Click here to switch to the map view.

The map label for this gene is cobB [H]

Identifier: 237813453

GI number: 237813453

Start: 3116772

End: 3117536

Strand: Reverse

Name: cobB [H]

Synonym: GBP346_A3228

Alternate gene names: 237813453

Gene position: 3117536-3116772 (Counterclockwise)

Preceding gene: 237813454

Following gene: 237813452

Centisome position: 76.06

GC content: 70.59

Gene sequence:

>765_bases
ATGTCCGACTCACGCCGCCCGCCTTCGAACCCGTCGCCCGCGATGCGCGATGGCGCGCCGCCCGTCGACGCCGAGCGCAT
CGACGCCGCCGTTCGCGCGCTGTCGCGCGCCGATGCGCTGCTCGTCACGGCGGGCGCGGGCATCGGCATCGATTCCGGAT
TGCCGGATTTTCGCGGCGCCGAAGGGTTGTGGCGCGCGTACCCGGGGCTCGGCCATGTCGGCTATGCATTCCACGAGATC
GCTTCGCCGCGCGCGTTTCGCGAGCGTCCGCGCCTCGCGTGGGGCTTTTACGGCCATCGGCTCGCGATGTACCGTGCAAC
CGTGCCGCACGAAGGGTTCGGCATCCTGCGGCGCTGGATCGGCGCGATGCGCCACGGCGGCTTCGTGTTCACGAGCAATG
TCGACGGTCAGTTTCAGAAGGCGGGCTTCGATCCCGAGCGAATCGTCGAGGTTCACGGCTCGATTCACGCGATGCAGTGC
ATGAGTCCTTGCTCGGCGCACACGTGGGATGCGGAATCGTTCGCGCCCGTCGTCGACGAGCCGGCGTGCAGCCTCGTCGG
CGCGCTCCCCCGCTGTCCGCGGTGCGGCGGCCTCGCACGGCCGAACATCCTGATGTTCGACGATGCGGACTGGCTCGGCG
CGCGTTACGACGCGCAGCACGAAGCGCTGCGCGCTTGGCGCGCGCGCGGGGCGCGTGGCGGTGGTCGAAGTGGGCGCCGG
CACCGCAGTGCCGACGGTGCGTGCCTTCAGCGAACGCACCGGTGA

Upstream 100 bases:

>100_bases
GTCGTTCGTCGTTTCACGTTCGAAGCGCTTCCGGCCGTGCGCCGCGCGAGCGTATGATCGTTCCCACTTCGAACGCAATC
CGGAACGAAAAAGCCGCGCC

Downstream 100 bases:

>100_bases
CGACGTGATTCGAATCAATGTCCGCGAAGCGCATGCGCGGCGCGCCGATGTGATCGGCCTGCCCGGCGGCGCGCTCGAGA
CATTGCGCGCGCTCGATGCC

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRADALLVTAGAGIGIDSGLPDFRGAEGLWRAYPGLGHVGYAFHEI
ASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRRWIGAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQC
MSPCSAHTWDAESFAPVVDEPACSLVGALPRCPRCGGLARPNILMFDDADWLGARYDAQHEALRAWRARGARGGGRSGRR
HRSADGACLQRTHR

Sequences:

>Translated_254_residues
MSDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRADALLVTAGAGIGIDSGLPDFRGAEGLWRAYPGLGHVGYAFHEI
ASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRRWIGAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQC
MSPCSAHTWDAESFAPVVDEPACSLVGALPRCPRCGGLARPNILMFDDADWLGARYDAQHEALRAWRARGARGGGRSGRR
HRSADGACLQRTHR
>Mature_253_residues
SDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRADALLVTAGAGIGIDSGLPDFRGAEGLWRAYPGLGHVGYAFHEIA
SPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRRWIGAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQCM
SPCSAHTWDAESFAPVVDEPACSLVGALPRCPRCGGLARPNILMFDDADWLGARYDAQHEALRAWRARGARGGGRSGRRH
RSADGACLQRTHR

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription per subunit [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI13787215, Length=192, Percent_Identity=29.6875, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI6912664, Length=192, Percent_Identity=29.6875, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI300795542, Length=181, Percent_Identity=28.1767955801105, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27707; Mature: 27575

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRADALLVTAGAGIGIDSGLPDFRGA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCC
EGLWRAYPGLGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRRWI
CCHHHHCCCCCHHHHHHHHHCCCHHHHHCCCEEEHHHHHEEEEEECCCCCCHHHHHHHHH
GAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQCMSPCSAHTWDAESFAPVVDE
HHHHCCCEEEECCCCCCHHHCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCC
PACSLVGALPRCPRCGGLARPNILMFDDADWLGARYDAQHEALRAWRARGARGGGRSGRR
HHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
HRSADGACLQRTHR
CCCCCCHHHHHCCC
>Mature Secondary Structure 
SDSRRPPSNPSPAMRDGAPPVDAERIDAAVRALSRADALLVTAGAGIGIDSGLPDFRGA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCC
EGLWRAYPGLGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFGILRRWI
CCHHHHCCCCCHHHHHHHHHCCCHHHHHCCCEEEHHHHHEEEEEECCCCCCHHHHHHHHH
GAMRHGGFVFTSNVDGQFQKAGFDPERIVEVHGSIHAMQCMSPCSAHTWDAESFAPVVDE
HHHHCCCEEEECCCCCCHHHCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCC
PACSLVGALPRCPRCGGLARPNILMFDDADWLGARYDAQHEALRAWRARGARGGGRSGRR
HHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
HRSADGACLQRTHR
CCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA