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The map label for this gene is nrdB [H]

Identifier: 237813879

GI number: 237813879

Start: 3527628

End: 3528839

Strand: Reverse

Name: nrdB [H]

Synonym: GBP346_A3657

Alternate gene names: 237813879

Gene position: 3528839-3527628 (Counterclockwise)

Preceding gene: 237813880

Following gene: 237813877

Centisome position: 86.1

GC content: 62.05

Gene sequence:

>1212_bases
ATGCTCAACTGGGATGACGAGAAGACTGCCGTAACTCCCGCGAGCGGAGCGCAGCACAATGCGATGCGCGACCCCGCAGG
AATGGCTGTCGGATTGCAGGCGGCGCCTGCCGCTCATCAAGCTTCGTCGGCCCGCGACATCTTCGCAGGCGATTTCGCCG
TGGCGCCGAATGCGTCGGCCGCCGTCGCTTCGGAAGCGCGGGTCAACGTCGCCGACAAGCGCATCATCAACGGCAAGACC
GACGTCAACCAGCTCGTCCCGTTCAAGTACAAGTGGGCGTGGGAGAAGTACCTGGCCGGCTGCGCGAATCACTGGATGCC
GCAGGAAATCAACATGTCCCGCGACATCGCGCTCTGGAAGGATCCGAACGGCCTGACGGAGGACGAGCGCCGGATCGTCA
AGCGCAACCTCGGTTTCTTCGTGACGGCCGATTCGCTCGCGGCGAACAACATCGTGCTCGGCACGTACCGCCACATCACG
GCGCCCGAGTGCCGGCAGTTCCTGCTGCGCCAGGCGTTCGAAGAGGCGATCCACACGCACGCGTACCAATATATTGTGGA
ATCGCTCGGCCTCGACGAAGGCGAGATCTTCAACGCGTACCACGAGGTGCCGTCGATCCGCGCGAAGGACGAGTTCCTGA
TTCCGTTCATCCATACGCTGACCGACCCGGCCTTCACGACGGGCACGCTGGAAGCCGATCAGAAGCTGCTGAAATCGCTG
ATCGTGTTCGCGTGCATCATGGAGGGCCTGTTCTTCTACGTCGGCTTCACGCAGATTCTCGCGCTCGGCCGTCAGAACAA
GATGACGGGCGCGGCGGAGCAATATCAGTACATCCTGCGCGACGAGTCGATGCACTGCAACTTCGGGATCGACCTGATCA
ACCAGATCAAGCTCGAGAACCCGCACCTGTGGACGGCCGAGTTCCGTGCCGAGATCCGCGAGCTGTTCAAGCACGCCGTC
GATCTCGAGTACCGCTACGCGGAGGACACGATGCCGCGCGGCGTGCTGGGCCTGAACGCGTCGATGTTCAAGAGCTATCT
GCGCTTCATCAGCAACCGCCGTTGCCAGCAGATCGGCCTCGACCCGCTGTTCCCGAACGAGGAAAACCCGTTCCCGTGGA
TGAGCGAGATGATCGACTTGAAGAAGGAGCGCAACTTCTTCGAGACGCGGGTGATCGAGTATCAGACGGGCGGCGCGCTG
TCGTGGGAATGA

Upstream 100 bases:

>100_bases
AGGTCGCAACGCGAATCGAAAAAAGGATTTTTCATGAGCGAACCCTTTTATCGCTCAGGAAAAGATGGTACAAACCGATC
TAAATTGATGGTGAGAATTT

Downstream 100 bases:

>100_bases
CCCGACGCGCAGCCGACGAGTAACGATGTGAATGCCGGGCCGCCGTGCCCGGTGCAAGGTTTAGGAGCAAGAACGCCTGA
TGCAAAGCATGTCCGGTGCC

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MLNWDDEKTAVTPASGAQHNAMRDPAGMAVGLQAAPAAHQASSARDIFAGDFAVAPNASAAVASEARVNVADKRIINGKT
DVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHIT
APECRQFLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVPSIRAKDEFLIPFIHTLTDPAFTTGTLEADQKLLKSL
IVFACIMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKHAV
DLEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGLDPLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGAL
SWE

Sequences:

>Translated_403_residues
MLNWDDEKTAVTPASGAQHNAMRDPAGMAVGLQAAPAAHQASSARDIFAGDFAVAPNASAAVASEARVNVADKRIINGKT
DVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHIT
APECRQFLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVPSIRAKDEFLIPFIHTLTDPAFTTGTLEADQKLLKSL
IVFACIMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKHAV
DLEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGLDPLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGAL
SWE
>Mature_403_residues
MLNWDDEKTAVTPASGAQHNAMRDPAGMAVGLQAAPAAHQASSARDIFAGDFAVAPNASAAVASEARVNVADKRIINGKT
DVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHIT
APECRQFLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVPSIRAKDEFLIPFIHTLTDPAFTTGTLEADQKLLKSL
IVFACIMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKHAV
DLEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGLDPLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGAL
SWE

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI289177074, Length=358, Percent_Identity=27.3743016759777, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI42544136, Length=346, Percent_Identity=26.878612716763, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI260064013, Length=364, Percent_Identity=27.7472527472527, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI4557845, Length=364, Percent_Identity=27.7472527472527, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI289177076, Length=296, Percent_Identity=28.7162162162162, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1788567, Length=293, Percent_Identity=26.2798634812287, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17551968, Length=321, Percent_Identity=27.7258566978193, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=22.3684210526316, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17567153, Length=224, Percent_Identity=26.7857142857143, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322434, Length=330, Percent_Identity=31.2121212121212, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=22.8125, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=27.5, Blast_Score=144, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 45817; Mature: 45817

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNWDDEKTAVTPASGAQHNAMRDPAGMAVGLQAAPAAHQASSARDIFAGDFAVAPNASA
CCCCCCCCCEECCCCCCCCCCCCCCCCCEECCCCCCCHHHCCCCCHHHCCCEEECCCCCH
AVASEARVNVADKRIINGKTDVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWK
HHHHHHHCCHHHHHEECCCCCHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
DPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTH
CCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AYQYIVESLGLDEGEIFNAYHEVPSIRAKDEFLIPFIHTLTDPAFTTGTLEADQKLLKSL
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IVFACIMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLEN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHEECCC
PHLWTAEFRAEIRELFKHAVDLEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGL
CCEEHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEECCCHHHHHHHHHHHCCCCHHHCCC
DPLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHEEEEEECCCCCCCC
>Mature Secondary Structure
MLNWDDEKTAVTPASGAQHNAMRDPAGMAVGLQAAPAAHQASSARDIFAGDFAVAPNASA
CCCCCCCCCEECCCCCCCCCCCCCCCCCEECCCCCCCHHHCCCCCHHHCCCEEECCCCCH
AVASEARVNVADKRIINGKTDVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIALWK
HHHHHHHCCHHHHHEECCCCCHHHCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
DPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTH
CCCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
AYQYIVESLGLDEGEIFNAYHEVPSIRAKDEFLIPFIHTLTDPAFTTGTLEADQKLLKSL
HHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHH
IVFACIMEGLFFYVGFTQILALGRQNKMTGAAEQYQYILRDESMHCNFGIDLINQIKLEN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHEECCC
PHLWTAEFRAEIRELFKHAVDLEYRYAEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGL
CCEEHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEECCCHHHHHHHHHHHCCCCHHHCCC
DPLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]