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The map label for this gene is uvrD [H]

Identifier: 237811975

GI number: 237811975

Start: 1660075

End: 1662438

Strand: Direct

Name: uvrD [H]

Synonym: GBP346_A1715

Alternate gene names: 237811975

Gene position: 1660075-1662438 (Clockwise)

Preceding gene: 237811972

Following gene: 237811976

Centisome position: 40.5

GC content: 69.04

Gene sequence:

>2364_bases
ATGCCCGATCTGCTCGCGAACCTGAACCCCGAACAACTCGCCGCCGTCACGTTGCCGAACGAGCCGGCGCTGATCCTCGC
CGGGGCGGGCAGCGGCAAGACCCGCGTGCTCATCACGCGGATCGCGTGGCTGATCCGGCAAGGCTATGCGTCGCCCGCCA
CCGTGCTCGCCGTCACGTTCACGAACAAGGCCGCGCGCGAGATGATGGCGCGCCTGTCCGCGATGATGCCGATCGACACG
CGCGGCATGTGGATCGGCACGTTCCACGGCCTGTGCAACCGGATGCTGCGCGCGCACTACCGCGACGCGGGGCTGCCGCA
GACGTTCCAGATCCTCGATACCGCCGACCAGCTCTCCGCGATCAAGCGGCTGATGAAGGCGGCGAACGTCGACGACGAGA
AGTACCCGCCGAAGAACGTCCAGTACTTCATCAACAACGCGAAGGAGCAGGGGCTGCGCCCCGAGAAGGTCGACGCGACC
GACAGCTTCAACCGCAAGTTCGTCGAGCTGTACCAGGCGTACGAGCAGCAGTGCCAGCGCGAGGGCGTCGTCGATTTCCC
CGAGCTGCTGTTGCGCTGCTACGAGTTGCTCGCGCACAACCCGCCGCTGCGCGCGCACTACCAGGCGCGCTTCAAGCACA
TCCTCGTCGACGAGTTCCAGGATACGAACAAGCTGCAGTACGCGTGGCTCAAGCTCCTCGCGGGCGGCCACAACGCGATC
TTCGCGGTCGGCGACGACGACCAGTCGATCTATGCGTTTCGCGGCGCGAACGTCGGCAACATGCGCGATTTCGAGCACGA
ATTCCGCGTGCGCAACCTGATCAAGCTCGAGCAGAACTACCGCTCGCACGGCAACATCCTCGACGCGGCGAACCACCTGA
TCGCGAACAACGCGCACCGGCTCGGCAAGAACCTGCGCACCGACGCGGGCCACGGCGAGCCCGTGCGCGTGTACGAAGCG
GCCACCGACGCGCAGGAAGCGGCGTGGATCGTCGAGGAGATCCGCTCGCTCGTGAACGCGGGGCTCGCGCGCAGCGAGGT
GGCGGTGCTGTACCGGAGCAACGCGCAGTCGCGCTCGATCGAGCACACGCTGATGACGGCGGGCATCGCGTACCGCGTGT
ACGGCGGCCTGCGCTTCTTCGAGCGCCAGGAGGTGAAGCACGCGCTCGCGTATCTGCGCCTCATCGACAATCCGAACGAC
GACACCGCGTTCGCGCGCGTCGTCAACTTTCCGACGCGCGGCATCGGCGCGCGCTCGATCGAGCAGCTCGCCGACGCGGC
GCGCCTGTACGACTGCTCGATGGCGGCCGCGATTCCGTACGTGGCGGGCAAGGCGGGCTCGAGCCTGGCGTCGTTCGCGA
ACCTGATCGCGAAGATGCGTGCGGAGACCGCGCGGATGAGCCTGCCCGAGACGGTCGAGCACGTCGTGCGCGCGAGCGGC
CTCGCCGATTTCTACCAGGGCGAGCGCGAAGGGCAGGATCGCCTCGAGAACCTGCAGGAACTGGTGAACGCGGCCACCGC
GTTCGTCTCCGAGGAGGGCTACGGGCTCGACACGCCCGCGCGCTCGATTCCGCTGCATGCGCGCGCGAGCGCGGCGCCGG
AGCTCGCCGCGGGCGGCGCCGATCCGGCCGACGCGGTGCTCGCGCCCGCGAACCTCGCCGATCCCGCGCAGAACCCGGAC
GCGATGACGCCGCTCGCCGGCTTCCTGTCGCACGCGTCGCTGGAGGCGGGCGACAACCAGGCGCAGGCGGGCCAGGACGC
GGTGCAACTGATGACGGTCCACGCGGCGAAGGGGCTCGAGTTCACCGCGGTGTTCATCACCGGGCTCGAGGAAGGGCTCT
TCCCGCACGAGAACAGCGCGCTCGAATCCGACGGCCTCGAAGAGGAACGCCGGCTGATGTACGTCGCGATCACGCGCGCC
AAGGAGCGGCTCTACCTGTCGTTCGCGCAGAGCCGGATGCTGCACGGCCAGACCCGCTACAACATCCGCTCGCGCTTTTT
CGACGAGCTGCCGCAGCACGTGCTCAAGTGGCTCACGCCGAAGGTCGAGGCGGGCGCCCGCTGGGGCGGCCGCTCGGACA
ACGCCGGCTGGGGCCGCGACTGGTTCGCGCGGCCGGGCGGCGGCGCGCGGCAGGGCGTGGTCGACGCGGCGGTGTCCGCG
CCGCTGCCCGCGTTCGCGAACCAGCAGCGCGAGGCGCAGAACGGCTTGCGGATCGGCCAGCAGGTGTTCCACACGAAGTT
CGGCGAAGGCACGGTGACGGCGCTCGAAGGCAGCGGCACCGACGCGAAGGCGCAAGTCAAATTCAAGCGGCACGGCGAGA
AGTGGCTCGCGCTCGCGGTCGCGAAACTGCAGGCGGTCGAATGA

Upstream 100 bases:

>100_bases
ACCTTCGATTATAAATGGATGAGCATCCCCCTGGGCGGCGCGGGCCGCGCGCGATTTATAATGTCGGGTCCGCGTCCACC
CGCCCGACCGCTTTCTCTCC

Downstream 100 bases:

>100_bases
ATCAGCAGACGTTTTTCGATCGGCCGCTCGGCATTCTCGCCGCGCTGCCGGAGGAGCTGGGCGACCTCGTCGCGGCGATG
CGCGACGACGGGCCCGTCGA

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 787; Mature: 786

Protein sequence:

>787_residues
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIRQGYASPATVLAVTFTNKAAREMMARLSAMMPIDT
RGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPEKVDAT
DSFNRKFVELYQAYEQQCQREGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAI
FAVGDDDQSIYAFRGANVGNMRDFEHEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHRLGKNLRTDAGHGEPVRVYEA
ATDAQEAAWIVEEIRSLVNAGLARSEVAVLYRSNAQSRSIEHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSIEQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETARMSLPETVEHVVRASG
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGADPADAVLAPANLADPAQNPD
AMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFTAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGGGARQGVVDAAVSA
PLPAFANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAVAKLQAVE

Sequences:

>Translated_787_residues
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIRQGYASPATVLAVTFTNKAAREMMARLSAMMPIDT
RGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPEKVDAT
DSFNRKFVELYQAYEQQCQREGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAI
FAVGDDDQSIYAFRGANVGNMRDFEHEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHRLGKNLRTDAGHGEPVRVYEA
ATDAQEAAWIVEEIRSLVNAGLARSEVAVLYRSNAQSRSIEHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSIEQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETARMSLPETVEHVVRASG
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGADPADAVLAPANLADPAQNPD
AMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFTAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGGGARQGVVDAAVSA
PLPAFANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAVAKLQAVE
>Mature_786_residues
PDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIRQGYASPATVLAVTFTNKAAREMMARLSAMMPIDTR
GMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPEKVDATD
SFNRKFVELYQAYEQQCQREGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAIF
AVGDDDQSIYAFRGANVGNMRDFEHEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHRLGKNLRTDAGHGEPVRVYEAA
TDAQEAAWIVEEIRSLVNAGLARSEVAVLYRSNAQSRSIEHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDD
TAFARVVNFPTRGIGARSIEQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETARMSLPETVEHVVRASGL
ADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGADPADAVLAPANLADPAQNPDA
MTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFTAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRAK
ERLYLSFAQSRMLHGQTRYNIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGGGARQGVVDAAVSAP
LPAFANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAVAKLQAVE

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=792, Percent_Identity=45.2020202020202, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=684, Percent_Identity=35.3801169590643, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1787196, Length=342, Percent_Identity=28.6549707602339, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=762, Percent_Identity=28.2152230971129, Blast_Score=223, Evalue=9e-59,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 86680; Mature: 86549

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00579 RIBOSOMAL_L29

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIRQGYASPATVLAVTF
CCCCCCCCCHHHEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPEKVDATDSFNRKFVELYQAYEQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFEHEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHR
EEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LGKNLRTDAGHGEPVRVYEAATDAQEAAWIVEEIRSLVNAGLARSEVAVLYRSNAQSRSI
HCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCHHHH
EHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETARMSLPETVEHVVRASG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGA
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCC
DPADAVLAPANLADPAQNPDAMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLE
CCHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHCCCE
FTAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEEHHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGGGARQGVVDAAVSA
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
PLPAFANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHCCHHHHHHHH
AKLQAVE
HHHHHCC
>Mature Secondary Structure 
PDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIRQGYASPATVLAVTF
CCCCCCCCHHHEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPEKVDATDSFNRKFVELYQAYEQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFEHEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHR
EEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LGKNLRTDAGHGEPVRVYEAATDAQEAAWIVEEIRSLVNAGLARSEVAVLYRSNAQSRSI
HCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCHHHH
EHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETARMSLPETVEHVVRASG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGA
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCC
DPADAVLAPANLADPAQNPDAMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLE
CCHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHCCCE
FTAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEEHHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGGGARQGVVDAAVSA
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
PLPAFANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHCCHHHHHHHH
AKLQAVE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]