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The map label for this gene is zraR [H]

Identifier: 237813254

GI number: 237813254

Start: 2936435

End: 2937895

Strand: Direct

Name: zraR [H]

Synonym: GBP346_A3021

Alternate gene names: 237813254

Gene position: 2936435-2937895 (Clockwise)

Preceding gene: 237813251

Following gene: 237813255

Centisome position: 71.65

GC content: 69.68

Gene sequence:

>1461_bases
GTGCCAGACTTCCGCCCCCCTTCCGATTGCGCGCCGCCCGGCCATGCCGCGCAGCGCTCCGCCTCACCGGCCGATGCGGC
CGCGCGCCAGCTCGTCTACCTGTCGCGCACGCCCGACACGACGCTCGTCGCGCACCTGCGCGCACGACGCTGGAACGTGC
ACGTCGCGCGCTCCGCGAACGAAGCGGCGCGGCGCGTGAAGCCGAATCAGCCGCAGGCCGGCATCGCCGATCTCGACGGC
TTCGCGCCGCGCGAGTTGCCGACGCTCGAAGCGGTGTTGCGCCAGCAGCAGGTCGGCTGGATCGCGCTCGCGGGTGACAC
GCGCATCAACGATCCCGACGTGCGCCGGCTGATTCGCCAGTACTGCTTCGACTACATGCAGGGCCTGCCCCCGCACGAGA
CGATTGATTATCTCGTCGGCCATGCCTACGGGATGGTCGCGCTGTGCGATCTCGACGTCACGGCGGGCGCCGCCGCGACG
GGCGACGAGATGGTGGGCGCGTGCGACGCGATGCAGCAGTTGTTCCGGACGATCCGCAAGGTCGCCGCGACCGACGCGAC
CGTGTTCATCTCCGGCGAATCGGGCACCGGCAAGGAGCTGACCGCGCTCGCGATCCACGAGCGCTCCGAGCGCCGCAAGG
CGCCGTTCGTCGCGATCAACTGCGGCGCGATTCCGAATCATCTGCTGCAATCCGAACTGTTCGGCTACGAGCGCGGCGCA
TTCACGGGCGCGAGCCAGCGCAAGGTCGGCCGTGTCGAAGCGGCGGACGGCGGCACGCTGTTTCTCGACGAAATCGGCGA
CATGCCGCTCGAAAGCCAGGCGAGCATGCTGCGCTTCCTGCAGGAAGGCAAGATCGAACGGCTCGGCGGGCACGAGTCGA
TTCCGGTCGACGTGCGGATCATCTCCGCGACGCACGTCGATCTCGACGCGGCGATGCGCGAAGGCCGCTTTCGCGACGAC
CTGTACCACCGGCTGTGCGTGCTGAAGCTCGACGAGCCGCCGTTGCGCGCGCGCGGCAAGGACATCGAAATCCTCGCGCA
TCACATCCTGCATCAGTTCAGGAGCGACGGCGCGCGCCGCATTCACGGCTTCACGTCGTGCGCGATCGAAGCGATGTACA
ACTATCACTGGCCCGGCAACGTGCGCGAGCTGATCAACCGGATCCGGCGCGCGATCGTGATGTCGGACAGCCGGCAACTG
TCGGCCGCCGACCTCGATCTCGCGCCGTTCGCCGCGCGCCAGGCGACGACGCTCGCCGAAGCGCGCGAGCGCGCCGAGCG
CCGGACGATCGAGGCGTCGCTGCTGCGGCATCGCAACCGTCTGACCGAAGCGGCGGCGGAACTCGGCGTGTCGCGCGCGA
CGCTGTATCGGCTGATGGTGTCGCACGGCCTGCGCGAACTGTCGTGGGGCGCGCAACGCGCCGGCGCGAGCGACGCGGAC
GACGAGGCCGGGCCCGCATGA

Upstream 100 bases:

>100_bases
GGCAACGACGCCCGCGGCGCGCGCCGGCGCGCCCACCTCGAACTCCGCTCGCCGCGCTCGCCCCGACACGTTCCGAACAA
CATCCCAGCTGAGGTGCATC

Downstream 100 bases:

>100_bases
TGCGCGCGCGGCATGCGCACGTGCTGCTCGCGTGCGGCACGTGACACGTCGGCCGCCGCGAGACGCGCGGGAGCGCGCCC
GTCGAGCCCGCGCGACGCGT

Product: sigma-54 dependent transcriptional regulator, Fis family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MPDFRPPSDCAPPGHAAQRSASPADAAARQLVYLSRTPDTTLVAHLRARRWNVHVARSANEAARRVKPNQPQAGIADLDG
FAPRELPTLEAVLRQQQVGWIALAGDTRINDPDVRRLIRQYCFDYMQGLPPHETIDYLVGHAYGMVALCDLDVTAGAAAT
GDEMVGACDAMQQLFRTIRKVAATDATVFISGESGTGKELTALAIHERSERRKAPFVAINCGAIPNHLLQSELFGYERGA
FTGASQRKVGRVEAADGGTLFLDEIGDMPLESQASMLRFLQEGKIERLGGHESIPVDVRIISATHVDLDAAMREGRFRDD
LYHRLCVLKLDEPPLRARGKDIEILAHHILHQFRSDGARRIHGFTSCAIEAMYNYHWPGNVRELINRIRRAIVMSDSRQL
SAADLDLAPFAARQATTLAEARERAERRTIEASLLRHRNRLTEAAAELGVSRATLYRLMVSHGLRELSWGAQRAGASDAD
DEAGPA

Sequences:

>Translated_486_residues
MPDFRPPSDCAPPGHAAQRSASPADAAARQLVYLSRTPDTTLVAHLRARRWNVHVARSANEAARRVKPNQPQAGIADLDG
FAPRELPTLEAVLRQQQVGWIALAGDTRINDPDVRRLIRQYCFDYMQGLPPHETIDYLVGHAYGMVALCDLDVTAGAAAT
GDEMVGACDAMQQLFRTIRKVAATDATVFISGESGTGKELTALAIHERSERRKAPFVAINCGAIPNHLLQSELFGYERGA
FTGASQRKVGRVEAADGGTLFLDEIGDMPLESQASMLRFLQEGKIERLGGHESIPVDVRIISATHVDLDAAMREGRFRDD
LYHRLCVLKLDEPPLRARGKDIEILAHHILHQFRSDGARRIHGFTSCAIEAMYNYHWPGNVRELINRIRRAIVMSDSRQL
SAADLDLAPFAARQATTLAEARERAERRTIEASLLRHRNRLTEAAAELGVSRATLYRLMVSHGLRELSWGAQRAGASDAD
DEAGPA
>Mature_485_residues
PDFRPPSDCAPPGHAAQRSASPADAAARQLVYLSRTPDTTLVAHLRARRWNVHVARSANEAARRVKPNQPQAGIADLDGF
APRELPTLEAVLRQQQVGWIALAGDTRINDPDVRRLIRQYCFDYMQGLPPHETIDYLVGHAYGMVALCDLDVTAGAAATG
DEMVGACDAMQQLFRTIRKVAATDATVFISGESGTGKELTALAIHERSERRKAPFVAINCGAIPNHLLQSELFGYERGAF
TGASQRKVGRVEAADGGTLFLDEIGDMPLESQASMLRFLQEGKIERLGGHESIPVDVRIISATHVDLDAAMREGRFRDDL
YHRLCVLKLDEPPLRARGKDIEILAHHILHQFRSDGARRIHGFTSCAIEAMYNYHWPGNVRELINRIRRAIVMSDSRQLS
AADLDLAPFAARQATTLAEARERAERRTIEASLLRHRNRLTEAAAELGVSRATLYRLMVSHGLRELSWGAQRAGASDADD
EAGPA

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=429, Percent_Identity=39.3939393939394, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1788550, Length=304, Percent_Identity=46.7105263157895, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1788905, Length=295, Percent_Identity=45.0847457627119, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1789233, Length=322, Percent_Identity=42.5465838509317, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082117, Length=325, Percent_Identity=42.4615384615385, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1790299, Length=333, Percent_Identity=43.5435435435435, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789087, Length=308, Percent_Identity=42.5324675324675, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87082152, Length=331, Percent_Identity=41.6918429003021, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1786524, Length=316, Percent_Identity=41.7721518987342, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87081872, Length=322, Percent_Identity=36.9565217391304, Blast_Score=209, Evalue=5e-55,
Organism=Escherichia coli, GI1787583, Length=323, Percent_Identity=34.0557275541796, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87081858, Length=295, Percent_Identity=32.2033898305085, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789828, Length=286, Percent_Identity=29.7202797202797, Blast_Score=115, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53535; Mature: 53404

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDFRPPSDCAPPGHAAQRSASPADAAARQLVYLSRTPDTTLVAHLRARRWNVHVARSAN
CCCCCCCCCCCCCCCHHHCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHCEEEEECCHH
EAARRVKPNQPQAGIADLDGFAPRELPTLEAVLRQQQVGWIALAGDTRINDPDVRRLIRQ
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH
YCFDYMQGLPPHETIDYLVGHAYGMVALCDLDVTAGAAATGDEMVGACDAMQQLFRTIRK
HHHHHHHCCCCHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAATDATVFISGESGTGKELTALAIHERSERRKAPFVAINCGAIPNHLLQSELFGYERGA
HHCCCCEEEEECCCCCCCCEEHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCC
FTGASQRKVGRVEAADGGTLFLDEIGDMPLESQASMLRFLQEGKIERLGGHESIPVDVRI
CCCCCCCCCCCEEECCCCEEEHHHHCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCEEEEE
ISATHVDLDAAMREGRFRDDLYHRLCVLKLDEPPLRARGKDIEILAHHILHQFRSDGARR
EEEECCCHHHHHHCCCCHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
IHGFTSCAIEAMYNYHWPGNVRELINRIRRAIVMSDSRQLSAADLDLAPFAARQATTLAE
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
ARERAERRTIEASLLRHRNRLTEAAAELGVSRATLYRLMVSHGLRELSWGAQRAGASDAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHHHHHCCHHHCCCCCCC
DEAGPA
CCCCCC
>Mature Secondary Structure 
PDFRPPSDCAPPGHAAQRSASPADAAARQLVYLSRTPDTTLVAHLRARRWNVHVARSAN
CCCCCCCCCCCCCCHHHCCCCCHHHHHHHEEEEECCCCHHHHHHHHHHHCEEEEECCHH
EAARRVKPNQPQAGIADLDGFAPRELPTLEAVLRQQQVGWIALAGDTRINDPDVRRLIRQ
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHH
YCFDYMQGLPPHETIDYLVGHAYGMVALCDLDVTAGAAATGDEMVGACDAMQQLFRTIRK
HHHHHHHCCCCHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VAATDATVFISGESGTGKELTALAIHERSERRKAPFVAINCGAIPNHLLQSELFGYERGA
HHCCCCEEEEECCCCCCCCEEHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCC
FTGASQRKVGRVEAADGGTLFLDEIGDMPLESQASMLRFLQEGKIERLGGHESIPVDVRI
CCCCCCCCCCCEEECCCCEEEHHHHCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCEEEEE
ISATHVDLDAAMREGRFRDDLYHRLCVLKLDEPPLRARGKDIEILAHHILHQFRSDGARR
EEEECCCHHHHHHCCCCHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
IHGFTSCAIEAMYNYHWPGNVRELINRIRRAIVMSDSRQLSAADLDLAPFAARQATTLAE
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
ARERAERRTIEASLLRHRNRLTEAAAELGVSRATLYRLMVSHGLRELSWGAQRAGASDAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHHHHHCCHHHCCCCCCC
DEAGPA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]