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The map label for this gene is trpC [H]

Identifier: 237813949

GI number: 237813949

Start: 3605274

End: 3606059

Strand: Direct

Name: trpC [H]

Synonym: GBP346_A3733

Alternate gene names: 237813949

Gene position: 3605274-3606059 (Clockwise)

Preceding gene: 237813948

Following gene: 237813950

Centisome position: 87.96

GC content: 67.56

Gene sequence:

>786_bases
ATGAGCGACATCCTCGACAAAATCATCGCCGTCAAGCGCGAAGAGATCGCCGCCGCGCTCGAGAGCGCGCCGCTCGAAGA
ACTGAAGGTGCAGGCGTCGGCGCGCGATTCGCGCGACTTCGTCGGCGCGCTGCGCGACAAGCACGCGGCCGGACACGCCG
CCGTCATCGCCGAGGTGAAGAAGGCGAGCCCGTCGAAAGGCGTGCTGCGCGAGCATTTCGTGCCGGCCGCCATCGCCCGC
TCGTACGCGCAGCACGGCGCCGCATGCCTGTCGGTGCTGACCGACGAGCGGTTCTTCCAGGGCAGCGCGCGCTATCTCGA
ACAGGCGCGCGCCGCGTGCGCCCTGCCCGTGCTGCGCAAGGACTTCATCGTCGACGCGTACCAGGTGCTCGAAGCGCGCG
CGATGGGCGCGGACGCGATCCTGCTGATCGCCGCGGCGCTCGACACGCCGCTGATGATCGATCTCGAGGCGTACGCGCAT
TCGCTCGGGCTCGCGGTGCTCGTCGAAGTGCACAACCGCGGCGAACTGGACGAAGCGTTGAAACTGAAGACGCCGCTCGT
CGGCATCAACAACCGCAACCTGCGTACATTCGAGACGACGATCGACACGACGCTCGGCATGCTCGACGCGATTCCGGACG
ATCGGATCGTCGTCACCGAATCCGGCATCCTGTCGCGCGCGGACGTCGAGCGGATGGAGGCGGCGGGCGTGCATACGTTC
CTCGTCGGCGAAGCGTTCATGCGCGCCGAGAACCCGGGCGCGGAACTCGCGCGGATGTTCTTCTGA

Upstream 100 bases:

>100_bases
ACGAGCTCGTGCGCTTCACGCAGCAGTTCAAGCGCTGATCCGGCGCCCCGCGCGCGCCTCAACCGAATCCGAATCGAATC
CAGCACACAGGACAGCCCCC

Downstream 100 bases:

>100_bases
GCGCCCCGCGATGGCGATCGAACAGGAAATCAAGCTCGCGCTGCCTGCCGCGCAAGTCGACGCGGCGCAGCGCTTCCTCG
ATGCGCGCGCCGGCGCCGGC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSDILDKIIAVKREEIAAALESAPLEELKVQASARDSRDFVGALRDKHAAGHAAVIAEVKKASPSKGVLREHFVPAAIAR
SYAQHGAACLSVLTDERFFQGSARYLEQARAACALPVLRKDFIVDAYQVLEARAMGADAILLIAAALDTPLMIDLEAYAH
SLGLAVLVEVHNRGELDEALKLKTPLVGINNRNLRTFETTIDTTLGMLDAIPDDRIVVTESGILSRADVERMEAAGVHTF
LVGEAFMRAENPGAELARMFF

Sequences:

>Translated_261_residues
MSDILDKIIAVKREEIAAALESAPLEELKVQASARDSRDFVGALRDKHAAGHAAVIAEVKKASPSKGVLREHFVPAAIAR
SYAQHGAACLSVLTDERFFQGSARYLEQARAACALPVLRKDFIVDAYQVLEARAMGADAILLIAAALDTPLMIDLEAYAH
SLGLAVLVEVHNRGELDEALKLKTPLVGINNRNLRTFETTIDTTLGMLDAIPDDRIVVTESGILSRADVERMEAAGVHTF
LVGEAFMRAENPGAELARMFF
>Mature_260_residues
SDILDKIIAVKREEIAAALESAPLEELKVQASARDSRDFVGALRDKHAAGHAAVIAEVKKASPSKGVLREHFVPAAIARS
YAQHGAACLSVLTDERFFQGSARYLEQARAACALPVLRKDFIVDAYQVLEARAMGADAILLIAAALDTPLMIDLEAYAHS
LGLAVLVEVHNRGELDEALKLKTPLVGINNRNLRTFETTIDTTLGMLDAIPDDRIVVTESGILSRADVERMEAAGVHTFL
VGEAFMRAENPGAELARMFF

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=263, Percent_Identity=39.1634980988593, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322638, Length=220, Percent_Identity=42.2727272727273, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28261; Mature: 28130

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILDKIIAVKREEIAAALESAPLEELKVQASARDSRDFVGALRDKHAAGHAAVIAEVK
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
KASPSKGVLREHFVPAAIARSYAQHGAACLSVLTDERFFQGSARYLEQARAACALPVLRK
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFIVDAYQVLEARAMGADAILLIAAALDTPLMIDLEAYAHSLGLAVLVEVHNRGELDEAL
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHEEEEECCCCCHHHHH
KLKTPLVGINNRNLRTFETTIDTTLGMLDAIPDDRIVVTESGILSRADVERMEAAGVHTF
HHCCCEEECCCCCCEEHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCHHHH
LVGEAFMRAENPGAELARMFF
HHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure 
SDILDKIIAVKREEIAAALESAPLEELKVQASARDSRDFVGALRDKHAAGHAAVIAEVK
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
KASPSKGVLREHFVPAAIARSYAQHGAACLSVLTDERFFQGSARYLEQARAACALPVLRK
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFIVDAYQVLEARAMGADAILLIAAALDTPLMIDLEAYAHSLGLAVLVEVHNRGELDEAL
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHEEEEECCCCCHHHHH
KLKTPLVGINNRNLRTFETTIDTTLGMLDAIPDDRIVVTESGILSRADVERMEAAGVHTF
HHCCCEEECCCCCCEEHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCHHHH
LVGEAFMRAENPGAELARMFF
HHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA