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The map label for this gene is gltX [H]

Identifier: 237812850

GI number: 237812850

Start: 2541760

End: 2543274

Strand: Reverse

Name: gltX [H]

Synonym: GBP346_A2609

Alternate gene names: 237812850

Gene position: 2543274-2541760 (Counterclockwise)

Preceding gene: 237812852

Following gene: 237812849

Centisome position: 62.05

GC content: 66.86

Gene sequence:

>1515_bases
GTGCTCTTTCCGTTCCGGTCGCGTGCGCACCCGGCAGAGCCGTGCGGCGTGCGCCGCCGCGTCGTTTCAATTGATGCGCC
GCTTGAGGCGTTCGAGCTATCGTTTATGACCCGTCCTGTACGCACCCGTTTTGCGCCGAGCCCCACCGGCTTCATCCATC
TCGGCAACATCCGATCCGCGCTCTATCCGTGGGCGTTCGCCCGCAAGATGAAGGGCACGTTCGTGCTGCGGATCGAGGAT
ACGGATCTCGAGCGCTCGACCGAGGCGTCGGTCGATGCGATCCTCGAAGGGATGGCATGGCTCGGGCTCGACTACGACGA
AGGCCCGTACTACCAGATGCAGCGGATGGACCGCTATCGCGAGGTGCTCGCGCAGATGCTCGAGAAAGACCTCGTCTACC
CGTGCTACATGTCGACCGAAGAACTCGATGCGTTGCGCGAGCGCCAGCGCGCGGCGGGCGAGAAGCCGCGCTACGATGGC
ACGTGGCGCCCCGAGCCGGGCAAGGTGCTGCCCGAGCCGCCGGCGGGCGTGACCCCCGTGCTGCGCTTTCGCAATCCGCT
GACGGGGTCGGTCGTCTGGGACGACGCCGTGAAGGGCCGCGTCGAGATCTCGAACGAGGAGCTCGACGATCTCGTCATCG
CGCGCCCCGACGGCACGCCGACGTACAACTTCTGCGTCGTCGTCGACGATCTCGACATGGGCATCACGCACGTGATCCGC
GGGGACGACCATGTGAACAATACGCCGCGCCAGATCAACATCCTGCGCGCGCTCGGCGGCGAAGTGCCGGTGTACGCGCA
TCTGCCGACCGTGCTCAACGAGCAGGGCGAGAAGATGAGCAAGCGCCACGGCGCGATGAGCGTGATGGGCTACCGCGATG
CCGGCTATCTGCCGGAGGCGGTGCTCAACTATCTCGCGCGTCTCGGCTGGTCGCACGGCGACGCGGAGATCTTCTCGCGC
GAGCAGTTCGTCGAATGGTTCGATCTCGAGCATCTCGGCAAGTCGCCCGCGCAGTACGATCACAACAAGCTGAACTGGCT
GAACAACCACTACATCAAGGAAGCGGACGACGCGCGCCTGGCCGAGCTGGCAAAGCCGTTCTTCGCGGCGCTCGGCATCG
ACGCCGACACGATCGCGCGGGGCCCGGACCTCGTGGGCGTGATGGGGCTGATGAAGGATCGCGCGTCGACGGTGAAGGAG
ATCGCGGAGAATTCGACGATGTTCTACCGTTCGCCCGCCCCGGATGCGCAAGCGCTCGCGCAGCACGTGACCGACGCGGT
GCGCCCGGCGCTCGCCGAGTTTGCCGCGGCGCTGAAGACGGCCGAGTGGACGAAGGAGGCGATCGCGGCCGCGCTGAAGG
CCGTGCTCGGCGCGCACAAGCTGAAGATGCCGCAGCTTGCGATGCCGGTGCGCCTGCTCGTCGCGGGCACGACGCATACG
CCGTCGATCGACGCGGTGCTGCTGCTGTTCGGCCGCGACGTCGTCGTGTCGCGCCTCGCGTCGGCGCTCGCATAG

Upstream 100 bases:

>100_bases
GGGGGCGGGAGGACGGGGGGGCGAGCGACGAGACACGCCGCGCCTGGTCGCGCAGCCGGGCGCGACGCGACGAGGAACCG
CGGCGCGACGAGTATAATTC

Downstream 100 bases:

>100_bases
GCGCGCGGGGCGTCCGGGAAGCCGTGCGGTTGAGGCAACGAACCGAGGCAACGCACGCGTCGAACGCACGGCTTCCAAAA
ATTTTGCGCGAAACGCAAAT

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase; GluRS [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MLFPFRSRAHPAEPCGVRRRVVSIDAPLEAFELSFMTRPVRTRFAPSPTGFIHLGNIRSALYPWAFARKMKGTFVLRIED
TDLERSTEASVDAILEGMAWLGLDYDEGPYYQMQRMDRYREVLAQMLEKDLVYPCYMSTEELDALRERQRAAGEKPRYDG
TWRPEPGKVLPEPPAGVTPVLRFRNPLTGSVVWDDAVKGRVEISNEELDDLVIARPDGTPTYNFCVVVDDLDMGITHVIR
GDDHVNNTPRQINILRALGGEVPVYAHLPTVLNEQGEKMSKRHGAMSVMGYRDAGYLPEAVLNYLARLGWSHGDAEIFSR
EQFVEWFDLEHLGKSPAQYDHNKLNWLNNHYIKEADDARLAELAKPFFAALGIDADTIARGPDLVGVMGLMKDRASTVKE
IAENSTMFYRSPAPDAQALAQHVTDAVRPALAEFAAALKTAEWTKEAIAAALKAVLGAHKLKMPQLAMPVRLLVAGTTHT
PSIDAVLLLFGRDVVVSRLASALA

Sequences:

>Translated_504_residues
MLFPFRSRAHPAEPCGVRRRVVSIDAPLEAFELSFMTRPVRTRFAPSPTGFIHLGNIRSALYPWAFARKMKGTFVLRIED
TDLERSTEASVDAILEGMAWLGLDYDEGPYYQMQRMDRYREVLAQMLEKDLVYPCYMSTEELDALRERQRAAGEKPRYDG
TWRPEPGKVLPEPPAGVTPVLRFRNPLTGSVVWDDAVKGRVEISNEELDDLVIARPDGTPTYNFCVVVDDLDMGITHVIR
GDDHVNNTPRQINILRALGGEVPVYAHLPTVLNEQGEKMSKRHGAMSVMGYRDAGYLPEAVLNYLARLGWSHGDAEIFSR
EQFVEWFDLEHLGKSPAQYDHNKLNWLNNHYIKEADDARLAELAKPFFAALGIDADTIARGPDLVGVMGLMKDRASTVKE
IAENSTMFYRSPAPDAQALAQHVTDAVRPALAEFAAALKTAEWTKEAIAAALKAVLGAHKLKMPQLAMPVRLLVAGTTHT
PSIDAVLLLFGRDVVVSRLASALA
>Mature_504_residues
MLFPFRSRAHPAEPCGVRRRVVSIDAPLEAFELSFMTRPVRTRFAPSPTGFIHLGNIRSALYPWAFARKMKGTFVLRIED
TDLERSTEASVDAILEGMAWLGLDYDEGPYYQMQRMDRYREVLAQMLEKDLVYPCYMSTEELDALRERQRAAGEKPRYDG
TWRPEPGKVLPEPPAGVTPVLRFRNPLTGSVVWDDAVKGRVEISNEELDDLVIARPDGTPTYNFCVVVDDLDMGITHVIR
GDDHVNNTPRQINILRALGGEVPVYAHLPTVLNEQGEKMSKRHGAMSVMGYRDAGYLPEAVLNYLARLGWSHGDAEIFSR
EQFVEWFDLEHLGKSPAQYDHNKLNWLNNHYIKEADDARLAELAKPFFAALGIDADTIARGPDLVGVMGLMKDRASTVKE
IAENSTMFYRSPAPDAQALAQHVTDAVRPALAEFAAALKTAEWTKEAIAAALKAVLGAHKLKMPQLAMPVRLLVAGTTHT
PSIDAVLLLFGRDVVVSRLASALA

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) [H]

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI134288884, Length=330, Percent_Identity=35.1515151515151, Blast_Score=195, Evalue=8e-50,
Organism=Escherichia coli, GI1788743, Length=466, Percent_Identity=49.5708154506438, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI226510925, Length=245, Percent_Identity=37.1428571428571, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71993394, Length=475, Percent_Identity=29.0526315789474, Blast_Score=182, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324540, Length=332, Percent_Identity=36.144578313253, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321192, Length=233, Percent_Identity=26.6094420600858, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24665321, Length=498, Percent_Identity=28.9156626506024, Blast_Score=215, Evalue=5e-56,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c [H]

EC number: =6.1.1.17 [H]

Molecular weight: Translated: 56194; Mature: 56194

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFPFRSRAHPAEPCGVRRRVVSIDAPLEAFELSFMTRPVRTRFAPSPTGFIHLGNIRSA
CCCCCCCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHCCHHHCCCCCCCCEEEECCHHHH
LYPWAFARKMKGTFVLRIEDTDLERSTEASVDAILEGMAWLGLDYDEGPYYQMQRMDRYR
HHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
EVLAQMLEKDLVYPCYMSTEELDALRERQRAAGEKPRYDGTWRPEPGKVLPEPPAGVTPV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LRFRNPLTGSVVWDDAVKGRVEISNEELDDLVIARPDGTPTYNFCVVVDDLDMGITHVIR
HHHCCCCCCCEEECCCCCCEEEECCCCCCCEEEECCCCCCCEEEEEEEECCCCCCCEEEC
GDDHVNNTPRQINILRALGGEVPVYAHLPTVLNEQGEKMSKRHGAMSVMGYRDAGYLPEA
CCCCCCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
VLNYLARLGWSHGDAEIFSREQFVEWFDLEHLGKSPAQYDHNKLNWLNNHYIKEADDARL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCHHHH
AELAKPFFAALGIDADTIARGPDLVGVMGLMKDRASTVKEIAENSTMFYRSPAPDAQALA
HHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHH
QHVTDAVRPALAEFAAALKTAEWTKEAIAAALKAVLGAHKLKMPQLAMPVRLLVAGTTHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEECCCCC
PSIDAVLLLFGRDVVVSRLASALA
CCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLFPFRSRAHPAEPCGVRRRVVSIDAPLEAFELSFMTRPVRTRFAPSPTGFIHLGNIRSA
CCCCCCCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHCCHHHCCCCCCCCEEEECCHHHH
LYPWAFARKMKGTFVLRIEDTDLERSTEASVDAILEGMAWLGLDYDEGPYYQMQRMDRYR
HHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
EVLAQMLEKDLVYPCYMSTEELDALRERQRAAGEKPRYDGTWRPEPGKVLPEPPAGVTPV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LRFRNPLTGSVVWDDAVKGRVEISNEELDDLVIARPDGTPTYNFCVVVDDLDMGITHVIR
HHHCCCCCCCEEECCCCCCEEEECCCCCCCEEEECCCCCCCEEEEEEEECCCCCCCEEEC
GDDHVNNTPRQINILRALGGEVPVYAHLPTVLNEQGEKMSKRHGAMSVMGYRDAGYLPEA
CCCCCCCCCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
VLNYLARLGWSHGDAEIFSREQFVEWFDLEHLGKSPAQYDHNKLNWLNNHYIKEADDARL
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCHHHH
AELAKPFFAALGIDADTIARGPDLVGVMGLMKDRASTVKEIAENSTMFYRSPAPDAQALA
HHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHH
QHVTDAVRPALAEFAAALKTAEWTKEAIAAALKAVLGAHKLKMPQLAMPVRLLVAGTTHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEECCCCC
PSIDAVLLLFGRDVVVSRLASALA
CCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA