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The map label for this gene is hemF [H]

Identifier: 237811525

GI number: 237811525

Start: 1210621

End: 1211544

Strand: Reverse

Name: hemF [H]

Synonym: GBP346_A1255

Alternate gene names: 237811525

Gene position: 1211544-1210621 (Counterclockwise)

Preceding gene: 237811526

Following gene: 237811524

Centisome position: 29.56

GC content: 69.16

Gene sequence:

>924_bases
ATGACCGATTCGACTTACGACGTCAACCGAGTACGCGCTTACCTGCAAGGGCTGCAGACGCGCATCGCCGATGCGCTCGG
CGCCTTCGACGGCACGCCGCTCGCCGCCGACACGTGGCGGCGCGGCCCCGGCGAGCGGCTGCGCGGCGGCGGCTGCACGC
GCATTCTCGAGGCAGGCGGCTTCTTCGAGCGCGCGGGCATCGGCTTTTCCGACGTCGCGGGCGACGCGCTGCCGCCGTCG
GCGAGCGCATCGCGCCCGCAGCTCGCCGGGCGCGGCTTCGAGGCGCTCGGCGTATCGCTCGTGCTGCACCCGCGCAATCC
GTACTGCCCGACCGTCCACATGAACGTGCGGATGCTGATCGCGACGAAGCCGGGCGAGGCGCCCGTGTTCTGGTTCGGCG
GCGGCATGGATCTGACGCCGATTTACGGCTTCGAAGAGGATGCACGGCACTTCCACCGCACGTGCCGCGCGGCGCTCGAG
CCGTTCGGCGCCGAGCTGTACCCGCGCTTCAAGAAATGGTGCGACGACTATTTCTTCCTGAAACATCGCAACGAGGCGCG
CGGGATCGGCGGCATCTTCTTCGACGACTTCTCCGAGCTCGGCTTCGAACGCTCGTTCGAGATGCTGCAAAGCGTCGGCG
GCGCGTTCCTGCCATCGTACCTGCCGATCGTCGAGCACCGCCGCGACACGCCTTACGGCGAGCGCGAGCGCGCGTTCCAG
GCATACCGGCGCGGCCGCTACGTCGAGTTCAACCTGGTGTTCGACCGCGGCACGCTGTTCGGGCTGCAAAGCGGCGGGCG
CACCGAGTCCATCCTGCTGTCGATGCCGCCGACGGCGGGCTGGCGCTATGACTGGCATCCGGACCCGGGCACGCCCGAAG
CACGCCTGCAAAGCGAGTTCCTCGTGCCGCGCGACTGGGCATGA

Upstream 100 bases:

>100_bases
CAAGCCGGCCGGCGCGCCCTCTCCTCTGCCGGGGTTCGCTAGAATGCCCGGCAGAAGCATTTTTCGACGGCGTCCGCCAA
GCGGATGCCGCCCCACACCG

Downstream 100 bases:

>100_bases
GCCGCGCCGCCACCGGCCGAGCGGCCGCCCCGCAAGGCCCCACGCCGAACGCCGAGCCCGCGGGCCTGCCCGCGCTGCCG
CGCCGCATCGGCATCCTCGG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTDSTYDVNRVRAYLQGLQTRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGGFFERAGIGFSDVAGDALPPS
ASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALE
PFGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGGAFLPSYLPIVEHRRDTPYGERERAFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEFLVPRDWA

Sequences:

>Translated_307_residues
MTDSTYDVNRVRAYLQGLQTRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGGFFERAGIGFSDVAGDALPPS
ASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALE
PFGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGGAFLPSYLPIVEHRRDTPYGERERAFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEFLVPRDWA
>Mature_306_residues
TDSTYDVNRVRAYLQGLQTRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGGFFERAGIGFSDVAGDALPPSA
SASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALEP
FGAELYPRFKKWCDDYFFLKHRNEARGIGGIFFDDFSELGFERSFEMLQSVGGAFLPSYLPIVEHRRDTPYGERERAFQA
YRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEFLVPRDWA

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=302, Percent_Identity=44.7019867549669, Blast_Score=252, Evalue=4e-67,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=61.1295681063123, Blast_Score=380, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=43.8485804416404, Blast_Score=270, Evalue=3e-73,
Organism=Drosophila melanogaster, GI17864388, Length=313, Percent_Identity=45.3674121405751, Blast_Score=259, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34462; Mature: 34331

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSTYDVNRVRAYLQGLQTRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHCCC
FFERAGIGFSDVAGDALPPSASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLI
CHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHEECEEEEEECCCCCCCEEEEEEEEEE
ATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALEPFGAELYPRFKKWCDDYFFL
EECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHEEE
KHRNEARGIGGIFFDDFSELGFERSFEMLQSVGGAFLPSYLPIVEHRRDTPYGERERAFQ
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEF
HHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHCC
LVPRDWA
CCCCCCC
>Mature Secondary Structure 
TDSTYDVNRVRAYLQGLQTRIADALGAFDGTPLAADTWRRGPGERLRGGGCTRILEAGG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHCCC
FFERAGIGFSDVAGDALPPSASASRPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLI
CHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHEECEEEEEECCCCCCCEEEEEEEEEE
ATKPGEAPVFWFGGGMDLTPIYGFEEDARHFHRTCRAALEPFGAELYPRFKKWCDDYFFL
EECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHEEE
KHRNEARGIGGIFFDDFSELGFERSFEMLQSVGGAFLPSYLPIVEHRRDTPYGERERAFQ
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILLSMPPTAGWRYDWHPDPGTPEARLQSEF
HHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHCC
LVPRDWA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA