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The map label for this gene is cbl [H]

Identifier: 237812142

GI number: 237812142

Start: 1827873

End: 1828799

Strand: Direct

Name: cbl [H]

Synonym: GBP346_A1888

Alternate gene names: 237812142

Gene position: 1827873-1828799 (Clockwise)

Preceding gene: 237812141

Following gene: 237812143

Centisome position: 44.6

GC content: 65.8

Gene sequence:

>927_bases
ATGAATTTCCAACAGTTGCGCTTCGTGCGCGAAGCGGTGCGGCAGAACATGAACCTGACGGAAGTCGCGAACGTGCTGTA
CACGTCGCAGTCGGGCGTGTCCAAGCAGATCAAGGATCTGGAGGACGAGCTCGGCGTCGACATCTTCATTCGCCGCGGCA
AGCGCCTCACGGGGCTGACCGAGCCCGGCAAGGCGGTTCATCAATTGATCGAGCGGATGCTGCTCGACGCGGAGAACCTG
CGCCGCGTCGCGCGCCAGTTCGCGGACCAGGACAGCGGCCACCTCGTCGTCGCGACGACGCACACGCAGGCGCGCTACGC
GCTGCCGAAGGTGATCCGCCAGTTCACCGAGGTCTACCCGAAGGTGCATCTCGCGCTGCGCCAGGGCAGCCCGCAGCAGA
TCGCGCAGATGATCCTGAACGGCGAGGCGGATCTCGGCATCTCGACCGAGGCGCTCGACCGCTTTCCGGATATCGTCACG
TTCCCGTGCTATTCGTGGCATCACGTCGTCGTCGTGCCGAAGGGGCATCCGCTCGTCGGCCGCGAGAACGTGACGCTCGA
CGACATCGCCGAATATCCGATCATCACCTACGACCAGGATTTCACCGGCCGCTCGCACATCGACCAGGCGTTCGCGAACG
CGGGCGCGGTGCCGGACGTCGTGCTGACGGCGATCGACGCGGACGTGATCAAGACCTACGTCGAGCTCGGGATGGGGATC
GGCGTCGTCGCCGCGATGGCGTATGACGCGCAGCGCGACACCGGGCTCGTCGCGCTCGATACGCAGCATCTGTTCGAGGC
GAGCACGACGCGCGTCGGCCTGCGTCGCGGCGCGTTCCTGCGCGCGTATGCGTACCGGTTGATCGAGATGTTCGCGCCGC
ATCTGTCCGAAGGCGAGATCGCGGGGCAATTGCGGGAAGCGGCCTGA

Upstream 100 bases:

>100_bases
GCGCGCGGTGCGCGTGTTCCCGGCGCGCTGACGACGCTCCCGCGAGCGACTCGCGCATGCGGATTTCAGACCAACAAAGA
CATCGCCTGAGAGGCTACCC

Downstream 100 bases:

>100_bases
GCGGAAGCGCCGGGGGGCGGGCGACGGCGGGCGTCGAGCCGGCCGCTTGGCCGTTTGAAACCTCGCCGCCGCGCCGGCGC
GAACCGGCGCGGATGTCTCC

Product: transcriptional regulator CysB-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLTEPGKAVHQLIERMLLDAENL
RRVARQFADQDSGHLVVATTHTQARYALPKVIRQFTEVYPKVHLALRQGSPQQIAQMILNGEADLGISTEALDRFPDIVT
FPCYSWHHVVVVPKGHPLVGRENVTLDDIAEYPIITYDQDFTGRSHIDQAFANAGAVPDVVLTAIDADVIKTYVELGMGI
GVVAAMAYDAQRDTGLVALDTQHLFEASTTRVGLRRGAFLRAYAYRLIEMFAPHLSEGEIAGQLREAA

Sequences:

>Translated_308_residues
MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLTEPGKAVHQLIERMLLDAENL
RRVARQFADQDSGHLVVATTHTQARYALPKVIRQFTEVYPKVHLALRQGSPQQIAQMILNGEADLGISTEALDRFPDIVT
FPCYSWHHVVVVPKGHPLVGRENVTLDDIAEYPIITYDQDFTGRSHIDQAFANAGAVPDVVLTAIDADVIKTYVELGMGI
GVVAAMAYDAQRDTGLVALDTQHLFEASTTRVGLRRGAFLRAYAYRLIEMFAPHLSEGEIAGQLREAA
>Mature_308_residues
MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLTEPGKAVHQLIERMLLDAENL
RRVARQFADQDSGHLVVATTHTQARYALPKVIRQFTEVYPKVHLALRQGSPQQIAQMILNGEADLGISTEALDRFPDIVT
FPCYSWHHVVVVPKGHPLVGRENVTLDDIAEYPIITYDQDFTGRSHIDQAFANAGAVPDVVLTAIDADVIKTYVELGMGI
GVVAAMAYDAQRDTGLVALDTQHLFEASTTRVGLRRGAFLRAYAYRLIEMFAPHLSEGEIAGQLREAA

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=308, Percent_Identity=54.2207792207792, Blast_Score=350, Evalue=8e-98,
Organism=Escherichia coli, GI1787530, Length=296, Percent_Identity=49.6621621621622, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI157672245, Length=225, Percent_Identity=31.1111111111111, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788887, Length=259, Percent_Identity=29.3436293436293, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788481, Length=258, Percent_Identity=26.3565891472868, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1790399, Length=298, Percent_Identity=25.503355704698, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI2367136, Length=241, Percent_Identity=24.0663900414938, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789204, Length=246, Percent_Identity=25.609756097561, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790208, Length=224, Percent_Identity=28.125, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693105, Length=241, Percent_Identity=24.0663900414938, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787806, Length=282, Percent_Identity=23.0496453900709, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87082132, Length=122, Percent_Identity=34.4262295081967, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790262, Length=256, Percent_Identity=23.4375, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787601, Length=189, Percent_Identity=26.4550264550265, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34297; Mature: 34297

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLT
CCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCC
EPGKAVHQLIERMLLDAENLRRVARQFADQDSGHLVVATTHTQARYALPKVIRQFTEVYP
CCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
KVHLALRQGSPQQIAQMILNGEADLGISTEALDRFPDIVTFPCYSWHHVVVVPKGHPLVG
HHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCCCCEEEEEEECCCCCCC
RENVTLDDIAEYPIITYDQDFTGRSHIDQAFANAGAVPDVVLTAIDADVIKTYVELGMGI
CCCCCHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCH
GVVAAMAYDAQRDTGLVALDTQHLFEASTTRVGLRRGAFLRAYAYRLIEMFAPHLSEGEI
HHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
AGQLREAA
HHHHHHCC
>Mature Secondary Structure
MNFQQLRFVREAVRQNMNLTEVANVLYTSQSGVSKQIKDLEDELGVDIFIRRGKRLTGLT
CCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCC
EPGKAVHQLIERMLLDAENLRRVARQFADQDSGHLVVATTHTQARYALPKVIRQFTEVYP
CCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
KVHLALRQGSPQQIAQMILNGEADLGISTEALDRFPDIVTFPCYSWHHVVVVPKGHPLVG
HHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEECCCCCEEEEEEECCCCCCC
RENVTLDDIAEYPIITYDQDFTGRSHIDQAFANAGAVPDVVLTAIDADVIKTYVELGMGI
CCCCCHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCH
GVVAAMAYDAQRDTGLVALDTQHLFEASTTRVGLRRGAFLRAYAYRLIEMFAPHLSEGEI
HHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
AGQLREAA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]