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The map label for this gene is arpR [H]

Identifier: 237812180

GI number: 237812180

Start: 1865966

End: 1866637

Strand: Reverse

Name: arpR [H]

Synonym: GBP346_A1926

Alternate gene names: 237812180

Gene position: 1866637-1865966 (Counterclockwise)

Preceding gene: 237812185

Following gene: 237812179

Centisome position: 45.54

GC content: 70.24

Gene sequence:

>672_bases
ATGGCCCGCAAGACGCGCGAAGAATCGCTGAACACGAAGAACCGGATCCTCGACGCCGCCGAGCTCGTGCTGCTGGAAAA
GGGCGTCGGCCAGACCGCGATGGCCGACATCGCGGAGGCGGCCGGCATGTCGCGCGGCGCGGTGTACGGGCACTTCAACG
GCAAGATCGAGGTGTGCGTCGCGGTGTGCGACCGCGCGTTCTCGCGCGCGGTGGAAGGCTTCGACCTGTCCGACGAGCGG
CCCGCGCTCGCGACGCTGCGCCTTGCCGCGTCGCACTATCTGCACCAGTGCGGCGAGCCCGGCTCGATGCAGCGCGTGCT
CGAGATCCTCTATATGAAATGCGAGCAGAGCGAAGAGAACGCGCCGCTGATGCGCCGGCGCGCGCTCTACGAACTGCAGA
CGCTGCGCATCGCGAAGGCGCTGCTGCGCCGCGCGGTCGCCGCGGGCGAGCTCGACGCGTCGCTCGACGTGCACCTCGCG
GGCGTCTATCTGCTGTCGCTGCTCGAAGGCATCTTCGGCTCGATGATCTGGACCACCCGGCTGCGCGGCGATCGCTGGCG
TGACGCCGAGGCAATGCTCGACGCGGGCGTCGACACGCTGCGCGCGTCGCCCGCGCTGCGCGTGGCCGAGGCTTGCGCGG
CGCGCGGATTGCCGCGCGCAAACGTGCACTGA

Upstream 100 bases:

>100_bases
TCGGGGCGATCGATTATAATCAGTCACGATTGATTAAATAATGTCGCCCAATATATTGTCGTAAGAAAGCGACACGCATT
CGTAAGGGAGCACCACCCCC

Downstream 100 bases:

>100_bases
ACGCGCACTGAACGCGCATCGAGCACGCATTGAGCACGCATTGAGCGCGTGGGGCATCCGCCCCTACATAAAAACGTCAA
ATTGCGAGGAACAATTGCGC

Product: regulator AmrR

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MARKTREESLNTKNRILDAAELVLLEKGVGQTAMADIAEAAGMSRGAVYGHFNGKIEVCVAVCDRAFSRAVEGFDLSDER
PALATLRLAASHYLHQCGEPGSMQRVLEILYMKCEQSEENAPLMRRRALYELQTLRIAKALLRRAVAAGELDASLDVHLA
GVYLLSLLEGIFGSMIWTTRLRGDRWRDAEAMLDAGVDTLRASPALRVAEACAARGLPRANVH

Sequences:

>Translated_223_residues
MARKTREESLNTKNRILDAAELVLLEKGVGQTAMADIAEAAGMSRGAVYGHFNGKIEVCVAVCDRAFSRAVEGFDLSDER
PALATLRLAASHYLHQCGEPGSMQRVLEILYMKCEQSEENAPLMRRRALYELQTLRIAKALLRRAVAAGELDASLDVHLA
GVYLLSLLEGIFGSMIWTTRLRGDRWRDAEAMLDAGVDTLRASPALRVAEACAARGLPRANVH
>Mature_222_residues
ARKTREESLNTKNRILDAAELVLLEKGVGQTAMADIAEAAGMSRGAVYGHFNGKIEVCVAVCDRAFSRAVEGFDLSDERP
ALATLRLAASHYLHQCGEPGSMQRVLEILYMKCEQSEENAPLMRRRALYELQTLRIAKALLRRAVAAGELDASLDVHLAG
VYLLSLLEGIFGSMIWTTRLRGDRWRDAEAMLDAGVDTLRASPALRVAEACAARGLPRANVH

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789664, Length=203, Percent_Identity=28.0788177339901, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786669, Length=180, Percent_Identity=27.2222222222222, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24437; Mature: 24305

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTREESLNTKNRILDAAELVLLEKGVGQTAMADIAEAAGMSRGAVYGHFNGKIEVCV
CCCCCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHH
AVCDRAFSRAVEGFDLSDERPALATLRLAASHYLHQCGEPGSMQRVLEILYMKCEQSEEN
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
APLMRRRALYELQTLRIAKALLRRAVAAGELDASLDVHLAGVYLLSLLEGIFGSMIWTTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGDRWRDAEAMLDAGVDTLRASPALRVAEACAARGLPRANVH
HCCCCCHHHHHHHHHCHHHHHCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ARKTREESLNTKNRILDAAELVLLEKGVGQTAMADIAEAAGMSRGAVYGHFNGKIEVCV
CCCCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHH
AVCDRAFSRAVEGFDLSDERPALATLRLAASHYLHQCGEPGSMQRVLEILYMKCEQSEEN
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCC
APLMRRRALYELQTLRIAKALLRRAVAAGELDASLDVHLAGVYLLSLLEGIFGSMIWTTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGDRWRDAEAMLDAGVDTLRASPALRVAEACAARGLPRANVH
HCCCCCHHHHHHHHHCHHHHHCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]