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The map label for this gene is norM [H]

Identifier: 237812575

GI number: 237812575

Start: 2291176

End: 2292531

Strand: Direct

Name: norM [H]

Synonym: GBP346_A2325

Alternate gene names: 237812575

Gene position: 2291176-2292531 (Clockwise)

Preceding gene: 237812574

Following gene: 237812576

Centisome position: 55.9

GC content: 69.84

Gene sequence:

>1356_bases
ATGTTCGGCGACATCCGCCGGATCGCCGGTCTCGCCTGGCCGGTGCTCGTCGGCCAGCTCGCGATCATCGCGTTCGGCGT
GATCGATACCGCGATGGTCGGCCGCTTCTCCGCGCTCGATCTCGCGGCGCTCGGGCTCGGCATGTCGATCTATGTGTCGA
TCTACATCGGGCTGACGGGCATCCTGTCCGCGCTGCAGCCGATCGCGGGGCAACTGTACGGCGCGCGGCGCTACGCGGAG
ATCGGCGAGGAGGTGCGCCAGGCGATGTGGCTCGCGGTGCTGCTCGCCGCGCCCGGCTTTCTGTTGCTGCATTTCCCGCA
TCCGCTGCTGCGGCTCGCGCATGCGCCCGCGGAGCTGACCGATCGCACGGTCGCCTATCTGCGCATCCTGTCGTTCGGAC
TGCCCGCCAGCCTCCTGTTCCGCATCTACAACGCGCTCACCAACGCGGCGGGCAAGCCACGGCTCGCGATGATCCTGCAG
GTGGGCGCGCTCGCCGTCAAAGTGCCGCTCAACCTCTGGTTCATCTTCGGCGGCCTCGGCGTGCCGGCGCTCGGCGGCCC
CGGTTGCGGCCTCGCGAGCACGCTGATCAACTGGGCGCTCGCGATCGTCGGCTTCACGCTGCTCGCGAGGCTCGACGTGT
TCGAGCCGCTCGCGATCTTCGCGCGCTTCACGCGGCCCGTCTGGCATCGACAGAAGGCGCTTCTCGTGCTCGGCGTGCCG
ATGGGTCTGTCGTATCTGATCGAGGTCACGTCTTACACGTTCATGGCGCTGTTCATCGCGCAGTTCGGCACGACGACGCT
CGCCGGTCACCAGATCGCCGGCAACATCGGCGCGGTGCTGTACATGACGCCGTTGTCGATCGGCGTCGCGTCATCGACGC
TCGTCGCGCGCGCGCTCGGCGCCGGGCGCTTCGACGAAGCCCGCGTGCTCGGCCGGCACGGCGTCGCGCTCGCGTGCGGG
CTCGCGTGCGCGTACGGCATCGTCGTGTTCGCGCTGCGGCCGCTGATCGTATCGGGCTACACGCCGAATCCGGCCGTCGC
CGCGGCCGCGATGCCGCTCGTCGCGATCGTCACGGTCTATCATTTCTTCGACGCGCTGCAGATCACGACCGCGTTCGTGC
TGCGCGCGCACAAGGTGGCCGTCGTGCCGACCGCGATCTACGCGATCGCGCTGTGGGGCGTCGGGCTCGGCGGCGGCTAC
CTGCTGGGGTTCGACGTCGGCGGCGCGGTGCCGGCGCAGTTCACCGGCGCGCGCGGCTTCTGGATCGCGAGCGCGGCGAG
CTTGATGCTCGCGGGCGGCGGGCTCGCGCTTTATCTGCGGCACATCGGAAAGCGGGAAACGGGTGGCGCGCGGTAG

Upstream 100 bases:

>100_bases
CCGCGTCGCCGACCGCGACGAGCGCTTCCGCCTGTACGAGCGAATCGAGCGCCCGAAGACGCCCGTCAAGCGCCGCCCGC
CGCGCAAGGCCCGCTGACCG

Downstream 100 bases:

>100_bases
CGCGCGGTAGCGCGCGGCAGGCGGGGCGGGCGCGGTGGCGGGCGGACAGCAGCGGACGCGCGCGCCGCGTGCGTCGCTCG
CCCGGCCGGCCACCGCTGTC

Product: mate efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGMSIYVSIYIGLTGILSALQPIAGQLYGARRYAE
IGEEVRQAMWLAVLLAAPGFLLLHFPHPLLRLAHAPAELTDRTVAYLRILSFGLPASLLFRIYNALTNAAGKPRLAMILQ
VGALAVKVPLNLWFIFGGLGVPALGGPGCGLASTLINWALAIVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLVLGVP
MGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVASSTLVARALGAGRFDEARVLGRHGVALACG
LACAYGIVVFALRPLIVSGYTPNPAVAAAAMPLVAIVTVYHFFDALQITTAFVLRAHKVAVVPTAIYAIALWGVGLGGGY
LLGFDVGGAVPAQFTGARGFWIASAASLMLAGGGLALYLRHIGKRETGGAR

Sequences:

>Translated_451_residues
MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGMSIYVSIYIGLTGILSALQPIAGQLYGARRYAE
IGEEVRQAMWLAVLLAAPGFLLLHFPHPLLRLAHAPAELTDRTVAYLRILSFGLPASLLFRIYNALTNAAGKPRLAMILQ
VGALAVKVPLNLWFIFGGLGVPALGGPGCGLASTLINWALAIVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLVLGVP
MGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVASSTLVARALGAGRFDEARVLGRHGVALACG
LACAYGIVVFALRPLIVSGYTPNPAVAAAAMPLVAIVTVYHFFDALQITTAFVLRAHKVAVVPTAIYAIALWGVGLGGGY
LLGFDVGGAVPAQFTGARGFWIASAASLMLAGGGLALYLRHIGKRETGGAR
>Mature_451_residues
MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGMSIYVSIYIGLTGILSALQPIAGQLYGARRYAE
IGEEVRQAMWLAVLLAAPGFLLLHFPHPLLRLAHAPAELTDRTVAYLRILSFGLPASLLFRIYNALTNAAGKPRLAMILQ
VGALAVKVPLNLWFIFGGLGVPALGGPGCGLASTLINWALAIVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLVLGVP
MGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVASSTLVARALGAGRFDEARVLGRHGVALACG
LACAYGIVVFALRPLIVSGYTPNPAVAAAAMPLVAIVTVYHFFDALQITTAFVLRAHKVAVVPTAIYAIALWGVGLGGGY
LLGFDVGGAVPAQFTGARGFWIASAASLMLAGGGLALYLRHIGKRETGGAR

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=423, Percent_Identity=24.113475177305, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI48994890, Length=442, Percent_Identity=30.9954751131222, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI226510954, Length=437, Percent_Identity=22.6544622425629, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320545, Length=455, Percent_Identity=25.4945054945055, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321821, Length=356, Percent_Identity=23.0337078651685, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47375; Mature: 47375

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGMSIYVSIYIGLTG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHH
ILSALQPIAGQLYGARRYAEIGEEVRQAMWLAVLLAAPGFLLLHFPHPLLRLAHAPAELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCHHHH
DRTVAYLRILSFGLPASLLFRIYNALTNAAGKPRLAMILQVGALAVKVPLNLWFIFGGLG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEHHHHEEEECCCC
VPALGGPGCGLASTLINWALAIVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLVLGVP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
MGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVASSTLVARALG
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCEEEEEECHHHHHHHHHHHHHHHC
AGRFDEARVLGRHGVALACGLACAYGIVVFALRPLIVSGYTPNPAVAAAAMPLVAIVTVY
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HFFDALQITTAFVLRAHKVAVVPTAIYAIALWGVGLGGGYLLGFDVGGAVPAQFTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCH
WIASAASLMLAGGGLALYLRHIGKRETGGAR
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFGDIRRIAGLAWPVLVGQLAIIAFGVIDTAMVGRFSALDLAALGLGMSIYVSIYIGLTG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHH
ILSALQPIAGQLYGARRYAEIGEEVRQAMWLAVLLAAPGFLLLHFPHPLLRLAHAPAELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCHHHH
DRTVAYLRILSFGLPASLLFRIYNALTNAAGKPRLAMILQVGALAVKVPLNLWFIFGGLG
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEHHHHEEEECCCC
VPALGGPGCGLASTLINWALAIVGFTLLARLDVFEPLAIFARFTRPVWHRQKALLVLGVP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
MGLSYLIEVTSYTFMALFIAQFGTTTLAGHQIAGNIGAVLYMTPLSIGVASSTLVARALG
HHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCEEEEEECHHHHHHHHHHHHHHHC
AGRFDEARVLGRHGVALACGLACAYGIVVFALRPLIVSGYTPNPAVAAAAMPLVAIVTVY
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HFFDALQITTAFVLRAHKVAVVPTAIYAIALWGVGLGGGYLLGFDVGGAVPAQFTGARGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCH
WIASAASLMLAGGGLALYLRHIGKRETGGAR
HHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA