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The map label for this gene is pyrE [H]

Identifier: 237814183

GI number: 237814183

Start: 3818697

End: 3819383

Strand: Direct

Name: pyrE [H]

Synonym: GBP346_A3977

Alternate gene names: 237814183

Gene position: 3818697-3819383 (Clockwise)

Preceding gene: 237814180

Following gene: 237814184

Centisome position: 93.17

GC content: 64.19

Gene sequence:

>687_bases
ATGACAGGCTTCGATCGTCAGACGATCTCCGACACGACCGCCAAAATGCTGCTCGAAGTGCAAGCGGTGCACTTCAACGC
CGACAAGCCCTTCATCTTCACGTCCGGATGGGCGAGCCCCGTCTACATCGACTGCCGCAAGCTGATCTCGTTTCCGCGCG
TGCGCCGTGGGCTGATGGAAATGGCCGAGGCGACGATCCTGCGCGACGTCGGCTTCGAGCAGATCGACGCGGTGGCGGGC
GGCGAAACCGCCGGCATCCCGTTCGCCGCGTGGATCGCCGACCGGATGATGCTGCCGATGCAGTACGTGCGCAAGAAGCC
GAAGGGATTCGGCCGCAACGCGCAGATCGAGGGCTATCTGGAAGAAGGCTCGCGCGTGCTGCTCGTCGAGGACCTGACGA
CCGACAGCCGCAGCAAGATCAACTTCGTCAACGCGCTGCGCACCGCGGGCGCGAAGGTGAACCACTGCTTCGTGCTGTTC
CATTACGACATCTTCAAGGAAAGCGTGTCGGTGCTGAAGGACATCGACGTCGACCTGCACGCGCTCGCGACCTGGTGGGA
CGTGCTGCGCGTCGCGAAGGCGTCCGGCTATTTCGAGACGAAGACGCTCGACGAAGTCGAGAAATTCCTGCACGCGCCGG
CCGAATGGTCGGCCGCGCACGGCGGCGCGACGGGCGCGCAGGAGTAA

Upstream 100 bases:

>100_bases
TCGCCCTATCGGCCCGCCACCCGGCTCTCACGGCGGGAATCACGCGAGCTGCGCCGCCGGGCCCGCGCCCGCCCCTCGCT
CATCATCAAGGAACGCCCCC

Downstream 100 bases:

>100_bases
CGCCGCCCCGCATCGCCCGCGTTCGGCCGCGCGAGCCCGGCTGACGCGACGAACCGCCCGCCGTCGCCGACGGCGGGCGT
TTTTTTGCGCGCACGCGAGC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTGFDRQTISDTTAKMLLEVQAVHFNADKPFIFTSGWASPVYIDCRKLISFPRVRRGLMEMAEATILRDVGFEQIDAVAG
GETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGYLEEGSRVLLVEDLTTDSRSKINFVNALRTAGAKVNHCFVLF
HYDIFKESVSVLKDIDVDLHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATGAQE

Sequences:

>Translated_228_residues
MTGFDRQTISDTTAKMLLEVQAVHFNADKPFIFTSGWASPVYIDCRKLISFPRVRRGLMEMAEATILRDVGFEQIDAVAG
GETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGYLEEGSRVLLVEDLTTDSRSKINFVNALRTAGAKVNHCFVLF
HYDIFKESVSVLKDIDVDLHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATGAQE
>Mature_227_residues
TGFDRQTISDTTAKMLLEVQAVHFNADKPFIFTSGWASPVYIDCRKLISFPRVRRGLMEMAEATILRDVGFEQIDAVAGG
ETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGYLEEGSRVLLVEDLTTDSRSKINFVNALRTAGAKVNHCFVLFH
YDIFKESVSVLKDIDVDLHALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATGAQE

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=207, Percent_Identity=28.0193236714976, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508631, Length=119, Percent_Identity=36.1344537815126, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17554964, Length=169, Percent_Identity=28.9940828402367, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17933654, Length=198, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 25465; Mature: 25334

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFDRQTISDTTAKMLLEVQAVHFNADKPFIFTSGWASPVYIDCRKLISFPRVRRGLME
CCCCCCCHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHH
MAEATILRDVGFEQIDAVAGGETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGYL
HHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
EEGSRVLLVEDLTTDSRSKINFVNALRTAGAKVNHCFVLFHYDIFKESVSVLKDIDVDLH
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCCHHH
ALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATGAQE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGFDRQTISDTTAKMLLEVQAVHFNADKPFIFTSGWASPVYIDCRKLISFPRVRRGLME
CCCCCCHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHH
MAEATILRDVGFEQIDAVAGGETAGIPFAAWIADRMMLPMQYVRKKPKGFGRNAQIEGYL
HHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
EEGSRVLLVEDLTTDSRSKINFVNALRTAGAKVNHCFVLFHYDIFKESVSVLKDIDVDLH
CCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHCCCHHH
ALATWWDVLRVAKASGYFETKTLDEVEKFLHAPAEWSAAHGGATGAQE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA