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The map label for this gene is proY [H]

Identifier: 237811668

GI number: 237811668

Start: 1351478

End: 1352842

Strand: Reverse

Name: proY [H]

Synonym: GBP346_A1405

Alternate gene names: 237811668

Gene position: 1352842-1351478 (Counterclockwise)

Preceding gene: 237811669

Following gene: 237811665

Centisome position: 33.01

GC content: 68.86

Gene sequence:

>1365_bases
ATGAAGAACTTGCAGCGCCATCTGAGCGCGCGGCACATCCGCTTTCTCGCGCTCGGCTCGGCGATCGGCACGGGCCTCTT
CTACGGCTCGGCGTCCGCGATCCGGCTGGCGGGCCCCGCCGTCATCCTCGCTTACATCGTCGGCGGCGCGGCCGTCTACA
TGGTGATGCGCGCGCTCGGCGAAATGGCGGTGCGCGAGCCCGTGCCGGGCTCGTTCGGCCACTACGCGACCGAGAACCTC
GGCCCGTTCGCGGGCTTCGTCACCGGCTGGACCTACACGCTCGAGATGGTGATCGTCGCGATCGCCGACATCACCGCGTT
CGGCATCTACATGGGCTTCTGGTTTCCGCACGTCCCGCAGTGGATCTGGGTGCTCGCGATCGTCGCGATCATCTGCGGGC
TGAACCTCTGCCACGTGAAGGTGTTCGGCGAGCTGGAGTTCTGGCTGTCGATCGTCAAGGTCGGCGCGATCGTGGCGATG
ATCGGCGGCGGCGCGGCGATCCTCTTCACCGGGATGAGGCTCGGCAGCGGCGGCGCGCCGTCGCTCGCGAACCTGTGGTC
GCACGGCGGCTTCCTGCCGAACGGCGTGGGCGGCCTCGTCGCGTCGCTGTCGGTCGTGATCTTCGCGTACGGCGGCATCG
AAGTGATCGGCATGAGCGCCGGCGAGGCGAAGGAGCCCGAGCGCGTGATCCCGCGCGCGATCAACGCGGTGCCGATGCGC
ATCCTGCTCTTCTACGTGCTGACGATGATCGTGCTGATGTCGATCTTTCCGTGGACGGGCGTCGGCGCGAACGGCAGCCC
GTTCGTGCAGATCTTCTCGGCGCTCGGCGTGCGCTCCGCGGCCGAGATCCTGAACCTCGTCGTGATCAGCGCCGCGATCT
CCGCGATCAACAGCGACATCTTCGGCGCGGGCCGAATGATGTACGCAATGGCGCTGCAGGGCCAGGCGCCGCGCGCGCTC
GCCGCGATGTCCGCGCGCGGCGTGCCGTGGGTCACGGTGCTCGTGATGGCGGGCGCGCTGCTCGTCGGCGTCGTGCTCAA
CTATCTGATGCCGAAGGACGTGTTCCTGATGGTCGCCGCGAGCGCGACGTTCGCGACCGTGTGGGTCTGGCTGATGATCC
TGCTGTCGCAGGTCGCGATGCGCCGCCGGCTCGGCGCGGCCGAGGTCGCCGCGCTGAAGTTCAAGGTGCCGTTCTGGCCC
GTCGGCCCCGCGCTCACGATCGCGTTCATGGCGTTCGTGATCGCGATGCTCGGCTACTTCGACGATACGCGCGTCGCGCT
CTTCGTCGGCGCCGCGTGGCTCGCGATCCTCGCGCTCGTGTTCTACACGCGGATCCGGCCGCGGCTCGCCGCCGTCGCGC
GCTGA

Upstream 100 bases:

>100_bases
TTGGTATGATCTATCCCGCGCCAAGTTGTCTATACAACTTCTCGAGCGCGAGCGCCGGGCCGCATCGTCCGGCCGACGAC
ACCAATCATTCGGAGACACG

Downstream 100 bases:

>100_bases
CGCGGCACACGGGCGCGGGGCGCGCCCCGCCTCCGCCACCTTCCGAACGCGGCACATCCCGGCACACCCCGGCACATCCC
GGCGCGGCCCCGCGAGGGCC

Product: proline-specific permease ProY

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALGEMAVREPVPGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPHVPQWIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAM
IGGGAAILFTGMRLGSGGAPSLANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERVIPRAINAVPMR
ILLFYVLTMIVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDIFGAGRMMYAMALQGQAPRAL
AAMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAASATFATVWVWLMILLSQVAMRRRLGAAEVAALKFKVPFWP
VGPALTIAFMAFVIAMLGYFDDTRVALFVGAAWLAILALVFYTRIRPRLAAVAR

Sequences:

>Translated_454_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALGEMAVREPVPGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPHVPQWIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAM
IGGGAAILFTGMRLGSGGAPSLANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERVIPRAINAVPMR
ILLFYVLTMIVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDIFGAGRMMYAMALQGQAPRAL
AAMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAASATFATVWVWLMILLSQVAMRRRLGAAEVAALKFKVPFWP
VGPALTIAFMAFVIAMLGYFDDTRVALFVGAAWLAILALVFYTRIRPRLAAVAR
>Mature_454_residues
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALGEMAVREPVPGSFGHYATENL
GPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPHVPQWIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAM
IGGGAAILFTGMRLGSGGAPSLANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERVIPRAINAVPMR
ILLFYVLTMIVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDIFGAGRMMYAMALQGQAPRAL
AAMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAASATFATVWVWLMILLSQVAMRRRLGAAEVAALKFKVPFWP
VGPALTIAFMAFVIAMLGYFDDTRVALFVGAAWLAILALVFYTRIRPRLAAVAR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=354, Percent_Identity=26.5536723163842, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI110347453, Length=342, Percent_Identity=27.4853801169591, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=60.6593406593407, Blast_Score=515, Evalue=1e-147,
Organism=Escherichia coli, GI1786789, Length=449, Percent_Identity=43.652561247216, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1786302, Length=453, Percent_Identity=42.6048565121413, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1790653, Length=440, Percent_Identity=39.3181818181818, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=43.3874709976798, Blast_Score=333, Evalue=2e-92,
Organism=Escherichia coli, GI87081915, Length=398, Percent_Identity=38.4422110552764, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI87081708, Length=456, Percent_Identity=37.280701754386, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1789017, Length=417, Percent_Identity=35.4916067146283, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1788480, Length=431, Percent_Identity=33.4106728538283, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI87081869, Length=193, Percent_Identity=25.3886010362694, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082023, Length=281, Percent_Identity=24.1992882562278, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532491, Length=420, Percent_Identity=25, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17540018, Length=420, Percent_Identity=24.047619047619, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=464, Percent_Identity=31.4655172413793, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=438, Percent_Identity=29.6803652968037, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6324924, Length=450, Percent_Identity=30.4444444444444, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=31.9796954314721, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=347, Percent_Identity=32.2766570605187, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=415, Percent_Identity=30.1204819277108, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324059, Length=417, Percent_Identity=30.2158273381295, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321629, Length=400, Percent_Identity=27.75, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6320251, Length=398, Percent_Identity=27.1356783919598, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6320717, Length=399, Percent_Identity=26.0651629072682, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319824, Length=417, Percent_Identity=26.378896882494, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319542, Length=397, Percent_Identity=26.7002518891688, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319543, Length=393, Percent_Identity=26.972010178117, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321053, Length=451, Percent_Identity=25.2771618625277, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324981, Length=399, Percent_Identity=26.8170426065163, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322967, Length=401, Percent_Identity=26.1845386533666, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319608, Length=379, Percent_Identity=26.6490765171504, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320364, Length=507, Percent_Identity=23.2741617357002, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667468, Length=331, Percent_Identity=27.190332326284, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI161077963, Length=345, Percent_Identity=25.2173913043478, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48292; Mature: 48292

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVREPVPGSFGHYATENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPHVPQ
HHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAMIGGGAAILFTGMRLGSGGAP
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCCCCCCCC
SLANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERVIPRAINAVPMR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLFYVLTMIVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDI
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
FGAGRMMYAMALQGQAPRALAAMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAA
HCCHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SATFATVWVWLMILLSQVAMRRRLGAAEVAALKFKVPFWPVGPALTIAFMAFVIAMLGYF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCC
DDTRVALFVGAAWLAILALVFYTRIRPRLAAVAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNLQRHLSARHIRFLALGSAIGTGLFYGSASAIRLAGPAVILAYIVGGAAVYMVMRALG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EMAVREPVPGSFGHYATENLGPFAGFVTGWTYTLEMVIVAIADITAFGIYMGFWFPHVPQ
HHHHCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIWVLAIVAIICGLNLCHVKVFGELEFWLSIVKVGAIVAMIGGGAAILFTGMRLGSGGAP
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCCCCCCCC
SLANLWSHGGFLPNGVGGLVASLSVVIFAYGGIEVIGMSAGEAKEPERVIPRAINAVPMR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
ILLFYVLTMIVLMSIFPWTGVGANGSPFVQIFSALGVRSAAEILNLVVISAAISAINSDI
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
FGAGRMMYAMALQGQAPRALAAMSARGVPWVTVLVMAGALLVGVVLNYLMPKDVFLMVAA
HCCHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SATFATVWVWLMILLSQVAMRRRLGAAEVAALKFKVPFWPVGPALTIAFMAFVIAMLGYF
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHCCC
DDTRVALFVGAAWLAILALVFYTRIRPRLAAVAR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]