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The map label for this gene is fsr [H]

Identifier: 237811977

GI number: 237811977

Start: 1663657

End: 1664910

Strand: Reverse

Name: fsr [H]

Synonym: GBP346_A1717

Alternate gene names: 237811977

Gene position: 1664910-1663657 (Counterclockwise)

Preceding gene: 237811979

Following gene: 237811974

Centisome position: 40.62

GC content: 67.07

Gene sequence:

>1254_bases
ATGGAAACCAGCCTCGACAACCGCCCGTCCGTTGCCCGTGCCGCCGCGTCGCCCGCGCCGGCCGCCGCCGTCTCGCGCAC
CGTCTACCCGGTGCTCGGCGCGATCAGCTTCTCGCATCTGCTCAACGACATGATCCAGTCGCTGATCCTCGCGATCTATC
CGATGCTGAAATCGGAATTCTCGCTGTCGTTCGCGCAGATCGGCCTCATCACGCTCACGTACCAGATCACCGCGTCACTG
CTGCAGCCCGTGATCGGCTTGTACACGGACAAGCGTCCGCAGCCGTTCTCGCTGCCCGTCGGCATGGGCTTCACGCTCAC
CGGCCTGCTGCTGATGGCGTTCGCGCCGACGTTCCCGTTCCTGCTCGTCGCGGCCGCGCTCGTCGGCTGCGGCTCATCGG
TGTTTCACCCGGAATCGTCGCGCGTCGCGCGGATGGCGTCGGGCGGCCGGCACGGGCTCGCGCAATCGCTGTTCCAGGTC
GGCGGCAACGCCGGCTCGTCGCTCGGGCCGCTGCTCGCCGCGCTGATCGTGATCCCGCACGGCCAGCGCAGCATCGCGTG
GTTTTCGGCCGCGGCGCTCGTCGCGATCTTCGTGCTCGTCCAGATCGGCCGCTGGTATCGGCGCCATCCGGCCGCGAAGA
AGAAGGCCGCACACGCCGCGCATCCGACGCTGTCGCGCCGGCAGGTCGGGCTCGCGCTCGGCGTGCTCGTGATGCTCGTG
TTCTCGAAGTACTTCTATCTGGCGAGCATCAACAGCTATTTCACGTTCTATCTGATCGACAAGTTCCACCTGTCGGTGCA
GGCCGCGCAGATCCACCTGTTCGTGTTCCTCGCGGCCGTCGCGGCGGGCACGATCATCGGCGGGCCCGTCGGCGACCGGA
TCGGGCGCAAGTACGTGATCTGGACGTCGATTCTCGGCGTCGCGCCGTTCACGCTGATGCTGCCGTATGCGAATCTGTTC
TGGACCACGGTGCTGACCATCGTGATCGGCGTCGTGCTCGCATCGGCGTTCGCGGCGATCATCGTCTACGGCCAGGAGCT
GATTCCGGGCAAGGTCGGCACGGTCGCCGGGCTCTTTTTCGGCCTGTCGTTCGGCCTCGGCGGCGTCGGCGCGGCAGTGC
TCGGCCAGCTCGCCGACGCGACGAGCATCGCGTTCGTCTACAAGATCTGCTCGTTCCTGCCGCTGATCGGCGTGCTGACG
GTGTTCCTGCCGAACGTCGAGGGCAGGACGACGCTCGACAAGCAACGCGCCTGA

Upstream 100 bases:

>100_bases
TGCCGATGAGACACATTACACTTCGTTGACCCATCAAAGAAAAACACGTGCCGTGCCCTGCCGGGGCACGCAGCGCCCCT
TCCGAGACACTCGCATTCCT

Downstream 100 bases:

>100_bases
CGGGGGCGCGCGATCCGCGCGGCCGCCCGCGAACGGGGGCGGCTTCGGGGGCCTCGGCGGCCCGAGCGGTCCGGCCGCTT
GGTGACTTGGTGACTTGGTG

Product: fosmidomycin resistance protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
METSLDNRPSVARAAASPAPAAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLKSEFSLSFAQIGLITLTYQITASL
LQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPTFPFLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQV
GGNAGSSLGPLLAALIVIPHGQRSIAWFSAAALVAIFVLVQIGRWYRRHPAAKKKAAHAAHPTLSRRQVGLALGVLVMLV
FSKYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRKYVIWTSILGVAPFTLMLPYANLF
WTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAGLFFGLSFGLGGVGAAVLGQLADATSIAFVYKICSFLPLIGVLT
VFLPNVEGRTTLDKQRA

Sequences:

>Translated_417_residues
METSLDNRPSVARAAASPAPAAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLKSEFSLSFAQIGLITLTYQITASL
LQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPTFPFLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQV
GGNAGSSLGPLLAALIVIPHGQRSIAWFSAAALVAIFVLVQIGRWYRRHPAAKKKAAHAAHPTLSRRQVGLALGVLVMLV
FSKYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRKYVIWTSILGVAPFTLMLPYANLF
WTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAGLFFGLSFGLGGVGAAVLGQLADATSIAFVYKICSFLPLIGVLT
VFLPNVEGRTTLDKQRA
>Mature_417_residues
METSLDNRPSVARAAASPAPAAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLKSEFSLSFAQIGLITLTYQITASL
LQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPTFPFLLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQV
GGNAGSSLGPLLAALIVIPHGQRSIAWFSAAALVAIFVLVQIGRWYRRHPAAKKKAAHAAHPTLSRRQVGLALGVLVMLV
FSKYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRKYVIWTSILGVAPFTLMLPYANLF
WTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAGLFFGLSFGLGGVGAAVLGQLADATSIAFVYKICSFLPLIGVLT
VFLPNVEGRTTLDKQRA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=406, Percent_Identity=67.2413793103448, Blast_Score=503, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44229; Mature: 44229

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METSLDNRPSVARAAASPAPAAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLKSEF
CCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLSFAQIGLITLTYQITASLLQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPTFPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNAGSSLGPLLAALIVIPH
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
GQRSIAWFSAAALVAIFVLVQIGRWYRRHPAAKKKAAHAAHPTLSRRQVGLALGVLVMLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FSKYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRKYVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCEEHH
WTSILGVAPFTLMLPYANLFWTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAGLFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GLSFGLGGVGAAVLGQLADATSIAFVYKICSFLPLIGVLTVFLPNVEGRTTLDKQRA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
METSLDNRPSVARAAASPAPAAAVSRTVYPVLGAISFSHLLNDMIQSLILAIYPMLKSEF
CCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLSFAQIGLITLTYQITASLLQPVIGLYTDKRPQPFSLPVGMGFTLTGLLLMAFAPTFPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LLVAAALVGCGSSVFHPESSRVARMASGGRHGLAQSLFQVGGNAGSSLGPLLAALIVIPH
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
GQRSIAWFSAAALVAIFVLVQIGRWYRRHPAAKKKAAHAAHPTLSRRQVGLALGVLVMLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FSKYFYLASINSYFTFYLIDKFHLSVQAAQIHLFVFLAAVAAGTIIGGPVGDRIGRKYVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCEEHH
WTSILGVAPFTLMLPYANLFWTTVLTIVIGVVLASAFAAIIVYGQELIPGKVGTVAGLFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GLSFGLGGVGAAVLGQLADATSIAFVYKICSFLPLIGVLTVFLPNVEGRTTLDKQRA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]