREF
AIAWLLFSRAGEYVTRRQLAGAIWGSTEDIVGRRLEQHIYKLRRKLELTGESGVALRTMYAHGYRIEQTDGVAIDADAEA
ARHALAEAQLDSLGVRTPAAGAACAPQPCGGLPLPADRANVVTPGAVATVHARHSLTASLAQPWASYANPWHIGATMIAK
AVHDDGAAAGQPLRVPTLSGSCSEG
>Mature_345_residues
MKFAVLTPNVSMFERLRQHFLDASVECIQFEDDVALARGLYRDDYRVILVDAATGIDGTRTVFARRAFYGGRRAPLLVVG
TFTDRDSLERAFDTGADDVVLAPFDRNELAARAFRAMRRVEAEPAPRDEQRVTLGAYTLDQQASTVQIAGRNVRVTTREF
AIAWLLFSRAGEYVTRRQLAGAIWGSTEDIVGRRLEQHIYKLRRKLELTGESGVALRTMYAHGYRIEQTDGVAIDADAEA
ARHALAEAQLDSLGVRTPAAGAACAPQPCGGLPLPADRANVVTPGAVATVHARHSLTASLAQPWASYANPWHIGATMIAK
AVHDDGAAAGQPLRVPTLSGSCSEG

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=176, Percent_Identity=30.1136363636364, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789402, Length=191, Percent_Identity=29.3193717277487, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786911, Length=154, Percent_Identity=30.5194805194805, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786599, Length=155, Percent_Identity=25.8064516129032, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 37458; Mature: 37458

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAVLTPNVSMFERLRQHFLDASVECIQFEDDVALARGLYRDDYRVILVDAATGIDGTR
CEEEEECCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCEEEEEEECCCCCCHH
TVFARRAFYGGRRAPLLVVGTFTDRDSLERAFDTGADDVVLAPFDRNELAARAFRAMRRV
HHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHH
EAEPAPRDEQRVTLGAYTLDQQASTVQIAGRNVRVTTREFAIAWLLFSRAGEYVTRRQLA
CCCCCCCCCCEEEEEEEEECCCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
GAIWGSTEDIVGRRLEQHIYKLRRKLELTGESGVALRTMYAHGYRIEQTDGVAIDADAEA
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEECCCCEEEECCHHH
ARHALAEAQLDSLGVRTPAAGAACAPQPCGGLPLPADRANVVTPGAVATVHARHSLTASL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEEHHHHHHHHH
AQPWASYANPWHIGATMIAKAVHDDGAAAGQPLRVPTLSGSCSEG
HHHHHHHCCCEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MKFAVLTPNVSMFERLRQHFLDASVECIQFEDDVALARGLYRDDYRVILVDAATGIDGTR
CEEEEECCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCEEEEEEECCCCCCHH
TVFARRAFYGGRRAPLLVVGTFTDRDSLERAFDTGADDVVLAPFDRNELAARAFRAMRRV
HHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHH
EAEPAPRDEQRVTLGAYTLDQQASTVQIAGRNVRVTTREFAIAWLLFSRAGEYVTRRQLA
CCCCCCCCCCEEEEEEEEECCCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
GAIWGSTEDIVGRRLEQHIYKLRRKLELTGESGVALRTMYAHGYRIEQTDGVAIDADAEA
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEECCCCEEEECCHHH
ARHALAEAQLDSLGVRTPAAGAACAPQPCGGLPLPADRANVVTPGAVATVHARHSLTASL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCEEEEEHHHHHHHHH
AQPWASYANPWHIGATMIAKAVHDDGAAAGQPLRVPTLSGSCSEG
HHHHHHHCCCEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA