BacMap

Definition	Burkholderia pseudomallei MSHR346 chromosome I, complete genome.
Accession	NC_012695
Length	4,098,576

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The map label for this gene is fadB1 [H]

Identifier: 237813936

GI number: 237813936

Start: 3591458

End: 3592252

Strand: Reverse

Name: fadB1 [H]

Synonym: GBP346_A3718

Alternate gene names: 237813936

Gene position: 3592252-3591458 (Counterclockwise)

Preceding gene: 237813942

Following gene: 237813934

Centisome position: 87.65

GC content: 62.77

Gene sequence:

>795_bases
TTGATCGAGGAGAAGCAGATGGCTTACGAGAACATTCTGGTGGAGACGCGGGGCAGGGTGGGGCTGATTACGCTGAACCG
TCCGAAGGCGCTGAATGCGTTGAATGACGCCCTGATGGATGAACTTGGCTTGGCGCTCAAAGCGTTCGACGCGGACGAGG
GTATTGGCGCGATCGTGCTGACGGGCAGCGAGAAGGCGTTCGCGGCGGGCGCCGACATCGGGATGATGGCGACCTATTCA
TACATGGACGTCTTCAAGGGCGACTACATCACGCGTAACTGGGAGACGGTGCGCCAGATCCGCAAGCCGATCATCGCGGC
GGTGGCGGGTTTCGCGCTGGGCGGCGGCTGCGAACTCGCGATGATGTGCGACATCATCTTTGCGGCCGATACGGCGAAGT
TCGGCCAGCCGGAAATCAAGCTCGGCGTGCTGCCGGGTGCGGGCGGCACGCAGCGCCTGCCGCGCGCGGTGTCGAAGGCG
AAAGCGATGGACATGTGCTTGACCGCGCGCTTCATGGACGCGGAGGAGGCTGAGCGGGCGGGCTTGGTGTCGAGGATCCT
GCCGGCGGAGAAGTTGCTCGACGAGGCGATCGCCGCGGCGACGACGATCGCGGAATTCTCGCTGCCTGCCGTAATGATGG
TGAAGGAGGCGGTGAATCGCGCATACGAGACGACCTTGTCCGAAGGGGTGCACTTCGAGCGTCGCTTGTTTCACTCGGCA
TTTGCGACTGAAGATCAGAAGGAAGGGATGGCGGCGTTCGTCGAGAAGCGCAAGCCCGTCTTCAAGCATCGCTGA

Upstream 100 bases:

>100_bases
GGTGAGCGTTGAGGGAAGCGATGGTCATTAATTAACCGACCGGTTGGTCGGAAAATGTTAGCATCAAATCATCCGTGCGT
GTGCGGCATTTCATGTTTCA

Downstream 100 bases:

>100_bases
ACACGCACAGGGCAAAGTGCTGCTTGCCCTTGCCTCGAATTTCCGGTCTGCCGATGCTTGAATTCGAGGCGTGAAAAATT
CTTTCAAAAAACGCTTGCAC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MIEEKQMAYENILVETRGRVGLITLNRPKALNALNDALMDELGLALKAFDADEGIGAIVLTGSEKAFAAGADIGMMATYS
YMDVFKGDYITRNWETVRQIRKPIIAAVAGFALGGGCELAMMCDIIFAADTAKFGQPEIKLGVLPGAGGTQRLPRAVSKA
KAMDMCLTARFMDAEEAERAGLVSRILPAEKLLDEAIAAATTIAEFSLPAVMMVKEAVNRAYETTLSEGVHFERRLFHSA
FATEDQKEGMAAFVEKRKPVFKHR

Sequences:

>Translated_264_residues
MIEEKQMAYENILVETRGRVGLITLNRPKALNALNDALMDELGLALKAFDADEGIGAIVLTGSEKAFAAGADIGMMATYS
YMDVFKGDYITRNWETVRQIRKPIIAAVAGFALGGGCELAMMCDIIFAADTAKFGQPEIKLGVLPGAGGTQRLPRAVSKA
KAMDMCLTARFMDAEEAERAGLVSRILPAEKLLDEAIAAATTIAEFSLPAVMMVKEAVNRAYETTLSEGVHFERRLFHSA
FATEDQKEGMAAFVEKRKPVFKHR
>Mature_264_residues
MIEEKQMAYENILVETRGRVGLITLNRPKALNALNDALMDELGLALKAFDADEGIGAIVLTGSEKAFAAGADIGMMATYS
YMDVFKGDYITRNWETVRQIRKPIIAAVAGFALGGGCELAMMCDIIFAADTAKFGQPEIKLGVLPGAGGTQRLPRAVSKA
KAMDMCLTARFMDAEEAERAGLVSRILPAEKLLDEAIAAATTIAEFSLPAVMMVKEAVNRAYETTLSEGVHFERRLFHSA
FATEDQKEGMAAFVEKRKPVFKHR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=259, Percent_Identity=57.1428571428571, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI4502327, Length=270, Percent_Identity=35.5555555555556, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI70995211, Length=271, Percent_Identity=31.3653136531365, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI31542718, Length=245, Percent_Identity=29.3877551020408, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI68989263, Length=230, Percent_Identity=32.1739130434783, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI20127408, Length=177, Percent_Identity=37.2881355932203, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI150378541, Length=244, Percent_Identity=32.3770491803279, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI37594471, Length=214, Percent_Identity=30.3738317757009, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI37594469, Length=214, Percent_Identity=30.3738317757009, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI260274832, Length=228, Percent_Identity=28.0701754385965, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI45643119, Length=228, Percent_Identity=28.0701754385965, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI260275230, Length=228, Percent_Identity=28.0701754385965, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4757968, Length=262, Percent_Identity=24.0458015267176, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI49355787, Length=262, Percent_Identity=24.0458015267176, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI157694516, Length=244, Percent_Identity=26.2295081967213, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI213417737, Length=244, Percent_Identity=26.2295081967213, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI25453481, Length=262, Percent_Identity=23.6641221374046, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI51538573, Length=262, Percent_Identity=23.6641221374046, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4757966, Length=217, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI51538581, Length=217, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI221307494, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI221136756, Length=192, Percent_Identity=29.1666666666667, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI221136753, Length=192, Percent_Identity=29.1666666666667, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI261878539, Length=135, Percent_Identity=31.8518518518519, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI157694520, Length=213, Percent_Identity=25.8215962441315, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787659, Length=253, Percent_Identity=44.2687747035573, Blast_Score=212, Evalue=2e-56,
Organism=Escherichia coli, GI221142681, Length=260, Percent_Identity=36.1538461538462, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1788597, Length=261, Percent_Identity=34.0996168582375, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=34.0996168582375, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082183, Length=265, Percent_Identity=32.4528301886792, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1788682, Length=189, Percent_Identity=31.2169312169312, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790281, Length=184, Percent_Identity=30.9782608695652, Blast_Score=91, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17554946, Length=260, Percent_Identity=56.1538461538462, Blast_Score=292, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI25145438, Length=243, Percent_Identity=54.7325102880658, Blast_Score=268, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17560910, Length=254, Percent_Identity=34.6456692913386, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17540306, Length=241, Percent_Identity=32.3651452282158, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=220, Percent_Identity=30.9090909090909, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17558304, Length=189, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144276, Length=182, Percent_Identity=34.6153846153846, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508951, Length=182, Percent_Identity=34.6153846153846, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17508953, Length=183, Percent_Identity=35.5191256830601, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17534483, Length=256, Percent_Identity=26.953125, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17536985, Length=266, Percent_Identity=30.0751879699248, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17549921, Length=179, Percent_Identity=34.0782122905028, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25144157, Length=219, Percent_Identity=28.7671232876712, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25144160, Length=219, Percent_Identity=28.7671232876712, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25141363, Length=199, Percent_Identity=27.6381909547739, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=259, Percent_Identity=24.7104247104247, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=193, Percent_Identity=29.0155440414508, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI20129971, Length=258, Percent_Identity=58.5271317829457, Blast_Score=301, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24653477, Length=258, Percent_Identity=58.5271317829457, Blast_Score=301, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24653139, Length=266, Percent_Identity=37.218045112782, Blast_Score=149, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21357171, Length=260, Percent_Identity=32.6923076923077, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24650670, Length=256, Percent_Identity=30.859375, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI19920382, Length=255, Percent_Identity=32.156862745098, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI19922422, Length=253, Percent_Identity=28.0632411067194, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24654903, Length=187, Percent_Identity=30.4812834224599, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19921000, Length=170, Percent_Identity=35.2941176470588, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583077, Length=174, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583079, Length=174, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571730, Length=188, Percent_Identity=28.7234042553192, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28571729, Length=188, Percent_Identity=28.7234042553192, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28718; Mature: 28718

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEEKQMAYENILVETRGRVGLITLNRPKALNALNDALMDELGLALKAFDADEGIGAIVL
CCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEE
TGSEKAFAAGADIGMMATYSYMDVFKGDYITRNWETVRQIRKPIIAAVAGFALGGGCELA
ECCCCCEECCCCCHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCHHH
MMCDIIFAADTAKFGQPEIKLGVLPGAGGTQRLPRAVSKAKAMDMCLTARFMDAEEAERA
HHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GLVSRILPAEKLLDEAIAAATTIAEFSLPAVMMVKEAVNRAYETTLSEGVHFERRLFHSA
HHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
FATEDQKEGMAAFVEKRKPVFKHR
HCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIEEKQMAYENILVETRGRVGLITLNRPKALNALNDALMDELGLALKAFDADEGIGAIVL
CCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEE
TGSEKAFAAGADIGMMATYSYMDVFKGDYITRNWETVRQIRKPIIAAVAGFALGGGCELA
ECCCCCEECCCCCHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCCHHH
MMCDIIFAADTAKFGQPEIKLGVLPGAGGTQRLPRAVSKAKAMDMCLTARFMDAEEAERA
HHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GLVSRILPAEKLLDEAIAAATTIAEFSLPAVMMVKEAVNRAYETTLSEGVHFERRLFHSA
HHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
FATEDQKEGMAAFVEKRKPVFKHR
HCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7751302; 11481430 [H]