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The map label for this gene is trpF

Identifier: 23502959

GI number: 23502959

Start: 2036442

End: 2037110

Strand: Reverse

Name: trpF

Synonym: BR2111

Alternate gene names: 23502959

Gene position: 2037110-2036442 (Counterclockwise)

Preceding gene: 23502960

Following gene: 23502958

Centisome position: 96.65

GC content: 58.59

Gene sequence:

>669_bases
ATGGCCCTTGATATCAAAATATGCGGGTTGAAGACGCCTGAGGCTGTTGCCGCCGCGCTTGACGGCGGTGCAACGCATAT
CGGCTTCATTTTCTTTCCGAAAAGCCCGCGCCATATCACGCCGGATGCGGCTGCAAGACTGCGCGCCGCCGCCACAGGCC
GCGCCGTGGCCGTTGCGGTAACGGTCGATGCCGACGATGAAGCGCTGGATGAAATCGTCAAGACGGTCAGACCCGATATG
CTGCAACTGCATGGCGGAGAAACGCCGGAACGGGTGCGGTTTCTAAAAGAGCGTTATAACCTTCCGGTGATGAAGGCGTT
TTCAATCCGTGAAGCCGGCGATCTTGAAGCAATTGCGCCCTATCGGGGCATTGCCGATCGCTTCCTTTTCGACGCCAAGC
CGCCCAAGGGTTCCGAACTTCCAGGCGGCAACGGCATATCCTTCGACTGGAACCTGCTGGCCGCGCTTGACGCGGATATC
GATTACATGCTTTCCGGTGGATTGAATGCGGACAATATCGCCGAGGCGCTTTTGAAGACAGGCGCCCCCGGCATCGATAT
ATCGTCCGGGGTGGAGTGCGCGCCCGGCGAAAAGGACGTGCGTCTTATTGAGAATTTTTTCCAGGCCGTAGCGGATGCGA
ATGCTCAGCCATTCGCCAGGCGCGCCTGA

Upstream 100 bases:

>100_bases
AGGTCATGGAGGCGTATGATTTTCTGATCGAACAGGGTTTCGACGGGCATCCGGTCCGATAGCAACTTGAGTAGCGCCCT
GATTTGTGCGACGGAAACCT

Downstream 100 bases:

>100_bases
ACATGACGGAGCGGAAACGTTGAACAAGCCGGTTGCACCCAATTCCTACAAGACGGGCCCTGACGAAGAGGGCATGTTCG
GCATATTCGGTGGCCGCTTC

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MALDIKICGLKTPEAVAAALDGGATHIGFIFFPKSPRHITPDAAARLRAAATGRAVAVAVTVDADDEALDEIVKTVRPDM
LQLHGGETPERVRFLKERYNLPVMKAFSIREAGDLEAIAPYRGIADRFLFDAKPPKGSELPGGNGISFDWNLLAALDADI
DYMLSGGLNADNIAEALLKTGAPGIDISSGVECAPGEKDVRLIENFFQAVADANAQPFARRA

Sequences:

>Translated_222_residues
MALDIKICGLKTPEAVAAALDGGATHIGFIFFPKSPRHITPDAAARLRAAATGRAVAVAVTVDADDEALDEIVKTVRPDM
LQLHGGETPERVRFLKERYNLPVMKAFSIREAGDLEAIAPYRGIADRFLFDAKPPKGSELPGGNGISFDWNLLAALDADI
DYMLSGGLNADNIAEALLKTGAPGIDISSGVECAPGEKDVRLIENFFQAVADANAQPFARRA
>Mature_221_residues
ALDIKICGLKTPEAVAAALDGGATHIGFIFFPKSPRHITPDAAARLRAAATGRAVAVAVTVDADDEALDEIVKTVRPDML
QLHGGETPERVRFLKERYNLPVMKAFSIREAGDLEAIAPYRGIADRFLFDAKPPKGSELPGGNGISFDWNLLAALDADID
YMLSGGLNADNIAEALLKTGAPGIDISSGVECAPGEKDVRLIENFFQAVADANAQPFARRA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=209, Percent_Identity=34.4497607655502, Blast_Score=94, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320210, Length=212, Percent_Identity=30.6603773584906, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_BRUA1 (B2S9A6)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935932.1
- ProteinModelPortal:   B2S9A6
- SMR:   B2S9A6
- GeneID:   6327080
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I19760
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   PRK01222
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23614; Mature: 23483

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDIKICGLKTPEAVAAALDGGATHIGFIFFPKSPRHITPDAAARLRAAATGRAVAVAV
CEEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEE
TVDADDEALDEIVKTVRPDMLQLHGGETPERVRFLKERYNLPVMKAFSIREAGDLEAIAP
EECCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
YRGIADRFLFDAKPPKGSELPGGNGISFDWNLLAALDADIDYMLSGGLNADNIAEALLKT
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEEEECCCHHHHCCCCCCHHHHHHHHHHC
GAPGIDISSGVECAPGEKDVRLIENFFQAVADANAQPFARRA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ALDIKICGLKTPEAVAAALDGGATHIGFIFFPKSPRHITPDAAARLRAAATGRAVAVAV
EEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEE
TVDADDEALDEIVKTVRPDMLQLHGGETPERVRFLKERYNLPVMKAFSIREAGDLEAIAP
EECCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
YRGIADRFLFDAKPPKGSELPGGNGISFDWNLLAALDADIDYMLSGGLNADNIAEALLKT
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHEEEEECCCHHHHCCCCCCHHHHHHHHHHC
GAPGIDISSGVECAPGEKDVRLIENFFQAVADANAQPFARRA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA