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The map label for this gene is phoP [H]

Identifier: 237811863

GI number: 237811863

Start: 1539423

End: 1540118

Strand: Direct

Name: phoP [H]

Synonym: GBP346_A1603

Alternate gene names: 237811863

Gene position: 1539423-1540118 (Clockwise)

Preceding gene: 237811862

Following gene: 237811864

Centisome position: 37.56

GC content: 65.52

Gene sequence:

>696_bases
GTGGTGCTTATTTACCTGATCGAGGACGACGAGGTCCAGGCGCGGTGTTACGCGGCCATCCTGCAGCATGCCGGTTACAG
CGTGCGCGTCCTGCCGGACGGCGAGCGCGCGTTGCGCGAGATACAGCGCGCGGCGCCCGACCTGATCGTGCTGGACCGGC
GCCTGCCGGACATCGACGGCCTGGAGATCATCGCGTGGGTGCGCGAGCGCTGCGCGCCGCTGCCGATACTCGTGCTGACC
AACGCGGTGCTCGAGACCGATCTCGTCGAAGCGCTCGAGGCGGGCGCCGACGACTATCTGATCAAGCCGCCACGAGAACG
GGAATTCGTTGCCCGCGTCAATGCGCTTCGCCGCCGCGCGAGCATCAGCAAGCAATTCGAAGGCACGATCGAAATCGGCG
GCTACCGGATCGCGACCGTCGAGCGCGCCGTCTATCTCGCGGGCGAGCGCATTCCGTTGTCGCCGAAGGAGTACGAGATC
GTCGAGTTGCTCGCGCGGCACGTCGGGCAGGTCGTGCCGCGCAAGACCATCATCAGCCGCGTCTGGGGGCGCGCGGCCGA
GGAGGAAGTTTCCCGCTCGCTCGACACCCACATCTACCGCATCCGCAGGAAGATGAATCTGTCGCGCCGCAATGGCGCGA
TGCTTCGCGTCATCTATACGCATGGATTCCGGCTGGACGATTTTAGCCATGTGTGA

Upstream 100 bases:

>100_bases
GCTGTTCAAGCAGTGCACGATCCCGGCTTGCTCGTTCCTCGAGGTTCGGGGGAGGCGGTTCGTCGGACTGCTGCGTGGTC
GCTGGTTGTCGAGACAAAAA

Downstream 100 bases:

>100_bases
TTGCTTATTCGAGATAGCGGCGCGCGTGAGACAAGTGCCGTTTCTAATTGGATGACGATATTTTTGAGATATTGAATGTG
CGGCGCGCGGCGATGGCGAG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MVLIYLIEDDEVQARCYAAILQHAGYSVRVLPDGERALREIQRAAPDLIVLDRRLPDIDGLEIIAWVRERCAPLPILVLT
NAVLETDLVEALEAGADDYLIKPPREREFVARVNALRRRASISKQFEGTIEIGGYRIATVERAVYLAGERIPLSPKEYEI
VELLARHVGQVVPRKTIISRVWGRAAEEEVSRSLDTHIYRIRRKMNLSRRNGAMLRVIYTHGFRLDDFSHV

Sequences:

>Translated_231_residues
MVLIYLIEDDEVQARCYAAILQHAGYSVRVLPDGERALREIQRAAPDLIVLDRRLPDIDGLEIIAWVRERCAPLPILVLT
NAVLETDLVEALEAGADDYLIKPPREREFVARVNALRRRASISKQFEGTIEIGGYRIATVERAVYLAGERIPLSPKEYEI
VELLARHVGQVVPRKTIISRVWGRAAEEEVSRSLDTHIYRIRRKMNLSRRNGAMLRVIYTHGFRLDDFSHV
>Mature_231_residues
MVLIYLIEDDEVQARCYAAILQHAGYSVRVLPDGERALREIQRAAPDLIVLDRRLPDIDGLEIIAWVRERCAPLPILVLT
NAVLETDLVEALEAGADDYLIKPPREREFVARVNALRRRASISKQFEGTIEIGGYRIATVERAVYLAGERIPLSPKEYEI
VELLARHVGQVVPRKTIISRVWGRAAEEEVSRSLDTHIYRIRRKMNLSRRNGAMLRVIYTHGFRLDDFSHV

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=206, Percent_Identity=33.0097087378641, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=31.0810810810811, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=33.0357142857143, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1790860, Length=204, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082012, Length=203, Percent_Identity=33.0049261083744, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=28.5067873303167, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=30.3571428571429, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1786911, Length=205, Percent_Identity=31.219512195122, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1787375, Length=204, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367329, Length=218, Percent_Identity=31.651376146789, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1787229, Length=214, Percent_Identity=34.5794392523364, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI145693140, Length=215, Percent_Identity=31.6279069767442, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=25.3275109170306, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790437, Length=100, Percent_Identity=32, Blast_Score=61, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=100, Percent_Identity=31, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26434; Mature: 26434

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLIYLIEDDEVQARCYAAILQHAGYSVRVLPDGERALREIQRAAPDLIVLDRRLPDIDG
CEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCEEEECCCCCCCCC
LEIIAWVRERCAPLPILVLTNAVLETDLVEALEAGADDYLIKPPREREFVARVNALRRRA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
SISKQFEGTIEIGGYRIATVERAVYLAGERIPLSPKEYEIVELLARHVGQVVPRKTIISR
HHHHHCCCEEEECCEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
VWGRAAEEEVSRSLDTHIYRIRRKMNLSRRNGAMLRVIYTHGFRLDDFSHV
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEECCCCCCC
>Mature Secondary Structure
MVLIYLIEDDEVQARCYAAILQHAGYSVRVLPDGERALREIQRAAPDLIVLDRRLPDIDG
CEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCEEEECCCCCCCCC
LEIIAWVRERCAPLPILVLTNAVLETDLVEALEAGADDYLIKPPREREFVARVNALRRRA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
SISKQFEGTIEIGGYRIATVERAVYLAGERIPLSPKEYEIVELLARHVGQVVPRKTIISR
HHHHHCCCEEEECCEEEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
VWGRAAEEEVSRSLDTHIYRIRRKMNLSRRNGAMLRVIYTHGFRLDDFSHV
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]