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The map label for this gene is lolC [H]

Identifier: 237813004

GI number: 237813004

Start: 2692362

End: 2693615

Strand: Reverse

Name: lolC [H]

Synonym: GBP346_A2764

Alternate gene names: 237813004

Gene position: 2693615-2692362 (Counterclockwise)

Preceding gene: 237813006

Following gene: 237813003

Centisome position: 65.72

GC content: 67.07

Gene sequence:

>1254_bases
TTGAAACTCCCGTACGAATGGCAGATCGGCTGGCGCTACACGCGCGCCGGCAAACGCACGACCGGCAACGGCTTCATTTC
CTTCATCGCGCTCGTGTCGATGCTCGGGATCGCGCTCGGCGTCGCGGCGCTCATCGTCGTGCTGTCGGTGATGAACGGCT
TCCAGAAAGAGGTGCGCGACCGGATGCTGTCGGTGCTCGCGCACGTCGAGATCTTCTCGCCGACGGGCTCGATGCCCGAC
TGGCAACTGACCGCGAAGGAAGCGCGCCTGAACCGCTCGGTGATCGGCGCGGCGCCGTATGTCGACGCGCAGGCGCTGCT
CACGCGGCAGGACGCGGTGAGCGGCGTGATGCTGCGCGGCGTCGAGCCGTCGCTCGAGCCGCAGGTGTCCGACATCGGCA
AGGACATGAAGGCGGGCGCGCTCACCGCGCTCGCGCCCGGCCAGTTCGGGATCGTGCTCGGCAACGCGCTCGCGGGCAAT
CTCGGCGTGGGCGTCGGCGACAAGGTCACGCTCGTCGCGCCGGAAGGCACGATCACGCCGGCCGGGATGATGCCGCGCCT
GAAGCAGTTCACGGTGGTCGGCATCTTCGAGTCCGGGCACTACGAATACGACAGCACGCTTGCGATGATCGACATCCAGG
ATGCGCAGGCGCTCTTCAGGCTGCCCGCGCCGACGGGCGTGCGGCTGCGCCTCACGGACATGCAGAAGGCGCCGCAGGTC
GCGCGCGAGCTCGCGCACACGCTGTCGGGCGACCTGTACATCCGCGACTGGACGCAGCAGAACAAGACGTGGTTCTCCGC
GGTGCAGATCGAGAAGCGGATGATGTTCATCATCCTCACGCTGATCATCGCGGTCGCGGCGTTCAATCTCGTGTCGTCGC
TCGTGATGACCGTGACGAACAAGCAGGCGGACATCGCGATCCTGCGCACGCTCGGCGCGCAGCCGGGCTCGATCATGAAG
ATCTTCGTCGTGCAGGGCGTGACGATCGGCTTCGTCGGGACCGCGACGGGCGTCGCGCTCGGCTGCCTGATCGCGTGGAG
CATTCCGTGGCTCATTCCGATGATCGAGCATGCGTTCGGCGTGCAGTTCCTGCCGCCGTCGGTGTACTTCATCAGCGAGC
TGCCGTCCGAGCTCGTCGCGGGCGACGTGATCAAGATCGGCGTGATCGCTTTCGCGCTGTCCGCGCTCGCGACGCTCTAT
CCGAGCTGGCGCGGCGCGAAGGTGCGCCCGGCGGAGGCGCTGCGCTATGAATGA

Upstream 100 bases:

>100_bases
TTAAGCATTGTGTGGCACACTGCGCGCGTAACCGGGGCCGCCGGCTCCGGCGCGCCGCTTCACGCAGCGCGCGGCGTCCC
AACCAGCAGAAAGGATACGC

Downstream 100 bases:

>100_bases
CCGGGTTTTCGAGCAGACGATGAATCAGAACCATCAGGATGGCGGCGCGCGCGAATGCGTGCTGGAAGCGCGCGGCGTCA
CGAAGACGTTCGTGCAGGGC

Product: lipoprotein releasing system, hypothetical protein, LolC/E family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKLPYEWQIGWRYTRAGKRTTGNGFISFIALVSMLGIALGVAALIVVLSVMNGFQKEVRDRMLSVLAHVEIFSPTGSMPD
WQLTAKEARLNRSVIGAAPYVDAQALLTRQDAVSGVMLRGVEPSLEPQVSDIGKDMKAGALTALAPGQFGIVLGNALAGN
LGVGVGDKVTLVAPEGTITPAGMMPRLKQFTVVGIFESGHYEYDSTLAMIDIQDAQALFRLPAPTGVRLRLTDMQKAPQV
ARELAHTLSGDLYIRDWTQQNKTWFSAVQIEKRMMFIILTLIIAVAAFNLVSSLVMTVTNKQADIAILRTLGAQPGSIMK
IFVVQGVTIGFVGTATGVALGCLIAWSIPWLIPMIEHAFGVQFLPPSVYFISELPSELVAGDVIKIGVIAFALSALATLY
PSWRGAKVRPAEALRYE

Sequences:

>Translated_417_residues
MKLPYEWQIGWRYTRAGKRTTGNGFISFIALVSMLGIALGVAALIVVLSVMNGFQKEVRDRMLSVLAHVEIFSPTGSMPD
WQLTAKEARLNRSVIGAAPYVDAQALLTRQDAVSGVMLRGVEPSLEPQVSDIGKDMKAGALTALAPGQFGIVLGNALAGN
LGVGVGDKVTLVAPEGTITPAGMMPRLKQFTVVGIFESGHYEYDSTLAMIDIQDAQALFRLPAPTGVRLRLTDMQKAPQV
ARELAHTLSGDLYIRDWTQQNKTWFSAVQIEKRMMFIILTLIIAVAAFNLVSSLVMTVTNKQADIAILRTLGAQPGSIMK
IFVVQGVTIGFVGTATGVALGCLIAWSIPWLIPMIEHAFGVQFLPPSVYFISELPSELVAGDVIKIGVIAFALSALATLY
PSWRGAKVRPAEALRYE
>Mature_417_residues
MKLPYEWQIGWRYTRAGKRTTGNGFISFIALVSMLGIALGVAALIVVLSVMNGFQKEVRDRMLSVLAHVEIFSPTGSMPD
WQLTAKEARLNRSVIGAAPYVDAQALLTRQDAVSGVMLRGVEPSLEPQVSDIGKDMKAGALTALAPGQFGIVLGNALAGN
LGVGVGDKVTLVAPEGTITPAGMMPRLKQFTVVGIFESGHYEYDSTLAMIDIQDAQALFRLPAPTGVRLRLTDMQKAPQV
ARELAHTLSGDLYIRDWTQQNKTWFSAVQIEKRMMFIILTLIIAVAAFNLVSSLVMTVTNKQADIAILRTLGAQPGSIMK
IFVVQGVTIGFVGTATGVALGCLIAWSIPWLIPMIEHAFGVQFLPPSVYFISELPSELVAGDVIKIGVIAFALSALATLY
PSWRGAKVRPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=416, Percent_Identity=34.375, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1787360, Length=421, Percent_Identity=36.3420427553444, Blast_Score=208, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45017; Mature: 45017

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPYEWQIGWRYTRAGKRTTGNGFISFIALVSMLGIALGVAALIVVLSVMNGFQKEVRD
CCCCCEEEECEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLSVLAHVEIFSPTGSMPDWQLTAKEARLNRSVIGAAPYVDAQALLTRQDAVSGVMLRG
HHHHHHHHHEEECCCCCCCCCEEEHHHHHHCHHHCCCCCCCCHHHHHHHHHHHCCCEEEC
VEPSLEPQVSDIGKDMKAGALTALAPGQFGIVLGNALAGNLGVGVGDKVTLVAPEGTITP
CCCCCCCCHHHHCCHHHCCCEEEECCCCEEEEECCHHCCCCCCCCCCEEEEECCCCCCCC
AGMMPRLKQFTVVGIFESGHYEYDSTLAMIDIQDAQALFRLPAPTGVRLRLTDMQKAPQV
CCCCCHHHHEEEEEEEECCCEECCCEEEEEEECCCHHHHCCCCCCCCEEEECCHHHHHHH
ARELAHTLSGDLYIRDWTQQNKTWFSAVQIEKRMMFIILTLIIAVAAFNLVSSLVMTVTN
HHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KQADIAILRTLGAQPGSIMKIFVVQGVTIGFVGTATGVALGCLIAWSIPWLIPMIEHAFG
CCHHHHHHHHHCCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VQFLPPSVYFISELPSELVAGDVIKIGVIAFALSALATLYPSWRGAKVRPAEALRYE
CEECCCCHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCC
>Mature Secondary Structure
MKLPYEWQIGWRYTRAGKRTTGNGFISFIALVSMLGIALGVAALIVVLSVMNGFQKEVRD
CCCCCEEEECEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLSVLAHVEIFSPTGSMPDWQLTAKEARLNRSVIGAAPYVDAQALLTRQDAVSGVMLRG
HHHHHHHHHEEECCCCCCCCCEEEHHHHHHCHHHCCCCCCCCHHHHHHHHHHHCCCEEEC
VEPSLEPQVSDIGKDMKAGALTALAPGQFGIVLGNALAGNLGVGVGDKVTLVAPEGTITP
CCCCCCCCHHHHCCHHHCCCEEEECCCCEEEEECCHHCCCCCCCCCCEEEEECCCCCCCC
AGMMPRLKQFTVVGIFESGHYEYDSTLAMIDIQDAQALFRLPAPTGVRLRLTDMQKAPQV
CCCCCHHHHEEEEEEEECCCEECCCEEEEEEECCCHHHHCCCCCCCCEEEECCHHHHHHH
ARELAHTLSGDLYIRDWTQQNKTWFSAVQIEKRMMFIILTLIIAVAAFNLVSSLVMTVTN
HHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KQADIAILRTLGAQPGSIMKIFVVQGVTIGFVGTATGVALGCLIAWSIPWLIPMIEHAFG
CCHHHHHHHHHCCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VQFLPPSVYFISELPSELVAGDVIKIGVIAFALSALATLYPSWRGAKVRPAEALRYE
CEECCCCHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]