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The map label for this gene is panE_3

Identifier: 237812690

GI number: 237812690

Start: 2390692

End: 2391681

Strand: Reverse

Name: panE_3

Synonym: GBP346_A2442

Alternate gene names: NA

Gene position: 2391681-2390692 (Counterclockwise)

Preceding gene: 237812691

Following gene: 237812689

Centisome position: 58.35

GC content: 73.94

Gene sequence:

>990_bases
ATGGATCGAGCACCGGTGCGCGCGGCGATCGTCGGGATCGGCGCGATCGGCGGGCTGTTTGCGGCGGGGCTCGCGCGCGC
GGGCTGGGACGTGAGCGCGCTTGCGCGCGGCGCGACGCTCGATGCGCTGCGCGGGCGCGGGCTGCGAATCGTCGGCGAGT
CGGGCGGCGAAACGGCGGTCGCGCTGCGCGCGAGCGACGACGCGCACGCGCTCGGCGAACAGGATTATGTCGTCGTCGCG
TTGAAGGCGCACGCGCTGCCGGCGCTTGCTTCGCGCATCGCGCCGCTCGTCGGGCCGCGCACGATCATCGTCGCCGCGAT
GAACGGGCTGCCGTGGTGGTTTTTCGACGGCTTCGGCGGCCCGCTCGACGGCGCGGCGCTCGACGCGGTCGATCCGGGCG
GCGTGACGGCTGCCGCGCTGCCGCCGGCGCGCGCGATCGGCTGCGTGGTGCACCTGTCGTCGGCGACGCGCGAACCGGGC
GTCGTCGTGCGCGGCCGCGGCAACCGGCTGATCGTCGGCGCGCCGCGCGCCGCGCTGCGCGAGCCGGGCGAGCGCGTTGC
CGACGCGCTCGCGGCGGGCGGCTTCGACGTCGAGCGTTCGGCCGACATCCGCACCGACATCTGGGCGAAGCTCTGGGGCA
ACATGAACATGAATCCGCTCAGCGCGCTGACGGGATCGGCGGCGGACCGCCTGCTCGACGATCCGCATACGAACGCGCTC
GCGCTGCGGATGATGGAGGAGGCCGACGCGATCGGCGCGCGGCTCGGCTTGTCGGCGGGGATGAGCGGCGCCGAGCGGAT
CGCGGTGACGCGCCAGTTGGGCGCGTTCAGGACGTCGATGCTGCAGGACCTGGAGGCCGGGCGTGCGCTCGAGATCGGGC
CGATTCTGGGCGTGTTTCCGGAACTTGGGCGCCGGCTGGGCGTGCCGACGCCGTATTGCGACGCGGTGCTCGGATTGTTG
CGCCAGCGCGCGTTCAATGCCGGGCTGTGA

Upstream 100 bases:

>100_bases
GCGACATCGACGGCTGACGCGCGGTGCGCGCGGCCGGATGGTTGTGCATGCAACTATTTGGCTCTATGCTCGCGGCTTCA
TCGAACGAGGAGAAACGCAT

Downstream 100 bases:

>100_bases
GGCGTCGCGCGGCGGCTGGAGTCGGCCGCCGCGAGCGGCGCGTCGGCGATGCGGCAAGGGATGGGGCCGCGCAGGCGCGG
CGGAACCGGGATTGGGTTGG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MDRAPVRAAIVGIGAIGGLFAAGLARAGWDVSALARGATLDALRGRGLRIVGESGGETAVALRASDDAHALGEQDYVVVA
LKAHALPALASRIAPLVGPRTIIVAAMNGLPWWFFDGFGGPLDGAALDAVDPGGVTAAALPPARAIGCVVHLSSATREPG
VVVRGRGNRLIVGAPRAALREPGERVADALAAGGFDVERSADIRTDIWAKLWGNMNMNPLSALTGSAADRLLDDPHTNAL
ALRMMEEADAIGARLGLSAGMSGAERIAVTRQLGAFRTSMLQDLEAGRALEIGPILGVFPELGRRLGVPTPYCDAVLGLL
RQRAFNAGL

Sequences:

>Translated_329_residues
MDRAPVRAAIVGIGAIGGLFAAGLARAGWDVSALARGATLDALRGRGLRIVGESGGETAVALRASDDAHALGEQDYVVVA
LKAHALPALASRIAPLVGPRTIIVAAMNGLPWWFFDGFGGPLDGAALDAVDPGGVTAAALPPARAIGCVVHLSSATREPG
VVVRGRGNRLIVGAPRAALREPGERVADALAAGGFDVERSADIRTDIWAKLWGNMNMNPLSALTGSAADRLLDDPHTNAL
ALRMMEEADAIGARLGLSAGMSGAERIAVTRQLGAFRTSMLQDLEAGRALEIGPILGVFPELGRRLGVPTPYCDAVLGLL
RQRAFNAGL
>Mature_329_residues
MDRAPVRAAIVGIGAIGGLFAAGLARAGWDVSALARGATLDALRGRGLRIVGESGGETAVALRASDDAHALGEQDYVVVA
LKAHALPALASRIAPLVGPRTIIVAAMNGLPWWFFDGFGGPLDGAALDAVDPGGVTAAALPPARAIGCVVHLSSATREPG
VVVRGRGNRLIVGAPRAALREPGERVADALAAGGFDVERSADIRTDIWAKLWGNMNMNPLSALTGSAADRLLDDPHTNAL
ALRMMEEADAIGARLGLSAGMSGAERIAVTRQLGAFRTSMLQDLEAGRALEIGPILGVFPELGRRLGVPTPYCDAVLGLL
RQRAFNAGL

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33873; Mature: 33873

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRAPVRAAIVGIGAIGGLFAAGLARAGWDVSALARGATLDALRGRGLRIVGESGGETAV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHCCCCEEEEECCCCCEEE
ALRASDDAHALGEQDYVVVALKAHALPALASRIAPLVGPRTIIVAAMNGLPWWFFDGFGG
EEEECCCHHHCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCC
PLDGAALDAVDPGGVTAAALPPARAIGCVVHLSSATREPGVVVRGRGNRLIVGAPRAALR
CCCCCEECCCCCCCEEEECCCCHHHHHHEEEECCCCCCCCEEEECCCCEEEEECCHHHHH
EPGERVADALAAGGFDVERSADIRTDIWAKLWGNMNMNPLSALTGSAADRLLDDPHTNAL
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHH
ALRMMEEADAIGARLGLSAGMSGAERIAVTRQLGAFRTSMLQDLEAGRALEIGPILGVFP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHH
ELGRRLGVPTPYCDAVLGLLRQRAFNAGL
HHHHHCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDRAPVRAAIVGIGAIGGLFAAGLARAGWDVSALARGATLDALRGRGLRIVGESGGETAV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHCCCCEEEEECCCCCEEE
ALRASDDAHALGEQDYVVVALKAHALPALASRIAPLVGPRTIIVAAMNGLPWWFFDGFGG
EEEECCCHHHCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCC
PLDGAALDAVDPGGVTAAALPPARAIGCVVHLSSATREPGVVVRGRGNRLIVGAPRAALR
CCCCCEECCCCCCCEEEECCCCHHHHHHEEEECCCCCCCCEEEECCCCEEEEECCHHHHH
EPGERVADALAAGGFDVERSADIRTDIWAKLWGNMNMNPLSALTGSAADRLLDDPHTNAL
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHH
ALRMMEEADAIGARLGLSAGMSGAERIAVTRQLGAFRTSMLQDLEAGRALEIGPILGVFP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHH
ELGRRLGVPTPYCDAVLGLLRQRAFNAGL
HHHHHCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]