Click here to switch to the map view.

The map label for this gene is ppiC [C]

Identifier: 23502793

GI number: 23502793

Start: 1873109

End: 1874104

Strand: Reverse

Name: ppiC [C]

Synonym: BR1943

Alternate gene names: 23502793

Gene position: 1874104-1873109 (Counterclockwise)

Preceding gene: 23502794

Following gene: 23502792

Centisome position: 88.91

GC content: 57.83

Gene sequence:

>996_bases
ATGAAAGCCATTCTCAAAGTCCCTTGCCGCAAGGCTCTGGCCGTTCTTGCAGCGTCGGTTGCGCTGGCAAGTTTTTCCGC
TCCTTTTTCTGCATCGGCTGTCTTTGCGCAAGATGCCGCTCCAGGCACTGAAAAGGTCGCTGCCACAACGGCGGCAGCGT
CTGCGGAAAAGGACGATCCGTCCAAGGTTCTGGCGACCATCAACGGCAAGGACATCACGGTTGGTGAGGTCGATCAGGCT
GCTGGCGATCTCGACCCGCAGTTCGCTCGCCTTCCGGTCGAGCAGCGTCGCCTTGCAGCCCTTGCAGCCCTGATCGACAT
CAAGGCGATGGCTGGTGAAGCGGAAAAAGACAAGCTCGACCAGACCAAGGAATTCAAGGACCGTATGGAATTCCTGCGCG
AACGCGCGCTCCATAACGAATATTTCAAGAATGCGATTGTTGACAAGATCAGCGACGCGGATGTTCGCGCCCGCTACGAC
AAGGAAATCGCCGCCATGCCGCCGCAGGTGGAAGTGCGCGCGCGTCACATTCTTGTAAAGACCAAGGAAGAAGCCGAAGC
CATCATCAAGAAGCTTGAAGGCGGCGCCAAGTTCGAGGACCTTGCCAAGGCAAGCTCGACCGATGGCACGGCCTCCAGCG
GAGGTGATCTCGGCTACTTCAGCGAAGGCCAGATGGTGCCTGAATTTGAAAAGGCAGCTTTTGCGCTGAAGCCCGGCGAA
TACACCAAGGAGCCGGTTCAGACCCAGTTCGGCTATCATGTGATCCAGCTTGAGGACCGCCGCACCAAGCAGCCACCGGC
ATATGACCAGGTCAAGGACCAGATCCGCTCCATCATCATGCGCGAGCGCTACATCGAAACGGTGAAGAAGCTGCGTGATG
GCTTGAAGATCGACTATAAGGATCCTGCCATCGAAAAAGCCATGAAGGATGCGGCCGCTGCGCAGGAAGCCTCCGGAAAG
GACGATGCGTCGGAAGACGACGCCCCGCAGGAGTAG

Upstream 100 bases:

>100_bases
GGCTGGAAAACCTGTCGGTTGTTACAATACAGGGCATATCCGGGCCAAATTCCGCCGCATTCATCGGGCCGGTAAGCGGT
CCCGAAGGAGAGAATTTCAT

Downstream 100 bases:

>100_bases
GCCGTTTTATAGGCCTGCCTCCCGGTGAGGGGCAGGCTCTATTAATCTGGTCACAATAGTGTGAGGCCATCCGTTCGGAT
ACGAGCCGAAAAGACGAAGG

Product: peptidyl-prolyl cis-trans isomerase

Products: peptidylproline (omega=0) [C]

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKAILKVPCRKALAVLAASVALASFSAPFSASAVFAQDAAPGTEKVAATTAAASAEKDDPSKVLATINGKDITVGEVDQA
AGDLDPQFARLPVEQRRLAALAALIDIKAMAGEAEKDKLDQTKEFKDRMEFLRERALHNEYFKNAIVDKISDADVRARYD
KEIAAMPPQVEVRARHILVKTKEEAEAIIKKLEGGAKFEDLAKASSTDGTASSGGDLGYFSEGQMVPEFEKAAFALKPGE
YTKEPVQTQFGYHVIQLEDRRTKQPPAYDQVKDQIRSIIMRERYIETVKKLRDGLKIDYKDPAIEKAMKDAAAAQEASGK
DDASEDDAPQE

Sequences:

>Translated_331_residues
MKAILKVPCRKALAVLAASVALASFSAPFSASAVFAQDAAPGTEKVAATTAAASAEKDDPSKVLATINGKDITVGEVDQA
AGDLDPQFARLPVEQRRLAALAALIDIKAMAGEAEKDKLDQTKEFKDRMEFLRERALHNEYFKNAIVDKISDADVRARYD
KEIAAMPPQVEVRARHILVKTKEEAEAIIKKLEGGAKFEDLAKASSTDGTASSGGDLGYFSEGQMVPEFEKAAFALKPGE
YTKEPVQTQFGYHVIQLEDRRTKQPPAYDQVKDQIRSIIMRERYIETVKKLRDGLKIDYKDPAIEKAMKDAAAAQEASGK
DDASEDDAPQE
>Mature_331_residues
MKAILKVPCRKALAVLAASVALASFSAPFSASAVFAQDAAPGTEKVAATTAAASAEKDDPSKVLATINGKDITVGEVDQA
AGDLDPQFARLPVEQRRLAALAALIDIKAMAGEAEKDKLDQTKEFKDRMEFLRERALHNEYFKNAIVDKISDADVRARYD
KEIAAMPPQVEVRARHILVKTKEEAEAIIKKLEGGAKFEDLAKASSTDGTASSGGDLGYFSEGQMVPEFEKAAFALKPGE
YTKEPVQTQFGYHVIQLEDRRTKQPPAYDQVKDQIRSIIMRERYIETVKKLRDGLKIDYKDPAIEKAMKDAAAAQEASGK
DDASEDDAPQE

Specific function: Ppiases Accelerate The Folding Of Proteins. It Prefers Amino Acid Residues With Hydrophobic Side Chains Like Leucine And Phenylalanine In The P1 Position Of The Peptides Substrates. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=96, Percent_Identity=41.6666666666667, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790211, Length=88, Percent_Identity=44.3181818181818, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17537235, Length=96, Percent_Identity=46.875, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356303, Length=95, Percent_Identity=41.0526315789474, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 36108; Mature: 36108

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAILKVPCRKALAVLAASVALASFSAPFSASAVFAQDAAPGTEKVAATTAAASAEKDDP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCH
SKVLATINGKDITVGEVDQAAGDLDPQFARLPVEQRRLAALAALIDIKAMAGEAEKDKLD
HHEEEEECCCEEEECCHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QTKEFKDRMEFLRERALHNEYFKNAIVDKISDADVRARYDKEIAAMPPQVEVRARHILVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHCCCCCHHHHHHHHEEE
TKEEAEAIIKKLEGGAKFEDLAKASSTDGTASSGGDLGYFSEGQMVPEFEKAAFALKPGE
CHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEECCCC
YTKEPVQTQFGYHVIQLEDRRTKQPPAYDQVKDQIRSIIMRERYIETVKKLRDGLKIDYK
CCCCHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
DPAIEKAMKDAAAAQEASGKDDASEDDAPQE
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKAILKVPCRKALAVLAASVALASFSAPFSASAVFAQDAAPGTEKVAATTAAASAEKDDP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCH
SKVLATINGKDITVGEVDQAAGDLDPQFARLPVEQRRLAALAALIDIKAMAGEAEKDKLD
HHEEEEECCCEEEECCHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QTKEFKDRMEFLRERALHNEYFKNAIVDKISDADVRARYDKEIAAMPPQVEVRARHILVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHCCCCCHHHHHHHHEEE
TKEEAEAIIKKLEGGAKFEDLAKASSTDGTASSGGDLGYFSEGQMVPEFEKAAFALKPGE
CHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEECCCC
YTKEPVQTQFGYHVIQLEDRRTKQPPAYDQVKDQIRSIIMRERYIETVKKLRDGLKIDYK
CCCCHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
DPAIEKAMKDAAAAQEASGKDDASEDDAPQE
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]