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The map label for this gene is edd [H]

Identifier: 237813809

GI number: 237813809

Start: 3464460

End: 3466313

Strand: Reverse

Name: edd [H]

Synonym: GBP346_A3587

Alternate gene names: 237813809

Gene position: 3466313-3464460 (Counterclockwise)

Preceding gene: 237813813

Following gene: 237813808

Centisome position: 84.57

GC content: 70.12

Gene sequence:

>1854_bases
ATGGCCACGCTGCACCCCACTCTTGCGTCCGTCACCGAGCGCGTGATCGCGCGCAGCCGTCCGACCCGCCAAGCCTATCT
CGCCCGCATCGACGCCGCCCAGGGGCATTTCCCCGCGCGCGGCGCGCTGTCGTGCGCGAACCTCGCGCATGGCTTCGCGG
GCCTGGAGGGCAGCGACAAGTTCGCGATCAAGGCGATCCGCGAGCCGAACATCGGCATCGTGTCGGCGTACAACGAGATG
CTGTCCGCGCATGCGCCGTACAAGGGCTTTCCCGACATCATCAAGGCGGCCGCGCGCGAGCGCGGCGGCGTCGCGCAGTT
CGCGGGCGGCGTGCCGGCGATGTGCGACGGCGTCACGCAGGGCAACGCGGGGATGGAGCTGTCGCTGTTCTCGCGCGAGG
TGATCGCGATGAGCACGGCCGTCGCGCTCACGCACAACATGTTCGATGCGGCCCTTTGCCTCGGCATCTGCGACAAGATC
GTGCCGGGCCTCTTGATCGGCGCGCTGCAGTTCGGCCACCTGCCGACGATCTTCGTGCCGGCCGGCCCGATGACGAGCGG
CCTGTCGAACGACGACAAGGCGAAGATCCGCCAGCAGTTCGCGACAGGCCAGGTGGGCCGCGACGCGCTGCTCGAGGCGG
AATCGGCCGCGTATCACGGCCACGGCACCTGCACGTTCTACGGCACCGCGAACAGCAACCAGATGCTGATGGAAGTGATG
GGTCTGCATCTGCCGAGCGCCGCGTTCGTTCATCCGCACACGCCGCTGCGCGACGCGCTGACGGCCGAGGCCGCGCGCCG
CGTGCTCGAGCTCACGGCCGAGCGCGGCCAATACACGCCGATCGGCCATGTGATCGACGAGCGCGCGATCGTCAACGGCA
TCGTCGCGCTGCTCGCCACCGGCGGCTCGACGAACCACACGCTGCACCTCGTCGCGATCGCGCGCGCGGCGGGCATCCTG
ATCGACTGGGACGATTTCGACGCGCTGTCGGCCGCGGTGCCGCTTCTCGCGAAGATCTACCCGAACGGCAAGGCCGACGT
GAACCATTTCCACGCGGCGGGCGGCATCGCGTTCCTCGTGCGCAACCTGCTCGAAGGCGGCCTGCTGCACGAAGACGTGA
CGACGGTCGCGGGCAAGGGCCTTGCGCATTACACGAAGGAGCCGCGCCTGATCGACGGCAAGCTGACGTGGGTCGACGGC
GTCGGCGAGAGCGCCGACGACAAGGTGCTGCGCCCGATCGCCGCGCCGTTCCAGCCGGACGGCGGGCTGCGCCTGATGCA
GGGCAGGCTCGGGCGCGGCGTGATCAAGATTTCGGCGGTTGCGCCCGAGCACCGCAAGGTGACGGCGCCCGCGATCGTGT
TCGATTCGCAGGAAGCCGTGCAAGCCGCGTTCGACGCGGGCGAGCTCAAGCGCGATTTCGTCGCGGTCGTGCGCTTCCAG
GGCGCGCGCGCGAACGGGATGCCGGAACTGCACCGGCTGACGCCGCTGCTCGGCGTGTTGCAGGATCAGGGTTTTCGCGT
CGCGCTCGTGACGGACGGCCGGATGTCGGGCGCGTCGGGCAAGGTGCCGGCCGTGATCCACGTGTCGCCCGAGGCGCTGT
TGAGCGGCCCGCTCGGCAAGGTATGCACGGGCGACACGATCGTGATCGACGCGCAAGCGGGCGTGCTCGACGTCGAGATC
GACGAGCAAGCGTGGGCCGCGCGCGCGGTCGCGCAGCCCGCGCATCAGGCGGAAAACGAAGTCGGCTTCGGCCGCGAACT
GTTCGGCGTGTTCCGCGCGGCGGCCGCGCCGGCGGAGCAGGGCGCGTCGGTGTTCGGCGCGTCGGTGGGCGAAGCGGCCC
ACGTCACCGCATAA

Upstream 100 bases:

>100_bases
GTAGTTTTTCTACTAAACTCGCGCCGTTCGTCCGACGACCCGGACGTCCCCACGATTCCAGCTTGCCGGCTTCGCCCGGC
TCATGTGAGGAGCGCCCAGC

Downstream 100 bases:

>100_bases
GCGAAAAAAGGAGTCGCATTGATGAAGACGATTGGCGAGATCGTGAAGCTGGGCCCGGTGATTCCGGTGCTCGCGTTCGA
TTCGGTCGAACAGGGCGAAC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MATLHPTLASVTERVIARSRPTRQAYLARIDAAQGHFPARGALSCANLAHGFAGLEGSDKFAIKAIREPNIGIVSAYNEM
LSAHAPYKGFPDIIKAAARERGGVAQFAGGVPAMCDGVTQGNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMEVM
GLHLPSAAFVHPHTPLRDALTAEAARRVLELTAERGQYTPIGHVIDERAIVNGIVALLATGGSTNHTLHLVAIARAAGIL
IDWDDFDALSAAVPLLAKIYPNGKADVNHFHAAGGIAFLVRNLLEGGLLHEDVTTVAGKGLAHYTKEPRLIDGKLTWVDG
VGESADDKVLRPIAAPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFRVALVTDGRMSGASGKVPAVIHVSPEALLSGPLGKVCTGDTIVIDAQAGVLDVEI
DEQAWAARAVAQPAHQAENEVGFGRELFGVFRAAAAPAEQGASVFGASVGEAAHVTA

Sequences:

>Translated_617_residues
MATLHPTLASVTERVIARSRPTRQAYLARIDAAQGHFPARGALSCANLAHGFAGLEGSDKFAIKAIREPNIGIVSAYNEM
LSAHAPYKGFPDIIKAAARERGGVAQFAGGVPAMCDGVTQGNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMEVM
GLHLPSAAFVHPHTPLRDALTAEAARRVLELTAERGQYTPIGHVIDERAIVNGIVALLATGGSTNHTLHLVAIARAAGIL
IDWDDFDALSAAVPLLAKIYPNGKADVNHFHAAGGIAFLVRNLLEGGLLHEDVTTVAGKGLAHYTKEPRLIDGKLTWVDG
VGESADDKVLRPIAAPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFRVALVTDGRMSGASGKVPAVIHVSPEALLSGPLGKVCTGDTIVIDAQAGVLDVEI
DEQAWAARAVAQPAHQAENEVGFGRELFGVFRAAAAPAEQGASVFGASVGEAAHVTA
>Mature_616_residues
ATLHPTLASVTERVIARSRPTRQAYLARIDAAQGHFPARGALSCANLAHGFAGLEGSDKFAIKAIREPNIGIVSAYNEML
SAHAPYKGFPDIIKAAARERGGVAQFAGGVPAMCDGVTQGNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGICDKIV
PGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMEVMG
LHLPSAAFVHPHTPLRDALTAEAARRVLELTAERGQYTPIGHVIDERAIVNGIVALLATGGSTNHTLHLVAIARAAGILI
DWDDFDALSAAVPLLAKIYPNGKADVNHFHAAGGIAFLVRNLLEGGLLHEDVTTVAGKGLAHYTKEPRLIDGKLTWVDGV
GESADDKVLRPIAAPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQG
ARANGMPELHRLTPLLGVLQDQGFRVALVTDGRMSGASGKVPAVIHVSPEALLSGPLGKVCTGDTIVIDAQAGVLDVEID
EQAWAARAVAQPAHQAENEVGFGRELFGVFRAAAAPAEQGASVFGASVGEAAHVTA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=58.9700996677741, Blast_Score=717, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=584, Percent_Identity=29.6232876712329, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI2367371, Length=502, Percent_Identity=31.6733067729084, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1786464, Length=498, Percent_Identity=31.1244979919679, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322476, Length=529, Percent_Identity=28.5444234404537, Blast_Score=188, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64640; Mature: 64508

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLHPTLASVTERVIARSRPTRQAYLARIDAAQGHFPARGALSCANLAHGFAGLEGSDK
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
FAIKAIREPNIGIVSAYNEMLSAHAPYKGFPDIIKAAARERGGVAQFAGGVPAMCDGVTQ
EEEEEECCCCCEEEHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCHHHCCCCC
GNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMEVM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCEECCCEEEEEEECCCCCHHHHHHH
GLHLPSAAFVHPHTPLRDALTAEAARRVLELTAERGQYTPIGHVIDERAIVNGIVALLAT
HCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGILIDWDDFDALSAAVPLLAKIYPNGKADVNHFHAAGGIAFLV
CCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
RNLLEGGLLHEDVTTVAGKGLAHYTKEPRLIDGKLTWVDGVGESADDKVLRPIAAPFQPD
HHHHCCCCCHHHHHHHHCCCHHHHCCCCEEECCEEEEECCCCCCCCCHHHHHHCCCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQ
CCCEEECCCCCCCEEEEEEECCCCCCEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHCC
GARANGMPELHRLTPLLGVLQDQGFRVALVTDGRMSGASGKVPAVIHVSPEALLSGPLGK
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECHHHHHCCCCCC
VCTGDTIVIDAQAGVLDVEIDEQAWAARAVAQPAHQAENEVGFGRELFGVFRAAAAPAEQ
CCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHC
GASVFGASVGEAAHVTA
CCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ATLHPTLASVTERVIARSRPTRQAYLARIDAAQGHFPARGALSCANLAHGFAGLEGSDK
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
FAIKAIREPNIGIVSAYNEMLSAHAPYKGFPDIIKAAARERGGVAQFAGGVPAMCDGVTQ
EEEEEECCCCCEEEHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHCCCCCHHHCCCCC
GNAGMELSLFSREVIAMSTAVALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMEVM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCEECCCEEEEEEECCCCCHHHHHHH
GLHLPSAAFVHPHTPLRDALTAEAARRVLELTAERGQYTPIGHVIDERAIVNGIVALLAT
HCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGILIDWDDFDALSAAVPLLAKIYPNGKADVNHFHAAGGIAFLV
CCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
RNLLEGGLLHEDVTTVAGKGLAHYTKEPRLIDGKLTWVDGVGESADDKVLRPIAAPFQPD
HHHHCCCCCHHHHHHHHCCCHHHHCCCCEEECCEEEEECCCCCCCCCHHHHHHCCCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDAGELKRDFVAVVRFQ
CCCEEECCCCCCCEEEEEEECCCCCCEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHCC
GARANGMPELHRLTPLLGVLQDQGFRVALVTDGRMSGASGKVPAVIHVSPEALLSGPLGK
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECHHHHHCCCCCC
VCTGDTIVIDAQAGVLDVEIDEQAWAARAVAQPAHQAENEVGFGRELFGVFRAAAAPAEQ
CCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHC
GASVFGASVGEAAHVTA
CCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]