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The map label for this gene is ytpA [H]

Identifier: 237813284

GI number: 237813284

Start: 2964626

End: 2965468

Strand: Direct

Name: ytpA [H]

Synonym: GBP346_A3051

Alternate gene names: 237813284

Gene position: 2964626-2965468 (Clockwise)

Preceding gene: 237813277

Following gene: 237813286

Centisome position: 72.33

GC content: 72.24

Gene sequence:

>843_bases
GTGCGTACCGCCGACGGGCTCGAGCTCGCGTGCTACCGTTGGCCGTCTACCGCGCCTTCGTGCGCCGCGCCGCGCGCGAC
CGTCGCGCTCGTGCACGGGCTCGCCGAGCACGCGGGACGCTATCAGGCGTTCGCCGAGCGGCTGAACGCGGCGGGCATCG
AAGTCGTCGCGATCGATCTGCGCGGCCACGGGCGCTCGCCCGGCGAACGCGCATGGGCCGAGCGCTTCGACCGGTATCTG
GACGACGCGGACGCGCTCGTCGCGAGCGCCGCGCGCGAGAACACGCCGCTCTTCCTGATGGGGCACAGCATGGGCGGCGC
AATCGCCGCACTCTATGCGATCGAGCGCGCGGCCGCGCGCCACGCGAGCCTGGCGGGCCTGATCCTGTCGAGCCCCGCGC
TCGCGCCGGGGCGCGACGTGCCGCAATGGATGCTCGCGATGAGCCGCTTCATCAGCCGCGTGTGGCCTCGCTTTCCGGCG
CTCAAGATCGACGCCGCATTGCTGTCACGCGATCCGGCCGTGGTCGCCGCGAATCGCGCCGATCCGCTCGTCCATCACGG
CTCGGTGCCGGCGCGCACGGGCGCCGAGATTCTCGACGCGATGCGGCGAATCGCGGCCGGCCGCGCGGCGCTGCGCATCC
CCGTCCTCGTCTATCACGGCACCGCCGACAAGCTGACCGAGCCCGACGGCAGCCGCGACTTCGGCGCGCACGTCGGCTCG
CCCGATCGCACGCTCACGCTATACGAAGGCAACTATCACGAGACGATGAACGATCTGGAACGCGAGCGGGTGATCGGCGC
GCTGATCGACTGGATCGCCGCGCGCGTGCCGGCTCGCGGTTGA

Upstream 100 bases:

>100_bases
TTCGTCACGACACGCCACGGAGACGCCCGCCATGGACGCTGCTGCCCCGACTTCGCCCCGCTCGGCCGACGCTTCCCGCG
CCGCCCCTCAGCCCACGCGC

Downstream 100 bases:

>100_bases
CGCGGAACAACGGCCGGAGCGCGTCGCGCGAAAGCGAAGACGGATCGGCGTCGACGGCATGCGGCGCGCCGATCGTTTCA
CGCGGATGGCGCGATAGTGC

Product: alpha/beta hydrolase family protein

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MRTADGLELACYRWPSTAPSCAAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYL
DDADALVASAARENTPLFLMGHSMGGAIAALYAIERAAARHASLAGLILSSPALAPGRDVPQWMLAMSRFISRVWPRFPA
LKIDAALLSRDPAVVAANRADPLVHHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVGS
PDRTLTLYEGNYHETMNDLERERVIGALIDWIAARVPARG

Sequences:

>Translated_280_residues
MRTADGLELACYRWPSTAPSCAAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYL
DDADALVASAARENTPLFLMGHSMGGAIAALYAIERAAARHASLAGLILSSPALAPGRDVPQWMLAMSRFISRVWPRFPA
LKIDAALLSRDPAVVAANRADPLVHHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVGS
PDRTLTLYEGNYHETMNDLERERVIGALIDWIAARVPARG
>Mature_280_residues
MRTADGLELACYRWPSTAPSCAAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDLRGHGRSPGERAWAERFDRYL
DDADALVASAARENTPLFLMGHSMGGAIAALYAIERAAARHASLAGLILSSPALAPGRDVPQWMLAMSRFISRVWPRFPA
LKIDAALLSRDPAVVAANRADPLVHHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVGS
PDRTLTLYEGNYHETMNDLERERVIGALIDWIAARVPARG

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=285, Percent_Identity=32.280701754386, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI6005786, Length=285, Percent_Identity=32.280701754386, Blast_Score=140, Evalue=9e-34,
Organism=Escherichia coli, GI1787678, Length=280, Percent_Identity=25, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 30133; Mature: 30133

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTADGLELACYRWPSTAPSCAAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDL
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
RGHGRSPGERAWAERFDRYLDDADALVASAARENTPLFLMGHSMGGAIAALYAIERAAAR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHH
HASLAGLILSSPALAPGRDVPQWMLAMSRFISRVWPRFPALKIDAALLSRDPAVVAANRA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCC
DPLVHHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVGS
CCCEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCHHHCCCCCCCCCCCCCCCC
PDRTLTLYEGNYHETMNDLERERVIGALIDWIAARVPARG
CCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRTADGLELACYRWPSTAPSCAAPRATVALVHGLAEHAGRYQAFAERLNAAGIEVVAIDL
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
RGHGRSPGERAWAERFDRYLDDADALVASAARENTPLFLMGHSMGGAIAALYAIERAAAR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHH
HASLAGLILSSPALAPGRDVPQWMLAMSRFISRVWPRFPALKIDAALLSRDPAVVAANRA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCC
DPLVHHGSVPARTGAEILDAMRRIAAGRAALRIPVLVYHGTADKLTEPDGSRDFGAHVGS
CCCEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCHHHCCCCCCCCCCCCCCCC
PDRTLTLYEGNYHETMNDLERERVIGALIDWIAARVPARG
CCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]