Click here to switch to the map view.

The map label for this gene is hemE

Identifier: 23502914

GI number: 23502914

Start: 1992831

End: 1993856

Strand: Reverse

Name: hemE

Synonym: BR2066

Alternate gene names: 23502914

Gene position: 1993856-1992831 (Counterclockwise)

Preceding gene: 23502920

Following gene: 23502913

Centisome position: 94.59

GC content: 55.65

Gene sequence:

>1026_bases
ATGAATCGCAAGGTCTTGAAAGTGATCGACGGGGAAACAGTCTTTCCACCACCCATCTGGATGATGCGGCAGGCTGGGCG
CTATCTTCCCGAATATCGCGAAACACGGAAGAAGGCCGGAAGCTTTCTCGATTTGTGTTATTCGCCCGATCTGGCAGTTG
AAGTGACATTGCAGCCAATCCGCCGTTTCGGTTTTGATGCCGCCATTCTGTTTTCAGATATTCTTGTCGTCCCTCATGCA
CTTGGGCGAGACCTTCGCTTTGAAGAAGGCAAGGGACCATTGATGACGCCTATCGACGCCGATGAAATATTCTGGCTGGA
AACAGAAGGTGTCGCAAAGAGGCTGGAGCCGGTCTATGAGACGGTACGGCTGGTGCGCGAGCAACTCCCCGACGAAACCA
CGCTGCTTGGCTTCTGTGGCGCTCCCTGGACCGTTGCAACCTATATGATAGCCGGTCATGGCACACCCGATCAGGCGCCA
GCCCGTCTTTTCGCCTATCGTTTCCCCGAAGCTTTTGAAAAGCTCCTCAACGATCTCGCCGATGTTTCTGCGGAATATCT
GATCGAACAGCTTGGAGCTGGCGCAGATGCGGTCCAGATTTTCGATTCCTGGTCCGGTGTTCTGGATGAGGATTGCTTTG
AACGGTTCTGTATCCGCCCTGTTGCCCGGATCGTGCAGAAGGTGAGGGCGGTTTACCCGCAGGCCCGGATCATCGGCTTT
CCGAAGGGAGCGGGGATGCTCTATGCCGGGTATCGCGAGAAAACCGGCGTGGATATGCTGGGCCTCGACTGGTCGGTTCC
CCTGTCCTTTGCTGCCCTTCTTCAGGAAGAGGGCGCCGTTCAGGGCAATCTCGATCCCTTGCGCGTGGTTGCTGGCGGAA
ATGCGCTTGATGAAGGTGTTGATGCCATTCTGGAGCGTATGGGGCAGGGGCCGCTTGTCTTCAATCTCGGCCATGGTATT
ACACCGCAGGCGCCAATTGAAAATGTTCAGCGTATGATCGACAGGGTTCGCGGGGGGAAATCATGA

Upstream 100 bases:

>100_bases
AAGAATCAAAAGATTCCTGAATCATCCTTTCTTTATGAGAACCGGAACTGGATAAGTACGGAACCGGCCAACCCAACCAA
CAGCGTGGAATGGACAACCA

Downstream 100 bases:

>100_bases
CAGCAGCAACACCGGACAATAGTGGGCGGGCTGTGCTGATACGCACCGTCGTTTCACTGGTAATCGTGGTGCTCGGCGTC
TGGGCATTGTTTCACGTGAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MNRKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHA
LGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYETVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAP
ARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGF
PKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGVDAILERMGQGPLVFNLGHGI
TPQAPIENVQRMIDRVRGGKS

Sequences:

>Translated_341_residues
MNRKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHA
LGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYETVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAP
ARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGF
PKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGVDAILERMGQGPLVFNLGHGI
TPQAPIENVQRMIDRVRGGKS
>Mature_341_residues
MNRKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHA
LGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYETVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAP
ARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGF
PKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGVDAILERMGQGPLVFNLGHGI
TPQAPIENVQRMIDRVRGGKS

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=344, Percent_Identity=37.5, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI2367337, Length=345, Percent_Identity=41.1594202898551, Blast_Score=226, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6320252, Length=338, Percent_Identity=36.094674556213, Blast_Score=194, Evalue=1e-50,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=37.5, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=37.7906976744186, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_BRUA1 (B2S965)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935891.1
- ProteinModelPortal:   B2S965
- SMR:   B2S965
- GeneID:   6327039
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I19350
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37831; Mature: 37831

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 73-73 BINDING 148-148 BINDING 203-203 BINDING 318-318

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPI
CCCCEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEEHHHH
RRFGFDAAILFSDILVVPHALGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYE
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHH
TVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFAYRFPEAFEKLLNDLA
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHH
DVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGF
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEC
PKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGV
CCCCCEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHH
DAILERMGQGPLVFNLGHGITPQAPIENVQRMIDRVRGGKS
HHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNRKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPI
CCCCEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEEHHHH
RRFGFDAAILFSDILVVPHALGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYE
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHH
TVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFAYRFPEAFEKLLNDLA
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHH
DVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGF
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEC
PKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGV
CCCCCEEEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHH
DAILERMGQGPLVFNLGHGITPQAPIENVQRMIDRVRGGKS
HHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA