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The map label for this gene is hdaH [H]

Identifier: 237812694

GI number: 237812694

Start: 2395585

End: 2396694

Strand: Direct

Name: hdaH [H]

Synonym: GBP346_A2446

Alternate gene names: 237812694

Gene position: 2395585-2396694 (Clockwise)

Preceding gene: 237812693

Following gene: 237812695

Centisome position: 58.45

GC content: 68.29

Gene sequence:

>1110_bases
ATGACAAAAACCGCTTTCTTCACCGACGAACGCACTTTCTGGCACACGGGCGGCGCGCATGCGCTGTTCTTTCCGGTCGG
CGGCTGGGTGCAGCCGCCATCGAGCGCGGGCTATGCGGAATCGCCCGATTCGAAGCGGCGTCTGCTGTCGCTCGTGCACG
CGTCCGGGCTCGCGGCGAAACTCGACATGTCGAGCGCGCCCGCCGCGGCCGACGACGATCTGCGGCGCATCCACCCCGCG
CACTACCTCGACGCGTTCAAGCGCGCGAGCGACGCGGGTGGCGGCGATCTCGGCGAACTCGCGCCGTTCGGCCGTGGCAG
CTACGAGATCGCGGCGCTATCCGCGGGGCTCGCGCTCGCCGCCGTCGACGCGGTGCTCGCCGAGCGCACGGCCAACGCGT
TCTCGCTGTCGCGCCCGCCCGGCCATCACTGCCTGCGTGACAAGCCGATGGGTTTTTGCCTGCTCGCGAACATTCCGATC
GCGATCGAGGCCGCGCGCGCGAAACATCGCGTCGAGCGCGTCGCGGTGATCGACTGGGACGTGCATCACGGCAACGGCAC
GCAGTCGATCTACTACGACGATCCGAACACGCTGACGATCTCGCTGCATCAGGACCGCTGCTTTCCGCCCGGCTACAGCG
GCGCCGACGAACGCGGCGCGGGCGCAGGTGCGGGCGCGAACGTCAACGTCCCGCTCCTCGCGGGCGCCGGCGACGACGCG
TATCGATACGCATTCGAGCGAATCGTGCTGCCCGCGCTCGATGCGTTCCGGCCGGAGCTCGTCATCGTCGCGAGCGGGCT
CGACGCGAATGCGGTCGACCCGCTCGCGCGGATGCAACTGCACAGCGACAGCTACCGGTACATGACGCATGCGCTGAAGC
AGGCCGCGCAGCGGCACTGCGGGGGACGGCTCGTCATCGTGCACGAGGGCGGTTATTCGGAGGCCTACGTACCGTTTTGC
GGGCATGCGATCGTCGAGGCACTGGCGGGCATGCGCACCGACGTCGCCGATCCGATGCTCGAGCTCGCGATCGCGCAACA
GCCCGGCGAGCGTTTCAACGCATTCCAGCGGCAACTGATCGACGAAATGGCGACGAGCTTCGGTTACTGA

Upstream 100 bases:

>100_bases
TCTCGCTCGCGGCCATGCTGCGCGTCGAGCGCGACGCGCGCTGACGCCTCGACACTCCGTGTCGTTGCTTTCCCTTCCCT
CTTCGCTTCGGCCCATCGCC

Downstream 100 bases:

>100_bases
CCGGTCGAAAAAGCACAACGGCACGATGCACGTTCGGCACGGCGGGCGCGGCGCCGTTCGTCGGCGGGGTGAGACGCGCG
AACGAGCGTGACGGCGGCGA

Product: histone deacetylase family protein

Products: NA

Alternate protein names: HDAC-like amidohydrolase; HDAH [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTKTAFFTDERTFWHTGGAHALFFPVGGWVQPPSSAGYAESPDSKRRLLSLVHASGLAAKLDMSSAPAAADDDLRRIHPA
HYLDAFKRASDAGGGDLGELAPFGRGSYEIAALSAGLALAAVDAVLAERTANAFSLSRPPGHHCLRDKPMGFCLLANIPI
AIEAARAKHRVERVAVIDWDVHHGNGTQSIYYDDPNTLTISLHQDRCFPPGYSGADERGAGAGAGANVNVPLLAGAGDDA
YRYAFERIVLPALDAFRPELVIVASGLDANAVDPLARMQLHSDSYRYMTHALKQAAQRHCGGRLVIVHEGGYSEAYVPFC
GHAIVEALAGMRTDVADPMLELAIAQQPGERFNAFQRQLIDEMATSFGY

Sequences:

>Translated_369_residues
MTKTAFFTDERTFWHTGGAHALFFPVGGWVQPPSSAGYAESPDSKRRLLSLVHASGLAAKLDMSSAPAAADDDLRRIHPA
HYLDAFKRASDAGGGDLGELAPFGRGSYEIAALSAGLALAAVDAVLAERTANAFSLSRPPGHHCLRDKPMGFCLLANIPI
AIEAARAKHRVERVAVIDWDVHHGNGTQSIYYDDPNTLTISLHQDRCFPPGYSGADERGAGAGAGANVNVPLLAGAGDDA
YRYAFERIVLPALDAFRPELVIVASGLDANAVDPLARMQLHSDSYRYMTHALKQAAQRHCGGRLVIVHEGGYSEAYVPFC
GHAIVEALAGMRTDVADPMLELAIAQQPGERFNAFQRQLIDEMATSFGY
>Mature_368_residues
TKTAFFTDERTFWHTGGAHALFFPVGGWVQPPSSAGYAESPDSKRRLLSLVHASGLAAKLDMSSAPAAADDDLRRIHPAH
YLDAFKRASDAGGGDLGELAPFGRGSYEIAALSAGLALAAVDAVLAERTANAFSLSRPPGHHCLRDKPMGFCLLANIPIA
IEAARAKHRVERVAVIDWDVHHGNGTQSIYYDDPNTLTISLHQDRCFPPGYSGADERGAGAGAGANVNVPLLAGAGDDAY
RYAFERIVLPALDAFRPELVIVASGLDANAVDPLARMQLHSDSYRYMTHALKQAAQRHCGGRLVIVHEGGYSEAYVPFCG
HAIVEALAGMRTDVADPMLELAIAQQPGERFNAFQRQLIDEMATSFGY

