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The map label for this gene is ghrB [H]

Identifier: 237812475

GI number: 237812475

Start: 2184903

End: 2185880

Strand: Reverse

Name: ghrB [H]

Synonym: GBP346_A2224

Alternate gene names: 237812475

Gene position: 2185880-2184903 (Counterclockwise)

Preceding gene: 237812476

Following gene: 237812474

Centisome position: 53.33

GC content: 72.8

Gene sequence:

>978_bases
ATGAAGCATCGCATCGTCGTCTACAAGCCGCTCCCCGACGACGTACTCGCGGCCTTGCGCGCGCGCGCCGACGTCGTGCT
CGCCGAGGGCGCCGACGCGCTCGCGCGCGCGCTGCCCGACGCCGACGGCGCGCTCGGCGCGAGCCTGCGGATCACGCCCG
AGCTGCTCGATCGTGCACCGCGGCTGCGCGCGTGGTCGACGATCTCGGTCGGCTTCGACAACTTCGACGTCGCCGATCTG
ACGCGCCGCGGGATCGTGCTCGCGCACACGCCCGACGTGCTCACCGAGGCGACCGCCGACACCGTGTTCGCGCTGATCCT
CGCGAGCGCGCGGCGCGTCGTGGAGCTCGCCGAATACGTGAAGGCGGGGCAGTGGCGCCAGAGCATCGGCGAGGCGCTGT
ACGGCACCGACGTGAACGGCAAGACGCTCGGCATCGTCGGGCTCGGGCGCATCGGCACGGCGCTCGCGCGGCGCGCGGCG
CTCGGCTTCCGGATGCCGGTGCTCTACACGAGCCGCAGCCCGCATCCGCAGGCCGAGGCGCAGTTCGGCGCGCGCCGCGT
CGAGCTCGACGAGCTGCTCGCCACGGCCGATTTCGTGTGCCTGCAGGTGCCGCTTTCGCCGCAGACGCGGCACCTGATCG
GCGCGCGCGAACTCGCGAAGATGAAGCGCGACGCGATACTCGTGAACGCGTCGCGCGGGCCCGTCGTCGACGAGGCGGCG
TTAATCGACGCGCTGCGCGCGGGAGCGATCCGTGCGGCGGGGCTCGACGTGTTCGAGCACGAGCCGCTCGCCGCGGATTC
GCCGTTGCTGTCGATGCGCAACGTCGTCGCGCTGCCGCACATCGGCTCGGCGACGCGCGAGACGCGCCACGCGATGGCGC
GCTGCGCGGCCGAGAACGTGATCGCGGCGCTCGACGGCACGCTCGCGCGCAATATCGTCAATCGCGACGTGCTGCAGCGC
ACGCCGTCGACGCCGTGA

Upstream 100 bases:

>100_bases
ATGAGCGCCGCGCTCGTCGCGGCCGTCGTGCTCACGCTGTCGGTGAAGCAGCCGGGCGCGACGCCGCCGCTCGCCCATCC
GTTGCAAGGAAAGTGAAGAC

Downstream 100 bases:

>100_bases
ACCTGCGATGAGCGCGCGAGACGTGCCCGCCGCGCGCGACGCGGAATGCGGCGGCATCGCGGCGGGAGCGGGCCCGCGTC
GCACCCGTTGCCGCCGTTGC

Product: 2-ketogluconate reductase (2KR) (2-ketoaldonatereductase)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKHRIVVYKPLPDDVLAALRARADVVLAEGADALARALPDADGALGASLRITPELLDRAPRLRAWSTISVGFDNFDVADL
TRRGIVLAHTPDVLTEATADTVFALILASARRVVELAEYVKAGQWRQSIGEALYGTDVNGKTLGIVGLGRIGTALARRAA
LGFRMPVLYTSRSPHPQAEAQFGARRVELDELLATADFVCLQVPLSPQTRHLIGARELAKMKRDAILVNASRGPVVDEAA
LIDALRAGAIRAAGLDVFEHEPLAADSPLLSMRNVVALPHIGSATRETRHAMARCAAENVIAALDGTLARNIVNRDVLQR
TPSTP

Sequences:

>Translated_325_residues
MKHRIVVYKPLPDDVLAALRARADVVLAEGADALARALPDADGALGASLRITPELLDRAPRLRAWSTISVGFDNFDVADL
TRRGIVLAHTPDVLTEATADTVFALILASARRVVELAEYVKAGQWRQSIGEALYGTDVNGKTLGIVGLGRIGTALARRAA
LGFRMPVLYTSRSPHPQAEAQFGARRVELDELLATADFVCLQVPLSPQTRHLIGARELAKMKRDAILVNASRGPVVDEAA
LIDALRAGAIRAAGLDVFEHEPLAADSPLLSMRNVVALPHIGSATRETRHAMARCAAENVIAALDGTLARNIVNRDVLQR
TPSTP
>Mature_325_residues
MKHRIVVYKPLPDDVLAALRARADVVLAEGADALARALPDADGALGASLRITPELLDRAPRLRAWSTISVGFDNFDVADL
TRRGIVLAHTPDVLTEATADTVFALILASARRVVELAEYVKAGQWRQSIGEALYGTDVNGKTLGIVGLGRIGTALARRAA
LGFRMPVLYTSRSPHPQAEAQFGARRVELDELLATADFVCLQVPLSPQTRHLIGARELAKMKRDAILVNASRGPVVDEAA
LIDALRAGAIRAAGLDVFEHEPLAADSPLLSMRNVVALPHIGSATRETRHAMARCAAENVIAALDGTLARNIVNRDVLQR
TPSTP

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=278, Percent_Identity=42.4460431654676, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=32.6460481099656, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI61743967, Length=294, Percent_Identity=35.3741496598639, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI4557497, Length=294, Percent_Identity=35.3741496598639, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI145580578, Length=296, Percent_Identity=34.4594594594595, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4557499, Length=296, Percent_Identity=34.4594594594595, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=283, Percent_Identity=34.6289752650177, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI87082289, Length=322, Percent_Identity=57.1428571428571, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1789279, Length=270, Percent_Identity=32.2222222222222, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787645, Length=192, Percent_Identity=31.7708333333333, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI87081824, Length=145, Percent_Identity=34.4827586206897, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=313, Percent_Identity=32.5878594249201, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=291, Percent_Identity=29.8969072164948, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=233, Percent_Identity=42.0600858369099, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320925, Length=258, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=278, Percent_Identity=33.0935251798561, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6325144, Length=194, Percent_Identity=31.9587628865979, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=176, Percent_Identity=31.8181818181818, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=241, Percent_Identity=27.8008298755187, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=179, Percent_Identity=28.4916201117318, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571528, Length=322, Percent_Identity=40.0621118012422, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI45552429, Length=310, Percent_Identity=38.7096774193548, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24585514, Length=310, Percent_Identity=38.7096774193548, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI28574282, Length=310, Percent_Identity=38.7096774193548, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI28574284, Length=310, Percent_Identity=38.7096774193548, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI45551003, Length=310, Percent_Identity=38.7096774193548, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI28574286, Length=256, Percent_Identity=41.796875, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24585516, Length=311, Percent_Identity=32.475884244373, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI19921140, Length=298, Percent_Identity=33.8926174496644, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24646446, Length=297, Percent_Identity=35.016835016835, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24646448, Length=297, Percent_Identity=35.016835016835, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24646452, Length=297, Percent_Identity=35.016835016835, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24646450, Length=297, Percent_Identity=35.016835016835, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI62472511, Length=297, Percent_Identity=35.016835016835, Blast_Score=134, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34807; Mature: 34807

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHRIVVYKPLPDDVLAALRARADVVLAEGADALARALPDADGALGASLRITPELLDRAP
CCCCEEEECCCCHHHHHHHHHHCCEEEECCHHHHHHHCCCCCCCCCCEEEECHHHHCCCC
RLRAWSTISVGFDNFDVADLTRRGIVLAHTPDVLTEATADTVFALILASARRVVELAEYV
CCCCCEEEEECCCCCCHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAGQWRQSIGEALYGTDVNGKTLGIVGLGRIGTALARRAALGFRMPVLYTSRSPHPQAEA
HHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHH
QFGARRVELDELLATADFVCLQVPLSPQTRHLIGARELAKMKRDAILVNASRGPVVDEAA
HHCCHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHH
LIDALRAGAIRAAGLDVFEHEPLAADSPLLSMRNVVALPHIGSATRETRHAMARCAAENV
HHHHHHHCCHHHCCCCHHCCCCCCCCCCHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHH
IAALDGTLARNIVNRDVLQRTPSTP
HHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKHRIVVYKPLPDDVLAALRARADVVLAEGADALARALPDADGALGASLRITPELLDRAP
CCCCEEEECCCCHHHHHHHHHHCCEEEECCHHHHHHHCCCCCCCCCCEEEECHHHHCCCC
RLRAWSTISVGFDNFDVADLTRRGIVLAHTPDVLTEATADTVFALILASARRVVELAEYV
CCCCCEEEEECCCCCCHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAGQWRQSIGEALYGTDVNGKTLGIVGLGRIGTALARRAALGFRMPVLYTSRSPHPQAEA
HHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHH
QFGARRVELDELLATADFVCLQVPLSPQTRHLIGARELAKMKRDAILVNASRGPVVDEAA
HHCCHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHH
LIDALRAGAIRAAGLDVFEHEPLAADSPLLSMRNVVALPHIGSATRETRHAMARCAAENV
HHHHHHHCCHHHCCCCHHCCCCCCCCCCHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHH
IAALDGTLARNIVNRDVLQRTPSTP
HHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA