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The map label for this gene is gmd [H]

Identifier: 237813645

GI number: 237813645

Start: 3303231

End: 3304244

Strand: Reverse

Name: gmd [H]

Synonym: GBP346_A3422

Alternate gene names: 237813645

Gene position: 3304244-3303231 (Counterclockwise)

Preceding gene: 237813646

Following gene: 237813644

Centisome position: 80.62

GC content: 59.07

Gene sequence:

>1014_bases
ATGGCAAAGCGTGTTTTGATTACGGGTATTACGGGGATGGTGGGGTCGCATCTGGCCGACTTTTTGCTGGAGAATACGGA
TTGGGAAATCTACGGCCTGTGCCGTTGGCGCAGCCCGCTCGACAACGTTTCTCACCTGCTTCCGCGTATCAACGAGAAGA
ACAGGATCCGCCTGGTGTACGGCGATTTGCGCGATTACCTCTCTATTCACGAGGCCGTCAAGCAGTCGACGCCCGATTTC
GTGTTCCACCTGGCCGCGCAAAGCTACCCGAAAACCAGCTTCGATTCGCCGCTCGACACGCTGGAGACCAACGTCCAGGG
AACGGCCAACGTGCTGGAAGCGCTGCGCAAGAACAACATCGACGCCGTCACGCATGTTTGCGCGTCGTCCGAAGTGTTCG
GGCGGGTGCCCCGCGAAAAGTTGCCGATCGATGAAGAGTGCACGTTCCATCCGGCATCGCCGTATGCCATCTCCAAGGTG
GGTACGGACCTGATCGGCCGGTACTATGCCGAAGCGTACAACATGACCGTGATGACCACGCGGATGTTCACGCATACCGG
CCCGCGTCGTGGCGACGTGTTTGCCGAATCGACGTTTGCCAAGCAGATCGCGATGATCGAGCGCGGGCTGATTCCGCCGG
TCGTGAAGACTGGCAACCTCGACTCGCTGCGCACGTTTGCCGACGTACGAGATGCGGTACGCGCGTATTACATGCTCGTG
ACGATCAACCCGATTCCGGGCGCCTATTACAACATTGGCGGCACGTATTCCTGCACGGTCGGCCAGATGCTCGACACGCT
GATCTCCATGTCGACTTCCAAGGACGTCATCCGCGTCGAGACGGATCCGGAGCGGCTGCGCCCGATCGATGCGGATCTGC
AAGTTCCGAACACGCGGAAATTCGAGGCCGTCACCGGTTGGAAGCCCGAGATTTCGTTCGAGAAGACCATGGAAGATCTG
CTGAATTACTGGCGCGCCCGGATTTCCGCCGGCGAGAAGTTCTTGACCCGATAG

Upstream 100 bases:

>100_bases
CATTAATGTAAGTTCTGCTCGTTTCGAGAAACTGCTGGGGCGGCGCCCCCGCAGTCTTGGCGAAGCGATTAATCTCGAGT
TGTCTAATTAACGGTGCGAT

Downstream 100 bases:

>100_bases
GAACATGGACGACCGATGAATCCGACAATCATTCGCGCACGGGCCCCGCTGCGGTTGGGCCTGGCGGGAGGGGGGACCGA
CGTCGCTCCCTATGCCGATA

Product: GDP-4-dehydro-6-deoxy-D-mannose reductase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAKRVLITGITGMVGSHLADFLLENTDWEIYGLCRWRSPLDNVSHLLPRINEKNRIRLVYGDLRDYLSIHEAVKQSTPDF
VFHLAAQSYPKTSFDSPLDTLETNVQGTANVLEALRKNNIDAVTHVCASSEVFGRVPREKLPIDEECTFHPASPYAISKV
GTDLIGRYYAEAYNMTVMTTRMFTHTGPRRGDVFAESTFAKQIAMIERGLIPPVVKTGNLDSLRTFADVRDAVRAYYMLV
TINPIPGAYYNIGGTYSCTVGQMLDTLISMSTSKDVIRVETDPERLRPIDADLQVPNTRKFEAVTGWKPEISFEKTMEDL
LNYWRARISAGEKFLTR

Sequences:

>Translated_337_residues
MAKRVLITGITGMVGSHLADFLLENTDWEIYGLCRWRSPLDNVSHLLPRINEKNRIRLVYGDLRDYLSIHEAVKQSTPDF
VFHLAAQSYPKTSFDSPLDTLETNVQGTANVLEALRKNNIDAVTHVCASSEVFGRVPREKLPIDEECTFHPASPYAISKV
GTDLIGRYYAEAYNMTVMTTRMFTHTGPRRGDVFAESTFAKQIAMIERGLIPPVVKTGNLDSLRTFADVRDAVRAYYMLV
TINPIPGAYYNIGGTYSCTVGQMLDTLISMSTSKDVIRVETDPERLRPIDADLQVPNTRKFEAVTGWKPEISFEKTMEDL
LNYWRARISAGEKFLTR
>Mature_336_residues
AKRVLITGITGMVGSHLADFLLENTDWEIYGLCRWRSPLDNVSHLLPRINEKNRIRLVYGDLRDYLSIHEAVKQSTPDFV
FHLAAQSYPKTSFDSPLDTLETNVQGTANVLEALRKNNIDAVTHVCASSEVFGRVPREKLPIDEECTFHPASPYAISKVG
TDLIGRYYAEAYNMTVMTTRMFTHTGPRRGDVFAESTFAKQIAMIERGLIPPVVKTGNLDSLRTFADVRDAVRAYYMLVT
INPIPGAYYNIGGTYSCTVGQMLDTLISMSTSKDVIRVETDPERLRPIDADLQVPNTRKFEAVTGWKPEISFEKTMEDLL
NYWRARISAGEKFLTR

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=340, Percent_Identity=28.2352941176471, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI7657641, Length=331, Percent_Identity=25.6797583081571, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1788366, Length=352, Percent_Identity=30.1136363636364, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1788353, Length=349, Percent_Identity=27.2206303724928, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI48994969, Length=348, Percent_Identity=26.4367816091954, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788589, Length=346, Percent_Identity=23.121387283237, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI133901786, Length=340, Percent_Identity=28.5294117647059, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI133901788, Length=340, Percent_Identity=28.8235294117647, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17539422, Length=340, Percent_Identity=28.8235294117647, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17539424, Length=340, Percent_Identity=28.8235294117647, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI133901790, Length=340, Percent_Identity=28.8235294117647, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17507723, Length=340, Percent_Identity=27.9411764705882, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17539532, Length=343, Percent_Identity=25.9475218658892, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17568069, Length=332, Percent_Identity=25.3012048192771, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI115532424, Length=325, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=252, Percent_Identity=26.1904761904762, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24158427, Length=341, Percent_Identity=30.2052785923754, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21356223, Length=344, Percent_Identity=25.5813953488372, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 38058; Mature: 37927

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRVLITGITGMVGSHLADFLLENTDWEIYGLCRWRSPLDNVSHLLPRINEKNRIRLVY
CCCEEEEECHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEEEE
GDLRDYLSIHEAVKQSTPDFVFHLAAQSYPKTSFDSPLDTLETNVQGTANVLEALRKNNI
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCC
DAVTHVCASSEVFGRVPREKLPIDEECTFHPASPYAISKVGTDLIGRYYAEAYNMTVMTT
HHHHHHHHCCHHHHCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEE
RMFTHTGPRRGDVFAESTFAKQIAMIERGLIPPVVKTGNLDSLRTFADVRDAVRAYYMLV
EHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEE
TINPIPGAYYNIGGTYSCTVGQMLDTLISMSTSKDVIRVETDPERLRPIDADLQVPNTRK
EECCCCCCEEECCCEEEEEHHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCCCCCCCCCC
FEAVTGWKPEISFEKTMEDLLNYWRARISAGEKFLTR
EEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
AKRVLITGITGMVGSHLADFLLENTDWEIYGLCRWRSPLDNVSHLLPRINEKNRIRLVY
CCEEEEECHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEEEE
GDLRDYLSIHEAVKQSTPDFVFHLAAQSYPKTSFDSPLDTLETNVQGTANVLEALRKNNI
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCC
DAVTHVCASSEVFGRVPREKLPIDEECTFHPASPYAISKVGTDLIGRYYAEAYNMTVMTT
HHHHHHHHCCHHHHCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEE
RMFTHTGPRRGDVFAESTFAKQIAMIERGLIPPVVKTGNLDSLRTFADVRDAVRAYYMLV
EHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEE
TINPIPGAYYNIGGTYSCTVGQMLDTLISMSTSKDVIRVETDPERLRPIDADLQVPNTRK
EECCCCCCEEECCCEEEEEHHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCCCCCCCCCC
FEAVTGWKPEISFEKTMEDLLNYWRARISAGEKFLTR
EEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]