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The map label for this gene is sdaA [H]

Identifier: 237814305

GI number: 237814305

Start: 3927875

End: 3929263

Strand: Direct

Name: sdaA [H]

Synonym: GBP346_A4103

Alternate gene names: 237814305

Gene position: 3927875-3929263 (Clockwise)

Preceding gene: 237814304

Following gene: 237814307

Centisome position: 95.84

GC content: 68.97

Gene sequence:

>1389_bases
ATGGCAGTCAGCGTGTTCGATCTTTTCAAAATCGGTATCGGCCCGTCGAGCTCGCATACGGTCGGGCCGATGCGCGCCGC
ACTGATGTTCGCGCAAGGGCTCGAGCGCGACGCGCTGCTCGCCGCGACCGCGAGCGTGAAGGTCGAGCTGTACGGCTCGC
TCGGCGCGACCGGCAAGGGCCACGGCACCGATCGCGGCGTGATGCTCGGCCTGATGGGCGACGCGCCCGACACCGTCGAT
CCGTCGACGATCGCCGCGCGGCTCGACGCGGTGCGCACCTCGAAAACGCTCGCGCTGCTCGGCACGCATCCGGTACCGTT
CGTGCCGAAGGAACACATCGCGTTCTACCGGCAGGCGCTGCCCGAGCACCCGAACGCGATGAAGCTGCGCGCGGCCGACG
CGGCGGGCGCGGTGCTGCGCGAGGCGACGTATCTTTCGGTGGGCGGCGGCTTCGTCGTCACCTCGGGCGCGCCGAACACG
AAAGTGCTCGCCGCCGCCGAACAGATGCCGCACCCGTTCCGCACGGGCGCCGAGCTGCTCGCGCTCACCGCGTCGACCGG
CAAGTCGATCGCGCAGCTGATGTGGGAGAACGAGCGCGCGTGGCACACCGAGGAGGAAACGCGCACGGGCCTGCTGAAGA
TCTGGGACGTGATGCAATCGTGCGTCGCGCGCGGCTGCGGAATCGGCAACCCCGACGCGGACGGCAACCTGCCCGGGCCG
TTCCAGGTCAAGCGCCGCGCGCCGCAGCTCTATCGCACGCTGACGGGCCATCCGGAACGCGCGCTGCAGGACCCGCTGTC
GATGGTCGACTGGATCAACCTGTATGCGATCGCGGTCAACGAGGAAAACGCGGCGGGCGGGCGCGTCGTCACCGCGCCGA
CCAACGGCGCGGCGGGCATCATCCCGGCCGTCCTCCATTACTACACGCGCTTCACGCCGGGCGCGAACGAGCAGGGCGTG
ATCGATTTCCTGATGACCGCGGCGGCGATCGGCATCCTCTACAAGCTCAACGCATCGATCTCGGGTGCCGAAGTCGGCTG
TCAGGGCGAAGTCGGCGTCGCGTGCTCGATGGCGGCGGGCGCGCTCGCCGCGGTGCTGGGCGGCACGCCGCAGCAGGTCG
AGAACGCGGCCGAGATCGGGATGGAGCATAACCTCGGCCTCACCTGCGATCCGGTCGGCGGGATGGTGCAGATTCCGTGC
ATCGAGCGCAACGCGATGGCATCGGTGAAGGCCGTCAACGCCGCGCGAATGGCGCTGCGCGGCGACGGCAGCCACTACGT
GTCGCTCGACTCCGTGATCAAGACGATGCGCGAAACCGGCGCGGACATGAAGACGAAGTACAAGGAGACCTCGCGCGGCG
GGCTCGCGGTGAATATCGTCGAGTGCTGA

Upstream 100 bases:

>100_bases
CGCCCAACAACTGTCGCCGATGCCGCCGGCGTGGCTGGCCGCGTGCCTGCCGCTGCCGGCGCGGTGATCCCCCAATACAT
CCCGTCACTCAGGAAACGAA

Downstream 100 bases:

>100_bases
CGCGAAAAGGCCGCGCGCCGTTGCGCCGCGGCCTTCAGCCGCCGTTCGCGCGCGGGCGGCTTCGGTGTTTCGGCGACGCC
GCCGCGCGCCCGGTCGCGCG

Product: L-serine ammonia-lyase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFAQGLERDALLAATASVKVELYGSLGATGKGHGTDRGVMLGLMGDAPDTVD
PSTIAARLDAVRTSKTLALLGTHPVPFVPKEHIAFYRQALPEHPNAMKLRAADAAGAVLREATYLSVGGGFVVTSGAPNT
KVLAAAEQMPHPFRTGAELLALTASTGKSIAQLMWENERAWHTEEETRTGLLKIWDVMQSCVARGCGIGNPDADGNLPGP
FQVKRRAPQLYRTLTGHPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYTRFTPGANEQGV
IDFLMTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAGALAAVLGGTPQQVENAAEIGMEHNLGLTCDPVGGMVQIPC
IERNAMASVKAVNAARMALRGDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIVEC

Sequences:

>Translated_462_residues
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFAQGLERDALLAATASVKVELYGSLGATGKGHGTDRGVMLGLMGDAPDTVD
PSTIAARLDAVRTSKTLALLGTHPVPFVPKEHIAFYRQALPEHPNAMKLRAADAAGAVLREATYLSVGGGFVVTSGAPNT
KVLAAAEQMPHPFRTGAELLALTASTGKSIAQLMWENERAWHTEEETRTGLLKIWDVMQSCVARGCGIGNPDADGNLPGP
FQVKRRAPQLYRTLTGHPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYTRFTPGANEQGV
IDFLMTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAGALAAVLGGTPQQVENAAEIGMEHNLGLTCDPVGGMVQIPC
IERNAMASVKAVNAARMALRGDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIVEC
>Mature_461_residues
AVSVFDLFKIGIGPSSSHTVGPMRAALMFAQGLERDALLAATASVKVELYGSLGATGKGHGTDRGVMLGLMGDAPDTVDP
STIAARLDAVRTSKTLALLGTHPVPFVPKEHIAFYRQALPEHPNAMKLRAADAAGAVLREATYLSVGGGFVVTSGAPNTK
VLAAAEQMPHPFRTGAELLALTASTGKSIAQLMWENERAWHTEEETRTGLLKIWDVMQSCVARGCGIGNPDADGNLPGPF
QVKRRAPQLYRTLTGHPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGIIPAVLHYYTRFTPGANEQGVI
DFLMTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAGALAAVLGGTPQQVENAAEIGMEHNLGLTCDPVGGMVQIPCI
ERNAMASVKAVNAARMALRGDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIVEC

Specific function: Deaminates Also Threonine, Particularly When It Is Present In High Concentration. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=462, Percent_Identity=52.5974025974026, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1789161, Length=461, Percent_Identity=53.3622559652928, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI48994925, Length=459, Percent_Identity=52.9411764705882, Blast_Score=455, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48388; Mature: 48257

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSVFDLFKIGIGPSSSHTVGPMRAALMFAQGLERDALLAATASVKVELYGSLGATGKG
CEEEHEEHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCCCCCC
HGTDRGVMLGLMGDAPDTVDPSTIAARLDAVRTSKTLALLGTHPVPFVPKEHIAFYRQAL
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHC
PEHPNAMKLRAADAAGAVLREATYLSVGGGFVVTSGAPNTKVLAAAEQMPHPFRTGAELL
CCCCCCEEEEECHHHHHHHHHCEEEEECCCEEEECCCCCCEEEEEHHHCCCCCCCCCEEE
ALTASTGKSIAQLMWENERAWHTEEETRTGLLKIWDVMQSCVARGCGIGNPDADGNLPGP
EEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FQVKRRAPQLYRTLTGHPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEECCCCCCCHH
IPAVLHYYTRFTPGANEQGVIDFLMTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHH
ALAAVLGGTPQQVENAAEIGMEHNLGLTCDPVGGMVQIPCIERNAMASVKAVNAARMALR
HHHHHHCCCHHHHHHHHHCCCCCCCCEEECCCCCEEEECEECCCHHHHHHHHHHHHHEEE
GDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIVEC
CCCCCEEEHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure 
AVSVFDLFKIGIGPSSSHTVGPMRAALMFAQGLERDALLAATASVKVELYGSLGATGKG
EEEHEEHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEECCCCCCCC
HGTDRGVMLGLMGDAPDTVDPSTIAARLDAVRTSKTLALLGTHPVPFVPKEHIAFYRQAL
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHC
PEHPNAMKLRAADAAGAVLREATYLSVGGGFVVTSGAPNTKVLAAAEQMPHPFRTGAELL
CCCCCCEEEEECHHHHHHHHHCEEEEECCCEEEECCCCCCEEEEEHHHCCCCCCCCCEEE
ALTASTGKSIAQLMWENERAWHTEEETRTGLLKIWDVMQSCVARGCGIGNPDADGNLPGP
EEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FQVKRRAPQLYRTLTGHPERALQDPLSMVDWINLYAIAVNEENAAGGRVVTAPTNGAAGI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEEEEEECCCCCCCEEEECCCCCCCHH
IPAVLHYYTRFTPGANEQGVIDFLMTAAAIGILYKLNASISGAEVGCQGEVGVACSMAAG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHH
ALAAVLGGTPQQVENAAEIGMEHNLGLTCDPVGGMVQIPCIERNAMASVKAVNAARMALR
HHHHHHCCCHHHHHHHHHCCCCCCCCEEECCCCCEEEECEECCCHHHHHHHHHHHHHEEE
GDGSHYVSLDSVIKTMRETGADMKTKYKETSRGGLAVNIVEC
CCCCCEEEHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]