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The map label for this gene is lpxB [H]

Identifier: 237812794

GI number: 237812794

Start: 2480509

End: 2481675

Strand: Reverse

Name: lpxB [H]

Synonym: GBP346_A2548

Alternate gene names: 237812794

Gene position: 2481675-2480509 (Counterclockwise)

Preceding gene: 237812795

Following gene: 237812793

Centisome position: 60.55

GC content: 69.58

Gene sequence:

>1167_bases
ATGGCGTTCCAACTCACACCGCTGCGCGTCGCGCTCGTCGCGGGCGAGCCGTCGGGCGACCTGCTCGGCGCGTCGCTCCT
CGGCGGGCTGCATGCGCGGCTGCCCGCGTCGTCCCGCTACTACGGGATCGGCGGGCCGCGCATGAGCGCCGTGGAATTCG
ATGCGCACTGGCCGATGGAAAAGCTCGCGGTGCGCGGCTACGTCGAGGCGCTCAAGCACATCCCCGAGATCCTGCGCATT
CGCGGCGAACTCAAGCGCCAGTTGCTCGCCGAGCCGCCCGACGCATTCGTCGGCATCGACGCGCCCGATTTCAACTTCGG
CCTCGAGCAGGCGTTGCGCGGCGCCGGCATTCCGACGATCCACTTCGTCTGCCCGTCGATCTGGGCATGGCGCGGCGGCC
GGATCAAGAAGATCGTCAAGGCCGTCGACCACATGCTGTGCCTGTTCCCGTTCGAGCTCGAACTGCTCGAGAAGGCGGGC
GTCGCGGCGACGTTCGTCGGCCATCCGCTGGCCGACGAGATTCCGCTCGAGCCCGATACGCACGGCGCGCGGATCGCGCT
CGGGCTGCCGGGCGGGGGGCCCGTGATCGCGGTGCTGCCGGGCAGCCGCCGCTCGGAGATCGAGTTGATCGGCCCGACAT
TCTTCGACGCGATGGAACTGATGCAGCAGCGCGAGCCCGGCGTGCGCTTCGTCGTGCCGGCCGCGACGCCTGCGCTGCGC
GCGTTGCTGCAGCCGCTCGTCGACGCGCATCCGTCGCTGTCGGTCACGCTGACCGAGGGGCGCGCGCAGGTCGCGATGAC
GGCGGCCGACGCGATCCTCGTGAAAAGCGGCACGGTGACGCTCGAAGCGGCGCTGCTCAAGAAGCCGATGGTGATTTCGT
ACAAGGTGCCATGGCTCACCGGGCAGATCATGCGCCGGCAGGGCTATCTGCCGTACGTCGGCCTGCCGAACATTCTCGCG
GGCCGCTTCGTCGTGCCCGAGCTGCTGCAGCATTTCGCGACGCCCGACGCGCTCGCCGACGCGACGCTCACGCAACTGCG
CGACGATGCGAACCGTCGCGCGCTCACCGACATTTTCACCGACATGCATCTCGCGTTGCGCCAGAATACCGCGCAGCGCG
CGGCCGAGGCCGTCGCGCGCGTGATCGACAGCAGGAAGCCGCGCTGA

Upstream 100 bases:

>100_bases
ACTGAGCGAGCTCGCGCAGGCGGGCGGCGACGGCGATGCGGCGGTGAAGTCGCTCGTCGACTTCGTCGAGTCTTCGCAGC
GCGGCATCATTCGCTGACCG

Downstream 100 bases:

>100_bases
TGGCGACGACGCGCAAACCCCGCGGCGGCGCCGGCGGCGCGACCCAGCCCGCGCTCGATTTCGACGCGCCGGGCGAGATC
GTCTGCGGCGTCGACGAAGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MAFQLTPLRVALVAGEPSGDLLGASLLGGLHARLPASSRYYGIGGPRMSAVEFDAHWPMEKLAVRGYVEALKHIPEILRI
RGELKRQLLAEPPDAFVGIDAPDFNFGLEQALRGAGIPTIHFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFELELLEKAG
VAATFVGHPLADEIPLEPDTHGARIALGLPGGGPVIAVLPGSRRSEIELIGPTFFDAMELMQQREPGVRFVVPAATPALR
ALLQPLVDAHPSLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILA
GRFVVPELLQHFATPDALADATLTQLRDDANRRALTDIFTDMHLALRQNTAQRAAEAVARVIDSRKPR

Sequences:

>Translated_388_residues
MAFQLTPLRVALVAGEPSGDLLGASLLGGLHARLPASSRYYGIGGPRMSAVEFDAHWPMEKLAVRGYVEALKHIPEILRI
RGELKRQLLAEPPDAFVGIDAPDFNFGLEQALRGAGIPTIHFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFELELLEKAG
VAATFVGHPLADEIPLEPDTHGARIALGLPGGGPVIAVLPGSRRSEIELIGPTFFDAMELMQQREPGVRFVVPAATPALR
ALLQPLVDAHPSLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILA
GRFVVPELLQHFATPDALADATLTQLRDDANRRALTDIFTDMHLALRQNTAQRAAEAVARVIDSRKPR
>Mature_387_residues
AFQLTPLRVALVAGEPSGDLLGASLLGGLHARLPASSRYYGIGGPRMSAVEFDAHWPMEKLAVRGYVEALKHIPEILRIR
GELKRQLLAEPPDAFVGIDAPDFNFGLEQALRGAGIPTIHFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFELELLEKAGV
AATFVGHPLADEIPLEPDTHGARIALGLPGGGPVIAVLPGSRRSEIELIGPTFFDAMELMQQREPGVRFVVPAATPALRA
LLQPLVDAHPSLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILAG
RFVVPELLQHFATPDALADATLTQLRDDANRRALTDIFTDMHLALRQNTAQRAAEAVARVIDSRKPR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=373, Percent_Identity=43.1635388739946, Blast_Score=290, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42078; Mature: 41947

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFQLTPLRVALVAGEPSGDLLGASLLGGLHARLPASSRYYGIGGPRMSAVEFDAHWPME
CCEEECCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEECCCCCHH
KLAVRGYVEALKHIPEILRIRGELKRQLLAEPPDAFVGIDAPDFNFGLEQALRGAGIPTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHCCCCCEE
HFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFELELLEKAGVAATFVGHPLADEIPLEPDT
EECCCHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCC
HGARIALGLPGGGPVIAVLPGSRRSEIELIGPTFFDAMELMQQREPGVRFVVPAATPALR
CCCEEEEECCCCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEECCCCHHHH
ALLQPLVDAHPSLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHCCCCCEEEEEECCCEEEEEEECCEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPDALADATLTQLRDDANRRALTDIFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHH
DMHLALRQNTAQRAAEAVARVIDSRKPR
HHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AFQLTPLRVALVAGEPSGDLLGASLLGGLHARLPASSRYYGIGGPRMSAVEFDAHWPME
CEEECCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEEECCCCCHH
KLAVRGYVEALKHIPEILRIRGELKRQLLAEPPDAFVGIDAPDFNFGLEQALRGAGIPTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHHHCCCCCEE
HFVCPSIWAWRGGRIKKIVKAVDHMLCLFPFELELLEKAGVAATFVGHPLADEIPLEPDT
EECCCHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCC
HGARIALGLPGGGPVIAVLPGSRRSEIELIGPTFFDAMELMQQREPGVRFVVPAATPALR
CCCEEEEECCCCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHCCCCCEEEECCCCHHHH
ALLQPLVDAHPSLSVTLTEGRAQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLT
HHHHHHHCCCCCEEEEEECCCEEEEEEECCEEEEECCCEEEEHHHHCCCEEEEEECCHHH
GQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPDALADATLTQLRDDANRRALTDIFT
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHH
DMHLALRQNTAQRAAEAVARVIDSRKPR
HHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA