Click here to switch to the map view.

The map label for this gene is mmgC [H]

Identifier: 237813587

GI number: 237813587

Start: 3249032

End: 3250219

Strand: Direct

Name: mmgC [H]

Synonym: GBP346_A3363

Alternate gene names: 237813587

Gene position: 3249032-3250219 (Clockwise)

Preceding gene: 237813584

Following gene: 237813589

Centisome position: 79.27

GC content: 66.16

Gene sequence:

>1188_bases
ATGGCTGCCGCAACCTTCCACTGGGACGATCCGCTGCTGCTCGACCAGCAGCTCACCGACGACGAGCGCATGGTGCGCGA
CGCCGCGCACGCTTACGCGCAAGGCAAGCTCGCGCCGCGCGTGACGGAAGCGTTCCGCCACGAGACCACCGACGCGGCGA
TCTTCCGCGAAATGGGCGAGATCGGCCTCCTCGGCCCGACGATCCCCGAGCAGTACGGCGGCCCCGGCCTCGACTACGTG
AGTTACGGGCTCATCGCGCGCGAAGTCGAGCGCGTCGATTCGGGTTATCGGTCGATGATGTCGGTGCAATCGTCGCTCGT
GATGGTGCCGATCTTCGAATTCGGCTCCGACGCGCAGAAGGAAAAGTACCTGCCGAAGCTCGCGACGGGCGAATGGATCG
GCTGCTTCGGGCTGACCGAGCCGAACCACGGCTCCGATCCCGGCAGCATGGTCACGCGCGCGAGGAAGGTGCCGGGCGGG
TACTCGCTGTCCGGCTCGAAGATGTGGATCACGAATTCGCCGATCGCCGACGTGTTCGTCGTCTGGGCGAAGCTCGACGA
AGACGGCCGCGACGAGATTCGCGGCTTCATTCTCGAAAAGGGCTGCAAAGGGCTGTCGGCGCCGGCGATCCACGGCAAGG
TGGGGCTGCGCGCGTCGATCACGGGCGAAATCGTGCTCGACGAAGCGTTCGTCCCCGAAGAGAACATCCTGCCGCACGTG
AAGGGGCTGCGCGGCCCGTTCACGTGCCTGAACTCGGCGCGCTACGGCATCGCGTGGGGCGCGCTCGGCGCGGCCGAATC
GTGCTGGCACATCGCGCGCCAATATGTGCTCGATCGCAAGCAGTTCGGCCGCCCGCTCGCCGCGAACCAGTTGATCCAGA
AGAAGCTCGCCGACATGCAGACCGAGATCACGCTCGGCCTGCAAGGCGTGCTGCGGCTCGGCCGGATGAAGGACGAAGGC
ACCGCCGCCGTCGAGATCACGTCGATCATGAAGCGCAATTCGTGCGGCAAGGCGCTCGACATCGCCCGCCTCGCCCGCGA
CATGCTGGGCGGCAATGGCATCTCGGACGAATTCGGCGTCGCGCGCCACCTCGTGAACCTCGAGGTGGTGAACACGTACG
AAGGTACGCACGACATCCACGCGCTGATTCTCGGCCGCGCGCAGACGGGGATTCAGGCGTTCTTCTGA

Upstream 100 bases:

>100_bases
GGCATCGATGGTCGAAAAATTCATGCGGTGATACACTGGGCTCAATTTGCAAAACATTGTTCCGCACAGCGGAACTATAG
TCAAGCGAGGAGATGACGAG

Downstream 100 bases:

>100_bases
ATGTTGCGCACGTCGCGCGGATGCGGCCCGCGCGTTCGCTGCGCGCTTTGCTTCGCGCCGATCTCGAGCCCGCCTGCGCC
CACGCAGCCGCGCGGACGAC

Product: glutaryl-CoA dehydrogenase, (GCD)

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MAAATFHWDDPLLLDQQLTDDERMVRDAAHAYAQGKLAPRVTEAFRHETTDAAIFREMGEIGLLGPTIPEQYGGPGLDYV
SYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQKEKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRARKVPGG
YSLSGSKMWITNSPIADVFVVWAKLDEDGRDEIRGFILEKGCKGLSAPAIHGKVGLRASITGEIVLDEAFVPEENILPHV
KGLRGPFTCLNSARYGIAWGALGAAESCWHIARQYVLDRKQFGRPLAANQLIQKKLADMQTEITLGLQGVLRLGRMKDEG
TAAVEITSIMKRNSCGKALDIARLARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF

Sequences:

>Translated_395_residues
MAAATFHWDDPLLLDQQLTDDERMVRDAAHAYAQGKLAPRVTEAFRHETTDAAIFREMGEIGLLGPTIPEQYGGPGLDYV
SYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQKEKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRARKVPGG
YSLSGSKMWITNSPIADVFVVWAKLDEDGRDEIRGFILEKGCKGLSAPAIHGKVGLRASITGEIVLDEAFVPEENILPHV
KGLRGPFTCLNSARYGIAWGALGAAESCWHIARQYVLDRKQFGRPLAANQLIQKKLADMQTEITLGLQGVLRLGRMKDEG
TAAVEITSIMKRNSCGKALDIARLARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF
>Mature_394_residues
AAATFHWDDPLLLDQQLTDDERMVRDAAHAYAQGKLAPRVTEAFRHETTDAAIFREMGEIGLLGPTIPEQYGGPGLDYVS
YGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQKEKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRARKVPGGY
SLSGSKMWITNSPIADVFVVWAKLDEDGRDEIRGFILEKGCKGLSAPAIHGKVGLRASITGEIVLDEAFVPEENILPHVK
GLRGPFTCLNSARYGIAWGALGAAESCWHIARQYVLDRKQFGRPLAANQLIQKKLADMQTEITLGLQGVLRLGRMKDEGT
AAVEITSIMKRNSCGKALDIARLARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=391, Percent_Identity=66.2404092071611, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI7669494, Length=371, Percent_Identity=64.6900269541779, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=34.8404255319149, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=35.5029585798817, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=32.0754716981132, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=29.9727520435967, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI76496475, Length=347, Percent_Identity=33.1412103746398, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=33.1412103746398, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI21361497, Length=348, Percent_Identity=32.7586206896552, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI4557231, Length=397, Percent_Identity=29.4710327455919, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI187960098, Length=397, Percent_Identity=29.4710327455919, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI7656849, Length=372, Percent_Identity=28.494623655914, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI4501857, Length=379, Percent_Identity=28.7598944591029, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786223, Length=361, Percent_Identity=25.7617728531856, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87081958, Length=331, Percent_Identity=27.190332326284, Blast_Score=93, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17534353, Length=395, Percent_Identity=62.7848101265823, Blast_Score=504, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=32.8877005347594, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17508101, Length=376, Percent_Identity=32.9787234042553, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17506239, Length=365, Percent_Identity=30.1369863013699, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71990804, Length=274, Percent_Identity=36.4963503649635, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71985184, Length=369, Percent_Identity=31.7073170731707, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17569725, Length=375, Percent_Identity=29.3333333333333, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=28.7234042553192, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71985192, Length=302, Percent_Identity=32.1192052980132, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=28.042328042328, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=31.8681318681319, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=26.0053619302949, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505929, Length=391, Percent_Identity=25.5754475703325, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17551932, Length=394, Percent_Identity=24.1116751269036, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17531909, Length=233, Percent_Identity=28.755364806867, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19920834, Length=397, Percent_Identity=61.9647355163728, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI21356377, Length=369, Percent_Identity=31.9783197831978, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=32.6027397260274, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24646207, Length=372, Percent_Identity=31.7204301075269, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=31.4666666666667, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI281363737, Length=411, Percent_Identity=30.9002433090024, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=30.4232804232804, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43148; Mature: 43017

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAATFHWDDPLLLDQQLTDDERMVRDAAHAYAQGKLAPRVTEAFRHETTDAAIFREMGE
CCCCEEECCCCEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHCC
IGLLGPTIPEQYGGPGLDYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQK
CCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHCCCCHHH
EKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRARKVPGGYSLSGSKMWITNSPIADVFV
HHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHE
VWAKLDEDGRDEIRGFILEKGCKGLSAPAIHGKVGLRASITGEIVLDEAFVPEENILPHV
EEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCCCCHH
KGLRGPFTCLNSARYGIAWGALGAAESCWHIARQYVLDRKQFGRPLAANQLIQKKLADMQ
HCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TEITLGLQGVLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARLARDMLGGNGISDEFGV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
ARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF
HHHHHEEEEEECCCCCHHEEHHEECCHHCCHHHCC
>Mature Secondary Structure 
AAATFHWDDPLLLDQQLTDDERMVRDAAHAYAQGKLAPRVTEAFRHETTDAAIFREMGE
CCCEEECCCCEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHCC
IGLLGPTIPEQYGGPGLDYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQK
CCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHCCCCHHH
EKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRARKVPGGYSLSGSKMWITNSPIADVFV
HHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHE
VWAKLDEDGRDEIRGFILEKGCKGLSAPAIHGKVGLRASITGEIVLDEAFVPEENILPHV
EEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCCCCHH
KGLRGPFTCLNSARYGIAWGALGAAESCWHIARQYVLDRKQFGRPLAANQLIQKKLADMQ
HCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TEITLGLQGVLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARLARDMLGGNGISDEFGV
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
ARHLVNLEVVNTYEGTHDIHALILGRAQTGIQAFF
HHHHHEEEEEECCCCCHHEEHHEECCHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]