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The map label for this gene is trpA [H]

Identifier: 23502956

GI number: 23502956

Start: 2033896

End: 2034735

Strand: Reverse

Name: trpA [H]

Synonym: BR2108

Alternate gene names: 23502956

Gene position: 2034735-2033896 (Counterclockwise)

Preceding gene: 23502957

Following gene: 23502955

Centisome position: 96.53

GC content: 58.93

Gene sequence:

>840_bases
ATGACTACTCGCATCGACACCAAATTCGCCGAACTGAAGGCCGAGGGCCGTCCGGCGCTCGTCACCTATTTCATGGGCGG
CGATCCCGATCTGGAAACCGCGCTGAAGGTGATGAAAGCCCTGCCGAAAGCCGGCGCTGACGTGATCGAGCTTGGTATGC
CCTTCTCCGACCCGATGGCGGATGGACCCGCCATTCAGGCGGCTGGCCTTCGCGCCCTGAACGCCGGACAGACGCTGGCG
AAGACGCTTTATATGGCAGCAGAATTCCGCAAGGAAGACGATACGACCCCGATCGTCATGATGGGCTATTACAATCCGAT
CTATGTCTATGGCGTGGAGCGTTTTCTGACCGATGCCAAGGCATCCGGCGTGGATGGGCTGATCGTTGTCGATCTTCCTT
CCGAAATGGATGCCGAGCTTTGCATTCCGGCAATGAAGGCGGGCATCAATTTCATCCGCCTCACCACGCCGACCACGGAC
GACAAGCGCCTGCCGAAAGTGCTGCATAATTCATCGGGCTTTGTCTATTATGTCTCGATGAACGGCATCACCGGCGCGGC
CATTGCCGATACGGCAAAGGTCGGCGAAGCGGTTCGCCATATCAAGAAAAGCACCGACCTGCCGATCTGTGTCGGTTTCG
GCGTCAAGACGCCGGAACAGGCTGCGGCAATCGCAACCCATGCCGATGGCGTCGTCGTGGGCACGGCCATTGTCAACGCA
ATTGCCGGTGAACTCGATGAAAAGGGCAAGGTGAAGGGTGATCCGGTTGCCGCCGCAACCCGGCTTGTCCACGCTCTTGC
AGAGAGTGTGCGCGCCACACGCCTTGAAGCCGCCCAATAA

Upstream 100 bases:

>100_bases
TTGGGATTATTGATTTTGAACGGCGTGCATGGATGGAAACGGCAATGGCTGGCAAGCCTGTTGCCGATTATCTCGCACGC
ACTTTGCCACGGGGCACGGT

Downstream 100 bases:

>100_bases
ATCGTCCATTTAAGCGGCTGAGAAGTCGTTGCCGAAGAACAAGAAACGGAACCAAACGTCATGAACTGGATCACCAACTA
CGTTCGTCCGAAGATCAATT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTTRIDTKFAELKAEGRPALVTYFMGGDPDLETALKVMKALPKAGADVIELGMPFSDPMADGPAIQAAGLRALNAGQTLA
KTLYMAAEFRKEDDTTPIVMMGYYNPIYVYGVERFLTDAKASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLTTPTTD
DKRLPKVLHNSSGFVYYVSMNGITGAAIADTAKVGEAVRHIKKSTDLPICVGFGVKTPEQAAAIATHADGVVVGTAIVNA
IAGELDEKGKVKGDPVAAATRLVHALAESVRATRLEAAQ

Sequences:

>Translated_279_residues
MTTRIDTKFAELKAEGRPALVTYFMGGDPDLETALKVMKALPKAGADVIELGMPFSDPMADGPAIQAAGLRALNAGQTLA
KTLYMAAEFRKEDDTTPIVMMGYYNPIYVYGVERFLTDAKASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLTTPTTD
DKRLPKVLHNSSGFVYYVSMNGITGAAIADTAKVGEAVRHIKKSTDLPICVGFGVKTPEQAAAIATHADGVVVGTAIVNA
IAGELDEKGKVKGDPVAAATRLVHALAESVRATRLEAAQ
>Mature_278_residues
TTRIDTKFAELKAEGRPALVTYFMGGDPDLETALKVMKALPKAGADVIELGMPFSDPMADGPAIQAAGLRALNAGQTLAK
TLYMAAEFRKEDDTTPIVMMGYYNPIYVYGVERFLTDAKASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLTTPTTDD
KRLPKVLHNSSGFVYYVSMNGITGAAIADTAKVGEAVRHIKKSTDLPICVGFGVKTPEQAAAIATHADGVVVGTAIVNAI
AGELDEKGKVKGDPVAAATRLVHALAESVRATRLEAAQ

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=265, Percent_Identity=34.7169811320755, Blast_Score=150, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6321412, Length=239, Percent_Identity=43.0962343096234, Blast_Score=197, Evalue=1e-51,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 29456; Mature: 29325

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRIDTKFAELKAEGRPALVTYFMGGDPDLETALKVMKALPKAGADVIELGMPFSDPMA
CCCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
DGPAIQAAGLRALNAGQTLAKTLYMAAEFRKEDDTTPIVMMGYYNPIYVYGVERFLTDAK
CCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEHHHHHHHHH
ASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLTTPTTDDKRLPKVLHNSSGFVYYVSM
CCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEE
NGITGAAIADTAKVGEAVRHIKKSTDLPICVGFGVKTPEQAAAIATHADGVVVGTAIVNA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCCCEEHHHHHHHH
IAGELDEKGKVKGDPVAAATRLVHALAESVRATRLEAAQ
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTRIDTKFAELKAEGRPALVTYFMGGDPDLETALKVMKALPKAGADVIELGMPFSDPMA
CCCCCCHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
DGPAIQAAGLRALNAGQTLAKTLYMAAEFRKEDDTTPIVMMGYYNPIYVYGVERFLTDAK
CCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEHHHHHHHHH
ASGVDGLIVVDLPSEMDAELCIPAMKAGINFIRLTTPTTDDKRLPKVLHNSSGFVYYVSM
CCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEE
NGITGAAIADTAKVGEAVRHIKKSTDLPICVGFGVKTPEQAAAIATHADGVVVGTAIVNA
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHCCCCCEEHHHHHHHH
IAGELDEKGKVKGDPVAAATRLVHALAESVRATRLEAAQ
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA