Click here to switch to the map view.

The map label for this gene is clcA [H]

Identifier: 237813394

GI number: 237813394

Start: 3064736

End: 3066382

Strand: Direct

Name: clcA [H]

Synonym: GBP346_A3168

Alternate gene names: 237813394

Gene position: 3064736-3066382 (Clockwise)

Preceding gene: 237813392

Following gene: 237813400

Centisome position: 74.78

GC content: 70.25

Gene sequence:

>1647_bases
ATGCAACGCCCCAGCCTGTTCCCGACTCTCACGCGCCGCACGCAGCGCATCTGGCGCCAATATGGCGTGTTCTGGCTCGG
CGCGGTCGTGGTGGGCCTGACGGCCGTGATGTACGCACGGCTCATCGACTGGGGCTACGAGGCGTTCCGTTCGCTCGGGC
AAGGGCGTCCGTGGCTGCCCTTCCTGCTGACGCCCGCCATCGCCGCGCTGTCCGTGTGGCTCACGCGCCGCTTCTTTCGC
GGCGCCGAGGGCAGCGGGATTCCTCAGGTGATCGCGACGCTGCACGCGCAGCCGAGCGCGTTCGGCTCGCGGCTGCTCAC
GCTGCGCATCCTGTTCGGCAAGGTCCTGATCTCGTTGCTCGGCATCGCCGGCGGCTTCACGATCGGCCGCGAAGGGCCGA
CCGTGCAGATCGGCGCGTCGCTGATGTTCAACCTGCGCCGCTTCTACCCGCGCTCGAACGCGCTGATCGAACGCCAGCTC
GTGCTCGCGGGCGCCGCCGCCGGCCTGTCCGCCGCGTTCAACACGCCGCTCGCCGGCGTCGTGTTCGCGATCGAGGAACT
GAGCCGCAGTTTTTCGGCACGCGCGAGCGGTGTGCTGATCACTGCGATCATCATCGCCGGCGTGATCGCGCTCGGCCTGA
ACGGCAACTACACCTACTTCGGCACGATCGAGATCGGCCAGCATTTTCCGAAGATGCTCGCGGCCGCCGTGCTGCTGACC
GCGCTCGTCACGGGCGTCGCGGGCGGTCTGTTCGGCTGGCTGCTGCTGAACACCGGCCGCTGGCTGCCGGCGAGGCTGCT
CGCGCTCTACCGCGAGCGGCCGATCGTGTTCGCGGCGGCCTGCGGCCTCGCGATCGCCGCCGTCGGCGTCGCATCCGGCG
GCACGACGTTCGGCAGCGGCTATGCGGAGGCGCGCGGGCTCCTCGACGGCCGCGAACAGCTGTCCGTCCTGTATCCGTTC
CTGAAAATGATCTCGATGGTCGCGTCGTACCTGCCCGGGATTCCGGGCGGGATCTTCGCGCCTTCGCTGTCGATCGGCGC
GGGTTTCGGCAATCTGCTGCACTTCGTGTTCAGCGGCATGCACCTGCCGATGCTGATCGCGCTCGCGATGGTCGGCTATC
TCGCGGCCGTCACGCAATCGCCGATCACGTCGTTCGTCATCGTGATGGAGATGATCAACGGCCACGCGCTCGTGATCTCG
TTGATGGCCACCGCGCTGATCGCAAGCCGCGTCTCGCGCCTGTTCGTGCCGCCGCTCTACGAGACGCTCGCCGAGCGCTA
TCTGAAGCCGCCGCAACCGAAGCAGGCGGCCACGGCCCCCGCGCACACCGGCATCGCGGCGGTCAAGATGCCCGAGGACG
CCGAATCGGCGCCCGCCGATCCGCTCGATACGCTGCGCGACGAAGCCGCGAACGAAGCGAATGCGAACGAGCCCGATGCG
GGCGACGCCGGCGGGCATACCGGCGCGGGCGCGGCGGCGCACGCCGATGATGCGCCGTGCGGCGCGGCCGATGCCGCCCG
CGCGGGCGCGCCGCCCGACGCGAGCCCGGCATCGGCGCCCGGCGCGTCGAACACGCGTGCGAACGGCCCGACACCGCCGT
CGGGCGACGACGAGAATCGTGAGCCGCCGCAGCGCCCCGCTCAATAG

Upstream 100 bases:

>100_bases
ACCACAAATTGCGAAGAATTTACATTTGTCACAACGTCGATGTCGTGCTAGCCGCGCTCGTCGCGCAACTATAATGTCAC
CTTTTTGCGCACCGACGCCC

Downstream 100 bases:

>100_bases
ATGACGACGGGCGCGGGCCGGTAGTACACCGGCCGCGCCGGCACGACGACGCAGCCGGCCAGCGTCAGCGCGACGAGCGC
GAGAGCGAACAAGGTCCGTT

Product: chloride transporter, ClC family

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MQRPSLFPTLTRRTQRIWRQYGVFWLGAVVVGLTAVMYARLIDWGYEAFRSLGQGRPWLPFLLTPAIAALSVWLTRRFFR
GAEGSGIPQVIATLHAQPSAFGSRLLTLRILFGKVLISLLGIAGGFTIGREGPTVQIGASLMFNLRRFYPRSNALIERQL
VLAGAAAGLSAAFNTPLAGVVFAIEELSRSFSARASGVLITAIIIAGVIALGLNGNYTYFGTIEIGQHFPKMLAAAVLLT
ALVTGVAGGLFGWLLLNTGRWLPARLLALYRERPIVFAAACGLAIAAVGVASGGTTFGSGYAEARGLLDGREQLSVLYPF
LKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHFVFSGMHLPMLIALAMVGYLAAVTQSPITSFVIVMEMINGHALVIS
LMATALIASRVSRLFVPPLYETLAERYLKPPQPKQAATAPAHTGIAAVKMPEDAESAPADPLDTLRDEAANEANANEPDA
GDAGGHTGAGAAAHADDAPCGAADAARAGAPPDASPASAPGASNTRANGPTPPSGDDENREPPQRPAQ

Sequences:

>Translated_548_residues
MQRPSLFPTLTRRTQRIWRQYGVFWLGAVVVGLTAVMYARLIDWGYEAFRSLGQGRPWLPFLLTPAIAALSVWLTRRFFR
GAEGSGIPQVIATLHAQPSAFGSRLLTLRILFGKVLISLLGIAGGFTIGREGPTVQIGASLMFNLRRFYPRSNALIERQL
VLAGAAAGLSAAFNTPLAGVVFAIEELSRSFSARASGVLITAIIIAGVIALGLNGNYTYFGTIEIGQHFPKMLAAAVLLT
ALVTGVAGGLFGWLLLNTGRWLPARLLALYRERPIVFAAACGLAIAAVGVASGGTTFGSGYAEARGLLDGREQLSVLYPF
LKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHFVFSGMHLPMLIALAMVGYLAAVTQSPITSFVIVMEMINGHALVIS
LMATALIASRVSRLFVPPLYETLAERYLKPPQPKQAATAPAHTGIAAVKMPEDAESAPADPLDTLRDEAANEANANEPDA
GDAGGHTGAGAAAHADDAPCGAADAARAGAPPDASPASAPGASNTRANGPTPPSGDDENREPPQRPAQ
>Mature_548_residues
MQRPSLFPTLTRRTQRIWRQYGVFWLGAVVVGLTAVMYARLIDWGYEAFRSLGQGRPWLPFLLTPAIAALSVWLTRRFFR
GAEGSGIPQVIATLHAQPSAFGSRLLTLRILFGKVLISLLGIAGGFTIGREGPTVQIGASLMFNLRRFYPRSNALIERQL
VLAGAAAGLSAAFNTPLAGVVFAIEELSRSFSARASGVLITAIIIAGVIALGLNGNYTYFGTIEIGQHFPKMLAAAVLLT
ALVTGVAGGLFGWLLLNTGRWLPARLLALYRERPIVFAAACGLAIAAVGVASGGTTFGSGYAEARGLLDGREQLSVLYPF
LKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHFVFSGMHLPMLIALAMVGYLAAVTQSPITSFVIVMEMINGHALVIS
LMATALIASRVSRLFVPPLYETLAERYLKPPQPKQAATAPAHTGIAAVKMPEDAESAPADPLDTLRDEAANEANANEPDA
GDAGGHTGAGAAAHADDAPCGAADAARAGAPPDASPASAPGASNTRANGPTPPSGDDENREPPQRPAQ

