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The map label for this gene is kgtP [H]

Identifier: 237812156

GI number: 237812156

Start: 1843391

End: 1844695

Strand: Direct

Name: kgtP [H]

Synonym: GBP346_A1902

Alternate gene names: 237812156

Gene position: 1843391-1844695 (Clockwise)

Preceding gene: 237812155

Following gene: 237812157

Centisome position: 44.98

GC content: 66.9

Gene sequence:

>1305_bases
ATGAATGACCAGACCGCCGTCGCCGCCGCTGCGCGGCAGGACGTCCGACGCCGCGTGCTCGCGATCGTCGGCGCTTCGTC
GGGCAACCTCGTCGAGTGGTTCGACTTCTACATCTACTCGTTCTGCGCGCTGTATTTCGCGCCCGCGTTTTTCCCGAGCG
GGAACACGACCACGCAGCTTCTCAACACCGCGGGCGTGTTCGCCGCGGGCTTCCTGATGCGGCCGATCGGCGGCTGGTTG
TTCGGCCGGATCGCCGACAAGCACGGCCGGCGCGCCGCGATGATGATCTCGGTGCTGATGATGTGCGGCGGCTCGCTCGT
GATCGCGGTGCTGCCGACGTATGCGCAGATCGGCGCGCTCGCGCCGTTGCTGCTGCTCGTCGCACGGCTGTTCCAGGGGC
TCTCGGTGGGCGGCGAGTACGGCACGAGCGCGACGTACATGAGCGAGGTCGCGCTCCAGGGCCGGCGCGGCTTCTTCGCG
TCGTTCCAGTACGTGACGCTGATCGGCGGCCAGCTCTGCGCGCTGCTCGTGCTCGTGATCCTGCAGCAGACGCTTTCGAG
CGACGCGCTCAAGGCTTGGGGGTGGCGGATTCCGTTCGTCGTCGGCGCGGCGGCCGCGCTGATCTCGCTGTATCTGCGCA
AGTCGCTCGACGAGACGTCGACGAGCGAATCGCGCAAGGCGAAGGACGCCGGCACGATCCGCGGCGTGTGGCAGCACAAG
GGCGCGTTCCTGACGGTGGTCGGCTTCACGGCGGGCGGCTCGCTGATCTTCTACACGTTCACGACCTACATGCAGAAGTA
CCTCGTCAACACGGCCGGCATGCATGCGAAGACGGCGAGCAACGTGATGACGGCCGCGCTCTTCGTCTACATGCTGATGC
AGCCGGTGTTCGGCGCGCTGTCCGACAAGATCGGCCGCCGCATGTCGATGATCCTGTTCGGCACGGGCGCCGTGATCGGC
ACGGTGCCGCTGATGCATGCGCTGGGCGGCGTGACGAGCCCGCTCGCCGCATTCGGGCTGATCGTCGTCGCGCTCGCGAT
CGTCAGCTTCTACACGTCGATCAGCGGCCTCATCAAGGCCGAAATGTTTCCGCCCGAGGTGCGCGCGATGGGCGTCGGCC
TGTCGTACGCGGTCGCCAACGCGATCTTCGGCGGCTCGGCCGAATATGTCGCGCTGTGGTTCAAGTCGGTCGGCAGCGAA
TCGAGCTTCTACTGGTACGTGACCGTGCTCTGCGCGATCTCGCTGCTCGTGTCGTGGCGGATGCGCGATCCGAGCCGGGA
AGGCTACCTGCGCAACGAGCCCTGA

Upstream 100 bases:

>100_bases
GCCACGCCAAGGTGGAACCGGTATCACCGCGTGCGTTTCACAAGAAGGCGGCAACCGTCACCGCCAGGCCATCCAGAGAA
CTTCAAGGAACAGACCATCC

Downstream 100 bases:

>100_bases
GCGCGGCTCGGCCGCGCGGCGGGCGGCGTCCGGTTCGGCGCCCGCCGCGCGGCGCGTTTGCCGGGCGCGGCCGGGGGCTC
GCGCCGCGCATGCAGACGGC

Product: alpha-ketoglutarate permease

Products: Proton [Cytoplasm]; 2-oxoglutarate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNDQTAVAAAARQDVRRRVLAIVGASSGNLVEWFDFYIYSFCALYFAPAFFPSGNTTTQLLNTAGVFAAGFLMRPIGGWL
FGRIADKHGRRAAMMISVLMMCGGSLVIAVLPTYAQIGALAPLLLLVARLFQGLSVGGEYGTSATYMSEVALQGRRGFFA
SFQYVTLIGGQLCALLVLVILQQTLSSDALKAWGWRIPFVVGAAAALISLYLRKSLDETSTSESRKAKDAGTIRGVWQHK
GAFLTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMHAKTASNVMTAALFVYMLMQPVFGALSDKIGRRMSMILFGTGAVIG
TVPLMHALGGVTSPLAAFGLIVVALAIVSFYTSISGLIKAEMFPPEVRAMGVGLSYAVANAIFGGSAEYVALWFKSVGSE
SSFYWYVTVLCAISLLVSWRMRDPSREGYLRNEP

Sequences:

>Translated_434_residues
MNDQTAVAAAARQDVRRRVLAIVGASSGNLVEWFDFYIYSFCALYFAPAFFPSGNTTTQLLNTAGVFAAGFLMRPIGGWL
FGRIADKHGRRAAMMISVLMMCGGSLVIAVLPTYAQIGALAPLLLLVARLFQGLSVGGEYGTSATYMSEVALQGRRGFFA
SFQYVTLIGGQLCALLVLVILQQTLSSDALKAWGWRIPFVVGAAAALISLYLRKSLDETSTSESRKAKDAGTIRGVWQHK
GAFLTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMHAKTASNVMTAALFVYMLMQPVFGALSDKIGRRMSMILFGTGAVIG
TVPLMHALGGVTSPLAAFGLIVVALAIVSFYTSISGLIKAEMFPPEVRAMGVGLSYAVANAIFGGSAEYVALWFKSVGSE
SSFYWYVTVLCAISLLVSWRMRDPSREGYLRNEP
>Mature_434_residues
MNDQTAVAAAARQDVRRRVLAIVGASSGNLVEWFDFYIYSFCALYFAPAFFPSGNTTTQLLNTAGVFAAGFLMRPIGGWL
FGRIADKHGRRAAMMISVLMMCGGSLVIAVLPTYAQIGALAPLLLLVARLFQGLSVGGEYGTSATYMSEVALQGRRGFFA
SFQYVTLIGGQLCALLVLVILQQTLSSDALKAWGWRIPFVVGAAAALISLYLRKSLDETSTSESRKAKDAGTIRGVWQHK
GAFLTVVGFTAGGSLIFYTFTTYMQKYLVNTAGMHAKTASNVMTAALFVYMLMQPVFGALSDKIGRRMSMILFGTGAVIG
TVPLMHALGGVTSPLAAFGLIVVALAIVSFYTSISGLIKAEMFPPEVRAMGVGLSYAVANAIFGGSAEYVALWFKSVGSE
SSFYWYVTVLCAISLLVSWRMRDPSREGYLRNEP

Specific function: Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788942, Length=414, Percent_Identity=71.4975845410628, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1790550, Length=416, Percent_Identity=28.125, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1788292, Length=418, Percent_Identity=29.6650717703349, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789941, Length=424, Percent_Identity=31.8396226415094, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082231, Length=317, Percent_Identity=27.1293375394322, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082404, Length=313, Percent_Identity=26.517571884984, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 46695; Mature: 46695

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 2-oxoglutarate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 2-oxoglutarate [Periplasm] = Proton [Cytoplasm] + 2-oxoglutarate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118499; 9205837; 9278503; 1709493; 2190187; 2053984; 8419306 [H]