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The map label for this gene is phbA [H]

Identifier: 237812524

GI number: 237812524

Start: 2238674

End: 2239855

Strand: Reverse

Name: phbA [H]

Synonym: GBP346_A2273

Alternate gene names: 237812524

Gene position: 2239855-2238674 (Counterclockwise)

Preceding gene: 237812525

Following gene: 237812523

Centisome position: 54.65

GC content: 69.2

Gene sequence:

>1182_bases
ATGACTGACGTAGTGATCGTATCGGCCGCGCGCACCGCGGTCGGCAAGTTCGGCGGCTCGCTCGCGAAGATCGCCGCGCC
GGAGCTCGGCGCGAGCGTGATTCGCGCGGTGCTCGAACGTGCGGGCGTGAAGCCCGAGCAGGTCAGCGAAGTGATTCTGG
GCCAGGTGCTGACGGCGGGCTCGGGCCAGAATCCGGCGCGCCAGGCGCTGATCGCGGCGGGGCTGCCGAACGCGGTGCCG
GGCATGACGATCAACAAGGTGTGCGGCTCCGGCCTGAAGGCCGTGATGCTTGCCGCGAACGCGGTCGTCGCGGGCGATGC
GGAGATCGTCGTCGCGGGCGGCCAGGAGAACATGAGCGCCGCGCCTCACGTGCTGCCGGGCTCGCGCGACGGCTTCCGGA
TGGGCGATGCGAAGCTCGTCGACAGCATGATCGTGGATGGCCTCTGGGACGTCTACAACAAGTACCACATGGGCATCACC
GCGGAGAACGTCGCGAAGGAGTACGGCATCACGCGCGAGGCGCAGGACCAGTTCGCCGCGCTCTCGCAGAACAAGGCGGA
AGCCGCGCAGAAGGCGGGCCGCTTCGACGACGAGATCGTGCCGATCGAGATCCCGCAGAGAAAGGGCGAGCCGCTGCGTT
TCGCGACCGACGAGTTCGTGCGTCACGGCGTGACGGCCGAGTCGCTCGCGGGCCTGAAGCCCGCGTTCGCGAAGGAAGGC
ACGGTGACGGCCGCGAACGCGTCCGGCATCAACGACGGCGCGGCCGCGGTGCTCGTGATGTCGGCGAAGAAGGCCGAGGC
GCTCGGCCTCGAGCCGCTCGCGCGGATCAAGGCGTACGCGAACGCGGGCGTCGATCCGAGCGTGATGGGCATGGGCCCCG
TTCCGGCGTCGCGCCGCTGTCTCGAGCGCGCGGGCTGGTCGGTGGGCGACCTCGACCTGATGGAGATCAACGAGGCGTTC
GCCGCGCAGGCGCTCGCGGTTCACAAGCAGATGGGCTGGGATACGTCGAAGGTCAACGTGAATGGCGGCGCGATCGCGAT
CGGCCATCCGATCGGCGCGTCGGGCTGCCGGATTCTCGTCACGCTGCTGCACGAAATGCTCAAGCGCGATGCGAAACGCG
GCCTCGCATCGCTTTGCATCGGCGGCGGGATGGGCGTCGCGCTCGCGCTCGAGCGTCCGTAA

Upstream 100 bases:

>100_bases
TTGACGAACGGCGCAAGGCGGAGCACGCTTTGCGTCGCGACCGATTTTTAACAGGGCGGTTCGCGGCGCGCCGTGCCGCG
CGCGCCCGGAGGATAGTGAA

Downstream 100 bases:

>100_bases
CGCGAATCAGGAGGCACCCGCGCGGGGCGCGCCGGCGGGCGCGGCCCGACGAACGGGCGATCGGCAGGCAGGCGACGGAG
AGGTTGCCGCTCGGCGCTTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGASVIRAVLERAGVKPEQVSEVILGQVLTAGSGQNPARQALIAAGLPNAVP
GMTINKVCGSGLKAVMLAANAVVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNKYHMGIT
AENVAKEYGITREAQDQFAALSQNKAEAAQKAGRFDDEIVPIEIPQRKGEPLRFATDEFVRHGVTAESLAGLKPAFAKEG
TVTAANASGINDGAAAVLVMSAKKAEALGLEPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWSVGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMLKRDAKRGLASLCIGGGMGVALALERP

Sequences:

>Translated_393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGASVIRAVLERAGVKPEQVSEVILGQVLTAGSGQNPARQALIAAGLPNAVP
GMTINKVCGSGLKAVMLAANAVVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNKYHMGIT
AENVAKEYGITREAQDQFAALSQNKAEAAQKAGRFDDEIVPIEIPQRKGEPLRFATDEFVRHGVTAESLAGLKPAFAKEG
TVTAANASGINDGAAAVLVMSAKKAEALGLEPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWSVGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMLKRDAKRGLASLCIGGGMGVALALERP
>Mature_392_residues
TDVVIVSAARTAVGKFGGSLAKIAAPELGASVIRAVLERAGVKPEQVSEVILGQVLTAGSGQNPARQALIAAGLPNAVPG
MTINKVCGSGLKAVMLAANAVVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNKYHMGITA
ENVAKEYGITREAQDQFAALSQNKAEAAQKAGRFDDEIVPIEIPQRKGEPLRFATDEFVRHGVTAESLAGLKPAFAKEGT
VTAANASGINDGAAAVLVMSAKKAEALGLEPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWSVGDLDLMEINEAFA
AQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMLKRDAKRGLASLCIGGGMGVALALERP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=56.2659846547315, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=44.1025641025641, Blast_Score=318, Evalue=4e-87,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=44.2748091603053, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=42.964824120603, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=30.6603773584906, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=32.4050632911392, Blast_Score=164, Evalue=9e-41,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=62.2448979591837, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=60.0508905852417, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.049504950495, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.1052631578947, Blast_Score=272, Evalue=3e-74,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=34.0425531914894, Blast_Score=192, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=46.1538461538462, Blast_Score=332, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=42.3772609819121, Blast_Score=301, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=40.6565656565657, Blast_Score=275, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=33.248730964467, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.5420560747664, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=43.3249370277078, Blast_Score=298, Evalue=8e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=40.8521303258145, Blast_Score=241, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=57.3979591836735, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.3104325699746, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=45.3846153846154, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.0588235294118, Blast_Score=184, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40514; Mature: 40383

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAARTAVGKFGGSLAKIAAPELGASVIRAVLERAGVKPEQVSEVILGQVLTAG
CCCEEEEEHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
SGQNPARQALIAAGLPNAVPGMTINKVCGSGLKAVMLAANAVVAGDAEIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHCEEEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNKYHMGITAENVAKEYGITREAQDQFAA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHH
LSQNKAEAAQKAGRFDDEIVPIEIPQRKGEPLRFATDEFVRHGVTAESLAGLKPAFAKEG
HHCHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEHHHHHHHCCCCHHHHHCCCCHHCCCC
TVTAANASGINDGAAAVLVMSAKKAEALGLEPLARIKAYANAGVDPSVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEECCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERAGWSVGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCHHHHHHH
TLLHEMLKRDAKRGLASLCIGGGMGVALALERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure 
TDVVIVSAARTAVGKFGGSLAKIAAPELGASVIRAVLERAGVKPEQVSEVILGQVLTAG
CCEEEEEHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
SGQNPARQALIAAGLPNAVPGMTINKVCGSGLKAVMLAANAVVAGDAEIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHCEEEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNKYHMGITAENVAKEYGITREAQDQFAA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHH
LSQNKAEAAQKAGRFDDEIVPIEIPQRKGEPLRFATDEFVRHGVTAESLAGLKPAFAKEG
HHCHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEHHHHHHHCCCCHHHHHCCCCHHCCCC
TVTAANASGINDGAAAVLVMSAKKAEALGLEPLARIKAYANAGVDPSVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEECCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERAGWSVGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCHHHHHHH
TLLHEMLKRDAKRGLASLCIGGGMGVALALERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]