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The map label for this gene is glyA

Identifier: 237813598

GI number: 237813598

Start: 3256357

End: 3257604

Strand: Reverse

Name: glyA

Synonym: GBP346_A3374

Alternate gene names: 237813598

Gene position: 3257604-3256357 (Counterclockwise)

Preceding gene: 237813608

Following gene: 237813597

Centisome position: 79.48

GC content: 64.74

Gene sequence:

>1248_bases
ATGTTTGACAGAGCCCAAAGCACCATTGCGAACGTCGATCCCGAGATCTGGCAAGCGATTCAGCAGGAAAACGTCCGTCA
GGAAGAGCACATCGAGCTGATCGCGTCGGAGAATTACACGAGCCCGGCCGTGATGGCGGCGCAAGGCTCGCAACTGACGA
ACAAGTACGCGGAAGGCTATCCGGGCAAGCGCTATTACGGCGGCTGCGAATACGTGGACATCGTCGAGCAGCTCGCGATC
GATCGCGTGAAGGCGCTGTTCGGCGCCGAAGCGGCGAACGTGCAGCCGAACTCGGGCTCGCAGGCGAACCAGGGCGTGTT
CTTCGCGATGCTCAAGCCGGGCGACACGATCATGGGCATGAGCCTCGCGCACGGCGGCCACCTCACGCACGGCTCGCCGG
TGAACATGTCGGGCAAGTGGTTCAACGTCGTGAGCTACGGGCTGAACGAGGCTGAAGACATCGATTACGAAGCGGCCGAG
CAGCTCGCGCACGAGCACAAGCCGAAGCTGATCGTCGCGGGCGCGTCGGCGTTCGCGCTGAAGATCGATTTCGAGCGCCT
CGCGAAGATCGCCAAGGCAGTGGGCGCGTACCTGATGGTCGACATGGCGCACTACGCGGGCCTGATCGCGGCGGGTGTCT
ATCCGAACCCGGTGCCGCATGCGGATTTCGTCACGACGACGACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCGTGATC
CTGATGAAGGCCGAGTACGAGAAGCAGATCAACTCGGCGATCTTCCCGGGCATCCAGGGCGGACCGCTGATGCACGTGAT
CGCCGCGAAGGCCGTCGCGTTCAAGGAAGCGCTGTCGCCGGAATTCAAGGAATACCAGCAGAAGGTGGTCGAGAACGCCC
GCGTGCTGGCGCAAACGCTCGTCAAGCGCGGCCTGCGCATCGTGTCGGGCCGCACCGAGAGCCATGTGATGCTGGTCGAC
CTGCGCGCGAAGAACATCACGGGCAAGGCGGCGGAAGCGGCGCTCGGCAATGCGCACATCACGGTCAACAAGAACGCGAT
CCCGAACGATCCGGAGAAGCCCTTCGTAACGAGCGGCGTGCGCCTGGGCTCGCCGGCGATGACGACGCGCGGCTTCGGCC
CGCAGGAAGCGGAGCTCGTCGGCAACCTGATCGCCGACGTGCTCGAGCATCCCGAAGACGCGGCGACGATCGAGCGCGTG
CGTGCGCAGGTCGCCGAGCTGACGAAGCGTTTCCCGGTCTATCGCTGA

Upstream 100 bases:

>100_bases
GTTCCTCGGAATCCCTCCGCCACGTCGAGCCGGTTGCGCTGCCGGCTGCGCGACGTATCCGGCCACTTCGGTCAACCTGT
ACACACTTAACGGAAACCGT

Downstream 100 bases:

>100_bases
TCGGCCATGCGCTGCCCGTTCTGCCGGCACGACGATACTCAGGTGGTGGATTCGCGCGTGTCGGAAGACGGCGCCGCGAT
CCGCCGGCGTCGGCGCTGCT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAI
DRVKALFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAE
QLAHEHKPKLIVAGASAFALKIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAQTLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERV
RAQVAELTKRFPVYR

Sequences:

>Translated_415_residues
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAI
DRVKALFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAE
QLAHEHKPKLIVAGASAFALKIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAQTLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERV
RAQVAELTKRFPVYR
>Mature_415_residues
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAI
DRVKALFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAE
QLAHEHKPKLIVAGASAFALKIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAQTLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERV
RAQVAELTKRFPVYR

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=41.4096916299559, Blast_Score=341, Evalue=6e-94,
Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=41.4096916299559, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=41.4096916299559, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=41.4096916299559, Blast_Score=341, Evalue=8e-94,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=41.0596026490066, Blast_Score=335, Evalue=4e-92,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=42.2897196261682, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI22547189, Length=413, Percent_Identity=40.6779661016949, Blast_Score=278, Evalue=8e-75,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=63.768115942029, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=45.75, Blast_Score=347, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=45.75, Blast_Score=347, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6319739, Length=415, Percent_Identity=46.0240963855422, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=433, Percent_Identity=43.64896073903, Blast_Score=337, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24640005, Length=455, Percent_Identity=41.978021978022, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI221329721, Length=455, Percent_Identity=41.978021978022, Blast_Score=354, Evalue=6e-98,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA1_BURMA (Q62I16)

Other databases:

- EMBL:   CP000010
- RefSeq:   YP_103654.1
- ProteinModelPortal:   Q62I16
- SMR:   Q62I16
- GeneID:   3088230
- GenomeReviews:   CP000010_GR
- KEGG:   bma:BMA2075
- TIGR:   BMA2075
- HOGENOM:   HBG301263
- OMA:   LNGNRMF
- PhylomeDB:   Q62I16
- ProtClustDB:   PRK00011
- BioCyc:   BMAL243160:BMA_2075-MONOMER
- BRENDA:   2.1.2.1
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 44986; Mature: 44986

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHEEEECCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDIVEQLAIDRVKALFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAEQLAHEHKPKLIVAGASAFAL
EECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEE
KIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAQTL
EEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGV
HHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHCCCEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERVRAQVAELTKRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDRAQSTIANVDPEIWQAIQQENVRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHEEEECCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDIVEQLAIDRVKALFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNEAEDIDYEAAEQLAHEHKPKLIVAGASAFAL
EECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEE
KIDFERLAKIAKAVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKEYQQKVVENARVLAQTL
EEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGNAHITVNKNAIPNDPEKPFVTSGV
HHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHCCCEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGPQEAELVGNLIADVLEHPEDAATIERVRAQVAELTKRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA