Click here to switch to the map view.

The map label for this gene is zraR [H]

Identifier: 237812494

GI number: 237812494

Start: 2205060

End: 2206463

Strand: Reverse

Name: zraR [H]

Synonym: GBP346_A2243

Alternate gene names: 237812494

Gene position: 2206463-2205060 (Counterclockwise)

Preceding gene: 237812498

Following gene: 237812493

Centisome position: 53.83

GC content: 71.08

Gene sequence:

>1404_bases
ATGGCAGAATTGGCAGCCAACGCGGCCGCGGGCCGCGCAGCCGGAGCTCCATGCATGAATCAGCGCGACGCCATTCCGAT
CGTTCCCATTTCGCCGCCCGACGTGGGCGTGCTCGTGTCGTACCTCGAGCAGGATCCGCAGCCGATGATCGTGCTCGATC
CGTCGTACCGGATCCTCGCGGCGAACGCCGCGTATCAGCGGCAGTTCGGCATCGCCGGCGAGGCGCACGTCGGGCGGCGC
TGCTACCAGGTCTCGCATCACTACGACATGCCGTGCGACCAGGCGGGCGAGCATTGCCCGATGAAGCAGGCGGGCGAATC
GCGCGGCCTGAACCGCGTGCTGCACATCCATCACACGCCGCGCGGGCCCGAGCACGTCGATGTCGAGCTGCGGCCGATCT
TCGATGCGCGCGGCGCGGTGATCGCATACGTCGAGCGGCTGACGACCGTGCGCAGCGCGTCGGCGAAGCCGAGCGGCGAG
GGGCTCGTCGGCGGCTCGGACGCGTTCAACGCGGCGCTGTCCGCGTTGCAGCGGGTCGCGCCTTCGATGCTGCCCGTGCT
GCTGCTCGGCGAATCGGGCACGGGCAAGGAGCTGTTCGCGCGTGCGTTGCACGAGGCGAGCGCGCGTGCGATGGGGCCGT
TCGTCGTCGTCGATTGCTCGGGGATTGCCGAGACGCTGTTCGAAAGCGAGCTGTTCGGCTATGAGAAAGGCGCGTTCACC
GGCGCGAGCGCGCGCAAGCCCGGCCTCGTCGAGACCGCGCAGGGCGGCACGCTGTTTCTCGACGAGATCGGCGACGTGCC
GCTGTCGATGCAGGTGAAGCTGCTGCGCCTCATCGAATCGGGCACGTTCCGGCGGGTGGGCGGCGTCGAGGCGCTGTGCG
CGGATTTCCGCCTCGTCGCGGCGACCCACAAACCGTTGAAGGCGATGATCGGCGACGGCCGCTTCCGGCCGGATCTGTAC
TACCGGATCAGCGCGTATCCGATTCCGCTGCCTGCGGTGCGCGAGCGCCCGGGCGACATGCCGCTCCTCGTCGACTCGAT
CCTGCGCCGGATCGCGGCGCTCGGGCCGGTTGCCGGGCAGCGTTTCGTCGTGGCGCCCGATGCGCTCGCGCGGCTCGAGG
CGTACGCGTGGCCGGGCAATATCCGCGAGCTGCGCAACGTGCTCGATCGCGCGTGCCTGCTCACCGACGACGGCGTGATC
CGCGTCGAGCACCTGCCCGACGAGGTGGCGGGCGGCGCGCGCATCGAGCCGGGCGCGCCGGCGAAGCTGTCCGACGACGA
GCTCGCGCGAATCGCGCGCGCGTTCGGCGGCACGCGGCGCGCGCTCGCCGAGCGCGTCGGGATGAGCGAGCGCACGCTGT
ACCGGCGGTTGCGCGCGCTGGGGATCGCGACGCGGGAGGCGTGA

Upstream 100 bases:

>100_bases
CAGGTACTTGATTCAAATCGTGTTTTGTTCCTCCGTCGCGCATCGCGCACCGCCGGGGCGGCGAGATTCGTCCCGCTTGA
CTGCCAAGGATGGCAGTTGA

Downstream 100 bases:

>100_bases
GGCTTGACCCGTGAGGCGTGGGCGGACGACGGCGAGCGGGCGCCGGGCGGTGCGCCGCGCGTGAATGGCATGGACGAGAG
GCCGACGGGACGGGAAAACG

Product: sigma-54 dependent transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAELAANAAAGRAAGAPCMNQRDAIPIVPISPPDVGVLVSYLEQDPQPMIVLDPSYRILAANAAYQRQFGIAGEAHVGRR
CYQVSHHYDMPCDQAGEHCPMKQAGESRGLNRVLHIHHTPRGPEHVDVELRPIFDARGAVIAYVERLTTVRSASAKPSGE
GLVGGSDAFNAALSALQRVAPSMLPVLLLGESGTGKELFARALHEASARAMGPFVVVDCSGIAETLFESELFGYEKGAFT
GASARKPGLVETAQGGTLFLDEIGDVPLSMQVKLLRLIESGTFRRVGGVEALCADFRLVAATHKPLKAMIGDGRFRPDLY
YRISAYPIPLPAVRERPGDMPLLVDSILRRIAALGPVAGQRFVVAPDALARLEAYAWPGNIRELRNVLDRACLLTDDGVI
RVEHLPDEVAGGARIEPGAPAKLSDDELARIARAFGGTRRALAERVGMSERTLYRRLRALGIATREA

Sequences:

>Translated_467_residues
MAELAANAAAGRAAGAPCMNQRDAIPIVPISPPDVGVLVSYLEQDPQPMIVLDPSYRILAANAAYQRQFGIAGEAHVGRR
CYQVSHHYDMPCDQAGEHCPMKQAGESRGLNRVLHIHHTPRGPEHVDVELRPIFDARGAVIAYVERLTTVRSASAKPSGE
GLVGGSDAFNAALSALQRVAPSMLPVLLLGESGTGKELFARALHEASARAMGPFVVVDCSGIAETLFESELFGYEKGAFT
GASARKPGLVETAQGGTLFLDEIGDVPLSMQVKLLRLIESGTFRRVGGVEALCADFRLVAATHKPLKAMIGDGRFRPDLY
YRISAYPIPLPAVRERPGDMPLLVDSILRRIAALGPVAGQRFVVAPDALARLEAYAWPGNIRELRNVLDRACLLTDDGVI
RVEHLPDEVAGGARIEPGAPAKLSDDELARIARAFGGTRRALAERVGMSERTLYRRLRALGIATREA
>Mature_466_residues
AELAANAAAGRAAGAPCMNQRDAIPIVPISPPDVGVLVSYLEQDPQPMIVLDPSYRILAANAAYQRQFGIAGEAHVGRRC
YQVSHHYDMPCDQAGEHCPMKQAGESRGLNRVLHIHHTPRGPEHVDVELRPIFDARGAVIAYVERLTTVRSASAKPSGEG
LVGGSDAFNAALSALQRVAPSMLPVLLLGESGTGKELFARALHEASARAMGPFVVVDCSGIAETLFESELFGYEKGAFTG
ASARKPGLVETAQGGTLFLDEIGDVPLSMQVKLLRLIESGTFRRVGGVEALCADFRLVAATHKPLKAMIGDGRFRPDLYY
RISAYPIPLPAVRERPGDMPLLVDSILRRIAALGPVAGQRFVVAPDALARLEAYAWPGNIRELRNVLDRACLLTDDGVIR
VEHLPDEVAGGARIEPGAPAKLSDDELARIARAFGGTRRALAERVGMSERTLYRRLRALGIATREA

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG3604

COG function: function code KT; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1789087, Length=331, Percent_Identity=41.3897280966767, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1788550, Length=301, Percent_Identity=41.5282392026578, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI1790437, Length=302, Percent_Identity=43.046357615894, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1789233, Length=333, Percent_Identity=38.7387387387387, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87082117, Length=325, Percent_Identity=39.0769230769231, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1788905, Length=222, Percent_Identity=45.045045045045, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1790299, Length=367, Percent_Identity=35.9673024523161, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI87081872, Length=238, Percent_Identity=44.9579831932773, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI87082152, Length=250, Percent_Identity=40.8, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1786524, Length=322, Percent_Identity=39.1304347826087, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787583, Length=446, Percent_Identity=31.390134529148, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI87081858, Length=295, Percent_Identity=32.5423728813559, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI1789828, Length=303, Percent_Identity=33.993399339934, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50195; Mature: 50064

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELAANAAAGRAAGAPCMNQRDAIPIVPISPPDVGVLVSYLEQDPQPMIVLDPSYRILA
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCEEEE
ANAAYQRQFGIAGEAHVGRRCYQVSHHYDMPCDQAGEHCPMKQAGESRGLNRVLHIHHTP
CCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHCCCCEEEEEEECC
RGPEHVDVELRPIFDARGAVIAYVERLTTVRSASAKPSGEGLVGGSDAFNAALSALQRVA
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
PSMLPVLLLGESGTGKELFARALHEASARAMGPFVVVDCSGIAETLFESELFGYEKGAFT
HHHCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCC
GASARKPGLVETAQGGTLFLDEIGDVPLSMQVKLLRLIESGTFRRVGGVEALCADFRLVA
CCCCCCCCCEEECCCCEEEEHHHCCCCHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHEE
ATHKPLKAMIGDGRFRPDLYYRISAYPIPLPAVRERPGDMPLLVDSILRRIAALGPVAGQ
CCCCHHHHHHCCCCCCCCEEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
RFVVAPDALARLEAYAWPGNIRELRNVLDRACLLTDDGVIRVEHLPDEVAGGARIEPGAP
EEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCEEEEECCCHHHCCCCCCCCCCC
AKLSDDELARIARAFGGTRRALAERVGMSERTLYRRLRALGIATREA
CCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCHHCCC
>Mature Secondary Structure 
AELAANAAAGRAAGAPCMNQRDAIPIVPISPPDVGVLVSYLEQDPQPMIVLDPSYRILA
CCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCEEEE
ANAAYQRQFGIAGEAHVGRRCYQVSHHYDMPCDQAGEHCPMKQAGESRGLNRVLHIHHTP
CCHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHCCCCEEEEEEECC
RGPEHVDVELRPIFDARGAVIAYVERLTTVRSASAKPSGEGLVGGSDAFNAALSALQRVA
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
PSMLPVLLLGESGTGKELFARALHEASARAMGPFVVVDCSGIAETLFESELFGYEKGAFT
HHHCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCC
GASARKPGLVETAQGGTLFLDEIGDVPLSMQVKLLRLIESGTFRRVGGVEALCADFRLVA
CCCCCCCCCEEECCCCEEEEHHHCCCCHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHEE
ATHKPLKAMIGDGRFRPDLYYRISAYPIPLPAVRERPGDMPLLVDSILRRIAALGPVAGQ
CCCCHHHHHHCCCCCCCCEEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
RFVVAPDALARLEAYAWPGNIRELRNVLDRACLLTDDGVIRVEHLPDEVAGGARIEPGAP
EEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHEECCCCEEEEECCCHHHCCCCCCCCCCC
AKLSDDELARIARAFGGTRRALAERVGMSERTLYRRLRALGIATREA
CCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]