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The map label for this gene is tyrS [H]

Identifier: 237813770

GI number: 237813770

Start: 3432741

End: 3434048

Strand: Reverse

Name: tyrS [H]

Synonym: GBP346_A3547

Alternate gene names: 237813770

Gene position: 3434048-3432741 (Counterclockwise)

Preceding gene: 237813772

Following gene: 237813769

Centisome position: 83.79

GC content: 64.37

Gene sequence:

>1308_bases
TTGAGCGGCCCGCGTGCAACTTATGGGAAAATCGCTCTTTTTGCGACATTCCTTCCTCTTGCACCGATGAGCACCGATCC
CACTTCCAAGCCCGCCTTCCCGATCACCGATGAAGTCCGCCATGCGCTCGCCGTCACGAAGCGCGGTGTTGACGAGCTGC
TGATCGAGGAAGAGTTCGCGCAGAAGCTCGCGAAAAGCGCGGCGACGGGCAAGCCGCTGCGCATCAAGCTGGGCCTCGAT
CCGACGGCGCCCGACATCCACCTCGGCCACACGGTCGTGCTGAACAAGATGCGCCAGTTGCAGGATCTCGGCCATACGGT
GATTTTCCTGATCGGCGATTTCACGTCGCTGATCGGCGATCCGTCGGGCCGCAACGCGACCCGCCCGCCGCTCACGCGCG
AGCAGATCGAATCGAACGCGAAGACCTACTTCGAGCAGGCCGCGCTCGTGCTCGATCGCGCAAAGACCGAGATCCGCTAC
AACAGCGAGTGGTCGATGCCGCTCGGCGCGGATGGGATGATCAAGCTCGCGTCGCGCTACACGGTCGCGCGCATGCTCGA
GCGCGAGGATTTCACGAAGCGCTTCCAGGGCGGCATCCCGATCTCGATCCATGAATTCCTGTACCCGCTGATGCAGGGTT
ACGATTCGGTCGCGCTGAACGCCGATCTCGAGCTCGGCGGCACCGACCAGAAATTCAACCTGCTCGTCGGCCGCGAGCTG
CAGAAGCAATACGGCCAGGAGCAGCAGTGCATCCTGACGATGCCGCTGCTCGAAGGCCTCGACGGCGTCGAGAAGATGTC
GAAATCGAAGGGCAACTACGTCGGCATCAGCGAGAAGCCGACCGACATGTTCGGCAAGCTGATGAGCATCTCGGACGTGC
TGATGTGGCGCTACTTCGAGCTGCTGTCGTTCCGCAGCCTCGACGAGATCGCGCGGTTCCGCGGCGAGGCCGAAGGCGGG
CGCAACCCGCGCGACTTCAAGGTGATGCTCGCGCAGGAGATCGTCGCGCGTTTCCATTCGCAGGCCGACGCCGAACGCGC
ACTCGAGGACTTCAACCATCGCGCGAAGGGCGGCGTGCCCGACGATATCCCGGCCGTGACGCTCGCCGGCGCGCCGCTCG
CGATCGGCCAGTTGCTGAAGCAGGCGGGGCTCGTGCCTTCGACGAGCGAGGCGCTGCGCAACATCGAGCAGGGCGGTGTG
AAGATCGACGGCGCGACGGTGTCCGACAAGGCGCTGAAAGTCGACGCGGGCGAGTTCGTCGTGCAGGTCGGCAAGCGCCG
CTTCGCGCGCGTGACGCTTACCGCATGA

Upstream 100 bases:

>100_bases
CCACGTGATCGCTCCGAAATCGAGGGTGGGGGGCACGCGAGGCTCGCCGCGCACCGTCGCCGCCGATTATCCGCGCAAAT
CCGCGTGAACGCGCGCGCCG

Downstream 100 bases:

>100_bases
GCGCGCGCATCGCCGCTTGGCCGGGCATGCCGCGCGCGGTGCGCGGCGCCGCGCGTGGCCGCCGCGCCGCGTGCGTGACG
CGGACGCGCGCATGATCGCC

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSGPRATYGKIALFATFLPLAPMSTDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFAQKLAKSAATGKPLRIKLGLD
PTAPDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDRAKTEIRY
NSEWSMPLGADGMIKLASRYTVARMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGREL
QKQYGQEQQCILTMPLLEGLDGVEKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFELLSFRSLDEIARFRGEAEGG
RNPRDFKVMLAQEIVARFHSQADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGV
KIDGATVSDKALKVDAGEFVVQVGKRRFARVTLTA

Sequences:

>Translated_435_residues
MSGPRATYGKIALFATFLPLAPMSTDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFAQKLAKSAATGKPLRIKLGLD
PTAPDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDRAKTEIRY
NSEWSMPLGADGMIKLASRYTVARMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGREL
QKQYGQEQQCILTMPLLEGLDGVEKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFELLSFRSLDEIARFRGEAEGG
RNPRDFKVMLAQEIVARFHSQADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGV
KIDGATVSDKALKVDAGEFVVQVGKRRFARVTLTA
>Mature_434_residues
SGPRATYGKIALFATFLPLAPMSTDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFAQKLAKSAATGKPLRIKLGLDP
TAPDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDRAKTEIRYN
SEWSMPLGADGMIKLASRYTVARMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQ
KQYGQEQQCILTMPLLEGLDGVEKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFELLSFRSLDEIARFRGEAEGGR
NPRDFKVMLAQEIVARFHSQADAERALEDFNHRAKGGVPDDIPAVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVK
IDGATVSDKALKVDAGEFVVQVGKRRFARVTLTA

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=401, Percent_Identity=25.9351620947631, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787925, Length=424, Percent_Identity=29.7169811320755, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25145802, Length=210, Percent_Identity=29.5238095238095, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325160, Length=402, Percent_Identity=24.6268656716418, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20130383, Length=450, Percent_Identity=26.2222222222222, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 47908; Mature: 47777

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPRATYGKIALFATFLPLAPMSTDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHH
QKLAKSAATGKPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGD
HHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCC
PSGRNATRPPLTREQIESNAKTYFEQAALVLDRAKTEIRYNSEWSMPLGADGMIKLASRY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHH
TVARMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGREL
HHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHH
QKQYGQEQQCILTMPLLEGLDGVEKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFE
HHHCCCCCCEEEEHHHHHCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHH
LLSFRSLDEIARFRGEAEGGRNPRDFKVMLAQEIVARFHSQADAERALEDFNHRAKGGVP
HHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DDIPAVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFV
CCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEECCCEECCCEEEECHHHHH
VQVGKRRFARVTLTA
HHHHHHHEEEEEECC
>Mature Secondary Structure 
SGPRATYGKIALFATFLPLAPMSTDPTSKPAFPITDEVRHALAVTKRGVDELLIEEEFA
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHH
QKLAKSAATGKPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGD
HHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCC
PSGRNATRPPLTREQIESNAKTYFEQAALVLDRAKTEIRYNSEWSMPLGADGMIKLASRY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHH
TVARMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGREL
HHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHH
QKQYGQEQQCILTMPLLEGLDGVEKMSKSKGNYVGISEKPTDMFGKLMSISDVLMWRYFE
HHHCCCCCCEEEEHHHHHCCHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHH
LLSFRSLDEIARFRGEAEGGRNPRDFKVMLAQEIVARFHSQADAERALEDFNHRAKGGVP
HHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DDIPAVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFV
CCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEECCCEECCCEEEECHHHHH
VQVGKRRFARVTLTA
HHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA