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The map label for this gene is moeA [H]

Identifier: 237813222

GI number: 237813222

Start: 2909697

End: 2910995

Strand: Direct

Name: moeA [H]

Synonym: GBP346_A2987

Alternate gene names: 237813222

Gene position: 2909697-2910995 (Clockwise)

Preceding gene: 237813220

Following gene: 237813223

Centisome position: 70.99

GC content: 74.6

Gene sequence:

>1299_bases
ATGACCACGCACACCACGCCTACGCCATCCGCCACGTCCGGGCACACCGTCGCGCTGAGCGTCGACGAAGCGCGCGCGCT
CGCGTTGCGCTTCGCCGAACGCGTCGCGCAGGTCGAACGCGTCGCGTTGCGCGATGCGCTCGGCCGCGTGCTCGCCGAAG
ACGTCGCGTCGCCGTTCGACATCCCCGCGTACGACAACGCCGCGATGGACGGCTACGCGTTCGACGGCGCGGCGCTCGCC
GCGCCCGCCGCCGACGGCGTGCTCGCGCTCGCCGTGGCGGGCCGCGCGCTCGCGGGGCACCCGTTCGACGGCCCTCGCAT
CGCGCCGCACGCATGCGTGCGCATCATGACCGGCGCGCAGATGCCGGCCGGCTGCGACACCGTGATTCCGCAGGAAAAAG
TCGACGCGACGGGCGACGTCGTGCGCTTTCCGGCCGCGGCCGTCGCGCGCGGCGAACACTGCCGCCGCGCGGGCGAAGAT
CTCGCGCGCGGCGCGCGCGCGCTCGCCGCCGGCCGCGTCGTGCGCGCAGCCGATCTCGGCCTGCTCGCGTCGCTCGGCAT
CGCCGAGGTCGCGGTGCGCCGCCGCGTGTGCGTCGCGTTCTTCTCGACGGGCGACGAACTCCAGACGCCGGGCGAGCCGC
CGCGCGAAGGCGGCCTCTACGACAGCAACCGCGCGACGCTCGCCGGCATGCTCGCCCGCATCGGCGTCGAGACGCTCGAT
CTCGGCATCGTGCGCGACGATCCCGCCGCGCTCGAAGGCGCGCTGACGACGGCGGCCGCGCAGGCGGACGCGGTGATCAC
GTCGGGCGGCGTATCGGTGGGCGACGCCGACTTCACGCGCGCGCTGCTCGCAACGCTTGGCGACGTCACGTTCGCGAGCG
TCGCGATGCGCCCCGGCCGGCCGCTCGCGTGCGGGCGCATTCGGGCAAGCGGGCGCGAGGAGCGGCCCGCGCTCTTCTTC
GGCCTGCCGGGCAACCCGGTCGCGGTCGCGGCGACCTTCATCGTGATCGTGCGCGACGCGCTCTTCGCGATGATGGGCGC
CGAGGCGCAACCGCTCCCCCGCTATCCGGCCGTCTGCGACGCGCCGATCAACAAACGCGCGGGTCGCACCGAATATCTGC
GCGGCCGGGCGGCGCGCGATGCGAGCGGCGTCTGGCGCGTGGCGCCCGCCGGCTCGCAAAGCTCGGCGTCGCTCAAGAGC
CTGAGCGACGCGAACTGCTTCATCGTGCTCGCGCACGACGCCGCACGCGTCGACGCCGGCACGACAGTGGACATCCTGCC
GTTCGACGGCGCCATCTGA

Upstream 100 bases:

>100_bases
GCGTTCCGCGCGCCGCCCCGCCGCCTGCGATGCGAGCGTTTCAAGCGGCGGCCGGGACGCCGACCCCGAACACAATCCGC
CTAGCGGCGCCTCGTCACCG

Downstream 100 bases:

>100_bases
ATCCGTACTCAGCACTTCCACGGGGGCAACTCGCATATGAAAAAACAAATCTCATCGATCGCGCCGGGGCAGACCGCGAA
AGCGCTGATCCTCGTCTATC

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTTHTTPTPSATSGHTVALSVDEARALALRFAERVAQVERVALRDALGRVLAEDVASPFDIPAYDNAAMDGYAFDGAALA
APAADGVLALAVAGRALAGHPFDGPRIAPHACVRIMTGAQMPAGCDTVIPQEKVDATGDVVRFPAAAVARGEHCRRAGED
LARGARALAAGRVVRAADLGLLASLGIAEVAVRRRVCVAFFSTGDELQTPGEPPREGGLYDSNRATLAGMLARIGVETLD
LGIVRDDPAALEGALTTAAAQADAVITSGGVSVGDADFTRALLATLGDVTFASVAMRPGRPLACGRIRASGREERPALFF
GLPGNPVAVAATFIVIVRDALFAMMGAEAQPLPRYPAVCDAPINKRAGRTEYLRGRAARDASGVWRVAPAGSQSSASLKS
LSDANCFIVLAHDAARVDAGTTVDILPFDGAI

Sequences:

>Translated_432_residues
MTTHTTPTPSATSGHTVALSVDEARALALRFAERVAQVERVALRDALGRVLAEDVASPFDIPAYDNAAMDGYAFDGAALA
APAADGVLALAVAGRALAGHPFDGPRIAPHACVRIMTGAQMPAGCDTVIPQEKVDATGDVVRFPAAAVARGEHCRRAGED
LARGARALAAGRVVRAADLGLLASLGIAEVAVRRRVCVAFFSTGDELQTPGEPPREGGLYDSNRATLAGMLARIGVETLD
LGIVRDDPAALEGALTTAAAQADAVITSGGVSVGDADFTRALLATLGDVTFASVAMRPGRPLACGRIRASGREERPALFF
GLPGNPVAVAATFIVIVRDALFAMMGAEAQPLPRYPAVCDAPINKRAGRTEYLRGRAARDASGVWRVAPAGSQSSASLKS
LSDANCFIVLAHDAARVDAGTTVDILPFDGAI
>Mature_431_residues
TTHTTPTPSATSGHTVALSVDEARALALRFAERVAQVERVALRDALGRVLAEDVASPFDIPAYDNAAMDGYAFDGAALAA
PAADGVLALAVAGRALAGHPFDGPRIAPHACVRIMTGAQMPAGCDTVIPQEKVDATGDVVRFPAAAVARGEHCRRAGEDL
ARGARALAAGRVVRAADLGLLASLGIAEVAVRRRVCVAFFSTGDELQTPGEPPREGGLYDSNRATLAGMLARIGVETLDL
GIVRDDPAALEGALTTAAAQADAVITSGGVSVGDADFTRALLATLGDVTFASVAMRPGRPLACGRIRASGREERPALFFG
LPGNPVAVAATFIVIVRDALFAMMGAEAQPLPRYPAVCDAPINKRAGRTEYLRGRAARDASGVWRVAPAGSQSSASLKSL
SDANCFIVLAHDAARVDAGTTVDILPFDGAI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=425, Percent_Identity=32.2352941176471, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI66932975, Length=425, Percent_Identity=32.2352941176471, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1787049, Length=412, Percent_Identity=43.4466019417476, Blast_Score=304, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI25147659, Length=314, Percent_Identity=31.8471337579618, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=373, Percent_Identity=27.3458445040214, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17136978, Length=416, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24638841, Length=416, Percent_Identity=26.9230769230769, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44449; Mature: 44318

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHTTPTPSATSGHTVALSVDEARALALRFAERVAQVERVALRDALGRVLAEDVASPFD
CCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IPAYDNAAMDGYAFDGAALAAPAADGVLALAVAGRALAGHPFDGPRIAPHACVRIMTGAQ
CCCCCCCCCCCEEECCCHHCCCCCCCCEEEEHHCHHHCCCCCCCCCCCHHHHHHHHHCCC
MPAGCDTVIPQEKVDATGDVVRFPAAAVARGEHCRRAGEDLARGARALAAGRVVRAADLG
CCCCCCCCCCHHHCCCCCCEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LLASLGIAEVAVRRRVCVAFFSTGDELQTPGEPPREGGLYDSNRATLAGMLARIGVETLD
HHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHEE
LGIVRDDPAALEGALTTAAAQADAVITSGGVSVGDADFTRALLATLGDVTFASVAMRPGR
EEEECCCHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCC
PLACGRIRASGREERPALFFGLPGNPVAVAATFIVIVRDALFAMMGAEAQPLPRYPAVCD
CCCCCHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
APINKRAGRTEYLRGRAARDASGVWRVAPAGSQSSASLKSLSDANCFIVLAHDAARVDAG
CCCCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCC
TTVDILPFDGAI
CEEEEECCCCCC
>Mature Secondary Structure 
TTHTTPTPSATSGHTVALSVDEARALALRFAERVAQVERVALRDALGRVLAEDVASPFD
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
IPAYDNAAMDGYAFDGAALAAPAADGVLALAVAGRALAGHPFDGPRIAPHACVRIMTGAQ
CCCCCCCCCCCEEECCCHHCCCCCCCCEEEEHHCHHHCCCCCCCCCCCHHHHHHHHHCCC
MPAGCDTVIPQEKVDATGDVVRFPAAAVARGEHCRRAGEDLARGARALAAGRVVRAADLG
CCCCCCCCCCHHHCCCCCCEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LLASLGIAEVAVRRRVCVAFFSTGDELQTPGEPPREGGLYDSNRATLAGMLARIGVETLD
HHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHEE
LGIVRDDPAALEGALTTAAAQADAVITSGGVSVGDADFTRALLATLGDVTFASVAMRPGR
EEEECCCHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCC
PLACGRIRASGREERPALFFGLPGNPVAVAATFIVIVRDALFAMMGAEAQPLPRYPAVCD
CCCCCHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
APINKRAGRTEYLRGRAARDASGVWRVAPAGSQSSASLKSLSDANCFIVLAHDAARVDAG
CCCCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCC
TTVDILPFDGAI
CEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]