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The map label for this gene is yogA [H]

Identifier: 237813529

GI number: 237813529

Start: 3189554

End: 3190561

Strand: Direct

Name: yogA [H]

Synonym: GBP346_A3305

Alternate gene names: 237813529

Gene position: 3189554-3190561 (Clockwise)

Preceding gene: 237813527

Following gene: 237813531

Centisome position: 77.82

GC content: 68.55

Gene sequence:

>1008_bases
ATGAAAGCCATCATGTTGCGTCAGCCCGCCGGCCTCGAGCATCTCGAACGCGTCACGCTCGCCGATCCCGGTGCACCGGC
CGCCGGCGAAATCCGCGTGCGCATTCACGCGAGTTCGCTCAACTATCACGATCTCGGCGTCGTCACCGGCAGGCTGAACC
CCGCCGACAAGCGCATTCCAATGTCCGACGGCGCAGGTGTCGTCGAAGCGATCGGCGAAGGCGTCACGGAGTTCGCGCCC
GGCGACGCGGTCGTGTCGACCTTTTTTCCGTACTGGCTCGACGGCGGGCCGACCGTCGCGGACTTCGCGACGGTCCCGGG
CGACGGTGTCGACGGCTACGCGCGCGAGTCGGTCGTGCGCCCCGCGCACTGGTTCACGCATGCGCCGCAGGGCTACACGC
ACGAGCAAGCCGCGACGCTAACGACGGCGGGCCTCACCGCATGGCGCGCGCTCGTCGTCGACGGCGGCCTGAAGGCGGGC
GACAGCGTGCTCGTGCTCGGCACGGGCGGCGTATCGATCTTCGCGCTGCAGTTCGCGAAGCGAATGGGCGCGACCGTGAT
CGCCACGTCGTCGTCGGACGAAAAGCTGGAACGCGCACGCGCGCTCGGCGCCGATCACGTCGTCAACTATCGTCGCGACG
CGAACTGGGCGGCGAAGGTGCTCGCGCTGACGAACGGGCGCGGCGTCGACCACGTGATCGAGGTCGGCGGCCCCGACACG
CTCCCGCAATCGATCCAGGCATGCCGGATCGGCGGCCATATCGCACTGATCGGCGTGCTGACGGGGATTGCCGGCCCGGT
GCCGACCGTCGCGCTGATGGCGCGCCAGCAGAACCTGCAAGGCCTGATCGTCGGCAGTCGCCGGCATCAGATCGACATGG
TGCGCGCGATCGACGCAACCGGCATCAAGCCGGTCGTCGATCGCACGTTCGCGCTCGACGACATCGCCGACGCGTTCGCC
CATCAAGCGGCCGGCAAGCACTTCGGCAAGATCTGCCTGTCGATCTGA

Upstream 100 bases:

>100_bases
CGGCACACGATACGCGCGCCGATCTCCCCGCCCGCCATTGCGGGCGCATCGGCCGCACACCGAGCGATGCGCTCGCTCAC
CACTCACAGGAGTCGAATCG

Downstream 100 bases:

>100_bases
GCGCGGCTTGCGCCGGCCGCCGCTCAGCCCATCGACCTGTGCCTCGTGTGAACGATCGGATTGTGCCGCGACGTGAAGCT
CATCGACGCGGCCAATCGCG

Product: oxidoreductase, zinc-binding dehydrogenase family

Products: Glycerol; Nicotinamide adenine dinucleotide [C]

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKAIMLRQPAGLEHLERVTLADPGAPAAGEIRVRIHASSLNYHDLGVVTGRLNPADKRIPMSDGAGVVEAIGEGVTEFAP
GDAVVSTFFPYWLDGGPTVADFATVPGDGVDGYARESVVRPAHWFTHAPQGYTHEQAATLTTAGLTAWRALVVDGGLKAG
DSVLVLGTGGVSIFALQFAKRMGATVIATSSSDEKLERARALGADHVVNYRRDANWAAKVLALTNGRGVDHVIEVGGPDT
LPQSIQACRIGGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVVDRTFALDDIADAFA
HQAAGKHFGKICLSI

Sequences:

>Translated_335_residues
MKAIMLRQPAGLEHLERVTLADPGAPAAGEIRVRIHASSLNYHDLGVVTGRLNPADKRIPMSDGAGVVEAIGEGVTEFAP
GDAVVSTFFPYWLDGGPTVADFATVPGDGVDGYARESVVRPAHWFTHAPQGYTHEQAATLTTAGLTAWRALVVDGGLKAG
DSVLVLGTGGVSIFALQFAKRMGATVIATSSSDEKLERARALGADHVVNYRRDANWAAKVLALTNGRGVDHVIEVGGPDT
LPQSIQACRIGGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVVDRTFALDDIADAFA
HQAAGKHFGKICLSI
>Mature_335_residues
MKAIMLRQPAGLEHLERVTLADPGAPAAGEIRVRIHASSLNYHDLGVVTGRLNPADKRIPMSDGAGVVEAIGEGVTEFAP
GDAVVSTFFPYWLDGGPTVADFATVPGDGVDGYARESVVRPAHWFTHAPQGYTHEQAATLTTAGLTAWRALVVDGGLKAG
DSVLVLGTGGVSIFALQFAKRMGATVIATSSSDEKLERARALGADHVVNYRRDANWAAKVLALTNGRGVDHVIEVGGPDT
LPQSIQACRIGGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQIDMVRAIDATGIKPVVDRTFALDDIADAFA
HQAAGKHFGKICLSI

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=350, Percent_Identity=28.8571428571429, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI22538444, Length=350, Percent_Identity=28.8571428571429, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI47519420, Length=347, Percent_Identity=28.8184438040346, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI194239674, Length=329, Percent_Identity=27.0516717325228, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI13236495, Length=329, Percent_Identity=27.0516717325228, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI262073058, Length=282, Percent_Identity=26.5957446808511, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI71743840, Length=282, Percent_Identity=26.5957446808511, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI18379349, Length=332, Percent_Identity=25.6024096385542, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI28557745, Length=334, Percent_Identity=28.7425149700599, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI194239676, Length=248, Percent_Identity=29.0322580645161, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI41872631, Length=329, Percent_Identity=26.7477203647416, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI156627571, Length=326, Percent_Identity=26.0736196319018, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI87081918, Length=316, Percent_Identity=27.2151898734177, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787863, Length=357, Percent_Identity=26.3305322128852, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789651, Length=288, Percent_Identity=27.0833333333333, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788073, Length=278, Percent_Identity=26.6187050359712, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17507255, Length=331, Percent_Identity=24.773413897281, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319520, Length=320, Percent_Identity=25.9375, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=347, Percent_Identity=25.0720461095101, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=323, Percent_Identity=25.3869969040248, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=349, Percent_Identity=23.7822349570201, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=295, Percent_Identity=25.0847457627119, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=251, Percent_Identity=25.4980079681275, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=347, Percent_Identity=24.7838616714697, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24581345, Length=223, Percent_Identity=30.4932735426009, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221330659, Length=221, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19920632, Length=221, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1 [C]

Molecular weight: Translated: 35135; Mature: 35135

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIMLRQPAGLEHLERVTLADPGAPAAGEIRVRIHASSLNYHDLGVVTGRLNPADKRIP
CCEEEECCCCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCC
MSDGAGVVEAIGEGVTEFAPGDAVVSTFFPYWLDGGPTVADFATVPGDGVDGYARESVVR
CCCCCHHHHHHHCCHHHCCCCHHHHHHHHHHHCCCCCCEEHEECCCCCCCCCHHHHHHCC
PAHWFTHAPQGYTHEQAATLTTAGLTAWRALVVDGGLKAGDSVLVLGTGGVSIFALQFAK
CHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCHHHHHHHHHH
RMGATVIATSSSDEKLERARALGADHVVNYRRDANWAAKVLALTNGRGVDHVIEVGGPDT
HCCCEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCHHEEEEEEECCCCCCEEEECCCCCC
LPQSIQACRIGGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQIDMVRAIDAT
CHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCC
GIKPVVDRTFALDDIADAFAHQAAGKHFGKICLSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MKAIMLRQPAGLEHLERVTLADPGAPAAGEIRVRIHASSLNYHDLGVVTGRLNPADKRIP
CCEEEECCCCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCC
MSDGAGVVEAIGEGVTEFAPGDAVVSTFFPYWLDGGPTVADFATVPGDGVDGYARESVVR
CCCCCHHHHHHHCCHHHCCCCHHHHHHHHHHHCCCCCCEEHEECCCCCCCCCHHHHHHCC
PAHWFTHAPQGYTHEQAATLTTAGLTAWRALVVDGGLKAGDSVLVLGTGGVSIFALQFAK
CHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEECCCHHHHHHHHHH
RMGATVIATSSSDEKLERARALGADHVVNYRRDANWAAKVLALTNGRGVDHVIEVGGPDT
HCCCEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCHHEEEEEEECCCCCCEEEECCCCCC
LPQSIQACRIGGHIALIGVLTGIAGPVPTVALMARQQNLQGLIVGSRRHQIDMVRAIDAT
CHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCC
GIKPVVDRTFALDDIADAFAHQAAGKHFGKICLSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+; NADH [C]

Metal ions: Co2+ Zn2+-depleted [C]

Kcat value (1/min): 150 [C]

Specific activity: 19

Km value (mM): 0.2 {tryptophol}} 0.0074 {NAD+}} 0.0069 {NAD+}} 13 {ethylene} 6 {methanol}} 27 {pentanol}} 0.44 {1-butanol}} 120 {ethanol}} 0.91 {acetaldehyde}} 0.1 {acetaldehyde}} 0.005 {1-octanol}} 0.004 {benzyl} 0.005 {cyclohe

Substrates: D-Glyceraldehyde; H+; Nicotinamide adenine dinucleotide - reduced [C]

Specific reaction: D-Glyceraldehyde + H+ + Nicotinamide adenine dinucleotide - reduced <==> Glycerol + Nicotinamide adenine dinucleotide [C]

General reaction: Redox reaction [C]

Inhibitor: 2, 2'-Bipyridyl; 4-Methyl pyrazole acetaldehyde; 8-Amino-6-methoxyquinoline; 8-Hydroxy quinoline-5-sulfonic acid; Acetaldehyde; Dipicolinic acid; EDTA; Ethanol; GSH; Heptafluorbutanol; Imidazole; Iodoacetamide; Iodoacetate; Isobutyramide EDTA; NAD+; NADH;

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]