Specific function: Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiat

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=284, Percent_Identity=35.9154929577465, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI153085395, Length=247, Percent_Identity=36.8421052631579, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI13128864, Length=287, Percent_Identity=33.7979094076655, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI148539870, Length=240, Percent_Identity=37.9166666666667, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI169234807, Length=240, Percent_Identity=37.9166666666667, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI17158039, Length=267, Percent_Identity=31.0861423220974, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI30795202, Length=266, Percent_Identity=32.3308270676692, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI30795204, Length=266, Percent_Identity=32.3308270676692, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI62750349, Length=244, Percent_Identity=34.8360655737705, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI62750347, Length=244, Percent_Identity=34.8360655737705, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI226529806, Length=284, Percent_Identity=33.0985915492958, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI8923769, Length=251, Percent_Identity=26.6932270916335, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI13128860, Length=254, Percent_Identity=25.9842519685039, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI13128862, Length=256, Percent_Identity=27.34375, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI293336691, Length=254, Percent_Identity=25.9842519685039, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI262073092, Length=223, Percent_Identity=27.3542600896861, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI262073088, Length=182, Percent_Identity=29.1208791208791, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17540334, Length=309, Percent_Identity=32.3624595469256, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI193206283, Length=309, Percent_Identity=32.3624595469256, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17540332, Length=309, Percent_Identity=32.3624595469256, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI193209491, Length=240, Percent_Identity=35, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17508561, Length=317, Percent_Identity=28.0757097791798, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25154020, Length=286, Percent_Identity=26.5734265734266, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17561978, Length=297, Percent_Identity=28.2828282828283, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25154022, Length=286, Percent_Identity=26.2237762237762, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17537347, Length=293, Percent_Identity=26.962457337884, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17534739, Length=244, Percent_Identity=27.4590163934426, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324307, Length=315, Percent_Identity=32.0634920634921, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323999, Length=350, Percent_Identity=25.4285714285714, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321244, Length=274, Percent_Identity=27.3722627737226, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6325141, Length=273, Percent_Identity=29.3040293040293, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325325, Length=199, Percent_Identity=22.6130653266332, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24642146, Length=326, Percent_Identity=34.0490797546012, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281360899, Length=326, Percent_Identity=34.0490797546012, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24642144, Length=326, Percent_Identity=34.0490797546012, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24642142, Length=326, Percent_Identity=34.0490797546012, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24641720, Length=238, Percent_Identity=36.9747899159664, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI281360801, Length=238, Percent_Identity=36.9747899159664, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI281360799, Length=238, Percent_Identity=36.9747899159664, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24657891, Length=255, Percent_Identity=29.8039215686275, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24644244, Length=259, Percent_Identity=27.7992277992278, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 39567; Mature: 39436

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTAFFTDERTFWHTGGAHALFFPVGGWVQPPSSAGYAESPDSKRRLLSLVHASGLAAK
CCCCEEEECCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LDMSSAPAAADDDLRRIHPAHYLDAFKRASDAGGGDLGELAPFGRGSYEIAALSAGLALA
ECCCCCCCCCCCHHHHHCHHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEEHHHHHHHH
AVDAVLAERTANAFSLSRPPGHHCLRDKPMGFCLLANIPIAIEAARAKHRVERVAVIDWD
HHHHHHHHHCCCCEECCCCCCCCCCCCCCCCEEEEECCCEEEEHHHHHHHHHEEEEEEEE
VHHGNGTQSIYYDDPNTLTISLHQDRCFPPGYSGADERGAGAGAGANVNVPLLAGAGDDA
EECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHH
YRYAFERIVLPALDAFRPELVIVASGLDANAVDPLARMQLHSDSYRYMTHALKQAAQRHC
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCC
GGRLVIVHEGGYSEAYVPFCGHAIVEALAGMRTDVADPMLELAIAQQPGERFNAFQRQLI
CCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DEMATSFGY
HHHHHHCCC
>Mature Secondary Structure 
TKTAFFTDERTFWHTGGAHALFFPVGGWVQPPSSAGYAESPDSKRRLLSLVHASGLAAK
CCCEEEECCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LDMSSAPAAADDDLRRIHPAHYLDAFKRASDAGGGDLGELAPFGRGSYEIAALSAGLALA
ECCCCCCCCCCCHHHHHCHHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEEHHHHHHHH
AVDAVLAERTANAFSLSRPPGHHCLRDKPMGFCLLANIPIAIEAARAKHRVERVAVIDWD
HHHHHHHHHCCCCEECCCCCCCCCCCCCCCCEEEEECCCEEEEHHHHHHHHHEEEEEEEE
VHHGNGTQSIYYDDPNTLTISLHQDRCFPPGYSGADERGAGAGAGANVNVPLLAGAGDDA
EECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHH
YRYAFERIVLPALDAFRPELVIVASGLDANAVDPLARMQLHSDSYRYMTHALKQAAQRHC
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCC
GGRLVIVHEGGYSEAYVPFCGHAIVEALAGMRTDVADPMLELAIAQQPGERFNAFQRQLI
CCEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DEMATSFGY
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA