Click here to switch to the map view.

The map label for this gene is dapA_2 [H]

Identifier: 237812983

GI number: 237812983

Start: 2673153

End: 2674055

Strand: Reverse

Name: dapA_2 [H]

Synonym: GBP346_A2743

Alternate gene names: 237812983

Gene position: 2674055-2673153 (Counterclockwise)

Preceding gene: 237812984

Following gene: 237812982

Centisome position: 65.24

GC content: 66.45

Gene sequence:

>903_bases
ATGGCTAACGGCACTCAAGACGGCATTCAAATCCGCGGCAGCGTCCCCGCGATCGTCACCCCGATGCTCGAGGACGGCGG
CCTCGATCTGGCGGCCTTCCGCAAGCTGATCGACTGGCATATCGAAGAGGGGACGGATGCCCTCGTCGTGGTCGGCACGA
GCGGCGAATCGGCGACGCTTTCCGTCGACGAGCACGTGCTCATGATCGAGACCGCGGTCAAGCACGCGGCGAAGCGGATT
CCGATCGTCGCGGGCGCGGGCGGCAACTCGACGACCGAGGCGATCGAACTGTCGAAGCATGCGAAGGCGGTGGGCGCCGA
TGCGACGCTGCAAGTGGTGCCGTACTACAACAAGCCGACGCAGGAAGGGATCTACCGCCACTTCAAGGCGATCGCCGAGG
CGGTGGACCTTCCGGTGATCCTGTACAACGTGCCGGGCCGCACTGTCGCGGACATGTCGAACGAGACGACCCTGCGGCTT
GCGCAAGTGCCGGGCATCATCGGCGTGAAAGACGCGACGGGCAATATCGATCGCGCCGCGCAACTGATCAAGGCGGCGCC
CGCGCACTTCTCGATCTACAGCGGCGACGATCCGACCGCGATCGCGCTGATGCTCCTCGGCGGCCACGGCAACATCTCGG
TGACGGCGAACGTCGCGCCGCGCGCGATGAGCGAGCTTTGCCGCGCGGCGCTCACCGCCGACGTGAAGACGGCGCGCGAG
ATCCACATGAAGCTCCTGTCGCTGCACAAGCATCTGTTCATCGAGGCGAACCCGATTCCGGTGAAGTGGGCGCTGCAACA
GATGGGCAAGATCGCGGGCGGCATCCGCCTGCCGCTCACGCCGCTCGACGAGCGCTGCCATGAAACCGTGCGCGGCGCGC
TTCGCGAGGCCGGCCTCCTGTGA

Upstream 100 bases:

>100_bases
AGCACGCGGCGCCGCAAGAAGGGGCGGGATTTCCGCGTTACGGACTGGCAGGCTAATCCGCTACAATCGACCTTTACCGA
TTTTTCATCGTGTTTGTTTC

Downstream 100 bases:

>100_bases
GGCCGGGCGCGGCCGCCCGGGCGGCCGCACCGCACCCCGATCGATCCGACGCTGGCCCGGACGCTCCCGGCGCCGCGCGT
GACACGCGTTCTAGCAAGAC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MANGTQDGIQIRGSVPAIVTPMLEDGGLDLAAFRKLIDWHIEEGTDALVVVGTSGESATLSVDEHVLMIETAVKHAAKRI
PIVAGAGGNSTTEAIELSKHAKAVGADATLQVVPYYNKPTQEGIYRHFKAIAEAVDLPVILYNVPGRTVADMSNETTLRL
AQVPGIIGVKDATGNIDRAAQLIKAAPAHFSIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALTADVKTARE
IHMKLLSLHKHLFIEANPIPVKWALQQMGKIAGGIRLPLTPLDERCHETVRGALREAGLL

Sequences:

>Translated_300_residues
MANGTQDGIQIRGSVPAIVTPMLEDGGLDLAAFRKLIDWHIEEGTDALVVVGTSGESATLSVDEHVLMIETAVKHAAKRI
PIVAGAGGNSTTEAIELSKHAKAVGADATLQVVPYYNKPTQEGIYRHFKAIAEAVDLPVILYNVPGRTVADMSNETTLRL
AQVPGIIGVKDATGNIDRAAQLIKAAPAHFSIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALTADVKTARE
IHMKLLSLHKHLFIEANPIPVKWALQQMGKIAGGIRLPLTPLDERCHETVRGALREAGLL
>Mature_299_residues
ANGTQDGIQIRGSVPAIVTPMLEDGGLDLAAFRKLIDWHIEEGTDALVVVGTSGESATLSVDEHVLMIETAVKHAAKRIP
IVAGAGGNSTTEAIELSKHAKAVGADATLQVVPYYNKPTQEGIYRHFKAIAEAVDLPVILYNVPGRTVADMSNETTLRLA
QVPGIIGVKDATGNIDRAAQLIKAAPAHFSIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALTADVKTAREI
HMKLLSLHKHLFIEANPIPVKWALQQMGKIAGGIRLPLTPLDERCHETVRGALREAGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=302, Percent_Identity=24.8344370860927, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13540533, Length=236, Percent_Identity=26.271186440678, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788823, Length=289, Percent_Identity=51.9031141868512, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI87082415, Length=265, Percent_Identity=34.7169811320755, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1786463, Length=281, Percent_Identity=34.5195729537367, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1789620, Length=277, Percent_Identity=27.4368231046931, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31826; Mature: 31695

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANGTQDGIQIRGSVPAIVTPMLEDGGLDLAAFRKLIDWHIEEGTDALVVVGTSGESATL
CCCCCCCCEEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEE
SVDEHVLMIETAVKHAAKRIPIVAGAGGNSTTEAIELSKHAKAVGADATLQVVPYYNKPT
ECCCEEEHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
QEGIYRHFKAIAEAVDLPVILYNVPGRTVADMSNETTLRLAQVPGIIGVKDATGNIDRAA
HHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCCEEEEEECCCEEEECCCCCCHHHHH
QLIKAAPAHFSIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALTADVKTARE
HHHHCCCCEEEEECCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
IHMKLLSLHKHLFIEANPIPVKWALQQMGKIAGGIRLPLTPLDERCHETVRGALREAGLL
HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ANGTQDGIQIRGSVPAIVTPMLEDGGLDLAAFRKLIDWHIEEGTDALVVVGTSGESATL
CCCCCCCEEEECCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEE
SVDEHVLMIETAVKHAAKRIPIVAGAGGNSTTEAIELSKHAKAVGADATLQVVPYYNKPT
ECCCEEEHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
QEGIYRHFKAIAEAVDLPVILYNVPGRTVADMSNETTLRLAQVPGIIGVKDATGNIDRAA
HHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCCEEEEEECCCEEEECCCCCCHHHHH
QLIKAAPAHFSIYSGDDPTAIALMLLGGHGNISVTANVAPRAMSELCRAALTADVKTARE
HHHHCCCCEEEEECCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
IHMKLLSLHKHLFIEANPIPVKWALQQMGKIAGGIRLPLTPLDERCHETVRGALREAGLL
HHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]