Click here to switch to the map view.

The map label for this gene is bioA [C]

Identifier: 238023578

GI number: 238023578

Start: 82032

End: 83396

Strand: Reverse

Name: bioA [C]

Synonym: bglu_2g00810

Alternate gene names: 238023578

Gene position: 83396-82032 (Counterclockwise)

Preceding gene: 238023579

Following gene: 238023577

Centisome position: 2.95

GC content: 68.35

Gene sequence:

>1365_bases
ATGGACTATCAACAGCGTCAAAAGCGATTCTGGCACCCGATGAGCTCGGCAGCCGCCGGGCATACGACTCCCACCGTCGT
GATCGCCCGCGGCGACGGCAACTACGTGTTCGACGTCGAGGGCCACCGCATGCTCGACGGCGTGGGCGGCCTGTGGAACG
TCAACGTCGGCCACAACCGGCCGGAAGTGAAAAGCGCGATCGCGCGGCAGATGGACGAGCTGTCCTACTATCAGACCTTC
GACGGCGTCGCCCACCCGCGCGTCTACGATCTGGCCGACCGCCTGTGCGCGATGTTCGCCCGGGAGGACATGCAGCGGGT
CATGTTCGGCAGCGGCGGGTCCGACGCGATCGAGACCGCGCTGAAGATGGCTCGCCAGTACTGGGTCGCCGCGGGCGAGC
CGTCGCGCACGAAATTCCTGTCGCTGCGCAACGGCTATCACGGCGTGCACATGGGCGGCACGTCGATCGGCGGCAACGGG
GTCTACCACTACAATCACGGCCCGCTGCTGCCCGGCTGCGTGCTGCTCGATACGCCGTGGCTCTACCGCAATCCGTGGAA
CTGCGAGGATCCCCGGCAGCTCGTCGAGCACTGCATCCGGCAGCTCGAGGAAACGATCGCGTTCCATGGCCCGCAGACCA
TCGCGGCATTCGTCGCCGAGCCGGTGCAGGGCGCCGGCGGCCTGATCGTCCCGCCGGCCGAGTACTGGCCGCGTGTGCGC
GAGGTGTGCGAGCGCAACGGCATCCTGTTGATCGCGGACGAGGTGGTCACCGGCTTCGGCCGTACCGGCAGCCTGCTCGG
CAGCCGCGGCTGGGGCGTCGCCGCCGACATCCTGTGCGTCGCCAAGGGCATTTCCGCCGGCTACGTGCCGCTCGGCGCGA
CGCTGTACAACGGCCGCATCGCGCAAGCGATCGAACACGGCAGCGGCTTCTCGCACGTGATCATGCACGGCTATACTTAC
AGCGGCCATCCGCTAGCCTGCGCCGCCTCGCTCGCCGTGCTCGACATCGTCGAGAGCGAGGACTTGCCGGGCAACGCGGC
TCGGGTCGGCGAGCGCCTTCTGGCGCAATTGCTGCCGCTGAAGGCCGACTTCGAGACCGTCGGCGACGTTCGCGGCAAGG
GGCTGATGCTCGCGCTCGACTTGGTGACCGACAAGGCCAGCCGCACGCCGCTCGATCCGGCCAAGGGTTTCGCCGCGCGT
GTGGCCGATGCCGCGCGCAGGCGCGGCGTCCTGGTCCGGGCCATCGCCAACAAGATCGTGATGTCGCCGCCGTTGACGCT
GCAGCAGAACGAAGCCGACTTCATGGCGGTGACGCTGCGCGAAGCGCTGCAGGAATGCTGCGCGGATTCGCGCGCGATCG
CCTGA

Upstream 100 bases:

>100_bases
CGATTCCTACCTCGAGGAAAAGCTCGTCACCGCGGCCCTGTAATCCGGCGGCGCACCCGGCGCGGCCATCTGTTCAAGCA
CTTCGCGAGAGAGACCCACC

Downstream 100 bases:

>100_bases
GCGCGCGACACCGTCCGCCGCATGGACAGCTCGCCGAAGGTTCACGAGCCTCGTCATCCTGCCGGCGGGCGACGAAGATC
GGCGCGGCACGCCGCAGCCA

Product: hypothetical protein

Products: S-Adenosyl-4-methylthio-2-oxobutanoate; 7,8-Diaminononanoate [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MDYQQRQKRFWHPMSSAAAGHTTPTVVIARGDGNYVFDVEGHRMLDGVGGLWNVNVGHNRPEVKSAIARQMDELSYYQTF
DGVAHPRVYDLADRLCAMFAREDMQRVMFGSGGSDAIETALKMARQYWVAAGEPSRTKFLSLRNGYHGVHMGGTSIGGNG
VYHYNHGPLLPGCVLLDTPWLYRNPWNCEDPRQLVEHCIRQLEETIAFHGPQTIAAFVAEPVQGAGGLIVPPAEYWPRVR
EVCERNGILLIADEVVTGFGRTGSLLGSRGWGVAADILCVAKGISAGYVPLGATLYNGRIAQAIEHGSGFSHVIMHGYTY
SGHPLACAASLAVLDIVESEDLPGNAARVGERLLAQLLPLKADFETVGDVRGKGLMLALDLVTDKASRTPLDPAKGFAAR
VADAARRRGVLVRAIANKIVMSPPLTLQQNEADFMAVTLREALQECCADSRAIA

Sequences:

>Translated_454_residues
MDYQQRQKRFWHPMSSAAAGHTTPTVVIARGDGNYVFDVEGHRMLDGVGGLWNVNVGHNRPEVKSAIARQMDELSYYQTF
DGVAHPRVYDLADRLCAMFAREDMQRVMFGSGGSDAIETALKMARQYWVAAGEPSRTKFLSLRNGYHGVHMGGTSIGGNG
VYHYNHGPLLPGCVLLDTPWLYRNPWNCEDPRQLVEHCIRQLEETIAFHGPQTIAAFVAEPVQGAGGLIVPPAEYWPRVR
EVCERNGILLIADEVVTGFGRTGSLLGSRGWGVAADILCVAKGISAGYVPLGATLYNGRIAQAIEHGSGFSHVIMHGYTY
SGHPLACAASLAVLDIVESEDLPGNAARVGERLLAQLLPLKADFETVGDVRGKGLMLALDLVTDKASRTPLDPAKGFAAR
VADAARRRGVLVRAIANKIVMSPPLTLQQNEADFMAVTLREALQECCADSRAIA
>Mature_454_residues
MDYQQRQKRFWHPMSSAAAGHTTPTVVIARGDGNYVFDVEGHRMLDGVGGLWNVNVGHNRPEVKSAIARQMDELSYYQTF
DGVAHPRVYDLADRLCAMFAREDMQRVMFGSGGSDAIETALKMARQYWVAAGEPSRTKFLSLRNGYHGVHMGGTSIGGNG
VYHYNHGPLLPGCVLLDTPWLYRNPWNCEDPRQLVEHCIRQLEETIAFHGPQTIAAFVAEPVQGAGGLIVPPAEYWPRVR
EVCERNGILLIADEVVTGFGRTGSLLGSRGWGVAADILCVAKGISAGYVPLGATLYNGRIAQAIEHGSGFSHVIMHGYTY
SGHPLACAASLAVLDIVESEDLPGNAARVGERLLAQLLPLKADFETVGDVRGKGLMLALDLVTDKASRTPLDPAKGFAAR
VADAARRRGVLVRAIANKIVMSPPLTLQQNEADFMAVTLREALQECCADSRAIA

Specific function: Biotin biosynthesis. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=460, Percent_Identity=30.4347826086957, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI37574042, Length=428, Percent_Identity=32.7102803738318, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI226442705, Length=428, Percent_Identity=32.4766355140187, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI226442709, Length=398, Percent_Identity=32.9145728643216, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4557809, Length=435, Percent_Identity=29.6551724137931, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI24119277, Length=442, Percent_Identity=28.9592760180996, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI284507298, Length=338, Percent_Identity=30.7692307692308, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI188536080, Length=445, Percent_Identity=23.1460674157303, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38679950, Length=445, Percent_Identity=23.1460674157303, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38679946, Length=445, Percent_Identity=23.1460674157303, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786991, Length=443, Percent_Identity=33.8600451467269, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI145693181, Length=445, Percent_Identity=29.438202247191, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=31.4634146341463, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789759, Length=353, Percent_Identity=30.028328611898, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788044, Length=404, Percent_Identity=28.4653465346535, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1787560, Length=419, Percent_Identity=28.6396181384248, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1786349, Length=337, Percent_Identity=27.893175074184, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=460, Percent_Identity=31.0869565217391, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI25144271, Length=416, Percent_Identity=27.6442307692308, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71992977, Length=427, Percent_Identity=27.6346604215457, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25144274, Length=223, Percent_Identity=33.1838565022422, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17541228, Length=380, Percent_Identity=21.3157894736842, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=440, Percent_Identity=28.6363636363636, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324386, Length=475, Percent_Identity=26.3157894736842, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6324432, Length=412, Percent_Identity=26.4563106796117, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI161085790, Length=463, Percent_Identity=33.9092872570194, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI28574759, Length=469, Percent_Identity=32.8358208955224, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI21356575, Length=439, Percent_Identity=33.0296127562642, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21357415, Length=414, Percent_Identity=29.4685990338164, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI281366494, Length=381, Percent_Identity=21.5223097112861, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24667139, Length=381, Percent_Identity=21.5223097112861, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24667143, Length=381, Percent_Identity=21.5223097112861, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62 [C]

Molecular weight: Translated: 49261; Mature: 49261

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYQQRQKRFWHPMSSAAAGHTTPTVVIARGDGNYVFDVEGHRMLDGVGGLWNVNVGHNR
CCHHHHHHHHCCCHHHCCCCCCCCEEEEEECCCCEEEEECCCEEECCCCCEEEECCCCCC
PEVKSAIARQMDELSYYQTFDGVAHPRVYDLADRLCAMFAREDMQRVMFGSGGSDAIETA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LKMARQYWVAAGEPSRTKFLSLRNGYHGVHMGGTSIGGNGVYHYNHGPLLPGCVLLDTPW
HHHHHHHHHCCCCCCHHHEEEECCCCCEEEECCCCCCCCCEEEECCCCCCCCEEEECCCH
LYRNPWNCEDPRQLVEHCIRQLEETIAFHGPQTIAAFVAEPVQGAGGLIVPPAEYWPRVR
HCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
EVCERNGILLIADEVVTGFGRTGSLLGSRGWGVAADILCVAKGISAGYVPLGATLYNGRI
HHHHHCCEEEEEHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEEECCHH
AQAIEHGSGFSHVIMHGYTYSGHPLACAASLAVLDIVESEDLPGNAARVGERLLAQLLPL
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
KADFETVGDVRGKGLMLALDLVTDKASRTPLDPAKGFAARVADAARRRGVLVRAIANKIV
CCCHHHHHCCCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHC
MSPPLTLQQNEADFMAVTLREALQECCADSRAIA
CCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDYQQRQKRFWHPMSSAAAGHTTPTVVIARGDGNYVFDVEGHRMLDGVGGLWNVNVGHNR
CCHHHHHHHHCCCHHHCCCCCCCCEEEEEECCCCEEEEECCCEEECCCCCEEEECCCCCC
PEVKSAIARQMDELSYYQTFDGVAHPRVYDLADRLCAMFAREDMQRVMFGSGGSDAIETA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LKMARQYWVAAGEPSRTKFLSLRNGYHGVHMGGTSIGGNGVYHYNHGPLLPGCVLLDTPW
HHHHHHHHHCCCCCCHHHEEEECCCCCEEEECCCCCCCCCEEEECCCCCCCCEEEECCCH
LYRNPWNCEDPRQLVEHCIRQLEETIAFHGPQTIAAFVAEPVQGAGGLIVPPAEYWPRVR
HCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHH
EVCERNGILLIADEVVTGFGRTGSLLGSRGWGVAADILCVAKGISAGYVPLGATLYNGRI
HHHHHCCEEEEEHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEEECCHH
AQAIEHGSGFSHVIMHGYTYSGHPLACAASLAVLDIVESEDLPGNAARVGERLLAQLLPL
HHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCC
KADFETVGDVRGKGLMLALDLVTDKASRTPLDPAKGFAARVADAARRRGVLVRAIANKIV
CCCHHHHHCCCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHC
MSPPLTLQQNEADFMAVTLREALQECCADSRAIA
CCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Amino-7-oxononanoate; S-Adenosyl-L-methionine [C]

Specific reaction: 8-Amino-7-oxononanoate + S-Adenosyl-L-methionine <==> S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]