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770840, Length=412, Percent_Identity=24.5145631067961, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI55770838, Length=412, Percent_Identity=24.5145631067961, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786350, Length=445, Percent_Identity=28.0898876404494, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081943, Length=309, Percent_Identity=29.7734627831715, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71996455, Length=507, Percent_Identity=23.4714003944773, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71996452, Length=507, Percent_Identity=23.4714003944773, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 57345; Mature: 57345

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRPSLFPTLTRRTQRIWRQYGVFWLGAVVVGLTAVMYARLIDWGYEAFRSLGQGRPWLP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
FLLTPAIAALSVWLTRRFFRGAEGSGIPQVIATLHAQPSAFGSRLLTLRILFGKVLISLL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
GIAGGFTIGREGPTVQIGASLMFNLRRFYPRSNALIERQLVLAGAAAGLSAAFNTPLAGV
HHHCCCEECCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
VFAIEELSRSFSARASGVLITAIIIAGVIALGLNGNYTYFGTIEIGQHFPKMLAAAVLLT
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHH
ALVTGVAGGLFGWLLLNTGRWLPARLLALYRERPIVFAAACGLAIAAVGVASGGTTFGSG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
YAEARGLLDGREQLSVLYPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHFVFSGM
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHCCCHHHHHHHHHCCC
HLPMLIALAMVGYLAAVTQSPITSFVIVMEMINGHALVISLMATALIASRVSRLFVPPLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHH
ETLAERYLKPPQPKQAATAPAHTGIAAVKMPEDAESAPADPLDTLRDEAANEANANEPDA
HHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
GDAGGHTGAGAAAHADDAPCGAADAARAGAPPDASPASAPGASNTRANGPTPPSGDDENR
CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EPPQRPAQ
CCCCCCCC
>Mature Secondary Structure
MQRPSLFPTLTRRTQRIWRQYGVFWLGAVVVGLTAVMYARLIDWGYEAFRSLGQGRPWLP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
FLLTPAIAALSVWLTRRFFRGAEGSGIPQVIATLHAQPSAFGSRLLTLRILFGKVLISLL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
GIAGGFTIGREGPTVQIGASLMFNLRRFYPRSNALIERQLVLAGAAAGLSAAFNTPLAGV
HHHCCCEECCCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
VFAIEELSRSFSARASGVLITAIIIAGVIALGLNGNYTYFGTIEIGQHFPKMLAAAVLLT
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHH
ALVTGVAGGLFGWLLLNTGRWLPARLLALYRERPIVFAAACGLAIAAVGVASGGTTFGSG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
YAEARGLLDGREQLSVLYPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHFVFSGM
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHCCCHHHHHHHHHCCC
HLPMLIALAMVGYLAAVTQSPITSFVIVMEMINGHALVISLMATALIASRVSRLFVPPLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHH
ETLAERYLKPPQPKQAATAPAHTGIAAVKMPEDAESAPADPLDTLRDEAANEANANEPDA
HHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
GDAGGHTGAGAAAHADDAPCGAADAARAGAPPDASPASAPGASNTRANGPTPPSGDDENR
CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EPPQRPAQ
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA